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Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer

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Genes & Diseases 2022年第2期9卷 347-357页

作者： Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022PR China Department of radiation and Medical Oncology Zhongnan HospitalWuhan UniversityWuhanHubei 430071PR China Hubei Cancer Clinical Study Center Zhongnan HospitalWuhan UniversityWuhanHubei 430071PR China Department of Orthopaedic Surgery Johns Hopkins UniversityBaltimoreMD 21205USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine Department of Clinical BiochemistrySchool of Laboratory MedicineChongqing Medical UniversityChongqing 400016PR China Departments of Nephrology and Obstetrics and GynecologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Department of Spine Surgery Second Xiangya HospitalCentral South UniversityChangshaHunan 410011PR China Department of Surgery The University of Chicago Medical CenterChicagoIL 60637USA

The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and *** drugs act by interfering with tumor growth and inducing the death of cancer ***-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy ***,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer *** is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer *** is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox *** review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment.

关键词： Cancer Cancer therapy Clinical application Ferroptosis Lipid peroxidation Pathogenesis

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马来西亚总理：丑闻？什么丑闻？

商业周刊（中文版） 2016年第16期 16-17页

作者： Shamim Adam Chris blake Anuradha raghu Y-Sing Liau 竹西

7月20日，美国华盛顿的检察官称马来西亚一家主权基金涉赚巨额欺诈，而马来西亚总理纳吉布·拉扎克（Najib razak）安之若素。在一场公务员晚宴上，他与出席者握手并合影自拍。

关键词：马来西亚总理丑闻检察官华盛顿公务员欺诈主权

Buffer standards for the physiological pH of the zwitterionic buffer 3-[<i>N</i>-tris(hydroxymethyl)methylamino]-2-hydroxypropanesulfonic Acid (TAPSO) From (278.15 to 328.15) K

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Journal of Biophysical Chemistry 2011年第4期2卷 414-421页

作者： Lakshmi N. roy rabindra N. roy blake M. Bodendorfer Zachary M. Downs Stephen D. rocchio Jessica M. Stegner Isaac B. Henson 不详

The second dissociation constant, pK2, and related thermodynamic quantities for TAPSO have been previously determined and reported from the temperatures (278.15 to 328.15) K. In the current study there are five buffer solutions without NaCl and five buffer solutions with NaCl present which yield an ionic strength (I = 0.16 mol·kg-1) similar to that of blood plasma. These buffer solutions have been evaluated in the temperature range of (278.15 to 328.15) K using the extended Debye-Hückel equation, due to the limitations of the Bates-Guggenheim convention such that it is only valid when I -1. The liquid junction potential (Ej) values between the TAPSO solution and the saturated KCl calomel electrode solution have been estimated at (298.15 and 310.15) K using a flowing junction cell measurement. The previously mentioned Ej values have been used in determining the operational pH values at (298.15 and 310.15) K. These TAPSO buffer solutions are recommended as reference solutions for pH measurements in saline media with an ionic strength of I = 0.16 mol·kg-1.

关键词： Zwitterionic Buffer pH Liquid Junction Physiological

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丁酸在猪和家禽无抗生素日粮中的应用

山西农业科学 2020年第9期48卷 1543-1546页

作者：王新成加拿大安大略省旺伦斯汀饲料公司安大略旺伦斯汀N0B 2N0

丁酸作为短链脂肪酸的一种,在动物的无抗生素养殖中受到越来越多的关注。虽然丁酸在体外有杀菌的功能,但在体内也能够杀菌,还缺乏有力的证据。在日粮中添加丁酸,可以使动物的生产性能得到改善。目前,普遍接受的观点是,丁酸可以为动物的... 详细信息

丁酸作为短链脂肪酸的一种,在动物的无抗生素养殖中受到越来越多的关注。虽然丁酸在体外有杀菌的功能,但在体内也能够杀菌,还缺乏有力的证据。在日粮中添加丁酸,可以使动物的生产性能得到改善。目前,普遍接受的观点是,丁酸可以为动物的肠道细胞提供能量,改善肠道的结构和功能。综合目前丁酸在人和鼠类的研究成果以及家禽和猪现有的关于丁酸的研究报告可以推定,丁酸在鸡和猪的营养代谢中,通过与特定的受体结合,产生一组肠道激素,对机体的营养代谢产生一系列宏观调控,其中包括:增加动物的饱腹感,导致胃的排空减慢,使胰岛素分泌增加,增加对营养物质的吸收和利用,促进动物的合成代谢,并且维持和改善肠道的结构与功能。

关键词：丁酸短链脂肪酸胰高血糖素样肽-1 胰高血糖素样肽-2 酪氨酸肽抗生素替代品

A review of recent advances(2018–2021)on tropical cyclone intensity change from operational perspectives,part 1:Dynamical model guidance

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Tropical Cyclone research and review 2023年第1期12卷 30-49页

作者： Zhan Zhang Weiguo Wang James D.Doyle Jonathan Moskaitis William A.Komaromi Julian Heming Linus Magnusson John P.Cangialosi Levi Cowan Michael Brennan Suhong Ma Ananda Kumar Das Hosomi Takuya Peter Clegg Thomas Birchard John A.Knaff John Kaplan Mrutyunjay Mohapatra Monica Sharma Ikegami Masaaki Liguang Wu Eric blake NOAA/NWS/NCEP Environmental Modeling Center USA SAIC@NOAA/NWS/NCEP Environmental Modeling Center USA Naval research Laboratory USA Met Office UK ECMWF ReadingUK NOAA/NWS/NCEP National Hurricane Center USA Joint Typhoon Warning Center USA China Meteorological Administration China Indian Meteorological Department India Japan Meteorological Agency Japan Bureau of Meteorology Australia Central Pacific Hurricane Center USA NOAA Center for Satellite Applications and research USA NOAA/AOML Hurricane research Division USA Fudan University ShanghaiChina IMSG@NOAA/NWS/OSTI USA

This review summarizes the rapporteur report on tropical cyclone(TC)intensity change from the operational perspective,as presented to the 10th International Workshop on TCs(IWTC-10)held in Bali,Indonesia,from Dec.5–9,*** accuracy of TC intensity forecasts issued by operational forecast centers depends on three aspects:real-time observations,TC dynamical model forecast guidance,and techniques and methods used by *** rapporteur report covers the progress made over the past four years(2018–2021)in all three *** review focuses on the progress of dynamical model forecast *** companion paper(Part II)summarizes the advance from operational *** dynamical model forecast guidance continues to be the main factor leading to the improvement of operational TC intensity ***,we describe recent advances and developments of major operational regional dynamical TC models and their intensity forecast performance,including HWrF,HMON,COAMPS-TC,Met Office regional Model,CMA-TYM,and newly developed *** performance of global dynamical models,including NOAA's GFS,Met Office Global Model(MOGM),JMA's GSM,and IFS(ECMWF),has also been improved in recent years due to their increased horizontal and vertical resolution as well as improved data assimilation *** challenging cases of rapid intensification are presented and discussed.

关键词： Dynamical models Intensity forecast Operational forecasts Tropical cyclone

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触摸屏的光学增强与EMI屏蔽

现代显示 2011年第3期 18-22页

作者： Brian E.Herr Jeff blake richard D.Paynton 代永平 Dontech公司南开大学

对触摸屏技术的期待已经渗透到每个配置有显示器的电子设备上,其结果是要求工程师使用触摸屏来扩展每个设备的应用范围和适用环境。通常成功的项目是易读性与电磁兼容性的平衡。

关键词：触摸屏光学增强 EMI屏蔽

A review of recent advances(2018–2021)on tropical cyclone intensity change from operational perspectives,part 2:Forecasts by operational centers

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Tropical Cyclone research and review 2023年第1期12卷 50-63页

作者： Weiguo Wang Zhan Zhang John P.Cangialosi Michael Brennan Levi Cowan Peter Clegg Hosomi Takuya Ikegami Masaaki Ananda Kumar Das Mrutyunjay Mohapatra Monica Sharma John A.Knaff John Kaplan Thomas Birchard James D.Doyle Julian Heming Jonathan Moskaitis Suhong Ma Charles Sampson Liguang Wu Eric blake NOAA/NWS/NCEP Environmental Modeling Center USA NOAA/NWS/NCEP National Hurricane Center USA Joint Typhoon Warning Center USA Bureau of Meteorology Australia Japan Meteorological Agency Japan Indian Meteorological Department India NOAA Center for Satellite Applications and research USA NOAA/AOML Hurricane research Division USA Central Pacific Hurricane Center USA Naval research Laboratory USA Met Office UK China Meteorological Administration China Fudan University ShanghaiChina IMSG@NOAA/NWS/OSTI USA

This paper summarizes the progress and activities of tropical cyclone(TC)operational forecast centers during the last four years(2018–2021).It is part II of the review on TC intensity change from the operational perspective in the rapporteur report presented to the 10th International Workshop on TCs(IWTC)held in Bali,Indonesia,from Dec.5–9,*** I of the review has focused on the progress of dynamical model forecast *** part discusses the performance of TC intensity and rapid intensification forecasts from several operational *** is shown that the TC intensity forecast errors have continued to decrease since the 9th IWTC held in *** particular,the improvement of rapid intensification forecasts has accelerated,compared with years before *** models,operational procedures,tools and techniques,as well as recent challenging cases from 2018 to 2021 identified by operational forecast centers are *** needs and recommendations are also discussed.©2023 The Shanghai Typhoon Institute of China Meteorological *** services by Elsevier *** behalf of KeAi Communication *** is an open access article under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Forecast error Intensity forecast Operational forecasts Tropical cyclone

流域管理东南亚大陆山区的生活和资源竞争 1

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Calculation of the pH of Buffer Solution of 2-[<i>N</i>-Morpholino]ethanesulfonic Acid (MES) from 5°C to 55°C

丛书名：世界资源研究所资助出版

2000年

作者：（美）布莱克·D.拉特纳（blake D.ratner）杨永平等译

世界资源研究所资助出版:本书包括：为什么有流域管理的问题、本地水平的挑战、国家水平的挑战、地区水平的挑战、结论等内容。

ISBN: (纸本)7541614394

世界资源研究所资助出版:本书包括：为什么有流域管理的问题、本地水平的挑战、国家水平的挑战、地区水平的挑战、结论等内容。

关键词：流域经济经济管理研究东南亚自然资源资源管理

来源：汇雅图书（南通市图书馆... 评论

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Open Journal of Physical Chemistry 2011年第3期1卷 77-84页

作者： blake M. Bodendorfer Meagan A. Harmon Isaac B. Henson Michael S. Martin Lakshmi N. roy rabindra N. roy Jessica M. Stegner Joshua T. Wollen 不详

This paper reports the results for the pH of three buffer solutions free of chloride ion. The remaining six buffer solutions have saline media of the ionic strength I = 0.16 ***-1, matching closely to that of the physiological sample. Conventional paH values for the three buffer solutions without the chloride ion and six buffer solutions with the chloride ion at I = 0.16 ***-1 from 5°C to 55°C have been calculated. The operational pH values for five buffer solutions at 5°C and 55°C have been determined based on the difference in the values of the liquid junction potentials between the blood phosphate standard and the experimental buffer solutions. Five of these buffers are recommended as standards for the physiological pH range 7.5 to 8.5.

关键词： Buffers MES BICINE Liquid Junction Ionic Strength Emf pH