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SAMPLING METHODS AND APPROACHES USING RADIONUCLIDE TRACERS IN THE STUDY OF SEDIMENT RESUSPENSION AND CROSS MARGIN TRANSPORT IN NEARSHORE OF THE LAURENTIAN GREAT LAKES

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International j.urnal of Sediment Research 2003年第2期 266-277页

作者： j. Val KLUMP,David N. EDGINGTON,j.mes T. WAPLES,donald C. SZMANIA,Bruce E. BROWN,Kent A. ORLANDINI Great Lakes WATER Institute University of Wisconsin-Milwaukee Great Lakes WATER Institute University of Wisconsin-Milwaukee Great Lakes WATER Institute University of Wisconsin-Milwaukee Great Lakes WATER Institute University of Wisconsin-Milwaukee Great Lakes WATER Institute University of Wisconsin-Milwaukee Environmental Research Division Argonne National Laboratory Milwaukee WI USA Milwaukee WI USA Milwaukee WI USA Milwaukee WI USA Milwaukee WI USA Argonne IL USA

Preliminary results from an investigation of the U-238/Th-234 parent/daughter pair in the nearshore environments of Lake Michigan show that short-lived, naturally-occurring radionuclides are useful in determining the time scales of sediment transport processes on the orders of days to weeks. While the long term, depositional sink for some new particles entering the lake, either from rivers or shoreline erosion, has been well documented, the aggregate time scale of the processes by which these particles move from source to sink is not well quantified. These relatively 搉ew?particles may undergo numerous episodes of resuspension and redeposition before making their way through the coastal margin and entering the long term focusing processes active in the depositional basins of the lake. These episodic events can be large in scale and magnitude, resuspending as much or more material than is permanently deposited in the lake on an annual basis. Th-234, a particle reactive radionuclide with a 24 day half-life, would appear to be well suited as a tracer for following rapid particle movement, particle residence times in the overlying water, and alongshore transport processes. The remotely operated vehicle (ROV) deployed technique for collection of surface sediments residing in non-depositional (hard bottom) lakebeds and some preliminary time series results for transient excess Th-234 inventories in the nearshore of Lake Michigan are described.

关键词： Sediments Resuspension ROV Radionuclides Great Lakes

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清醒大鼠前扣带皮层神经元群的伤害性反应(英文)

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北京大学学报（医学版） 2004年第1期36卷 47-51页

作者：王锦琰罗非张含荑张景渝 donald j.WOODWARD 韩济生北京大学基础医学院神经生物学系北京100083 美国维克林大学医学院生理与药理学系

目的 :利用多通道记录技术在清醒大鼠前扣带回 (ACC)记录神经元群的痛反应模式 ,以证实ACC在痛觉情绪编码中的作用。方法 :在 5只成年雄性SD大鼠的双侧ACC脑区植入微电极阵列 ,在大鼠术后清醒状态下给予尾部及四肢足底伤害性辐射热刺激 ... 详细信息

目的 :利用多通道记录技术在清醒大鼠前扣带回 (ACC)记录神经元群的痛反应模式 ,以证实ACC在痛觉情绪编码中的作用。方法 :在 5只成年雄性SD大鼠的双侧ACC脑区植入微电极阵列 ,在大鼠术后清醒状态下给予尾部及四肢足底伤害性辐射热刺激 ,神经元的放电信号经由电缆和连接器传送至多通道记录系统。结果 :伤害性辐射热刺激在大鼠ACC引起以兴奋为主的反应 ,该反应持续时间较长 ,可能与痛情绪有关 ;刺激开始附近ACC神经元有与痛刺激相关的预期性反应 ,可能与准备逃避的动机有关 ;同侧和对侧肢体刺激引起的ACC神经元的反应差别不显著 ,表明神经元感受野大 ,不适合精确定位。结论

关键词：扣带皮层神经元疼痛多通道记录技术伤害性反应微电极阵列大鼠

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MUC1及其C端活性片段突变体具有抑制肿瘤的活性

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生物化学与生物物理进展 2007年第4期34卷 375-381页

作者：魏玲易艳萍刘萱 donald KUFE 曹诚军事医学科学院生物工程研究所 Dana-Farber Cancer Institute Harvard Medical SchoolBostonMassachusetts 02115USA

MUC1蛋白翻译后成为一条多肽链,它很快在内质网被切割成2个亚基,形成稳定的异源二聚体.Cys-Gln-Cys(CQC)3个氨基酸位于MUC1C端亚基跨膜结构域与胞内结构域的连接处.研究发现,MUC1C端的CQCRRK结构域突变成AQARRK或使其缺失,突变体的致瘤... 详细信息

MUC1蛋白翻译后成为一条多肽链,它很快在内质网被切割成2个亚基,形成稳定的异源二聚体.Cys-Gln-Cys(CQC)3个氨基酸位于MUC1C端亚基跨膜结构域与胞内结构域的连接处.研究发现,MUC1C端的CQCRRK结构域突变成AQARRK或使其缺失,突变体的致瘤性明显降低.表明:通过突变CQC→AQA来阻碍与C端亚基相关的二聚体化,可能成为肿瘤治疗的新途径.

关键词： MUC1 C-ter CQC序列异源二聚体

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3个不同苹果品种果实品质及对1-MCP的吸附释放规律

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果树学报 2015年第2期32卷 291-297页

作者：董晓庆朱守亮 j.mes H.Lee donald j.Huber 贵州省果树工程技术研究中心.贵州大学农学院贵阳550025 贵州省果树蔬菜工作站贵阳550025 美国佛罗里达州佛罗里达大学盖恩斯维尔110690

【目的】探讨生产上苹果不同品种贮藏保鲜理论依据和技术。【方法】以3个苹果品种‘旭’、‘嘎拉’、‘蜜脆’为试验材料,用1-甲基环丙烯(1-MCP)进行处理,分析研究了其采收时的品质及对1-MCP的吸附释放特性规律。【结果】‘旭’、‘嘎... 详细信息

【目的】探讨生产上苹果不同品种贮藏保鲜理论依据和技术。【方法】以3个苹果品种‘旭’、‘嘎拉’、‘蜜脆’为试验材料,用1-甲基环丙烯(1-MCP)进行处理,分析研究了其采收时的品质及对1-MCP的吸附释放特性规律。【结果】‘旭’、‘嘎拉’、‘蜜脆’3个苹果品种硬度、可溶性固形物含量、可滴定酸、固酸比和果肉颜色之间的差异显著(P<0.05),采后1 d内部乙烯含量较低,但3者之间差异显著(P<0.05)。‘旭’、‘嘎拉’、‘蜜脆’果实经过20μL·L-11-MCP于20℃下处理12 h后,内部积累的1-MCP量显著不同,其中‘蜜脆’积累的最多,其次为‘嘎拉’,‘旭’果实内部基本没有积累;而瓶内的1-MCP消耗量没有差别(12 h后,‘旭’、‘嘎拉’和‘蜜脆’瓶内1-MCP消耗量分别为18.3%,17.3%和18.9%)。经过100μL·L-11-MCP于20℃下处理6 h后取出,1-MCP从不同品种果实向外释放的速率和释放量显著不同(P<0.05)。前3 h,‘嘎拉’的释放速率和释放量最大,3 h后,‘蜜脆’的释放速率和释放量最大,‘旭’的释放速率和释放量一直最小。【结论】‘旭’、‘嘎拉’、‘蜜脆’3个不同苹果品种在采后时的品质、内部乙烯含量以及对1-MCP的反应特性不同。经1-MCP处理后,内部积累的1-MCP量显著不同:‘旭’、‘嘎拉’和‘蜜脆’对1-MCP的吸附量(6 h)分别为16.2%、19.8%和7.0%。

关键词：苹果品种 1-甲基环丙烯吸附扩散品质

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Hepatic intra-arterial infusion of yttrium-90 microspheres in the treatment of recurrent hepatocellular carcinoma after liver transplantation: A case report

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World j.urnal of Gastroenterology 2006年第35期12卷 5729-5732页

作者： Louis Rivera Huan Giap William Miller j.nathan Fisher donald j.Hillebrand Christopher Marsh Randolph L Schaffer Naval Medical Center San Diego San Diego CA 92134 United States Department of Radiation Oncology Scripps Clinic/ Green Hospital La Jolla CA 92037 United States Department of Hematology/Oncology Scripps Clinic/Green Hospital La Jolla CA 92037 United States Scripps Center for Organ and Cell Transplantation Scripps Clinic/Green Hospital La Jolla CA 92037 United States

Hepatocellular carcinoma （HCC） recurs with a reported frequency of 12%-18% after liver transplantation. Recurrence is associated with a mortality rate exceeding 75%. Approximately one-third of recurrences develop in the transplanted liver and are therefore amenable to local therapy. A variety of treatment modalities have been reported including resection, transarterial chemoembolization （TACE）, radiofrequency ablation （RFA）, ethanol ablation, cryoablation, and external beam irradiation. Goals of treatment are tumor control and the minimization of toxic effect to functional parenchyma. Efficacy of treatment is mitigated by the need for ongoing immunosuppression. Yttrium-90 microspheres have been used as a treatment modality both for primary HCC and for pre-transplant management of HCC with promising results. Twenty-two months after liver transplantation for hepatitis C cirrhosis complicated by HCC, a 42-year old man developed recurrence of HCC in his transplant allograft. Treatment of multiple right lobe lesions with anatomic resection and adj.vant chemotherapy was unsuccessful. Multifocal recurrence in the remaining liver allograft was treated with hepatic intra-arterial infusion of yttrium-90 microspheres （SIR-Spheres, Sirtex Medical Inc., Lake Forest, IL, USA）. Efficacy was demonstrated by tumor necrosis on imaging and a decrease in alpha-fetoprotein （AFP） level. There were no adverse consequences of initial treatment.

关键词： Recurrent hepatocellular carcinoma Yttrium-90 microspheres Liver transplantation

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一分聚脲九分施工

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上海涂料 2008年第6期46卷 50-52页

作者：黄微波 dudley j.Primeaux Ⅱ 青岛理工大学 266033 Primeaux Associates LLC

给出了聚脲的科学定义,介绍了聚脲的成膜机理、施工隐患及解决方案。

关键词：喷涂聚脲施工

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3D Chromatin Architecture of Large Plant Genomes Determined by Local A/B Compartments

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Molecular Plant 2017年第12期10卷 1497-1509页

作者： Pengfei Dong Xiaoyu Tu Po-Yu Chu Peitao Lu Ning Zhu donald Grierson Baij.an Du Pinghua Li Silin Zhong State Key Laboratory of Crop Biology College of Agronomy Shandong Agricultural University Tai'an Shandong China State Key Laboratory of Agrobiotechnology School of Life Sciences The Chinese University of Hong Kong Hong Kong China Zhej.ang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang University Hangzhou Zhejiang China These authors contributed equally to this article.

The spatial organization of the genome plays an important role in the regulation of gene expression. How- ever, the core structural features of animal genomes, such as topologically associated domains （TADs） and chromatin loops, are not prominent in the extremely compact Arabidopsis genome. In this study, we examine the chromatin architecture, as well as their DNA methylation, histone modifications, accessible chromatin, and gene expression, of maize, tomato, sorghum, foxtail millet, and rice with genome sizes ranging from 0.4 to 2.4 Gb. We found that these plant genomes can be divided into mammalian-like A/B compartments. At higher resolution, the chromosomes of these plants can be further partitioned to local Aj. compartments that reflect their euchromatin, heterochromatin, and polycomb status. Chromatins in all these plants are organized into domains that are not conserved across species. They show similarity to the Drosophila compartment domains, and are clustered into active, polycomb, repressive, and interme- diate types based on their transcriptional activities and epigenetic signatures, with domain border overlaps with the local A/B compartment j.nctions. In the large maize and tomato genomes, we observed extensive chromatin loops. However, unlike the mammalian chromatin loops that are enriched at the TAD border, plant chromatin loops are often formed between gene islands outside the repressive domains and are closely associated with active compartments. Our study indicates that plants have complex and unique 3D chromatin architectures, which require further study to elucidate their biological functions.

关键词： Hi-C chromatin loop compartment domain local compartment

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Heavy Metals in Soil and Salad in the Proximity of Historical Ferroalloy Emission

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j.urnal of Environmental Protection 2012年第5期3卷 374-385页

作者： Roberta Ferri Filippo Donna donald R. Smith Stefano Guazzetti Annalisa Zacco Luigi Rizzo Elza Bontempi Neil j. Zimmerman Roberto G. Lucchini Department of Experimental and Applied Medicine University of Brescia Brescia Italy INSTM and Chemistry for Technologies Laboratory University of Brescia Brescia Italy Microbiology and Environmental Toxicology University of California Santa Cruz USA Public Health Service Reggio Emilia Italy School of Health Sciences Purdue University West Lafayette USA

Emissions of manganese (Mn), lead (Pb), iron (Fe), zinc (Zn), copper (Cu) from ferro-alloy operations has taken place in Valcamonica, a pre-Alp valley in the province of Brescia, Italy, for about a century until 2001. Metal concentrations were measured in the soil of local home gardens and in the cultivated vegetables. Soil analysis was carried out using a portable X-Ray Fluorescence (XRF) spectrometer in both surface soil and at 10 cm depth. A subset of soil samples (n = 23) additionally was analysed using the modified BCR sequential extraction method and ICP-OES for intercalibration with XRF (XRF Mn = 1.33 * total OES Mn – 71.8;R = 0.830, p Lactuca sativa and Chichorium spp.) were analyzed with a Total Reflection X-Ray Fluorescence (TXRF) technique. Vegetable and soil metal measurements were performed in 59 home gardens of Valcamonica, and compared with 23 gardens from the Garda Lake reference area. Results indicate significantly higher levels of soil Mn (median 986 ppm vs 416 ppm), Pb (median 46.1 ppm vs 30.2 ppm), Fe (median 19,800 ppm vs 13,100 ppm) in the Valcamonica compared to the reference area. Surface soil levels of all metals were significantly higher in surface soil compared to deeper soil, consistent with atmospheric deposition. Significantly higher levels of metals were shown also in lettuce from Valcamonica for Mn (median 53.6 ppm vs 30.2) and Fe (median 153 vs 118). Metals in Chichorium spp. did not differ between the two areas. Surface soil metal levels declined with increasing distance from the closest ferroalloy plant, consistent with plant emissions as the source of elevated soil metal levels. A correlation between Mn concentrations in soil and lettuce was also observed. These data show that historic ferroalloy plant activity, which ended nearly a decade before this study, has contributed to the persistence of increased Mn levels in locally grown vegetables. Further research is needed to assess whether this increase can lead to adverse effects i

关键词： Heavy Metals Ferroalloy Plant Soil Vegetables XRF ICP-OES

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纪念聚脲先锋——Thomas ***先生

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上海涂料 2008年第5期46卷 46-47页

作者：黄微波 dudley j.Primeaux Ⅱ 青岛理工大学 Primeaux Associates LLC TX.78621USA

Thomas ***(以下简称Tom)先生是笔者和世界聚脲技术的发明人dudley ***Ⅱ(以下简称dudley)的好友,今年2月因患急性心肌梗塞不幸去世。为了纪念这位曾经与dudley共同创立聚脲事业的先锋,dudley先生在2008年的"聚脲发展协会"第九次年会上... 详细信息

Thomas ***(以下简称Tom)先生是笔者和世界聚脲技术的发明人dudley ***Ⅱ(以下简称dudley)的好友,今年2月因患急性心肌梗塞不幸去世。为了纪念这位曾经与dudley共同创立聚脲事业的先锋,dudley先生在2008年的"聚脲发展协会"第九次年会上发表了纪念文章。本文是经dudley先生同意,并在他纪念性文章的基础上,结合笔者的亲历撰写完成的。

关键词：聚脲心肌梗塞发明人纪念性

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The landscape epidemiology of echinococcoses

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Infectious Diseases of Poverty 2016年第1期5卷 107-119页

作者： Angela M.Cadavid Restrepo Yu Rong Yang donald P.McManus Darren j.Gray Patrick Giraudoux Tamsin S.Barnes Gail M.Williams Ricardo j.Soares Magalhães Nicholas A.S.Hamm Archie C.A.Clements Research School of Population Health The Australian National UniversityCanberraNew South WalesAustralia Ningxia Medical University YinchuanNingxia Hui Autonomous RegionP.R.China Molecular Parasitology Laboratory QIMR Berghofer Medical Research InstituteBrisbaneQueenslandAustralia Chrono-environment lab UMR6249University of Bourgogne Franche-Comté/CNRSBesançonFrance Institut Universitaire de France ParisFrance The University of Queensland School of Veterinary ScienceGattonQueenslandAustralia The University of Queensland Queensland Alliance for Agriculture and Food InnovationGattonQueenslandAustralia School of Public Health The University of QueenslandBrisbaneQueenslandAustralia Child Health Research Centre The University of QueenslandBrisbaneQueenslandAustralia Faculty of Geo-Information Science and Earth Observation(ITC) University of TwenteEnschedeThe Netherlands

Echinococcoses are parasitic diseases of maj.r public health importance *** infection results in chronic disease with poor prognosis and serious medical,social and economic consequences for vulnerable *** to recent estimates,the geographical distribution of Echinococcus *** is expanding and becoming an emerging and re-emerging problem in several regions of the *** endemicity is geographically heterogeneous and over time it may be affected by global environmental ***,landscape epidemiology offers a unique opportunity to quantify and predict the ecological risk of infection at multiple spatial and temporal ***,we review the most relevant environmental sources of spatial variation in human echinococcosis risk,and describe the potential applications of landscape epidemiological studies to characterise the current patterns of parasite transmission across natural and human-altered *** advocate future work promoting the use of this approach as a support tool for decision-making that facilitates the design,implementation and monitoring of spatially targeted interventions to reduce the burden of human echinococcoses in disease-endemic areas.

关键词： Landscape epidemiology Helminth infection Human echinococcosis Echinococcus spp Environmental change Geographic information systems Remote sensing Geostatistics

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