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Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids

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Acta Pharmaceutica Sinica B 2015年第2期5卷 129-134页

作者： Courtney B.Ferrebee Paul a.dawson Department of Pediatrics Division of Gastroenterology Hepatology and Nutrition Emory University Molecular Medicine Graduate Program Wake Forest School of Medicine

The classical functions of bile acids include acting as detergents to facilitate the digestion and absorption of nutrients in the gut. In addition, bile acids also act as signaling molecules to regulate glucose homeostasis, lipid metabolism and energy expenditure. The signaling potential of bile acids in compartments such as the systemic circulation is regulated in part by an efficient enterohepatic circulation that functions to conserve and channel the pool of bile acids within the intestinal and hepatobiliary compartments. Changes in hepatobiliary and intestinal bile acid transport can alter the composition, size,and distribution of the bile acid pool. These alterations in turn can have significant effects on bile acid signaling and their downstream metabolic targets. This review discusses recent advances in our understanding of the inter-relationship between the enterohepatic cycling of bile acids and the metabolic consequences of signaling via bile acid-activated receptors, such as farnesoid X nuclear receptor(FXR)and the G-protein-coupled bile acid receptor(TGR5).

关键词： Bile acids Liver Intestine Transporters Lipid metabolism Energy homeostasis

Role of homologous recombination/recombineering on human adenovirus genome engineering:Not the only but the most competent solution

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Engineering Microbiology 2024年第1期4卷 90-107页

作者： Lisa-Marie dawson Montaha Alshawabkeh Katrin Schröer Fatima Arakrak Anja Ehrhardt Wenli Zhang Virology and Microbiology Center for Biomedical Education and Research(ZBAF)School of MedicineFaculty of HealthWitten/Herdecke UniversityStockumer Str.1058453 WittenGermany

Adenoviruses typically cause mild illnesses,but severe diseases may occur primarily in immunodeficient individuals,particularly ***,adenoviruses have garnered significant interest as a versatile tool in gene therapy,tumor treatment,and vaccine vector *** the past two decades,the advent of recombineering,a method based on homologous recombination,has notably enhanced the utility of adenoviral vectors in therapeutic *** review summarizes recent advancements in the use of human adenoviral vectors in medicine and discusses the pivotal role of recombineering in the development of these ***,it highlights the current achievements and potential future impact of therapeutic adenoviral vectors.

关键词： Adenoviral vector Gene therapy Homologous recombination Oncolytic virus Vaccine vector

Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler Stuart Lanham Andrew Rawlings Marta Roldo Gianluca Tozzi Jonathan I.dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-ECM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

In_(2)O_(3)/Bi_(19)Br_(3)S_(27)S型异质结增强光催化CO_(2)还原

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Science China Materials 2024年第2期67卷 514-523页

作者：卞玉琴何厚伟 Graham dawson 张金锋代凯 Laboratory of Green and Precise Synthetic Chemistry and Applications Ministry of EducationAnhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental RemediationAnhui Province Key Laboratory of Intelligent Computing and ApplicationsAnhui Province Industrial Generic Technology Research Center for Alumics MaterialsHuaibei Normal UniversityHuaibei 235000China Department of Chemistry Xi’an Jiaotong Liverpool UniversitySuzhou 215123China

近年来,半导体催化剂因其较强的氧化还原能力和较好的稳定性而受到广泛关注.然而,光生电子和空穴对易复合和低氧化性导致单一半导体催化剂难以实现实际应用.深入研究表明,S型异质结具有独特的电子和空穴分离机理、强大的氧化还原能力和... 详细信息

近年来,半导体催化剂因其较强的氧化还原能力和较好的稳定性而受到广泛关注.然而,光生电子和空穴对易复合和低氧化性导致单一半导体催化剂难以实现实际应用.深入研究表明,S型异质结具有独特的电子和空穴分离机理、强大的氧化还原能力和较强的载流子分离驱动力.本研究以在In_(2)O_(3)纳米球上生长的Bi_(19)Br_(3)S_(27)纳米花为原料,采用水热法合成了In_(2)O_(3)/Bi_(19)Br_(3)S_(27)梯形异质结.这种梯形异质结有效地促进了光生电荷载流子的分离和转移.结果表明,In_(2)O_(3)/Bi_(19)Br_(3)S_(27)复合材料对CO_(2)的还原产率高达28.36μmol h^(-1)g^(-1),分别是In_(2)O_(3)和Bi_(19)Br_(3)S_(27)的19和3.5倍.此外,通过原位漫反射红外傅里叶变换光谱对参与光催化反应的中间体进行了研究,揭示了光催化还原CO_(2)的反应过程.本工作为构建S型异质结光催化剂增强CO_(2)催化还原的方法提供了较好的研究思路.

关键词： photocatalytic CO_(2)reduction S-scheme heterojunction In_(2)O_(3) Bi_(19)Br_(3)S_(27)

Chalcogenide-based S-scheme heterojunction photocatalysts

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Chinese Journal of Catalysis 2024年第8期63卷 81-108页

作者： Chunguang Chen Jinfeng Zhang Hailiang Chu Lixian Sun Graham dawson Kai Dai Guangxi Key Laboratory of Information Materials Guilin University of Electronic TechnologyGuilin 541004GuangxiChina Laboratory of Green and Precise Synthetic Chemistry and Applications Ministry of EducationCollege of Physics and Electronic InformationHuaibei Normal UniversityHuaibei 235000AnhuiChina Department of Chemistry Xi’an Jiaotong Liverpool UniversitySuzhou 215123JiangsuChina

The unique photocatalytic mechanism of S-scheme heterojunction can be used to study new and efficient *** carefully selecting semiconductors for S-scheme heterojunction photo-catalysts,it is possible to reduce the rate of photogenerated carrier recombination and increase the conversion efficiency of light into *** are a group of compounds that include sulfides and selenides(e.g.,CdS,ZnS,Bi_(2)S_(3),MoS_(2),ZnSe,CdSe,and CuSe).Chalcogenides have at-tracted considerable attention as heterojunction photocatalysts owing to their narrow bandgap,wide light absorption range,and excellent photoreduction *** paper presents a thor-ough analysis of S-scheme heterojunction photocatalysts based on *** an introduction to the fundamental characteristics and benefits of S-scheme heterojunction photocata-lysts,various chalcogenide-based S-scheme heterojunction photocatalyst synthesis techniques are *** photocatalysts are used in numerous significant photocatalytic reactions,in-cluding the reduction of carbon dioxide,synthesis of hydrogen peroxide,conversion of organic matter,generation of hydrogen from water,nitrogen fixation,degradation of organic pollutants,and *** addition,cutting-edge characterization techniques,including in situ characterization techniques,are discussed to validate the steady and transient states of photocatalysts with an S-scheme ***,the design and challenges of chalcogenide-based S-scheme het-erojunction photocatalysts are explored and recommended in light of state-of-the-art research.

关键词： Photocatalysis Chalcogenide S-scheme heterojunction Charge separation Application

Transportation of AIE-visualized nanoliposomes is dominated by the protein corona

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National Science Review 2021年第6期8卷 23-33页

作者： Yi-Feng Wang Chunqiu Zhang Keni Yang Yufei Wang Shaobo Shan Yan Yan Kenneth a.dawson Chen Wang Xing-Jie Liang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of China University of Chinese Academy of Sciences State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials of Ministry of Educationand College of Life SciencesNankai University Centre for Bio Nano Interactions School of ChemistryUniversity College Dublin School of Biomolecular and Biomedical Science University College Dublin Guangdong Provincial Education Department Key Laboratory of Nano-Immuno-regulation Tumor Microenvironment The Second Affiliated HospitalGuangzhou Medical University

Liposomes, especially cationic liposomes, are the most common and well-investigated nanocarriers for biomedical applications, such as drug and gene delivery. Like other types of nanomaterials, once liposomes are incubated in a biological milieu, their surface can be immediately cloaked by biological components to form a protein corona, which confers a new ‘biological identity’ and modulates downstream interactions with cells. However, it remains unclear how the protein corona affects the transportation mechanism after liposomes interact with cells. Here, we employed home-made aggregation-induced-emission-visualized nanoliposomes TR4@Lipo as a model to investigate transportation with or without the protein corona by optical imaging techniques. The results show that the protein corona can change the cellular transportation mechanism of TR4@Lipo from energy-independent membrane fusion to energy-dependent *** protein corona also modulates the intracellular distribution of loaded cargoes. This knowledge furthers our understanding of bio-nano interactions and is important for the efficient use of cationic liposomes.

关键词： aggregation-induced emission (AIE) cationic liposomes protein corona endocytosis membrane fusion

The Yin and Yang of the protein corona on the delivery journey of nanoparticles

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Nano Research 2023年第1期16卷 715-734页

作者： Yi-Feng Wang Yaxin Zhou JiaBei Sun Xiaotong Wang Yaru Jia Kun Ge Yan Yan Kenneth a.dawson Shutao Guo Jinchao Zhang Xing-Jie Liang Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment Guangzhou Key Laboratory for Research and Development of Nano-Biomedical Technology for Diagnosis and Therapythe Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China Chinese Academy of Sciences(CAS)Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China Key Laboratory of Functional Polymer Materials of Ministry of Education State Key Laboratory of Medicinal Chemical Biology and Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China China National Institute of Food and Drug Control Beijing 100061China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Key Laboratory of Chemical Biology of Hebei ProvinceCollege of Chemistry and Environmental ScienceHebei UniversityBaoding 071002China Centre for BioNano Interactions School of ChemistrySchool of Biomolecular and Biomedical ScienceUniversity College DublinDublin D04V1W8Ireland

Nanoparticles-based drug delivery systems have attracted significant attention in biomedical fields because they can deliver loaded cargoes to the target site in a controlled ***,tremendous challenges must still be overcome to reach the expected targeting and therapeutic efficacy in *** challenges mainly arise because the interaction between nanoparticles and biological systems is complex and dynamic and is influenced by the physicochemical properties of the nanoparticles and the heterogeneity of biological ***,once the nanoparticles are injected into the blood,a protein corona will inevitably form on the *** protein corona creates a new biological identity which plays a vital role in mediating the bio–nano interaction and determining the ultimate ***,it is essential to understand how the protein corona affects the delivery journey of nanoparticles in vivo and what we can do to exploit the protein corona for better delivery *** this review,we first summarize the fundamental impact of the protein corona on the delivery journey of ***,we emphasize the strategies that have been developed for tailoring and exploiting the protein corona to improve the transportation behavior of nanoparticles in ***,we highlight what we need to do as a next step towards better understanding and exploitation of the protein *** hope these insights into the“Yin and Yang”effect of the protein corona will have profound implications for understanding the role of the protein corona in a wide range of nanoparticles.

关键词： protein corona nanoparticles biological identity drug delivery bio-nano interaction

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霉菌毒素结合制剂在营养策略中所扮演的角色

中国家禽 2001年第9期23卷 32-35页

作者： Karl a.dawson 肯塔基大学畜产系

1简介霉菌毒素是霉菌代谢的次级产物,这种物质很可能在饲料的制造与贮存过程中污染到饲料.目前已知至少有300种以上霉菌代谢产物会使动物及人类中毒,全世界谷物中有25%受到霉菌毒素的污染,而且达到可量测的浓度.在这些毒素中,已知有很... 详细信息

1简介霉菌毒素是霉菌代谢的次级产物,这种物质很可能在饲料的制造与贮存过程中污染到饲料.目前已知至少有300种以上霉菌代谢产物会使动物及人类中毒,全世界谷物中有25%受到霉菌毒素的污染,而且达到可量测的浓度.在这些毒素中,已知有很多种物质明显影响动物的健康,对动物生产造成重大影响.

关键词：饲料霉菌毒素结合剂营养策略饲料管理

Overview of legal traceability of GPS positioning in Australia

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Satellite Navigation 2020年第1期1卷 275-286页

作者： Guorong Hu John dawson National Positioning Infrastructure Branch Geoscience AustraliaCnr Jerrabomberra Avenue and Hindmarsh Drive SymonstonGPO Box 378CanberraACT 2601Australia

Global Positioning System(GPS)position verification and legal traceability in Australia supports industry,trade,science and innovation and is trusted and recognized domestically and *** the end of 2017,the Australia’s national datum was transitioned from the Geocentric Datum of Australia 1994(GDA94)to the Geocentric Datum of Australia 2020(GDA2020).As such,the datum for the legal traceability of GPS positions in Australia has also moved to *** paper highlights the importance of legal metrology and measurement in terms of GPS positions in accordance with the National Measurement Act 1960(Commonwealth of Australia).Here we provide an overview of the process of issuing the so-called‘Regulation 13 Certificates’for Continuously Operating Reference Stations(CORS)across *** position verification methodology is detailed,including the quality control,metadata assurance,and dynamic management of the certificates as well as positional uncertainty determination of CORS with varying quality.A quality monitoring system of positions is also discussed along with how measurement traceability is ensured including short-term and long-term position monitoring schemes.

关键词： GPS Regulation 13 certificate Legal traceability GDA2020 Position verification