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Exploring the multicomponent synergy mechanism of Zuogui Wan(左归丸) on postmenopausal osteoporosis by a systems pharmacology strategy

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Journal of Traditional Chinese Medicine 2024年第3期44卷 489-495页

作者： FENG Yanchen LIU Yali DANG Xue LIN Zixuan ZHANG Yunke CHE Zhiying LI Xiang pan Xiaolong LIU Feixiang ZHENG pan Traditional Chinese Medicine (Zhong Jing) School Henan University of Chinese Medicine Hospital of Encephalopathy the First Affiliated Hospital of Henan University of Chinese Medicine State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineResearch Units of Infectious Disease and MicroecologyChinese Academy of Medical Sciences

OBJECTIVE: To explore the multi-component synergistic mechanism of Zuogui Wan(左归丸, ZGW) in treating postmenopausal osteoporosis(PMOP). METHODS: The main components and target genes of ZGW were screened via the Traditional Chinese Medicine Systems Pharmacology(TCMSP). In addition, the target gene sets of PMOP were derived from the Gene Cards and Online Mendelian Inheritance in Man databases. The search tool for recurring instances of neighbouring genes(STRING) 11.0 software was used to analyze the interaction among intersecting genes. Cytoscape 3.6.1 software and the Matthews correlation coefficient(MCC) algorithm were used to screen the core genes. Fifty Sprague-Dawley female rats were randomly divided into the sham-operated(Sham) group and the four ovariectomized(OVX) subgroups. Rats subjected to Sham or OVX were administered with the vehicle(OVX, 1 m L water/100 g weight), 17β-estradiol(E2, 50 μg·kg-1·d-1), and lyophilized powder of ZGW at a low dose of 2.3(ZGW-L) and high dose of 4.6(ZGW-H) g·kg-1·d-1 for three months. The bone density and bone strength were assessed using dual-energy X-ray and three-point bending tests, respectively. Furthermore, enzyme-linked immunosorbent assay, Hematoxylin-eosin staining, and western blot analysis were used to determine the potential pharmacological mechanisms of action of ZGW in PMOP. RESULTS: A total of 117 active compounds of ZGW were screened from the TCMSP. Furthermore, 108 intersecting genes of drugs and diseases were identified. Using STRING software and the MCC algorithm, ten core genes, including C-X-C chemokine living 8(CXCL8), C-C chemokine receptor type 2(CCR2), alpha-2a active receptor(ADRA2A), melatonin receptor type 1B(MTNR1B), and amyloid-beta A4 protein(APP), were identified. The anti-osteoporosis regulation network of ZGW was constructed using the Cytoscape software. The animal experiments demonstrated that ZGW groups significantly reduced the serum levels of β-C-terminal telopeptide of type I collagen(β-CTX

关键词： Zuogui Wan network pharmacology osteoporosis, postmenopausal

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Light demand characteristics,production performance,and changes in the feeding patterns of broilers

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 68-73页

作者： Shouyi Wang Guoping Jiang Chenghao pan Thebano Santos Yasser Elhadidi Ahmed Jado Shufang Jin Jinming pan College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China Infinova(Hangzhou)Information System Technology Co. Ltd.Hangzhou 310012China Center of Information Technology"Renato Archer"(CIT) Ministry of ScienceTechnologyInnovation and CommunicationCEP:13069-901 Campinas(SP)Brazil Department of Agricultural Engineering Mansoura UniversityMansoura 35516Egypt

Poultry is a light-sensitive animal and the light environment has an important influence on the growth and development of these *** studies have mainly focused on the effects of the light environment on various physiological indicators of poultry but seldom explored the light demand characteristics of broilers under free *** experiment mainly studied the light demand characteristics of broilers under a yellow LED light environment and the influence of different breeding densities[low-density(2.5 broilers/m^(2)),high-density(7.5 broilers/m^(2))]on the production performance and diet characteristics of *** showed that the production performance indexes of low-density groups are higher than those of high-density *** feed and water consumption in the light area of the two experimental groups were significantly higher than those in the dark area,which means that the broilers showed a great preference for the light ***,as the age of the broilers increased,the food and water consumption of the broilers decreased,indicating that broilers had a lower preference for light in the middle and late stages of *** statistical results for the residence frequency distribution characteristics showed that broiler chickens had different light requirements at different growth stages under the condition of active selection:1)low-density breeding environment:23.8L(light):0.2D(dark)for chicks and 22.3L:1.7D for adult broilers;2)high-density breeding environment:22.6L:1.4D for chicks and 15.0L:9.0D for adult *** study will provide a reference for the optimization and control of light environment in broiler breeding.

关键词： broiler light-demand characteristics production performance feeding pattern

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A modified stochastic finite-fault method for estimating strong ground motion:Validation and application

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Earthquake Science 2024年第1期37卷 36-50页

作者： Xinjuan He Hua pan Institute of Geophysics China Earthquake AdministrationBeijing 100081China

We developed a modified stochastic finite-fault method for estimating strong ground *** adjustment to the dynamic corner frequency was introduced,which accounted for the effect of the location of the subfault relative to the hypocenter and rupture propagation direction,to account for the influence of the rupture propagation direction on the subfault dynamic corner *** comparing the peak ground acceleration(PGA),pseudo-absolute response spectra acceleration(PSA,damping ratio of 5%),and duration,the results of the modified and existing methods were compared,demonstrating that our proposed adjustment to the dynamic corner frequency can accurately reflect the rupture directivity *** applied our modified method to simulate near-field strong motions within 150 km of the 2008 MW7.9 Wenchuan earthquake *** modified method performed well over a broad period range,particularly at 0.04-4 *** total deviations of the stochastic finite-fault method(EXSIM)and the modified EXSIM were 0.1676 and 0.1494,*** modified method can effectively account for the influence of the rupture propagation direction and provide more realistic ground motion estimations for earthquake disaster mitigation.

关键词： stochastic finite-fault method dynamic corner frequency Wenchuan earthquake rupture propagation direction

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Effect of Polyvinyl Alcohol in Inner Aqueous Phase on Stability of Millimeter-scale Capsules

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 506-511页

作者：黄乐平 LI Shidong ZHANG Jiabei pan Chenchen 赵瑾朝 School of Material Science and Engineering Wuhan Textile UniversityWuhan 430200China Hubei Provincial Engineering Laboratory for Clean Production and High Value Utilization of Bio-Based Textile Materials Wuhan Textile UniversityWuhan 430200China

The millimeter-scale capsules with controllable morphology,ultra-low permeability and excellent mechanical stability were fabricated by *** of inner phase was adjusted to control the morphology and properties of the *** detail,as the concentration of polyvinyl alcohol(PVA)increased from 0 to 8% in the inner phase of the capsules,the diameter of capsules decreased from 3.33 ± 0.01mm to 2.97 ± 0.01 mm,the shell thickness of capsules decreased from 0.183 ± 0.004 mm to 0.155 ± 0.003 *** the capsules had round shape and high ***,the capsules with 2% PVA in the inner phase had remarkably decreased water permeability and good morphological ***,the end-time of water losing of the capsules was up to 49 days,while the dehydrated capsules maintained spherical appearance,and crushing force of the capsules was up to 13.73 ± 0.79 N,which ensured stability during processing and *** research provides a new strategy for stable encapsulation of small molecules.

关键词： capsule millimeter-scale millifluidics polyvinyl alcohol viscosity

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Lithospheric strength of the Anatolian plateau and implications for strong earthquake activity in Turkey

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Geodesy and Geodynamics 2024年第3期15卷 209-218页

作者： Yuhang pan Shi Chen Wen Shi Institute of Geophysics China Earthquake AdministrationBeijing 100081China Beijing Baijiatuan Earth Science National Observation and Research Station Beijing 100095China

On February 6, 2023, the doublet earthquake including two main shocks with magnitudes M_(W)7.8 and M_(W)7.5, occurred near the western side of the East Anatolian Fault at the southeast boundary of the Anatolian Plateau in Turkey. Based on the WGM2012 Bouguer gravity anomaly data and the Etopo1topography data, this study first introduced a joint inversion of admittance and coherence functions and used the Bayesian optimal parameter estimation method to obtain the effective elastic thickness Teand loading ratio F of the lithosphere for various tectonic units in the Anatolian Plateau. Secondly, we discussed the characteristics and influencing factors of the lithospheric mechanical strength and analyzed its relationship with seismic activity. The lithospheric mechanical strength of the Anatolian Plateau showed clear lateral heterogeneity and a "weak-strong-weak" spatial pattern from east to west,reflecting various tectonic processes. At last, the strong seismic activity was found where the lithospheric strength was low in the Anatolian Plate. We also incorporated GPS strain rate and other results to investigate the tectonic background and primary causes of the M_(W)7.8 and M_(W)7.5 doublet earthquakes in Turkey. The results have a good insight into urban safety design in the Turkish region, including postdisaster rehabilitation, earthquake hazard assessment, and loss reduction.

关键词： Effective elastic thickness Anatolian plateau Turkey doublet earthquakes Bayesian optimization

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Mycoplasma hominis Pneumonia Presented as a Cavitary Mass with a Halo Sign in an Immunocompetent Adult Male:A Case Report

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Infectious Diseases & Immunity 2024年第3期4卷 142-145页

作者： pan-pan Xie Yao Yao Ning Yang Wen-Kai Niu Xin Yuan Department of Respiratory and Critical Care Diseases Senior Department of Infectious Diseasesthe Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Anhui Medical University PLA 307 Clinical College Beijing 100039China.

Mycoplasma hominis is an opportunistic microorganism that colonizes the genitourinary tract and causes genitourinary ***,pulmonary infections caused by *** have rarely been reported in immunocompetent ***,we report a rare case of an immunocompetent adult male with *** pneumonia who presented with multiple pulmonary nodules that progressed to a cavitary mass with a halo *** presence of *** infection was confirmed using multiplex polymerase chain reaction(mPCR)of the bronchoalveolar lavage *** patient demonstrated no response to the initial levofloxacin therapy;however,the symptoms subsequently improved after the administration of *** may be an underestimated causative agent of community-acquired pneumonia of unknown etiology in immunocompetent adults,and the involvement of the organism should be especially suspected in sexually active *** diagnostic methods,such as mPCR,can be used to identify the etiology of atypical *** antibiotics are crucial for effective treatment.

关键词： M.hominis Halo sign Cavitary pneumonia Extragenital infections Case report

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A deep multimodal fusion and multitasking trajectory prediction model for typhoon trajectory prediction to reduce flight scheduling cancellation

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Journal of Systems Engineering and Electronics 2024年第3期35卷 666-678页

作者： TANG Jun QIN Wanting pan Qingtao LAO Songyang College of Systems Engineering National University of Defense TechnologyChangsha 410000China

Natural events have had a significant impact on overall flight activity,and the aviation industry plays a vital role in helping society cope with the impact of these *** one of the most impactful weather typhoon seasons appears and continues,airlines operating in threatened areas and passengers having travel plans during this time period will pay close attention to the development of tropical *** paper proposes a deep multimodal fusion and multitasking trajectory prediction model that can improve the reliability of typhoon trajectory prediction and reduce the quantity of flight scheduling *** deep multimodal fusion module is formed by deep fusion of the feature output by multiple submodal fusion modules,and the multitask generation module uses longitude and latitude as two related tasks for simultaneous *** more dependable data accuracy,problems can be analysed rapidly and more efficiently,enabling better decision-making with a proactive versus reactive *** multiple modalities coexist,features can be extracted from them simultaneously to supplement each other’s *** actual case study,the typhoon Lichma that swept China in 2019,has demonstrated that the algorithm can effectively reduce the number of unnecessary flight cancellations compared to existing flight scheduling and assist the new generation of flight scheduling systems under extreme weather.

关键词： flight scheduling optimization deep multimodal fusion multitasking trajectory prediction typhoon weather flight cancellation prediction reliability

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Review on birefringence in borates based on birefringence-active functional groups and arrangements

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Science China Chemistry 2024年第7期67卷 2155-2170页

作者： Qianzhen Zhang Ran An Zhihua Yang Xifa Long Shilie pan Yun Yang Research Center for Crystal Materials State Key Laboratory of Functional Materials and Devices for Special Environmental ConditionsXinjiang Key Laboratory of Functional Crystal MaterialsThe Xinjiang Technical Institute of Physics&ChemistryChinese Academy of SciencesUrumqi 830011China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

As a fundamental parameter of the optical crystals,birefringence plays a vital role in many optical applications,such as phase modulation,light splitting,and polarization,especially the phase matching process of the nonlinear optical *** big birefringence not only benefits to the miniaturization of related devices,but also broadens the phase-matching wavelength range of nonlinear optical *** design and synthesis of crystals with large birefringence becomes a hot research topic due to its more and more important applications in the optical modulation and laser technology ***,crystals with birefringence greater than 0.05 in the borate system are reviewed and classified according to different birefringent active groups,and the relationship between structure and properties is thoroughly *** is hoped that this review will provide a clear understanding of what kinds of building units and arrangements would have more opportunity to get adequate birefringence in borate systems and provide the statistical references to encourage the emergence of better crystal materials with large birefringence.

关键词： birefringence borate optical functional crystal structural anisotropy arrangement of functional units

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Co-influence of the start of thermal growing season and precipitation on vegetation spring green-up on the Tibetan Plateau

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Advances in Climate Change Research 2024年第2期15卷 327-337页

作者： Chen-Peng WANG Meng-Tian HUANG pan-Mao ZHAI State Key Laboratory of Severe Weather and Institute of Global Change and Polar Meteorology Chinese Academy of Meteorological SciencesBeijing 100081China University of Chinese Academy of Sciences Beijing 100049China

The climate in the Tibetan Plateau(TP)has undergone significant change in recent decades,mainly in thermal and water conditions,which plays a crucial role in phenological changes in vegetation spring ***,how the start of the thermal growing season(SOS-T)and the start of the rainy season(SORS)as key climatic factors affect vegetation green-up remains *** that these factors characterize thermal and water conditions required for vegetation green-up,this study investigated changes in the SOS-T and SORS from 1961 to 2022,using observation-based datasets with long time *** found that the SOS-T and SORS have advanced across the TP in 1961-2022 and have shown a spatial pattern of advancement in the east and delay in the west in ***,the co-effect of temperature and precipitation change on the start of vegetation growing season(SOS-V)in 2000-2022 was *** across TP,the SOS-V had an early onset of 1.3 d per decade during 2000-2022,corresponding to advanced SOS-T and ***,the SOS-V generally occurred nearly at the same time as the SOS-T in the high-altitude meadow region.A substantial delay in the SOS-V relative to the SOS-T was observed in the desert,shrub,grassland and forest regions and generally kept pace with the ***,for 50%of the vegetated regions on the TP,inter-annual variation in the delay in the SOS-V relative to the SOS-T was dominated by precipitation change,which was profound in warm-climate *** study highlights the co-regulation of precipitation and temperature change in the SOS-V in different vegetation cover regions in the TP,offering a scientific foundation for comprehending the impact of climate change and prospects for vegetation phenology on the TP.

关键词： Tibetan Plateau Start of growing season Temperature Precipitation Climate change

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Solid Bronsted acidity boosts adsorption reactivity of nano-adsorbent for water decontamination

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 23-34页

作者： Sikai Cheng Zhixian Li Kaisheng Zhang Qingrui Zhang Xiaolin Zhang Bingcai pan State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China Environmental Materials and Pollution Control Laboratory Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reused Qinhuangdao 066004China Research Center for Environmental Nanotechnology(ReCENT) Nanjing UniversityNanjing 210023China

Despite the development of various Lewis acidic nano-adsorbents for fluoride removal through innersphere coordination,strong competition for hydroxyl ions still hinders efficient water *** addition,the critical issue of polysilicate scaling that results from the ubiquitous silicates must be *** tackle these issues,an alternative approach to enhancing adsorption reactivity by modifying nano-adsorbents with dual Lewis and Bronsted acidity is *** feasibility of this approach is demonstrated by growing zirconium phosphate(ZrP)inside a gel-type anion exchanger,N201,to produce nanocomposite ZrP@N201,in which the confined ZrP contained an otherwise metastable amorphous phase with Lewis acidic Zr^(4+) sites and Bronsted acidic monohydrogen phosphate groups(-O_(3)POH).Compared with the Lewis acidic nano-zirconium oxide analog(HZ0@N201),ZrP@N201 exhibited a greatly improved adsorption capacity(117.9 vs.52.3 mg/g-Zr)and mass transfer rate(3.56×10^(-6) vs.4.55×10^(-7) cm/s),while bulk ZrP produced a thermodynamically stableα-phase with Bronsted acidity that exhibited negligible adsorption capability toward *** enhanced defluoridation activity of ZrP@N201 is attributed to Bronsted acidity and the increased outer electron density of ZA+sites,as corroborated using XPS and solid-state NMR ***,Bronsted acidity strengthens the resistance of ZrP@N201 to silicate,allowing its full regeneration during cyclic *** tests demonstrated 3-10 times the amount of clean water from(waste)for ZrP@N201 as compared to both HZO@N201 and the widely used activated aluminum *** study highlights the potential of developing nano-adsorbents with dual acidities for various environmental remediation applications.

关键词： Nanocomposite Selective adsorption Fluoride removal Dual Lewis and Bronsted acidity Regeneration

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