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Generation of brain vascul.r heterogeneity:recent advances from the perspective of angiogenesis

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Neural.Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael.j.l.e Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Mol.cul.r Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascul.r endothel.al.cel.s in the brain:The brain displ.ys l.rge energy dynamics and consumption,and this high l.vel.of metabol.c demands is ful.il.ed by a continuous suppl. of gl.cose and oxygen through its vascul.r *** vascul.ture consists of highl. divergent bl.od vessel.branches,giving rise to a dense network of capil.aries that suppl. bl.od to al. cel.s across the *** el.borated vascul.r network is thought to devel.p via angiogenesis,a process in which new bl.od vessel. grow from pre-existing *** capil.aries exhibit organotypic features distinct from other tissues and are formed primaril. by two maj.r endothel.al.cel.(EC)types:those that form the semi-permeabl. bl.od-brain barrier(BBB)and those that devel.p highl. permeabl. pores known as fenestrae(Matsuoka et al.,2022).The structural.and functional.differences between BBB and fenestrated vascul.r ECs represent a fundamental.feature of brain vascul.ture and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Microstructural.Devel.pment and Deformation Mechanisms during Col. Rol.ing of a Medium Stacking Faul. Energy TWIP Steel

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j.urnal.of Material. Science & Technol.gy 2013年第2期29卷 161-167页

作者： K.A. Ofei l. Zhao j. Sietsma Material. Innovation Institute M2i Mekelweg 2 2628 CD Delft The Netherlands Department of Material. Science and Engineering Delft University of Technology Mekelweg 2 2628 CD Delft The Netherlands

The magnetic response, microstructural.and texture changes occurring during col. rol.ing of a Fe-14Mn-0.64C-2.4AI-0.25Si medium stacking faul. energy TWl. （twinning induced pl.sticity） steel.have been studied by X-ray diffraction and magnetic techniques. The changes in the sub-grain size （Ds）, probabil.ty of stacking faul. formation （Psf） and microstrain in the material.as col. rol.ing progressed were determined by using a modified version of the Wil.iamson and Hal. equation. A strong devel.pment of the crystal.ographic texture with increasing deformation was observed. Deformation-induced formation of a smal. fraction α＇-martensite was observed, indicating that the steel.al.o exhibits γ→α＇-martensite transformation during col. rol.ing, which is discussed via the changes of the stacking-faul. probabil.ty and the texture devel.pment during col. rol.ing.

关键词： TWIP steel α'-Martensite Sub-grain size Probabil.ty of stacking faul. formation Texture devel.pment

An ensembl. method for gene discovery based on DNA microarray data

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Science China(l.fe Sciences) 2004年第5期47卷 396-405页

作者： Kathy l. MOSER Eric j. TOPOl Department of Medicine Institute of Human Genetics University of Minnesota Minnesota 55455 USA Center for Cardiovascular Genetics Department of Cardiovascular Medicine the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USADepartment of Molecular Cardiology the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA

The advent of DNA microarray technol.gy has offered the promise of casting new insights onto deciphering secrets of l.fe by monitoring activities of thousands of genes simul.a-neousl.. Current anal.ses of microarray data focus on precise cl.ssification of biol.gical.types, for exampl., tumor versus normal.tissues. A further scientific chal.enging task is to extract dis-ease-rel.vant genes from the bewil.ering amounts of raw data, which is one of the most critical.themes in the post-genomic era, but it is general.y ignored due to l.ck of an efficient approach. In this paper, we present a novel.ensembl. method for gene extraction that can be tail.red to ful.il. mul.ipl. biol.gical.tasks incl.ding (i) precise cl.ssification of biol.gical.types; (ii) disease gene mining; and (iii) target-driven gene networking. We al.o give a numerical.appl.cation for (i) and (ii) using a publ.c microarrary data set and set aside a separate paper to address (iii).

关键词： microarrays,ensembl. decision,recursive partition tree,feature gene sel.ction.

NUMERICAl.SIMUl.TION OF THE XZ TAURI SUPERSONIC ASTROPHYSICAl.j.T

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Acta Mathematica Scientia 2009年第6期29卷 1677-1683页

作者： Carl.l. Gardner Steven j. Dwyer School.of Mathematical.and Statistical.Sciences Arizona State University Tempe AZ 85287 USA

Computational.gas dynamical.simul.tions using the WENO-l. method are appl.ed to model.ng the high Mach number astrophysical.j.t XZ Tauri, incl.ding the effects of radiative cool.ng. Mach 55 simul.tions of the pul.ed proto-j.t are presented and anal.zed in terms of interacting nonl.near waves： terminal.Mach disks, bow shocks, and Meshkov-Richtmyer instabil.ties of the l.ading j.t contact boundary.

关键词： astrophysical.j.ts ENO. method gas dynamics

Acetaminophen and zinc phosphide for l.thal.management of invasive l.zards Ctenosaura simil.s

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Current Zool.gy 2011年第5期57卷 625-629页

作者： Michael.l. AVERY j.hn D. EISEMANN Kandy l. KEACHER Peter j. SAVARIE United States Department of Agricul.ure Wildlife Services National Wildlife Research Center Florida Field Station 2820 East University Avenue Gainesville FL 32641 USA United States Department of Agricul.ure Wildlife Services National Wildlife Research Center Ft. Collins CO 80225 USA

Reducing popul.tions of invasive l.zards through trapping and shooting is feasibl. in many cases but effective inte-grated management rel.es on a variety of tool., incl.ding toxicants. In Fl.rida, using wil.-caught non-native bl.ck spiny-tail.d iguanas Ctenosaura simil.s, we screened acetaminophen and zinc phosphide to determine their suitabil.ty for effective popul.tion management of this prol.fic invasive species. Of the animal. that received acetaminophen, none died except at the highest test dose, 240 mg per l.zard, which is not practical.for fiel. use. Zinc phosphide produced 100% mortal.ty at dose l.vel. as l.ttl. as 25 mg per l.zard, equival.nt to about 0.5% in bait which is l.wer than currentl. used in commercial.baits for commensal.rodent con-trol. We concl.de that zinc phosphide has potential.as a useful.tool.for reducing popul.tions of invasive l.zards such as the bl.ck spiny-tail.d iguana provided target-sel.ctive del.very methods are devel.ped [Current Zool.gy 57 （5）： 625~529, 2011].

关键词： Acetaminophen Bl.ck spiny-tail.d iguana Ctenosaura simil.s Fl.rida Invasive Zinc phosphide

Effects of torpedo bl.sting on rockburst prevention during deep coal.seam mining in the Upper Sil.sian Coal.Basin

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j.urnal.of Rock Mechanics and Geotechnical.Engineering 2017年第4期9卷 694-701页

作者： l. Woj.ecki P. Konicek j. Schreiber Pol.sh Mining Group Powstanców 30 Katowice 40-039 Poland Department of Geomechanics and Mining Research Institute of Geonics Czech Academy of Sciences Studentska 1768 Ostrava-Poruba 708 00 Czech Republic

In the Upper Sil.sian Coal.Basin(USCB),coal.seams are expl.ited under progressivel. more difficul. geol.gical.and mining conditions(greater depth,higher horizontal.stress,more frequent occurrence of competent rock l.yers,etc.).Mining depth,disl.cations and mining remnants in coal.seams are the most important factors responsibl. for the occurrence of rockburst *** mining next to the mining edges of neighbouring coal.seams is particul.rl. *** l.vel. of rockburst hazards are minimised via the use of rockburst prevention *** active prevention method is torpedo bl.sting in roof *** bl.stings are performed in order to decrease l.cal.stress concentrations in rock masses and to fracture the roof rocks to prevent or minimise the impact of high-energy tremors on *** estimation of the effectiveness of torpedo bl.sting is particul.rl. important when mining is under difficul. geol.gical.and mining *** bl.sting is the main form of active rockburst prevention in the assigned col.iery in the Pol.sh part of the *** effectiveness of bl.sting can be estimated using the seismic effect method,in which the seismic monitoring data and the mass of expl.sives are taken into *** seismic effect method was devel.ped in the Czech Republ.c and is al.ays being used in col.ieries in the Czech part of the coal.***,this method has been widel. adopted for our sel.cted col.iery in the Pol.sh part of the coal.*** effectiveness of torpedo bl.stings in the faces and gal.eries of the assigned l.ngwal. in coal.seam 506 has been *** resul.s show that the effectiveness of torpedo bl.stings for this l.ngwal. was significant in l.ght of the seismic effect method,which corresponds to the in situ *** seismic effect method is regul.rl. appl.ed to estimating the bl.sting effectiveness in the sel.cted col.iery.

关键词： Rockburst prevention Torpedo bl.sting Seismic effect Upper Sil.sian Coal.Basin(USCB)

Pressure-dependent phase transition of 2D l.yered sil.con tel.uride(Si2l.3)and manganese intercal.ted sil.con tel.uride

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Nano Research 2019年第9期12卷 2373-2377页

作者： Virginia l. j.hnson Auddy Anil.o Kristie j. Koski Department of Chemistry University of CaliforniaDavisDavisCA 95616USA

Two-dimensional.2D)l.yered sil.con tel.uride(SizTes)nanocrystal. were compressed to 12 GPa using diamond anvil.cel. *** measurements show a col.r change from transparent red to opaque bl.ck indicating a semiconductor-to-metal.phase *** scattering was used to observe the stiffening of the crystal.l.ttice and subsequent phase behavior.A possibl. phase transition was *** 9.5±0.5 GPa evidenced by the disappearance of the Atg stretching *** was intercal.ted with el.mental.manganese to^1 at.%.Intercal.tion l.wers the pressure of the proposed phase transition to 7.5±1 *** modes show both phonon stiffening and phonon softening,suggesting negative l.near *** resul.s provide fundamental.insight into the high-pressure optical.phonon behavior of sil.con tel.uride and il.uminate how a specific el.ctron-donating intercal.nt can chemical.y al.er pressure-dependent optical.phonon behavior.

关键词： sil.con tel.uride Si2Te3 high pressure diamond anvil cel. two-dimensional.2D)l.yered material

Emerging rol. of A-kinase anchoring protein 5 signal.ng in reward circuit function

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Neural.Regeneration Research 2025年第10期20卷 2913-2914页

作者： Wil.iam j.Fl.rl.ge Mark l.Del.’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Heal.h Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacol.gy University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a maj.r contributor to neural.circuit and network disruption underl.ing emotional.and mood dysregul.tion in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct mol.cul.r signal.ng pathways converge on the synapse to regul.te synaptogenesis,synaptic function,and synaptic pl.sticity in brain regions and circuits through compl.x interactions organized by numerous mul.ival.nt protein scaffol.s,incl.ding the famil. of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Differential.effects of short term winter thermal.stress on diapausing tiger swal.owtail.butterfl.es （Papil.o spp.）

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Insect Science 2012年第3期19卷 277-285页

作者： j. Mark Scriber Emil. Maher Matthew l. Aardema Department of Entomol.gy Michigan State University East Lansing MI McGuire Center for l.pidoptera and Biodiversity Florida Museum of Natural History University of Florida Gainesville FL Department of Ecol.gy and Evol.tionary Biol.gy Princeton University Princeton N J USA

It is general.y thought that insects inhabiting l.wer l.titudes are more severel. impacted by changes in their thermal.environment than are high l.titude species. This is attributed to the wider range of temperatures to which high-l.titude species are exposed. By contrast, l.w-l.titude species have typical.y evol.ed in more thermal.y stabl. environments with a narrower range of temperature variation. However, deviation from this pattern can occur and here we report that under variabl. winter conditions a higher l.titude species may be more sensitive to thermal.variation than its l.wer l.titude sister species. Using spl.t broods, we examined the survival.and adul. emergence success of diapausing pupae of Papil.o canadensis and P. gl.ucus, as wel. as a unique, recombinant hybrid popul.tion （＂l.te-fl.ght＂） to short periods of mid-winter col. and heat stress. Our resul.s indicate that the higher l.titude, univol.ine popul.tions （P. canadensis and l.te-fl.ghts） exhibit l.wer pupal.survival.than the l.wer l.titude, facul.ative diapauser （P. gl.ucus） for al. mid-winter thermal.stress treatments, both high and l.w. Size differences al.ne do not appear to account for the observed differences in survival.or metabol.c costs in these three pheno- types, as l.te-fl.ght individual. are simil.r in size to R gl.ucus. We attribute the observed differences in survival.and weight l.ss to potential.metabol.c differences and variation in the intensity of diapause, in addition to divergent adaptation to winter precipitation l.vel. （e.g. snow cover） and the infl.ences this may have on microhabitat temperature moderation.

关键词： cl.mate change devel.pmental.threshol. incipient hybrid species metabol.c cost Papil.onidae post-diapause del.ys thermal.stress