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苹果酸舒尼替尼治疗胰腺神经内分泌肿瘤

消化肿瘤杂志(电子版) 2010年第4期 225-225页

作者： Raymond E Dahan L raoul JL 张信华

背景胰腺神经内分泌肿瘤是起源于胰腺内分泌细胞的罕见肿瘤。生长抑素类似物可缓解因肿瘤激素过度分泌引起的相应症状,而且可延缓部分患者的疾病进展时间。链脲菌素单药或与阿霉素联合方案仍然是唯一已被批准用于治疗进展期胰腺神经内... 详细信息

背景胰腺神经内分泌肿瘤是起源于胰腺内分泌细胞的罕见肿瘤。生长抑素类似物可缓解因肿瘤激素过度分泌引起的相应症状,而且可延缓部分患者的疾病进展时间。链脲菌素单药或与阿霉素联合方案仍然是唯一已被批准用于治疗进展期胰腺神经内分泌肿瘤的化疗药物,然而其疗效并不满意。在临床前以及Ⅰ期和Ⅱ期临床试验中,多靶点酪氨酸激酶抑制剂舒尼替尼已显示出对于胰腺神经内分泌肿瘤的治疗活性。目的这是一项国际多中心、随机、双盲、安慰剂对照的Ⅲ期

关键词：胰腺神经内分泌肿瘤舒尼替尼进展期无进展生存

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拉乌尔·杜菲作品

初中生必读 2021年第7期 2-2页

作者：拉乌尔·杜菲不详

法国画家、设计师。1900年入巴黎美术学院学习,后受印象画派影响,1905年起转为野兽派。擅长作市街港口、赛船等风景画,独特地运用单线条和鲜明色彩将物体夸张变形,追求装饰效果。作为20世纪初叶现代绘画史开端的野兽主义画派成员之一,... 详细信息

法国画家、设计师。1900年入巴黎美术学院学习,后受印象画派影响,1905年起转为野兽派。擅长作市街港口、赛船等风景画,独特地运用单线条和鲜明色彩将物体夸张变形,追求装饰效果。作为20世纪初叶现代绘画史开端的野兽主义画派成员之一,杜菲是一位多元化创作的艺术家。除绘画之外,他的艺术创作领域扩展到挂毯、壁画、布料图案设计及陶瓷创作。

关键词：印象画派图案设计夸张变形野兽主义野兽派巴黎美术学院艺术创作

Petawatt and exawatt class lasers worldwide

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High Power Laser Science and Engineering 2019年第3期7卷 168-221页

作者： Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel AWE AldermastonReadingUK OxCHEDS Clarendon LaboratoryDepartment of PhysicsUniversity of OxfordOxfordUK CIFS Blackett LaboratoryImperial CollegeLondonUK NIF&Photon Science Directorate Lawrence Livermore National LaboratoryLivermoreUSA Fraunhofer Institute for Laser Technology(ILT) AachenGermany Chair for Laser Technology LLT RWTH Aachen UniversityAachenGermany University of Rochester Laboratory for Laser EnergeticsRochesterUSA Central Laser Facility STFC Rutherford Appleton LaboratoryChiltonDidcotUK LULI CNRSCEASorbonne UniversitesEcole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance Department of Physics The Ohio State UniversityColumbusUSA Centre for Ultrafast Optical Science University of MichiganAnn ArborUSA Intense Laser Irradiation Laboratory Istituto Nazionale di Ottica(INO)CNRPisaItaly Institute of Optics and Quantum Electronics Friedrich-Schiller-University Jena and Helmholtz InstituteJenaGermany The Graduate School for the Creation of New Photonics Industries NishikuHamamatsuJapan Institute of Applied Physics Russian Academy of SciencesNizhny NovgorodRussia Institute of Laser Engineering Osaka UniversitySuitaOsakaJapan ELI-Beamlines Institute of PhysicsCzech Academy of SciencesPragueCzech Republic State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Institute for Applied Physics(IAP)at Friedrich-Schiller-University Jena JenaGermany Helmholtz Institute Jena JenaGermany Fraunhofer Institute for Applied Optics and Precision Engineering(IOF) JenaGermany Key Laboratory for Laser Plasma(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Centre for Relativistic Laser Science(CoReLS) Institute for Basic ScienceDepartment of Physics and Photon ScienceGwangju Institute of Science and Techno

In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was *** was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has *** are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under *** addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR *** apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development.

关键词： exawatt lasers high-power lasers petawatt lasers ultra-high intensity

Global prevalence of occult hepatitis C virus: A systematic review and meta-analysis

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World Journal of Methodology 2022年第3期12卷 179-190页

作者： Donatien Serge Mbaga Sebastien Kenmoe Jacky Njiki Bikoï Guy Roussel Takuissu Marie Amougou-Atsama Etienne Atenguena Okobalemba Jean Thierry Ebogo-Belobo Arnol Bowo-Ngandji Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Alex Durand Nka Alfloditte Flore Feudjio Cromwel Zemnou-Tepap Elie Adamou Velhima Juliette Laure Ndzie Ondigui Rachel Audrey Nayang-Mundo Sabine Aimee Touangnou-Chamda Yrene Kamtchueng Takeu Jean Bosco Taya-Fokou Chris Andre Mbongue Mikangue raoul Kenfack-Momo Cyprien Kengne-Ndé Carole Stephanie Sake Seraphine Nkie Esemu Richard Njouom Lucy Ndip Sara Honorine Riwom Essama Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Department of Microbiology and Parasitology University of BueaBuea 00237Cameroon Department of Virology Centre Pasteur of CameroonYaounde 00237Cameroon Centre of Research in Food Food Security and NutritionInstitute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Centre de Recherche sur les Maladies Emergentes et Re-Emergentes Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Faculty of Medicine and Biomedical Science The University of Yaounde IYaounde 00237Cameroon Medical Research Centre Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Laboratory of Parasitology and Ecology The University of Yaounde IYaounde 00237Cameroon Department of Biochemistry The University of Yaounde IYaounde 00237Cameroon Virology Laboratory Chantal Biya International Reference Center for Research on HIV/AIDS Prevention and ManagementYaounde 00237Cameroon

BACKGROUND Occult hepatitis C infection(OCI)is characterized by the presence of hepatitis C virus(HCV)RNA in the liver,peripheral blood mononuclear cells(PBMC)and/or ultracentrifuged serum in the absence of detectable HCV-RNA in *** has been described in several categories of populations including hemodialysis patients,patients with a sustained virological response,immunocompromised individuals,patients with abnormal hepatic function,and apparently healthy *** To highlight the global prevalence of *** We performed a systematic and comprehensive literature search in the following 4 electronic databases PubMed,EMBASE,Global Index Medicus,and Web of Science up to 6th May 2021 to retrieve relevant studies published in the *** studies were unrestricted population categories with known RNA status in serum,PBMC,liver tissue and/or ultracentrifuged *** were extracted independently by each author and the Hoy et al tool was used to assess the quality of the included *** used the random-effect meta-analysis model to estimate the proportions of OCI and their 95%confidence intervals(95%CI).The Cochran's Q-test and the I2 test statistics were used to assess heterogeneity between *** plot and Egger test were used to examine publication bias.R software version 4.1.0 was used for all *** The electronic search resulted in 3950 *** obtained 102 prevalence data from 85 included *** pooled prevalence of seronegative OCI was estimated to be 9.61%(95%CI:6.84-12.73)with substantial heterogeneity[I^(2)=94.7%(95%CI:93.8%-95.4%),P<0.0001].Seropositive OCI prevalence was estimated to be 13.39%(95%CI:7.85-19.99)with substantial heterogeneity[I^(2)=93.0%(90.8%-94.7%)].Higher seronegative OCI prevalence was found in Southern Europe and Northern Africa,and in patients with abnormal liver function,hematological disorders,and kidney *** seropositive OCI prevalence was found in Southern Europe,Northern

关键词： Occult hepatitis C virus infection Prevalence Worldwide Peripheral blood mononuclear cells Hepatitis C virus

Nature:CD32a蛋白暴露艾滋病病毒"藏身地"

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现代生物医学进展 2017年第15期17卷 I0004-I0004页

作者： Benjamin Descours, Gaël Petitjean, raoul Raffel Monsef Benkirane José-Luis López-Zaragoza, Timothée Bruel, Christine Lacabaratz, Yves Levy, Olivier Schwartz Jean Daniel Lelievre José-Luis López-Zaragoza, Christine Lacabaratz, Yves Levy Jean Daniel Lelievre José-Luis López-Zaragoza, Christine Lacabaratz, Yves Levy Jean Daniel Lelievre Timothée Bruel Olivier Schwartz Christina Psomas Jacques Reynes Institut de Génétique Humaine Laboratoire de Virologie Moléculaire UMR9002 CNRS Université de Montpellier Montpellier France Vaccine Research Institute Université Paris-Est Faculté de Médecine INSERM U955 and Assistance Publique-Hôpitaux de Paris Groupe Henri-Mondor Albert-Chenevier Service d’Immunologie Clinique Créteil France Inserm U955 Equipe 16 Créteil France AP-HP Hôpital Henri-Mondor Albert-Chenevier Service d’Immunologie Clinique et Maladies Infectieuses 94000 Créteil France Institut Pasteur Virus and Immunity Unit URA CNRS 3015 Paris France Département Maladies Infectieuses et Tropicales Hôpital Universitaire Montpellier France

《自然》杂志近日发表了法国研究人员的一项最新成果：他们通过实验室研究发现，潜藏艾滋病病毒（HIV）的T细胞表面特定表达着一种名叫CD32a的蛋白，这种蛋白在未感染HIV的T细胞中却没有被检测出来。这意味着，CD32a蛋白可以作为一种生... 详细信息

《自然》杂志近日发表了法国研究人员的一项最新成果：他们通过实验室研究发现，潜藏艾滋病病毒（HIV）的T细胞表面特定表达着一种名叫CD32a的蛋白，这种蛋白在未感染HIV的T细胞中却没有被检测出来。这意味着，CD32a蛋白可以作为一种生物靶标，用来开发出针对”隐身”状态HIV的全新药物。

关键词：艾滋病病毒 a蛋白《自然》杂志研究人员细胞表面 HIV 实验室 T细胞

EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-Aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO René Gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression

四川省藏族牧区感染多房棘球绦虫犬只空间聚集性研究(英文)

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预防医学情报杂志 2012年第5期28卷 323-328页

作者：王谦克莉丝汀.布德克黄亮帕崔克.热合度弗兰西斯.豪尔多米尼克.维通菲利普.克瑞格邱东川 Sichuan Center for Disease Control and Prevention College of Veterinary Medicine and Biomedical Sciences Texas A&M University WHO Collaborating Centre for the Prevention and Treatment of Human Echinococcosis Research Unit "Chrono-environment " UMR CNRS 6249 usc INRAUniversity of Franche-ComtéPlace Leclerc25030 Besancon cedexFrance University of Franche-Comté and Besanon University Hospital 25030-BesanconFrance Cestode Zoonoses Research Group Biomedical sciences Research Institute and School of Environment and Life SciencesUniversity of SalfordSalford MS4WTUnited Kingdom

目的泡型包虫病(AE)是中国西部的一个重大公共卫生问题,在四川和青海2省藏族地区更为突出。多房棘球绦虫(***)是泡型包虫病的病原体。流行病学调查表明,犬是是泡型包虫病的显著流行风险因素,一些牧区犬只多房棘球绦虫感染率较高。这些... 详细信息

目的泡型包虫病(AE)是中国西部的一个重大公共卫生问题,在四川和青海2省藏族地区更为突出。多房棘球绦虫(***)是泡型包虫病的病原体。流行病学调查表明,犬是是泡型包虫病的显著流行风险因素,一些牧区犬只多房棘球绦虫感染率较高。这些研究表明犬可能作为终末宿主,在环境中维持多房棘球绦虫的生活史。但是普遍认为狐狸是环境中支撑多房棘球绦虫生活史的终末宿主。该研究旨在通过研究感染多房棘球绦虫犬只的空间聚集性,来进一步了解犬在环境中维持多房棘球绦虫生活史的证据。方法在中国四川省西部青藏高原石渠县的牧区,通过氢溴酸槟榔碱驱虫的方法,收集家牧犬感染多房棘球绦虫感染状态,并用GPS测量这些犬只的地理位置数据。通过BB join-count test分析,了解感染多房棘球绦虫犬只是否存在空间聚集性。结果在300～600、800、1600和1800～3900 m的距离,感染多房棘球绦虫犬只存在空间聚集性。结论感染多房棘球绦虫犬只存在空间聚集性,表明环境中犬可能在多房棘球绦虫生活史中发挥作用。

关键词：多房棘球绦虫泡型包虫病犬空间聚集性藏族牧区

多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识

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中国呼吸与危重监护杂志 2021年第2期20卷 77-84页

作者：王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi 中国人民解放军空军军医大学航空航天医学系陕西西安710032 Department of Cardiac Sciences King Abdulaziz Medical City and King Abdullah International Medical Research Center 不详

新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征... 详细信息

新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。

关键词：体征和症状肺炎公共卫生体系呼吸系统首次报道专家共识疫情