检索结果-南通市图书馆

Novel Heat Transfer Issues Associated with the design and Safe Operation of the MEGAPIE Spallation Source Target

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2007年第1期16卷 63-78页

作者： Brian l.smith Thermal Hydraulics laboratory Paul Scherrer InstituteSwitzerland

Critical heat transfer problems are discussed in the context of the operation of a spallation source target, which represents a first demonstration of the feasibility of an innovative concept for generating energy using a particle accelerator. Within the framework of the umbrella project MEGAPIE, an R＆d support group was organized to take responsibility for target cooling. This involved the use of advanced numerical methods - Computational Fluid dynamics （CFd） and Finite Element Method （FEM） - validated against suitable experimental data, and by means of appropriate benchmarking exercises. The design studies using CFd resulted in an optimum flow configuration being defined for the coolant circulation. Flow visualization tests were undertaken using a glass/water test section, with the velocity field mapped using optical and ultrasonic measuring techniques. These were followed by heat transfer tests, using the actual target materials （lead-bismuth-eutectic coolant and steel confinement）. Further CFd/FEM work to analyze operational transients and accident sequences was also carded out, and is described in the paper.

关键词： computational fluid dynamics finite element method liquid-metal coolant spallation source target

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.smith liwen Zhou Cameron l.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George d.Bittner department of Molecular Biosciences University of Texas at AustinAustinTXUSA department of Neuroscience University of Texas at AustinAustinTXUSA division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic lydia Jiménez-díaz Juan d.Navarro-lópez NeuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2d-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK dementia Research Institute at King’s College london LondonUK department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T d)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTd affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Addressing the impact of canine distemper spreading on an isolated tiger population in northeast Asia

在线全文

学校读者我要写书评

暂无评论

Integrative Zoology 2023年第6期18卷 994-1008页

作者： dawei WANG James l.d.smith Francesco ACCATINO Jianping GE Tianming WANG Ministry of Education Key laboratory for Biodiversity Science and Engineering NFGA Key Laboratory for Conservation Ecology of Northeast Tiger and Leopard&College of Life SciencesBeijing Normal UniversityBeijingChina department of Fisheries Wildlife and Conservation BiologyUniversity of MinnesotaSt.PaulMNUSA UMR SAdAPT INRAEAgroParisTechUniversitéParis-SaclayPALAISEAU CedexFrance

The continuation of the isolated Amur tiger(Panthera tigris altaica)population living along the China-Russia border is facing serious challenges due to factors such as its small size(including 38 individuals)and canine distemper virus(CdV).We use a population viability analysis metamodel,which consists of a traditional individual-based demographic model linked to an epidemiological model,to assess options for controlling the impact of negative factors through domestic dog management in protected areas,increasing connectivity to the neighboring large population(including more than 400 individuals),and habitat *** intervention,under inbreeding depression of 3.14,6.29,and 12.26 lethal equivalents,our metamodel predicted the extinction within 100 years is 64.4%,90.6%,and 99.8%,*** addition,the simulation results showed that dog management or habitat expansion independently will not ensure tiger population viability for the next 100 years,and connectivity to the neighboring population would only keep the population size from rapidly ***,when the above three conservation scenarios are combined,even at the highest level of 12.26 lethal equivalents inbreeding depression,population size will not decline and the probability of extinction will bedings highlight that protecting the Amur tiger necessitates a multifaceted synergistic *** key management recommendations for this population underline the importance of reducing CdV threats and expanding tiger occupancy to its former range in China,but re-establishing habitat connectivity to the neighboring population is an important long-term objective.

关键词： Amur tiger canine distemper virus habitat connectivity metamodel population viability analysis(PVA)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

三维地下水流动的热效应

地球物理学进展 1986年第2期 123-134页

作者： A.d.Woodbury l.smith 白武明

一、引言在盆地中近地表的热系统受到地下水流动的很大影响,smith和Chapman最近研究了地下水流动对近地表热系统扰动的强度和空间特征,他们的二维模型结果表明:热系统从以传导为主到以平流为主的转变是明显的,且主要依赖于潜水面的坡度... 详细信息

一、引言在盆地中近地表的热系统受到地下水流动的很大影响,smith和Chapman最近研究了地下水流动对近地表热系统扰动的强度和空间特征,他们的二维模型结果表明:热系统从以传导为主到以平流为主的转变是明显的,且主要依赖于潜水面的坡度;岩石渗透率的大小和空间分布;非理想流体液压的各向异性;以及流体流动深度等因素,地表热流相对于背景热流值

关键词：地表热流值热系统渗透率潜水面地下水盆地边缘

Competitive interactions and coexistence of sympatric flagship carnivores in Asia

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2024年第2期19卷 183-199页

作者： Zhilin lI Jiayu lU Xiaoyi SHI li’an dUO James l.d.smith Tianming WANG Tianjin Key laboratory of Conservation and Utilization of Animal diversity College of Life SciencesTianjin Normal UniversityTianjinChina department of Fisheries Wildlife and Conservation BiologyUniversity of MinnesotaSt.PaulMinnesotaUSA Ministry of Education Key laboratory for Biodiversity Science and Engineering College of Life SciencesBeijing Normal UniversityBeijingChina National Forestry and Grassland Administration Key laboratory for Conservation Ecology of Northeast Tiger and leopard BeijingChina

Understanding the competition and coexistence of flagship carnivores is key to creating strategies for their conservation in the face of global carnivore *** studies exploring the dynamics and competition between tigers(Panthera tigris)and leopards(***)span decades,there is a lack of understanding regarding the factors that influence their coexistence mechanisms on a broad scale,as well as the drivers determining their exploitative and interference *** gathered a comprehensive list of research papers among which 36 papers explored the interspecific interactions between tigers and leopards and tested the influence of biotic and abiotic factors on the coexistence mechanisms along three dimensions using multiple response variables regression models;we also tested the influence of ecological drivers determining the exploitative or interference competition between tigers and *** and ungulate density were the most important predictors in regulating the coexistence *** and leopards exhibited more positive relations/higher overlaps as elevation increased in the spatial *** addition,they showed a higher dietary overlap in the prey-rich *** determined that interference competition between tigers and leopards was less frequently observed in habitats with dense tree cover and homogeneous vegetation ***,studies with multiple metrics would promote the detection of interference *** study provides new insight into the competitive interactions and coexistence mechanisms of tigers and leopards on a broad ***-makers and managers should pay more attention to the factors of elevation,prey abundance,and habitat structures for the conservation of tigers and leopards.

关键词： carnivores coexistence mechanisms competitive interactions exploitative competition interference competition