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Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

siRNA therapeutics:a clinical reality

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Science China(Life Sciences) 2020年第4期63卷 485-500页

作者： Phei er Saw er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Zhongshan School of Medicine Breast SurgeryGuangzhou 510080China

Since the revolutionary discovery of RNA interference(RNAi),a remarkable progress has been achieved in understanding and harnessing gene silencing mechanism;especially in small interfering RNA(siRNA)*** its tremendous potential benefits,major challenges in most siRNA therapeutics remains unchanged-safe,efficient and target oriented delivery of *** years after the discovery of RNAi,siRNA therapeutics finally charts its way into *** we journey through the decades,we reminisce the history of siRNA discovery and its application in a myriad of disease ***,we highlight the breakthroughs in si RNA therapeutics,with special feature on the first FDA approved RNAi therapeutics Onpattro(Patisiran)and the consideration of effective siRNA delivery system focusing on current siRNA nanocarrier in clinical ***,we present some challenges and multiple barriers that are yet to be fully overcome in siRNA therapeutics.

关键词： siRNA therapeutic disease treatment systemic siRNA delivery clinical application

Phage display screening of therapeutic peptide for cancer targeting and therapy

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Protein & Cell 2019年第11期10卷 787-807页

作者： Phei er Saw er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Recently,phage display technology has been announced as the recipient of Nobel Prize in Chemistry *** display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched through the biopanning process;proving to be a powerful technique in the screening of peptide with high affinity and *** this review,we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands by in situ,in vitro,in vivo,and ex vivo screening *** will then discuss prominent examples of solid tumor targeting-peptides;namely peptide targeting tumor vasculature,tumor microenvironment(TME)and overexpressed receptors on cancer cells identified through phage display *** will also discuss the current challenges and future outlook for targeting peptidebased therapeutics in the clinics.

关键词： phage display tumor targeting peptide,tumor vasculature tumor microenvironment tumor stromal cells over-expressed receptor

Simple Traits among Diaspore Weight/Number,Plant height and Ability of Vegetative Propagation

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Journal of Integrative Plant Biology 2008年第12期50卷 1563-1569页

作者： Bozena erá Institute of Systems Biology and Ecology Academy of Sciences of the Czech Republiceské Budějovice 37005

Several expected correlations among followed internal plant traits were confirmed using the dataset of 492 herbaceous species from the temporal zone of Central Europe. Average diaspore weight （seed mass）, reproductive capacity of population （number of produced diaspores）, species height, and ability of lateral spread were the plant traits considered. The evident correlations were confirmed among all investigated traits：（i） The reproductive capacity of population negatively correlated with diaspore weight, plant height, and vegetative propagation. The diaspore weight and their number are closely correlated and co-adapted. （ii） Bigger plant species produce bigger diaspores. These trends are obvious at the inter- and intra-family levels. （iii） Larger plant species showed higher ability to vegetative propagation.

关键词： comparison lateral spread reproduction seed production seed weight strategy trade-off.

New Physicochemical Treatment Method of Poppy Seeds for Agriculture and Food Industries

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Plasma Science and Technology 2013年第9期15卷 935-938页

作者： Bozena er Iveta GAJDOV Michal er'Y Petr PATENKA Institute of Nanobiology and Structural Biology GCRC Academy of Sciences of the Czech RepublicDepartment of NanobiotechnologyNa Sadkach 7Ceske Budejovicecz-37005Czech Republic Department of Biology Faculty of EducationUniversity of South Bohemia in Ceske BudejoviceJeronymova 10Ceske Budejovicecz-37115Czech Republic Department of Applied Physics and Technics Faculty of EducationUniversity of South Bohemia in Ceske BudejoviceJeronymova 10Ceske Budejovicecz-37115Czech Republic

Poppy seeds （Papaver somniferum L.） are often attacked by various fungal dis- eases, and their field germination rate is low. The aim of this experiment was to increase the germination rate and growth of seedlings by modifying the poppy seeds using cold plasma dis- charge. The seeds were treated in a Plasonic AR-550-M under power of 500 W with argon gas flow of 50 mL/min, oxygen gas flow of 50 mL/min for different time durations in seconds （0, 180, 300, 600, 1800, 3000, 4200, and 5400）. The seed germination rate and growth of the seedlings were recorded. Cold plasma positively affected the seed germination rate for time exposure between 180～3000 s. Seedling acceleration on the sixth day of the experiment showed the highest values at exposure 180～600 s. Cold plasma seems to be a good physicochemical way to modify seeds without chemical agronomical application.

关键词： biotechnology early growth low-pressure discharge Papaver somniferum,seed modification seed germination

Gravitational lensing properties of an isothermal universal halo profile

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Research in Astronomy and Astrophysics 2013年第5期13卷 517-525页

作者： Xin-Zhong er National Astronomical Observatories Chinese Academy of Sciences

N-body simulations predict that dark matter halos with different mass scales are described by a universal model, the Navarro-Frenk-White （NFW） den- sity profiles. As a consequence of baryonic cooling effects, these halos will become more concentrated, and similar to an isothermal sphere over a large range in radii （～ 300 h-1 kpc）. The singular isothermal sphere （SIS） model however has to be trun- cated artificially at large radii since it extends to infinity. We model a massive galaxy halo as a combination of an isothermal sphere and an NFW density profile. We give an approximation for the mass concentration at different baryon fractions and present exact expressions for the weak lensing shear and flexion for such a halo. We compare the lensing properties with the SIS and NFW profiles. We find that the combined pro- file can generate higher order lensing signals at small radii and is more efficient in generating strong lensing events. In order to distinguish such a halo profile from the SIS or NFW profiles, one needs to combine strong and weak lensing constraints for small and large radii.

关键词： gravitational lensing -- galaxies: halos -- cosmology: dark matter

Study of the Structural Evolution of the Babadag-honaz and Pamukkale Fault Zones and the Related Earthquake Risk Potential of the Buldan Region in SW Anatolia, East of the Mediterranean

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Journal of Earth Science 2013年第3期24卷 397-409页

作者： Mete han er Geological Engineering Department Pamukkale University

Denizli graben （DG） is bounded in the NE by the Pamukkale fault zone and in the SW by the Babadag-honaz fault zone. The Babada and honaz fault zones are generally made up as nearly E-W directed two segments. The Pamukkale fault also contains many overlapping segments in the Denizli area along the NE margin of the graben. The DG contains an NW-SE trending horst （Karakova） controlled by normal faults with oppositely dipping high angles and that truncate the Plio-Quaternary rock units. The faults that bound the DG are likely to have been initiated during the Early to Late Miocene and appear to be active today. The faults of the DG are active and the potential energy that accumulates in them is easily conducted to the other faults that they come in contact with. This signifies that a movement in one of the faults forming the grabens in the Denizli region affects the other structures as well. Earthquakes in the Buldan region usually occur 2-3 years after seismical movements occur in the Denizli Basin. The Buldan region is a ridge between DG and Ala ehir graben （ALG）. Based on the fact that DG in its south and ALG in its north move seismically, there is a probability that a break would appear in the Buldan region in the near future.

关键词： Denizli Turkey Anatolia Pamukkale graben fault.