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In Vitro Propagation and Artificial Seed Production of Fritillaria cirrhosa D. don, an Endangered Medicinal Plant

Phyton-International Journal of Experimental Botany 2024年第6期93卷 1297-1310页

作者： Qian Tao Guiqi Han Bujin ma Hongmei Jia Can Zhao Wenshang Li Zhuyun Yan Chengdu University of Traditional Chinese Medicine State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest ChinaChengdu610000China

Fritillaria cirrhosa ***(Liliaceae)is an endangered perennial bulbous plant and its dry bulb is a valuable med-icinal material with antitussive and expectorant ***,lack of resources and expensive prices make it difﬁcult to meet clinical *** study presents a regeneration system aimed at overcoming the challenge of inadequate supply in ***,focusing on:(1)callus induction,(2)bulblets and adventitious bud induction,and(3)artiﬁcial seed *** development was achieved in 84.93%on Murashige and Skoog(MS)medium fortiﬁed with 1.0 mg·L^(-1) *** optimal medium for callus differentiation into regenerated bulb-lets was MS medium supplemented with 1.0 mg·L^(-1)6-benzyladenine(6-BA)and 0.2 mg·L^(-1)α-naphthaleneacetic acid(NAA).Subsequently,bulblets and adventitious buds were induced from regenerated bulblet sections cul-tured on MS medium fortiﬁed with 0.3 mg·L^(-1)6-BA+1.0 mg·L^(-1)2,4-dichlorophenoxyacetic acid(2,4-D),2.0 mg·L^(-1)6-BA+0.5 mg·L^(-1),and the induction rates were 88.17%and 84.24%,*** regenerated bulblets were transplanted into a substrate of humus soil,river sand,and pearlite(1:1:1)after low-temperature *** germination rate was 42.80%after culture for 30 *** bulblets were used for encap-sulations in liquid MS medium containing 3%sucrose(w/v)+0.5 mg·L^(-1) NAA+2.0 mg·L^(-1)6-BA+3%sodium alginate(w/v)with a 10 min exposure to 2%CaCl_(2).Under non-aseptic conditions,the germination rate reached 81.67%,while the rooting rate was 20.56%after 45 *** capsule added 1.0 g·L^(-1) carbendazim and 1.0 g·L^(-1) activated carbon was the best component of artiﬁcial *** study successfully established an efﬁcient regen-eration system for the rapid propagation of ***,involving in vitro bulblet regeneration and artiﬁcial seed *** method introduces a novel approach for efﬁcient breeding and germplasm preservation,making it suitable for large-scale industrial resou

关键词： Artiﬁcial seed callus induction Fritillaria cirrhosa organogenesis plant propagation

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Synergistic enhancement of ultrasound therapy for tumors using hypoxia-activated 6-diazo-5-oxo-L-norleucine(don)prodrug nanoparticles

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Nano Research 2024年第7期17卷 6323-6331页

作者： Mengfei Zheng Zhilin Liu Hang Xu Daping Ye Linjie Cui Chenguang Yang Lili ma Kun Wang Kazuo Sakurai Zhaohui Tang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China Department of Chemistry and Biochemistry The University of Kitakyushu1-1 HibikinoKitakyushu 808-0135Japan

Ultrasound(US)has been applied in clinical practice for its non-invasive and high ***,it is difficult to achieve a satisfactory anti-tumor effect with US ***,the use of US therapy alone can exacerbate tumor *** this study,we prepared hypoxia-activated 6-diazo-5-oxo-L-norleucine(don)prodrug nanoparticles(Hdon-NPs)to improve US therapeutic *** an H22 murine liver cancer model,US therapy selectively disrupted tumor blood vessels,leading to increased tumor hypoxia and a 1.67-fold increase in the expression of nitroreductase(NTR).The combination therapy of US and Hdon-NPs demonstrated a synergistic effect,resulting in a tumor suppression rate(TSR)of 90.2%±6.4%,which was 5.93-fold higher than that of US therapy *** combined treatment selectively blocked the glutamine metabolism of the tumor cells while simultaneously activating the T cells in the tumor microenvironment,thereby exerting a robust anti-tumor effect.

关键词： ultrasound therapy hypoxia-activated prodrug nanoparticles 6-diazo-5-oxo-L-norleucine(don) glutamine antagonist starvation therapy

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Therapeutic Profile and Prognostic Factors of Patients Suffering from Upper Digestive Bleeding at Sikasso Regional Hospital

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Open Journal of Gastroenterology 2024年第9期14卷 300-312页

作者： Oumar Traoré Abdoul Salam Diarra Dramane Touré Tawfiq Abu Amadou Boubeye maïga Kadiatou Cissé Saïdon Touré Mohomedine Touré Aboudou Dolo Youana Koné madou Traoré mamadou Togo Kalba Péliaba mamadou Samaké Hamadoun Sangho Service of Internal Medicine Regional Hospital Sikasso Mali National Center for Scientific and Technological Research Bamako Mali Department of Pediatric Health Referral Center of Kalaban Coro Koulikoro Mali Private Practice for Family and Emergency Medicine Casablanca Morocco Service of Nephrology Regional Hospital Sikasso Mali Department of Infectious Disease Regional Hospital Sikasso Mali Service de Mdecine Interne CHU Gabriel Tour Bamako Mali Service dHpato-Gastro-Entrologie CHU Gabriel Tour Bamako Mali Department of Public Health Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako Bamako Mali

Introduction: Upper digestive hemorrhage is one of the main digestive emergencies and remains a major cause of morbidity and mortality in mali. The aim of this study was to describe the therapeutic profile and outcome of patients suffering from upper digestive haemorrhage. Methodology: This was a prospective study carried out in the internal medicine department of the Sikasso Regional Hospital from August 2022 to July 2023. All adult patients presenting with upper digestive haemorrhage and having given their consent, were included. Data were analyzed using SPSS version 21 software. Results: Sixty-three patients were enrolled. The mean age was 49.7 ± 18.99 years, with a male-female sex ratio of 2.2. Ruptured esophageal varices (37.5%) and peptic ulcer (25%) were the main etiologies. Pharmacological treatment was dominated by proton pump inhibitors (85.7%). Hemostasis endoscopy accounted for 3.17%. The evolution was marked by hemorrhagic arrest (69.84%), recurrence of hemorrhage (11.11%) and death (19.04%), the main cause of which was hemorrhagic shock (58.3%). We found no statistically significant relationship between prognosis and etiologies (P = 0.11), and length of hospital stay (P = 0.18). Conclusion: Hemostasis endoscopy remains a challenge for Sikasso Hospital. A holistic strategy of communication and community awareness-raising, combined with adequate technical facilities, will help to improve patient care and outcomes.

关键词： Digestive Hemorrhage Digestive Endoscopy Treatment Outcome

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Tumor-targeted metabolic inhibitor prodrug labelled with cyanine dyes enhances immunoprevention of lung cancer

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Acta Pharmaceutica Sinica B 2024年第2期14卷 751-764页

作者： Wen Li Jiali Huang Chen Shen Weiye Jiang Xi Yang Jingxuan Huang Yueqing Gu Zhiyu Li Yi ma Jinlei Bian State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 210009China Jiangsu Key Laboratory of Drug Design and Optimization Department of Medicinal ChemistrySchool of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Recent progress in targeted metabolic therapy of cancer has been limited by the considerable toxicity associated with such *** address this challenge,we developed a smart theranostic prodrug system that combines a fluorophore and an anticancer drug,specifically 6-diazo-5-oxo-L-norleucine(don),using a thioketal linkage(TK).This system enables imaging,chemotherapy,photodynamic therapy,and on-demand drug release upon radiation *** optimized prodrug,don-TK-BM3,incorporating cyanine dyes as the fluorophore,displayed potent reactive oxygen species release and efficient tumor cell *** the parent drug don,don-TK-BM3 exhibited no toxicity toward normal ***,don-TK-BM3 demonstrated high tumor accumulation and reduced side effects,including gastrointestinal toxicity,in *** study provides a practical strategy for designing prodrugs of metabolic inhibitors with significant toxicity stemming from their lack of tissue selectivity.

关键词： Smart prodrug system Glutamineantagonists Immunotherapy Photodynamictherapy Reactive oxygen species Metabolicinhibitor Cyaninedye Non-small-cell lung cancer(NSCLC)

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文本阐释学视域下布德贡杰道歌修辞特点及其意义重析

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攀登（藏文版） 2024年第3期 56-70页

作者：朋毛当智万玛西藏阿里革吉县中学西藏大学西藏大学文学院

有关布德贡杰道歌意义的研究成果颇多,但已往的研究割裂了诗歌与历史的联系,未能表达出准确的诗义。在文学文本阐释学的视阈下,对“古鲁”的注释进行较为系统的分析和梳理,将此诗置于“历史文化语境”和平定罗安达兹叛乱的历史背景之中... 详细信息

有关布德贡杰道歌意义的研究成果颇多,但已往的研究割裂了诗歌与历史的联系,未能表达出准确的诗义。在文学文本阐释学的视阈下,对“古鲁”的注释进行较为系统的分析和梳理,将此诗置于“历史文化语境”和平定罗安达兹叛乱的历史背景之中,并结合当时的佛苯教义及古藏文语言特点,以“文学风格”为导向,才能更好地归纳此诗的修辞特点及重要涵义。

关键词：文学文本读解学道歌修辞特征

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Improving the Seismic Performance of Staircases in Building Structures with a Novel Isolator

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Computer Modeling in Engineering & Sciences 2020年第8期124卷 415-431页

作者： Yafei Zhang Ping Tan Haitao ma marco donà Key Laboratory of Earthquake Resistance Earthquake Mitigation and Structural SafetyMinistry of EducationGuangzhou UniversityGuangzhou510405China Guangdong Provincial Key Laboratory of Earthquake Engineering and Applied Technology Guangzhou UniversityGuangzhou510405China

A staircase provides the main escape way from a building in an ***,it may suffer severe damages or even collapse during an *** improving the seismic performance of staircases,this paper proposes an innovative staircase isolator with the features of lightweight,costeffective and ease of construction and replacement,which is formed by suitable engineering plastic shims between rubber layers.A connection construction scheme is also proposed for the isolated *** performance tests have been carried out to characterize the isolator in terms of mechanic behavior and ultimate *** test results show that mechanical properties of the proposed staircase isolator are excellent and suitable for staircase in building *** order to investigate the influence of staircase on building structural responses,time history analyses of a typical building structure without staircase(WS),with fixed staircase(FS)and with isolated staircase(IS)are conducted and compared within the environment of *** show that staircase isolation can effectively eliminate the diagonal bracing effect of staircase slab and make structural components uniformly *** the novel isolator is employed for staircase in a building structure,there is no vulnerable position in staircase and the performance of staircase in building structure can be greatly enhanced.

关键词： Seismic isolation seismic performance of staircases staircase isolation engineering-plastics rubber isolator rubber isolator

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Reshaping the active pocket of an aldo-keto reductase to enhance its detoxification activity towards 3-keto-deoxynivalenol

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Food Science and Human Wellness 2024年

作者： Jiafeng Niu Bin ma Hao Zhu Huawei Liu Haizhen Zhao Xiaomei Bie Fengxia Lu Ping Zhu College of Food Science and Technology， Nanjing Agricultural University State Key Laboratory of Desert and Oasis Ecology， Xinjiang Institute of Ecology and Geography， Chinese Academy of Sciences

Deoxynivalenol （don）， the most common mycotoxin in the world， poses serious health hazards to both humans and animals and causes significant economic losses to the food and feed industry. An intriguing method for don detoxification involves enzymatic cascade catalysis by dehydrogenase （DADH） and aldo-keto reductase （AKR13B3）. However， the poor catalytic activity of AKR13B3 has limited its usefulness. Here， structure-guided steric hindrance engineering， computer-assisted protein engineering， and combinatorial mutagenesis were carried out to increase the catalytic efficiency of AKR13B3. The best mutant in this project was M28S/S65V， which outperformed wild-type AKR13B3 in terms of catalytic efficiency (kcat/Km) and specific activity by factors of 45.08 and 43.11， respectively. Kinetic parameter determination revealed that the enhanced catalytic efficiency of M28S/S65V toward 3-keto-don was attributed to the decreased Kmand increased kcatvalues. Moreover， the engineered enzyme was applied to degrade don in contaminated corn steep liquor， for a 90.62% removal rate. Structure-based computational analysis provided insights into the enhanced catalytic efficiency of M28S/S65V， which was attributed to the enlarged substrate-binding pocket and reshaped pocket with a favorable hydrophilic attack distance. The results provide a reference for improving the catalytic activity of an enzyme toward non-native bulky substrates and pave the way for the development of enzymes as detoxification agents to mitigate don in the food and feed industry.

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Research advance in regulation of fruit quality characteristics by microRNAs

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Food Quality and Safety 2020年第1期4卷 1-7页

作者： Li ma Yan-na Shi don Grierson Kun-song Chen Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang UniversityZijingang CampusHangzhou The State Agriculture Ministry Laboratory of Horticultural Plant Growth Development and Quality ImprovementZhejiang UniversityZijingang CampusHangzhouPR China School of Biosciences University of NottinghamSutton Bonington CampusLoughborough LE125RDUK

MicroRNAs(miRNAs)are short(19-24 nucleotides in length)noncoding RNAs that have a profound effect on gene *** completely or almost perfectly base-pairing with their individual target mRNAs they cause mRNA cleavage or repression of *** important regulators,miRNAs plays an important role in the regulation of fruit *** studies have been reported in fruits,however current studies are mostly focused on the identification of miRNAs and the prediction and validation of target *** review summarizes research progress on the role of miRNAs in regulating fruit ripening and senescence and quality characteristics,such as coloration,flavor metabolism,and texture for providing information for future research.

关键词： miRNA fruit quality regulation.

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Reduction of Linear Systems of ODEs with Optimal Replacement Variables

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Communications in Computational Physics 2011年第3期9卷 756-779页

作者： Alex Solomonoff Wai Sun don Camberville Research Institute SomervilleMAUSA Department of mathematics Hong Kong Baptist UniversityKowloon TongHong Kong

In this exploratory study,we present a new method of approximating a large system of ODEs by one with fewer equations,while attempting to preserve the essential dynamics of a reduced set of variables of *** method has the following key elements:(i)put a(simple,ad-hoc)probability distribution on the phase space of the ODE;(ii)assert that a small set of replacement variables are to be unknown linear combinations of the not-of-interest variables,and let the variables of the reduced system consist of the variables-of-interest together with the replacement variables;(iii)find the linear combinations that minimize the difference between the dynamics of the original system and the reduced *** describe this approach in detail for linear systems of *** techniques and issues for carrying out the required minimization are *** of systems of linear ODEs and variable-coefficient linear PDEs are used to demonstrate the *** show that the resulting approximate reduced system of ODEs gives good approximations to the original ***,some directions for further work are outlined.

关键词： System reduction optimal replacement variables resolved variables optimal prediction

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时尚品租售供应链的绿色广告决策研究

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安徽建筑大学学报 2024年第3期32卷 80-89页

作者：马骏闵杰安徽建筑大学数理学院安徽合肥230601

共享经济推动时尚品制造商进入租赁市场,而绿色广告强调产品或服务的环保特性,能够吸引支持低碳减排的消费者。考虑由一个时尚品制造商和一个租赁平台构成的租售混合渠道供应链,通过博弈论模型研究时尚品租售定价与广告决策。根据制造... 详细信息

共享经济推动时尚品制造商进入租赁市场,而绿色广告强调产品或服务的环保特性,能够吸引支持低碳减排的消费者。考虑由一个时尚品制造商和一个租赁平台构成的租售混合渠道供应链,通过博弈论模型研究时尚品租售定价与广告决策。根据制造商与平台合作后的绿色广告投放方式分为四种模式:全部不投放广告模式(NN模式)、仅制造商投放广告模式(YN模式)、仅平台投放广告模式(NY模式)、全部投放广告模式(YY模式)。研究发现:(1)制造商一定会选择与平台合作,但制造商和平台的合作模式主要与绿色广告效率有关,绿色广告效率较小时,制造商和平台都倾向于YY模式;当绿色广告效率较大时,制造商和平台都倾向于NN模式。(2)制造商与平台的利润都与生产成本呈负相关,与残值呈正相关。(3)无论在哪种模式下,制造商制定的销售价格保持不变。

关键词：租售混合渠道绿色广告 Stackelberg博弈产品定价

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