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Gallbladder Metastasis of Non-small Cell Lung Cancer Presenting as Acute Cholecystitis

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Chinese Journal of Cancer Research 2012年第3期24卷 249-252页

作者： Yu-Sook Jeong Hye-Suk Han Sung-Nam Lim Mi-Jin Kim Joung-Ho Han Min-Ho Kang dong-hee ryu Ok-Jun Lee Ki-Hyeong Lee Seung-Taik Kim Department of Internal Medicine College of MedicineChungbuk National University Department of Radiology College of MedicineChungbuk National University Department of Surgery College of MedicineChungbuk National University Department of Pathology College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University

Although non-small cell lung cancer （NSCLC） can metastasize to almost any organ, metastasis to the gallbladder with significant clinical manifestation is relatively rare. Here, we report a case of gallbladder metastasis of NSCLC presenting as acute cholecystitis. A 79-year-old man presented with pain in the right upper quadrant and fever. A computed tomography （CT） scan of the chest and abdomen showed a cavitary mass in the right lower lobe of the lung and irregular wall thickening of the gallbladder. Open cholecystectomy and needle biopsy of the lung mass were performed. Histological examination of the gallbladder revealed a moderately-differentiated squamous cell carcinoma displaying the same morphology as the lung mass assessed by needle biopsy. Subsequent immunohistochemical examination of the gallbladder and lung tissue showed that the tumor cells were positive for P63 but negative for cytokeratin 7, cytokeratin 20 and thyroid transcription factor-1. A second primary tumor of the gallbladder was excluded by immunohistochemical methods, and the final pathological diagnosis was gallbladder metastasis of NSCLC. Although the incidence is extremely rare, acute cholecystitis can occur in association with lung cancer metastasis to the gallbladder.

关键词： Cholecystitis Gallbladder Non-small cell lung cancer Metastasis

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

New prognostic model for patients with advanced gastric cancer:Fluoropyrimidine/platinum doublet for first-line chemotherapy

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World Journal of Gastroenterology 2021年第48期27卷 8357-8369页

作者： dong-Hoe Koo Min-hee ryu Mi-Yeon Lee Mee-Sun Moon Yoon-Koo Kang Division of Hematology/Oncology Department of Internal MedicineKangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 03181South Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Biostatistics Department of R&D ManagementKangbuk Samsung HospitalSeoul 03181South Korea

BACKGROUND New prognostic factors have been reported in patients with metastatic or recurrent gastric cancer(MRGC),necessitating modifications to the previous prognostic *** To develop a new model,MRGC patients who received fluoropyrimidines/platinum doublet chemotherapy between 2008 and 2015 were *** A total of 1883 patients was divided into a training set(n=937)and an independent validation set(n=946).RESULTS Multivariate analysis showed that the following six factors were associated with poor overall survival(OS)in the training set:Eastern Cooperative Oncology Group performance score≥2 and bone metastasis(2 points each),peritoneal metastasis,high alkaline phosphatase level,low albumin level,and high neutrophil-lymphocyte ratio(1 point each).A prognostic model was developed by stratifying patients into good(0-1 point),moderate(2-3 points),and poor(≥4 points)risk *** the validation set,the median OS of the three risk groups was 15.8,10.1,and 5.7 mo,respectively,and those differences were significant(P<0.001).CONCLUSION We identified six factors readily measured in clinical practice that are predictive of poor prognosis in patients with *** new model is simpler than the old and more easily predicts OS.

关键词： Stomach neoplasms Chemotherapy Prognosis Validation Gastric cancer

Recent progress in quasi-two-dimensional and quantum dot perovskite light-emitting diodes harnessing the diverse effects of ligands:A review

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Nano Research 2022年第7期15卷 6449-6465页

作者： Yurim Bae Jun ryu Saemon Yoon dong-Won Kang School of Energy Systems Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Smart City Chung-Ang UniversitySeoul 06974Republic of Korea

Halide perovskites have been extensively studied for use as light-emitting diodes(LEDs)in next-generation displays due to their beneficial characteristics,including their high color purity and wide color *** perovskites can be categorized into four representative structures:three-dimensional(3D)bulk,two-dimensional(2D),quasi-two-dimensional(quasi-2D),and quantum dot(QD).Recently,excellent advances in the performance of perovskite LEDs(PeLEDs),especially those with quasi-2D and QD architectures,have been demonstrated with the incorporation of organic chain *** can both modify the structure of PeLEDs,such as forming multi-quantum wells in quasi-2D PeLEDs and essential passivation layers in QD PeLEDs,and also enhance their optical *** appropriate use of ligands in PeLEDs can thus lead to greater luminescence,current efficiency,power efficiency,and external quantum *** this review,the principal roles of ligands in quasi-2D and QD PeLEDs are systematically ***,current limitations and future perspectives are discussed in detail.

关键词： perovskites light emitting diode ligands quasi-two-dimensional(quasi-2D) quantum dot

Korean red ginseng promotes hippocampal neurogenesis in mice

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Neural Regeneration Research 2020年第5期15卷 887-893页

作者： Sun ryu Hyongjun Jeon hee-Young Kim Sungtae Koo Seungtae Kim Korean Medicine Research Center for Healthy Aging Pusan National University49 Busandaehak-roMulgeum-eupYangsan-siGyeongsangnam-do 50612Republic of Korea Department of Korean Medical Science School of Korean MedicinePusan National University49 Busandaehak-roMulgeum-eupYangsan-siGyeongsangnam-do 50612Republic of Korea

Neurogenesis in the adult hippocampus plays a major role in cognitive ability of animals including learning and *** red ginseng (KRG) has long been known as a medicinal herb with the potential to improve learning and memory;however,the mechanisms are still ***,we evaluated whether KRG can promote cognitive function and enhance neurogenesis in the ***-week-old male C57BL/6 mice received 50 mg/kg of 5-bromo-2′-deoxyuridine (BrdU) intraperitoneally and 100 mg/kg of KRG or vehicle orally once a day for 14 ***,Rotarod and Morris water maze tests were performed and the brains were collected after the last behavioral *** in the numbers of BrdU- and BrdU/ doublecortin (DCX;a marker for neuronal precursor cells and immature neurons)-positive cells in the dentate gyrus and the gene expression of proliferating cell nuclear antigen (a marker for cell differentiation),cerebral dopamine neurotrophic factor and ciliary neurotrophic factor in the hippocampus were then ***-treated mice came down the pole significantly faster and stood on the rotarod longer than vehicle-treated *** Morris water maze test showed that KRG administration enhanced the learning and memory abilities *** also significantly increased BrdU- and BrdU/DCX-positive cells in the dentate gyrus as well as the proliferating cell nuclear antigen,cerebral dopamine neurotrophic factor and ciliary neurotrophic factor mRNA expression levels in the hippocampus compared to *** of KRG promotes learning and memory abilities,possibly by enhancing hippocampal *** study was approved by the Pusan National University Institutional Animal Care and Use Committee (approval ***-2016-1071) on January 19,2016.

关键词： bromodeoxyuridine cerebral dopamine neurotrophic factor ciliary neurotrophic factor doublecortin ginseng hippocampus Korean red ginseng learning memory neurogenesis proliferating cell nuclear antigen red ginseng

Experimental Investigation of Flexible Hawkmoth-like Wings on the Wing-wake Interaction in Hovering Flight

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Journal of Bionic Engineering 2018年第1期15卷 139-153页

作者： YeongGyun ryu Jo Won Chang Joon Chung dong-Ha Kim Department of Aerospace Engineering Ryerson University Toronto Ontario M5B 2K3 Canada Department of Aeronautical Science and Flight Operation Korea Aerospace University 76 Hanggongdaehak-ro Deogyang-gu Goyang-si Gyeonggi-do 10540 Republic of Korea Aerodynamics Group Korean Air R&D Center Daejeon Metropolitan City 34054 Republic of Korea

To study wing-wake interaction for various wing flexibilities, force measurements and digital particle image velocimetry were carried out on flapping hawkmoth-like wings in a water tank. Wing thickness was employed as a design variable for the wing flexi- bility distributions. Abrupt flap-down and phase delay in flexible wings influenced the behaviors of the Leading-Edge Vortex （LEV） and Trailing-Edge Vortex （TEV）, generated by the previous stroke. While the rigid wing exhibited a detached LEV at the end of the stroke, wing with specific flexibilities obtained attached LEVs. The attached LEVs induced a relatively rapid flow toward the wing surface as a result of encountering the TEV, and the flow caused a higher lift peak. On the other hand, the wings with larger wing deformations generated distinctive changes in LEV and TEV behaviors. The flap-down helped the TEV form closer to the wing surface, and it thus caused a downwash rather than wing-wake interaction. Furthermore, the most flexible wing had a newly-formed pair of LEVs above the wing during the wing reversal, thereby being not able to generate the wing-wake interaction. These results help to understand the different vortex structures generated by flexible wings during the wing reversal and the corresponding effects of wing-wake interaction.

关键词： hovering flight flexible hawkmoth wings wing-wake interaction Digital Particle Image Velocimetry (DPIV)

Micro/nanofabrication of heat management materials for energy-efficient building facades

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Microsystems & Nanoengineering 2024年第4期10卷 115-137页

作者： Guanya Wang Keunhyuk ryu Zhaogang dong Yuwei Hu Yujie Ke ZhiLi dong Yi Long Department of Electronic Engineering The Chinese University of Hong KongShatinNew Territories999077 Hong Kong SARChina School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)2 Fusionopolis WayInnovis#08-03Singapore 138634Singapore School of Interdisciplinary Studies Lingnan UniversityTuen MunNew Territories999077 Hong Kong SARChina

Advanced building facades,which include windows,walls,and roofs,hold great promise for reducing building energy *** recent decades,the management of heat transfer via electromagnetic radiation between buildings and outdoor environments has emerged as a critical research field aimed at regulating solar irradiation and thermal emission *** advancements have led to the widespread utilization of advanced micro/nanofabrication *** review provides the first comprehensive summary of fabrication methods for heat management materials with potential applications in energy-efficient building facades,with a particular emphasis on recent developments in fabrication processing and material property *** methods include coating,vapor deposition,nanolithography,printing,etching,and ***,we present our perspectives regarding their advantages and disadvantages and our opinions on the opportunities and challenges in this *** review is expected to expedite future research by providing information on the selection,design,improvement,and development of relevant fabrication techniques for advanced materials with energy-efficient heat management capabilities.

关键词： energy walls printing

Adaptive Electrospinning System Based on Reinforcement Learning for Uniform‑Thickness Nanofiber Air Filters

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Advanced Fiber Materials 2023年第2期5卷 617-631页

作者： Seok Hyeon Hwang Jin Yeong Song Hyun Il ryu Jae hee Oh Seungwook Lee donggeun Lee dong Yong Park Sang Min Park School of Mechanical Engineering Pusan National University63‑2 Busan University‑roGeumjeong‑guBusan 46241South Korea Smart Manufacturing Technology R&D Group Korea Institute of Industrial Technology320 Techno Sunhwan‑roYuga‑eupDalseong‑gunDaegu 42994Republic of Korea

Electrospinning is a simple and versatile method to produce nanofiber ***,owing to bending instability that occurs during the electrospinning process,electrospinning has frequently produced a non-uniform-thickness nanofiber filter,which deteriorates its air ***,an adaptive electrospinning system based on reinforcement learning(E-RL)was developed to produce uniform-thickness nanofiber *** E-RL accomplished a real-time thickness measurement of an electrospun nanofiber filter by measuring the transmitted light through the nanofiber filter using a camera placed at the bottom of the collector and converting it into thickness using the Beer–Lambert *** on the measured thickness,the E-RL detected the non-uniformity of the nanofiber filter thickness and manipulated the movable collector to alleviate the non-uniformity of the thickness by a pre-trained reinforcement learning(RL)*** the training of the RL algo-rithm,the nanofiber production simulation software based on the empirical model of the deposition of the nanofiber filter was developed,and the training process of the RL algorithm was repeated until the optimal policy was *** the training process with the simulation software,the trained model was transferred to the adaptive electrospinning *** the movement of the collector under the optimal strategy of RL algorithm,the non-uniformity of such nanofiber filters was significantly reduced by approximately five times in standard deviation and error for both simulation and *** finding has great potential in improving the reliability of electrospinning process and nanofiber filters used in research and industrial fields such as environment,energy,and biomedicine.

关键词： Electrospinning Nanofiber filter Uniform thickness Reinforcement learning Deep Q-network

Difference in extrusion temperature dependences of microstructure and mechanical properties between extruded AZ61 and AZ91 alloys

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Journal of Magnesium and Alloys 2023年第5期11卷 1683-1696页

作者： dong hee Lee Gyo Myeong Lee Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

The effects of extrusion temperature on the microstructure and tensile properties of extruded AZ61 and AZ91 alloys are investigated by subjecting them to hot extrusion at 300 and 400℃.Although the average grain size of the extruded AZ61 alloy slightly increases from 9.5 to 12.6μm with increasing extrusion temperature,its resultant microstructural variation is *** contrast,the average grain size of the extruded AZ91 alloy significantly increases from 5.7 to 22.5μm with increasing extrusion temperature,and the type of Mg17Al12 precipitates formed in it changes from fine dynamic precipitates with a spherical shape to coarse static precipitates with a lamellar *** the extrusion temperature increases,the tensile yield strength of the extruded AZ61 alloy increases from 183 to 197 MPa while that of the extruded AZ91 alloy decreases from 232 to 224 *** tensile elongations of the extruded AZ61 and AZ91 alloys decrease with increasing extrusion temperature,but the degree of decrease is significant in the latter *** different extrusion temperature dependences of the tensile properties of the extruded AZ61 and AZ91 alloys are discussed in terms of their microstructural characteristics,strengthening mechanisms,and crack initiation sites.

关键词： Mg-Al-Zn alloys Extrusion temperature Precipitation Strengthening mechanism Tensile properties