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A special recurrent pattern in small hepatocellular carcinoma after treatment:Bile duct tumor thrombus formation

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World Journal of Gastroenterology 2011年第43期17卷 4817-4824页

作者： Qing-Yu Liu dong-Ming lai Chao Liu Lei Zhang Wei-dong Zhang Hai-Gang Li Ming Gao Department of Radiology Sun Yatsen Memorial Hospital Sun Yat-sen University Guangzhou 510120 Guangdong Province China

AIM:To investigate the clinicopathologic features of bile duct tumor thrombus(BDTT) occurrence after treatment of primary small hepatocellular carcinoma(sHCC) .METHODS:A total of 423 patients with primary sHCC admitted to our hospital underwent surgical resection or local *** follow-up,only six patients were hospitalized due to obstructive jaundice,which occurred 5-76 mo after initial *** clinicopathologic features of these six patients were ***:Six patients underwent hepatic resection(n=5) or radio-frequency ablation(n=1) due to primary *** cases had an R1 resection margin,and one case had an ablative margin less than 5.0 *** vascular infiltration,microsatellites or bile duct/canaliculus affection was noted in the initial resected *** the follow-up,imaging studies revealed a macroscopic BDTT extending to the common bile duct in all six *** patients had a concomitant intrahepatic recurrent *** re-resection of intrahepatic recurrent tumors and removal of BDTTs(n=4) ,BDTT removal through choledochotomy(n= 1) ,and conservative treatment(n=1) was *** portal vein invasion was noted in three of the four resected *** six patients died,with a mean survival of 11 mo after BDTT removal or conservative ***:BDTT occurrence is a rare,special recurrent pattern of primary *** with BDTTs extending to the common bile duct usually have an unfavorable prognosis even following aggressive *** resection or ablative margins against primary sHCC may be a risk factor for BDTT development.

关键词： Small hepatocellular carcinoma Recurrence Bile ducts Jaundice Diagnosis

慢性肺源性心脏病应用心脏彩超行病情评估的价值研究

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安徽医专学报 2024年第4期23卷 49-51页

作者：凌艳招赖东斌曾慧玲寻乌县中医院江西寻乌342200

目的:探讨心脏彩超中特异性指标在评估肺源性心脏病临床研究价值。方法:将医院收治的62例稳定期慢性肺源性心脏病患者依据住院治疗期间是否出现心脏失代偿临床表现分为代偿组(SP组,51例)及失代偿组(DP组,11例)。于接诊首日采用心脏彩超... 详细信息

目的:探讨心脏彩超中特异性指标在评估肺源性心脏病临床研究价值。方法:将医院收治的62例稳定期慢性肺源性心脏病患者依据住院治疗期间是否出现心脏失代偿临床表现分为代偿组(SP组,51例)及失代偿组(DP组,11例)。于接诊首日采用心脏彩超技术对两组的血管和心脏参数进行评估。Spearman分析法分析上述指标与肺源性心脏病临床的相关性;ROC曲线分析各指标的对失代偿转归的参考价值。结果:SP组患者Nakata指数、左室等容舒张时间、肺动脉压力指标均低于DP组(P<0.05);Mcgoon指数、主动脉瓣口面积、左室射血分数、E波减速时A峰E峰流速比值则升高(P<0.05)。Nakata指数、肺动脉压力与失代偿进展呈负相关;主动脉瓣口面积、左室射血分数、左室等容舒张时间、E波减速时A峰E峰流速比值与慢性肺源性心脏病失代偿进展存在线性正相关;全参数评估病情转归的ROC曲线下面积较优(AUC=0.806)。结论:心脏彩超指标在慢性肺源性心脏病早期病情评估、失代偿恶化进程中,有极高临床参考、应用意义及价值。

关键词：肺源性心脏病心脏彩超病情评估心血管参数

Controlling Flow Instability in Straight Spur Gear Forging Using Numerical Simulation and Response Surface Method

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Acta Metallurgica Sinica(English Letters) 2018年第1期31卷 82-96页

作者： Zhao-Yang Jin Nan-Nan Li Kai Yan Jing-Xin Chen dong-lai Wei Zhen-Shan Cui School of Mechanical Engineering Yangzhou University School of Mechanical Engineering Shanghai Dianji University National Die and Mold CAD Engineering Research Center Shanghai Jiao Tong University

Workability domain without the onset of flow instability was developed by numerical simulation and response surface method （RSM） for complex-shaped straight spur gear forging. The processing map of AZ31B alloys was calculated from flow stress curves and then integrated with the finite element model to simulate the distribution of flow instability in the straight spur gear undergoing isothermal forging process. Occurrence of flow instability depends on forging temperature, punch velocity and billet reduction. Taking forging temperature and punch velocity as design variables, while billet reduction as response variable, RSM of workability domain was established. Analysis of variance indicates that forging temperature is the most significant factor determining the appearance of flow instability in the forged gear. Flow instability is easier to take place at lower temperatures of 250 and 300 ℃ in the early stage of forging but at higher temperatures of 350 and 400 ℃ in the later stage of forging, which is attributed to different deformation mechanisms and dynamic recrystallization behaviors at different temperatures or deformation levels. Meanwhile, increasing punch velocity further reduces the workability of the forged gear. Four different processing paths were chosen to carry out the gear forging trials. Visual observations and metallographic examinations demonstrate that the developed workability domain contributes to optimization of forging parameters.

关键词： Processing map Finite element method Response surface method Straight spur gear Magnesium alloy

急诊创伤患者TEG最大振幅降低的影响因素分析

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中国输血杂志 2024年第6期37卷 638-642页

作者：姬长甫赖冬田艳赖飞林姝婷龙敏李方圆连芳玲厦门医学院附属第二医院输血科福建厦门361021

目的通过监测急诊创伤患者的凝血相关指标的变化,探究血栓弹力图(TEG)最大振幅(MA)异常降低的影响因素及其对预后的影响。方法回顾性分析2020年9月—2023年9月本院收治的319例创伤患者,观察入院后0 h和24 h的各项凝血相关指标。依据MA... 详细信息

目的通过监测急诊创伤患者的凝血相关指标的变化,探究血栓弹力图(TEG)最大振幅(MA)异常降低的影响因素及其对预后的影响。方法回顾性分析2020年9月—2023年9月本院收治的319例创伤患者,观察入院后0 h和24 h的各项凝血相关指标。依据MA结果分为MA正常组(>50 mm)和MA降低组(≤50 mm),比较2组患者血红蛋白(Hb)、血小板计数(Plt)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(Fib)、凝血酶时间(TT)、D-二聚体(D-D)、凝血反应时间(R)、血块形成动力学(Angle)、30 min血块溶解率(Ly30)、MA、凝血酶-抗凝血酶复合物(TAT)、纤溶酶-α2纤溶酶抑制物复合物(PIC)的结果;并对319例创伤患者MA与纤溶相关指标的相关性进行分析。根据是否使用氨甲环酸(TXA)再将MA降低组分为TXA组和未用药组,比较2组患者以上各凝血相关指标变化率的差异,以及死亡率和血制品用量的改变。结果与MA正常组比较,MA降低组Hb、Plt、Fib、舒张压和GCS评分明显下降,心率、ISS评分和死亡率升高(P0.05);TXA组死亡率降低(P<0.05)。结论急诊创伤患者出现MA值异常降低时,纤溶亢进可能是其异常下降的重要因素,使用TXA治疗可改善其对MA的影响,并减少血液制品输注,降低患者死亡率。

关键词：急性创伤血小板功能障碍氨甲环酸血栓弹力图最大振幅血栓分子标志物

PSA灰区(4~10 ng/ml)患者前列腺穿刺活检的策略

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中华泌尿外科杂志 2024年第5期45卷 386-390页

作者：尚金伟董来史嵘杰赵睿哲韩天潘敏杰杨斌王亚民夏炜华立新成功南京医科大学第一附属医院泌尿外科南京210000

目的探讨基于MRI前列腺影像报告和数据系统(PI-RADS)评分对前列腺特异性抗原(PSA)灰区(4~10 ng/ml)患者前列腺穿刺活检的策略。方法回顾性分析南京医科大学第一附属医院2020年1月至2022年12月收治的427例行经会阴前列腺穿刺活检患者的... 详细信息

目的探讨基于MRI前列腺影像报告和数据系统(PI-RADS)评分对前列腺特异性抗原(PSA)灰区(4~10 ng/ml)患者前列腺穿刺活检的策略。方法回顾性分析南京医科大学第一附属医院2020年1月至2022年12月收治的427例行经会阴前列腺穿刺活检患者的临床资料。中位年龄66(61,72)岁。中位tPSA6.62(5.46,8.19)ng/ml。中位前列腺体积(PV)43.68(31.12,56.82)ml。中位PSA密度(PSAD)0.15(0.11,0.21)ng/ml^(2)。MRI阴性(PI-RADS评分0.15ng/ml^(2)的患者,靶向联合系统活检、系统活检、靶向活检的CsPCa检出率分别为67.8%(61/90)、58.9%(53/90)67.8%(61/90)(P=0.354)。结论对于MRI阴性患者,当PSAV≥1.4ng/(ml·年)时,经会阴系统活检可检出全部的CsPCa;当PSAV0.15ng/ml^(2)时可仅行靶向活检,否则需行靶向联合系统活检。

关键词：前列腺肿瘤前列腺影像报告和数据系统双参数磁共振成像前列腺特异性抗原

不同采收期辛夷挥发油GC-MS分析及其抗氧化、抗菌活性

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药物分析杂志 2024年第9期44卷 1475-1484页

作者：王杰敏郭浩川赵梦薇孙会改宋永兴郑玉光马东来河北中医药大学药学院石家庄050200 河北省中药炮制技术创新中心石家庄050091 河北省中药资源利用与质量评价国际联合研究中心石家庄050091 河北化工医药职业技术学院石家庄050026

目的:分析不同采收期辛夷挥发油的组分和相对含量,探讨5个采收期辛夷化学成分的动态变化规律,并评价其抗氧化、抗菌活性。方法:采用水蒸气蒸馏法对5个采收期辛夷药材进行挥发油提取,利用气相色谱-质谱联用技术分析其化学成分,并计算各... 详细信息

目的:分析不同采收期辛夷挥发油的组分和相对含量,探讨5个采收期辛夷化学成分的动态变化规律,并评价其抗氧化、抗菌活性。方法:采用水蒸气蒸馏法对5个采收期辛夷药材进行挥发油提取,利用气相色谱-质谱联用技术分析其化学成分,并计算各成分的相对含量;对5个采收期辛夷的成分进行偏最小二乘法判别分析,筛选出差异性化合物;采用铁离子还原/抗氧化能力法测定辛夷挥发油的抗氧化活性,96孔板法研究其体外抗菌活性。结果:第4采收期(2023年2月10日)辛夷药材总挥发油平均含量最高;从辛夷挥发油中鉴定出38个成分,筛选得到12个差异性化合物,包括γ-衣兰油烯、榄香烯、δ-杜松烯、α-松油醇等,其中γ-衣兰油烯、别香橙烯、2-茨醇、樟脑和顺式-4-侧柏醇在第4采收期相对含量最大,与挥发油含量变化趋势基本一致;5个采收期辛夷挥发油均表现出一定的抗氧化、抗菌活性,第4采收期抗氧化能力最强,且对五种菌的抑制作用均较强。结论:5个采收期辛夷挥发油化学成分基本相同,但在各采收阶段其挥发性成分相对含量有明显差异,推测2月初为辛夷最佳采收期。

关键词：辛夷挥发油气相色谱-质谱联用(GC-MS) 偏最小二乘法判别分析(PLS-DA) 抗氧化抗菌

Hallopeau type of pemphigus vegetans confined to the right foot： case report

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Chinese Medical Journal 2009年第5期122卷 588-590页

作者： MA dong-lai FANG Kai Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

In pemphigus vegetans, intertriginous areas are more commonly involved, and verrucous vegetations develop easily in these areas. In this article, we report a case of Hallopeau type of pemphigus vegetans confined to th... 详细信息

关键词： pemphigus vegetans foot involvement

免疫细胞在肾脏缺血再灌注损伤修复中的作用研究进展

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中华细胞与干细胞杂志（电子版） 2024年第1期14卷 45-50页

作者：曹守青来东焦启龙安哲昆李修彬河北北方学院研究生院张家口075000 解放军总医院第三医学中心泌尿外科医学部北京100039 南开大学医学院天津300071 山西医科大学基础医学院太原030001

急性肾损伤(AKI)是一种常见的临床综合征,我国住院人群AKI的发病率高达11.6%,AKI发生后容易进展为慢性肾病(CKD)甚至终末期肾病(ESRD)。缺血再灌注损伤(IRI)是AKI的主要病因之一。肾小管上皮细胞是IRI致AKI发生过程中受损的主要细胞类型... 详细信息

急性肾损伤(AKI)是一种常见的临床综合征,我国住院人群AKI的发病率高达11.6%,AKI发生后容易进展为慢性肾病(CKD)甚至终末期肾病(ESRD)。缺血再灌注损伤(IRI)是AKI的主要病因之一。肾小管上皮细胞是IRI致AKI发生过程中受损的主要细胞类型,也是肾脏修复过程中细胞再生的主要细胞来源。在AKI发生发展以及损伤修复的过程中,免疫细胞能够调节肾小管上皮细胞的损伤、增殖以及再上皮化等多种生物过程,最终导致AKI的不同结局。本文就IRI导致的AKI发生过程中免疫细胞发挥的作用以及领域内的挑战和发展作一综述。

关键词：肾小管上皮细胞免疫细胞肾脏缺血再灌注肾脏损伤修复

Triple administration of osimertinib followed by chemotherapy for advanced lung adenocarcinoma: A case report

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World Journal of Clinical Cases 2021年第11期9卷 2627-2633页

作者： Xu-Yan Hu Yu-Cheng Fei Wen-Chao Zhou Jin-Miao Zhu dong-lai Lv Department of Clinical Medicine Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Department of Clinical Oncology 901 Hospital of Joint Logistics Support Force of People Liberation ArmyHefei 230031Anhui ProvinceChina Intelligent Pathology Institute The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Department of Pharmaceutical Engineering Hefei Normal UniversityHefei 230601Anhui ProvinceChina

BACKGROUND Osimertinib is the recommended first-line treatment for adult patients with epidermal growth factor receptor(EGFR)mutation positive advanced or metastatic non-small cell lung cancer(NSCLC).However,primary or acquired resistance to EGFR-tyrosine kinase inhibitors(EGFR-TKIs)seems inevitable,and when drug-resistance occurs during treatment with osimertinib,the standard of care is to discontinue the *** SUMMARY A 57-year-old female patient with lung adenocarcinoma presented with an irritating cough accompanied by chest distress of one month *** enhanced head magnetic resonance imaging scan showed brain *** EGFR mutation(exon 21 L858R)was detected in pleural *** patient was treated with oral osimertinib(80 mg once daily)from January 2018 but developed progressive disease on December *** was then successfully treated with rechallenge and tri-challenge with osimertinib(80 mg once daily)by resensitization chemotherapy twice after the occurrence of drug-resistance to osimertinib,and to date has survived for 31 *** This case may provide some selective therapeutic options for NSCLC patients with acquired drug-resistance who were previously controlled on osimertinib treatment.

关键词： Osimertinib Retreatment Epidermal growth factor receptor Tyrosine kinase inhibitor Non-small cell lung cancer Case report