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Bending reliability of screen-printed vias for a flexible energy module

npj Flexible Electronics 2020年第1期4卷 210-217页

作者： Manu Kujala Terho Kololuoma Jari Keskinen donald lupo Matti Mäntysalo Thomas M.Kraft Faculty of Computing and Electrical Engineering Tampere University(formerly Tampere University of Technology)Korkeakoulunkatu 3FI-33720TampereFinland Faculty of Information Technology and Communication Sciences Tampere UniversityKorkeakoulunkatu 3TampereFI-33720Finland Sasken Finland Oy Vissavedentie 1FI-69600KaustinenFinland VTT Technical Research Centre of Finland Ltd. Kaitoväylä1OuluFI-90590Finland

The future of printed electronics involves advancements not only related to full system integration,but also lean process manufacturing.A critical aspect of this progress is developed in this study,which evaluates a highly flexible screen printed through-hole-via using silver microparticle inks,for applications in energy harvesting and storage *** printed vias’fabrication and durability are evaluated by means of a double sided screen-printing method and repetitive(cyclic)bending ***,through 125-µm-thick PET foil,were laser cut(nominally 50,100,150,and 200µm diameters)then filled,and simultaneously connected to adjacent vias by screen *** investigate the use of the printed via in a monolithic energy module,the vias were used for the fabrication of a flexible printed supercapacitor containing aqueous electrolyte and carbon *** results indicate that the lower viscosity silver ink(DuPont 5064H)fills the via less effectively than the higher viscosity ink(Asahi LS411AW),and as the via size increases(≥150µm diameter)via walls are coated rather than ***,the more viscous ink fills the via thoroughly and exhibited a 100%yield(1010 vias;100µm nominal via diameter)with the two-step direct screen-printing *** 10-mm radius bending test showed no signs of via specific breakdown after 30,000 *** results indicate that this via filling process is likely roll-to-roll compatible to enable multi-layered printed electronic devices.

关键词： silver printing nominal

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From Slater to Mott physics by epitaxially engineering electronic correlations in oxide interfaces

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npj Computational Materials 2021年第1期7卷 846-851页

作者： Carla lupo Evan Sheridan Edoardo Fertitta David Dubbink Chris J.Pickard Cedric Weber Theory and Simulation of Condensed Matter King’s College LondonLondonUK Happy Electron Ltd LondonUK Department of Materials Science and Metallurgy University of CambridgeCambridgeUK Advanced Institute for Materials Research Tohoku UniversitySendaiJapan

Using spin-assisted ab initio random structure searches,we explore an exhaustive quantum phase diagram of archetypal interfaced Mott insulators,***-iron and lanthanum-titanium *** particular,we report that the charge transfer induced by the interfacial electronic reconstruction stabilises a high-spin ferrous Fe2+*** provide a pathway to control the strength of correlation in this electronic state by tuning the epitaxial strain,yielding a manifold of quantum electronic phases,***-Hubbard,charge transfer and Slater insulating ***,we report that the electronic correlations are closely related to the structural oxygen octahedral rotations,whose control is able to stabilise the low-spin state of Fe2+at low pressure previously observed only under the extreme high pressure conditions in the Earth’s lower ***,we provide avenues for magnetic switching via THz radiations which have crucial implications for next generation of spintronics technologies.

关键词： Slater lanthanum quantum

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Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone

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Neural Regeneration Research 2020年第10期15卷 1773-1783页

作者： Giancarlo Poiana Roberta Gioia Serena Sineri Silvia Cardarelli Giuseppe lupo Emanuele Cacci Department of Biology and Biotechnology "C.Darwin" Sapienza University of Rome

In rodents,well characterized neurogenic niches of the adult brain,such as the subventricular zone of the lateral ventricles and the subgranular zone of the hippocampus,support the maintenance of neural/stem progenitor cells(NSPCs)and the production of new neurons throughout the *** adult neurogenic process is dependent on the intrinsic gene expression signatures of NSPCs that make them competent for self-renewal and neuronal *** the same time,it is receptive to regulation by various extracellular signals that allow the modulation of neuronal production and integration into brain circuitries by various physiological stimuli.A drawback of this plasticity is the sensitivity of adult neurogenesis to alterations of the niche environment that can occur due to aging,injury or *** the core of the molecular mechanisms regulating neurogenesis,several transcription factors have been identified that maintain NSPC identity and mediate NSPC response to extrinsic ***,we focus on REST,Egr1 and Dbx2 and their roles in adult neurogenesis,especially in the subventricular *** review recent work from our and other laboratories implicating these transcription factors in the control of NSPC proliferation and differentiation and in the response of NSPCs to extrinsic influences from the *** also discuss how their altered regulation may affect the neurogenic process in the aged and in the diseased ***,we highlight key open questions that need to be addressed to foster our understanding of the transcriptional mechanisms controlling adult neurogenesis.

关键词： adult neurogenesis aging extracellular signaling gene regulation neural stem/progenitor cells transcription factors

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Potential therapeutic applications of mesenchymal stem cells for the treatment of eye diseases

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World Journal of Stem Cells 2021年第6期13卷 632-644页

作者： Giuliana Mannino Cristina Russo Anna Longo Carmelina Daniela Anfuso Gabriella lupo Debora Lo Furno Rosario Giuffrida Giovanni Giurdanella Department of Biomedical and Biotechnological Sciences School of MedicineUniversity of CataniaCatania 95123Italy

Stem cell-based treatments have been extensively explored in the last few decades to develop therapeutic strategies aimed at providing effective alternatives for those human pathologies in which surgical or pharmacological therapies produce limited *** stem cells of different sources,mesenchymal stem cells(MSCs)offer several advantages,such as the absence of ethical concerns,easy harvesting,low immunogenicity and reduced tumorigenesis *** than a multipotent differentiation ability,MSCs can release extracellular vesicles conveying proteins,mRNA and *** to these properties,new therapeutic approaches have been designed for the treatment of various pathologies,including ocular *** this review,the use of different MSCs and different administration strategies are described for the treatment of diabetic retinopathy,glaucoma,and retinitis *** a large number of investigations,positive results have been obtained by in vitro experiments and by MSC administration in animal *** authors agree that beneficial effects are likely related to MSC paracrine *** on these considerations,many clinical trials have already been carried ***,although some adverse effects have been described,promising outcomes are *** can be assumed that in the near future,safer and more effective protocols will be developed for more numerous clinical applications to improve the quality of life of patients affected by eye diseases.

关键词： Mesenchymal stem cells Eye diseases Diabetic retinopathy Glaucoma Retinitis pigmentosa Regenerative medicine

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Acute left-sided malignant colonic obstruction:Is there a role for endoscopic stenting?

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World Journal of Clinical Oncology 2023年第5期14卷 190-197页

作者： Salvatore Russo Rita Conigliaro Francesca Coppini Emanuela Dell'Aquila Giuseppe Grande Flavia Pigò Santi Mangiafico Marinella lupo Margherita Marocchi Helga Bertani Silvia Cocca Gastroenterology and Digestive Endoscopy Unit Modena University HospitalModena 41126Italy Gastroenterology and Digestive Endoscopy Unit Azienda USLIRCCs di Reggio EmiliaReggio Emilia 42122Italy Medical Oncology 1 IRCCS Regina Elena National Cancer InstituteRome 0144Italy

The therapy of left-sided malignant colonic obstruction continues to be one of the largest problems in clinical *** studies on colonic stenting for neoplastic colonic obstruction have been reported in the last *** the role of self-expandable metal stents(SEMS)in the treatment of malignant colonic obstruction has become better ***,numerous prospective and retrospective investigations have highlighted serious concerns about a possible worse outcome after endoscopic colorectal stenting as a bridge to surgery,particularly in case of *** review analyzes the most recent evidence in order to highlight pros and cons of SEMS placement in left-sided malignant colonic obstruction.

关键词： Colorectal neoplasm Intestinal obstruction Endoscopy Self expandable metallic stents Colorectal surgery Chemotherapy

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Genetic biomarkers for hepatocellular cancer risk in a caucasian population

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World Journal of Gastroenterology 2017年第36期23卷 6674-6684页

作者： Elena De Mattia Erika Cecchin Jerry Polesel Alessia Bignucolo Rossana Roncato Francesco lupo Marina Crovatto Angela Buonadonna Claudio Tiribelli Giuseppe Toffoli Clinical and Experimental Phar-macology “Centro di Riferimento Oncologico”-National Cancer Institute Unit of Cancer Epidemiology “Centro di Riferimento Oncologico”-National Cancer Institute General Surgery 2U and Liver Transplantation Center A.O.U.Cittàdella Salute e della Scienza di TorinoUniversity of Torino Cytogenetics and Molecular Biology Unit Santa Maria degli Angeli Hospital Pordenone Medical Oncology Unit “Centro di Riferimento Oncologico”-National Cancer Institute Fondazione Italiana Fegato AREA Science Park

AIM To uncover novel genetic markers that could contribute to predicting hepatocellular carcinoma(HCC)susceptibility in Caucasians. METHODS The present retrospective case-control study compared genotype frequencies between a cohort of HCC cases and two,independent,HCC-free,age/sex-matched control *** HCC cohort comprised 192 homogeneous patients that had undergone orthotopic liver *** first control group comprised167 patients that were matched to the HCC cohort for the percentage of hepatitis B(HBV)and/or hepatitis C(HCV)infections.A second control group included192 virus-free,healthy individuals that were used to evaluate the generalizability of the identified predictive *** cases and controls were *** three study populations were characterized with a panel of 31 markers derived from 21 genes that encoded key proteins involved in hepatocarcinogenesis-related *** study end-point was to assess the association between genetic variants and HCC onset. RESULTS Five genetic markers were identified as risk factors for HCC in high-risk patients infected with HBV/*** to a dominant model,reduced HCC risk was associated with three polymorphisms:ERCC1rs3212986(OR=0.46,95%CI:0.30-0.71,P=0.0005),GST-P1 rs1138272(OR=0.41,95%CI:0.21-0.81,P=0.0097),and CYP17A1 rs743572(OR=0.50,95%CI:0.31-0.79,P=0.0032).Conversely,according to a recessive model,increased HCC risk was associated with two polymorphisms:XRCC3 rs1799794(OR=3.70,95%CI:1.02-13.39,P=0.0461)and ABCB1 rs1128503(OR=2.06,95%CI:1.18-3.61,P=0.0111).These associations remained significant in a subgroup analysis,where patients were stratified according to viral status(HBV-or HCV-positive serology).Two variants exhibited a serology-specific effect:ABCB1 rs1128503(OR=4.18,95%CI:1.55-11.29,P=0.0048)showed an effect in the HBV-positive subgroup;and ERCC1 rs3212986(OR=0.33,95%CI:0.18-0.60,P=0.0003)showed an effect in the HCV-positive *** the five markers identified,E

关键词： ERCC1 XRCC3 GST-P1 CYP17A1 MDR-1 Polymorphisms Hepatocellular carcinoma risk Early diagnosis Antiviral therapy Hepatitis B viral/hepatitis C viral

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Restricted expression of XVAX2 in adult eye and brain of Xenopus laevis

Restricted expression of XVAX2 in adult eye and brain of Xen...

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第一届全国脑与认知科学学术研讨会

作者： Giuseppe lupo Giuseppina Barsacchi Department of Anatomy University of Cambridge CambridgeUK Department of Physiology and Biochemistry University of Pisa Italy

＜正＞As a homeobox gene, Xvax2 was proved to play an important role in the dorso-ventral patterning of eye development in Xenopus. To further investigate the functions of Xvax2 in adult, we prepared a specific polyclonal antibody against XVAX2, and extensively analyzed the expression of Xvax2 in eye and brain during the late embryonic stages and adult by immunohistochemistry and in situ hybridization.. In general, XVAX2 was detected in the ventral parts of olfactory placode, optic vesicle and forebrain at tailbud and tadpole stages, consistent with the distribution of Xvax2 transcripts

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What does the APO mean?

What does the APO mean?

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第34届中国气象学会年会

作者： Yafei Wang Anthony R.lupo Chinese Academy of Meteorological Sciences University of Missouri

The Asian-Pacific Oscillation（APO） is a relatively new teleconnection index and a number of peer-reviewed studies have confirmed its’ existence. This study reexamines the concept of the APO teleconnection as currently published in the literature. Most results have found that this pattern could be defined as its own teleconnection pattern within the Pacific Ocean Basin. This work demonstrates that the APO is inevitably associated with an additional action center located over the North Atlantic Ocean, and the index can be extended. Previous studies have used a variety of methods to represent the APO, and a method is proposed here to standardize the formulation. It is argued that the extended index proposed here provides a more robust result. The APO typically is identified using the eddy temperature rather than geopotential height as the source material for its construction, as geopotential could not adequately represent this teleconnection pattern. This leads to a discussion regarding the basic criterion for defining teleconnective activity within the extratropical regions. We also identify other problems in the current understanding of APO theory that need to be addressed.

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北大西洋振荡（NAO）产生的一个理论模式

北大西洋振荡（NAO）产生的一个理论模式

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第六次全国动力气象学术会议

作者：罗德海 Anthony,R.lupo 中国海洋大学海洋环境学院美国密密苏比大学土壤环境和大气科学系

＜正＞在这篇论文中,我们提出了天气尺度波激发北大西洋振荡（NAO）的一个新的理论模式。从这个模式可以发现天气尺度波可以激发生命期为两周的NAO环流。NAO的位相取决于NAO产生前期的行星波和天气尺度波强迫的结构。当行星波具有北高...

＜正＞在这篇论文中,我们提出了天气尺度波激发北大西洋振荡（NAO）的一个新的理论模式。从这个模式可以发现天气尺度波可以激发生命期为两周的NAO环流。NAO的位相取决于NAO产生前期的行星波和天气尺度波强迫的结构。当行星波具有北高南低的偶极子结构且天气尺度波强迫具有北负南正结构时,天气尺度波能激发负位相的NAO,反之则激发正位相的NAO。

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CD133 and CD24 expression in renal tissue of patients affected by autosomal dominant polcystic kidney disease

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Stem Cell Discovery 2013年第4期3卷 211-217页

作者： Daniele Lodi Giulia Ligabue Fabrizio Cavazzini Valentina lupo Gianni Cappelli Riccardo Magistroni Department of Medicine and Medical Specialties Division of Nephrology Dialysis and Transplantation University of Modena and Reggio Emilia Modena Italy

Background: Autosomal dominant polycystic kidney disease is a condition mainly characterized by the progressive development and enlargement of cysts in each kid ney. In this process a high rate of proliferation and apoptosis of tubular cells has been documented and interpreted as a futile attempt of tissue repair. In consideration of the role of stem cells in reparative processes we investigated the presence and localization of CD133 + CD24+ renal progenitors in renal ADPKD tissue and cells. Methods: Two normal kidneys and two ADPKD kidneys were examined. CD133 and CD24 expression was investigated by confocal microscopy and immunoblotting. Furthermore cystic isolated cells and cultured immortalized cells were characterized. Results: CD133 and CD24 have the same localization in ADPKD tissues and in normal kidneys: expression is restricted to a subset of epithelial cells (PEC) of Bowman’s capsule and to tubular cells in a focal and segmental pattern. Furthermore, in ADPKD tissue, cysts diffusely express CD133 and CD24. According to a quantitative analysis in ADPKD tissue CD133 + CD24 + cells are statistically more expressed in tubules (p < 0.001) and less expressed in the Bowman’s capsule (p = 0.0016) compared to the same localizations in control tissue. Conclusions: CD133 and CD24 antigens, typically expressed by renal epithelial progenitors, are more expressed in ADPKD tubules and highly expressed in ADPKD cysts. Whether CD133 and CD24 expression would signify renal progenitor recruitment or alternatively an expression pattern of the dedifferentiation of ADPKD cells remains unclear.

关键词： Renal Stem Cells CD133 CD24 ADPKD

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