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Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing Strengths,Limitations,and Its Therapeutic Landscape Position

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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： VICTOR Abiola Adepoju OKECHUKWU Innocent Onyezue SAFAYET Jamil OLALEKAN John Okesanya don Eliseo Lucero-Prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

Robotic-assisted retroperitoneal lymph node dissection for stage II testicular cancer

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Asian Journal of Urology 2024年第1期11卷 121-127页

作者： George McClintock Ahmed S.Goolam don Perera Ryan Downey Scott Leslie Peter Grimison Henry Woo Peter Ferguson Nariman Ahmadi Department of Urology Chris O'Brien LifehouseSydneyNSWAustralia Department of Anaesthesia Chris O'Brien LifehouseSydneyNSWAustralia The University of Sydney SydneyNSW2006Australia Department of Medical Oncology Chris O'Brien LifehouseSydneyNSWAustralia

Objective:To evaluate the perioperative as well as early oncological outcomes of patients undergoing robotic retroperitoneal lymph node dissection for treatment of testicular ***:We conducted a prospective consecutive case series of patients undergoing robotic assisted retroperitoneal lymph node dissection for metastatic testicular cancer between May 2018 and July 2021 at our *** were collected on patient and tumour characteristics,intraoperative and postoperative parameters,and functional and oncological *** statistics are ***:Nineteen patients were identified;18(94.7%)completed the procedure robotically and one was converted to open surgery;78.9%of patients had stage≥IIB and 12(63.2%)patients had undergone prior *** median operative time was 300(interquartile range[IQR]240-315)*** blood loss was 100(IQR 50-175)*** length of stay was 2(range 1-11)*** robotically completed patients commenced diet and passed flatus on Day 1 and were discharged by Day *** median lymph node yield was 40.5(IQR 38-51)*** patients undergoing nerve-sparing procedures recovered antegrade ejaculatory *** patient had a Clavien-Dindo III complication(chylous ascites requiring drainage).At a median follow-up of 22.3(IQR 16.3-24.9)months,one patient developed retroperitoneal recurrence,which was successfully treated with second-line chemotherapy;no other patients have had ***:Robotic retroperitoneal lymph node dissection is a safe and feasible alternative to open surgery in appropriately selected patients,offering low *** oncological outcomes are *** cohorts and longer follow-ups are required to validate our institution's findings.

关键词： Retroperitoneal lymph node dissection Robotic surgery Testicular cancer Retroperitoneal node dissection

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藏族英雄史诗格萨尔王传形式基础(续)

中国藏学 2024年第1期 106-114,215页

作者：丹珠昂奔中央民族大学北京100081

形式基础是格萨尔研究的基本理论问题,涉及史诗产生、发展、传播的特定时代的社会文化基础,渊源深长。格萨尔的形式集中于“两‘仲’、三要素、一模式”。仲与德乌、苯都是青藏高原古老的文化形式,当格萨尔作为史诗萌芽时,艺人们借用了... 详细信息

形式基础是格萨尔研究的基本理论问题,涉及史诗产生、发展、传播的特定时代的社会文化基础,渊源深长。格萨尔的形式集中于“两‘仲’、三要素、一模式”。仲与德乌、苯都是青藏高原古老的文化形式,当格萨尔作为史诗萌芽时,艺人们借用了他们最熟悉的“仲”的形式,形成了格萨尔王传的形式基础。深刻认识把握这一形式基础,既是认识格萨尔光辉存在的一把钥匙,也是传承、弘扬格萨尔史诗,汲取其精神精华的桥梁,有利于我们传承、研究、弘扬、开发、利用格萨尔的既有成果,确立文化自信,构建各民族共有精神家园。

关键词：格萨尔形式仲仲肯音乐

Quasi-Static, Poiseuille Flow of Analgesics from an Elastomeric Pump: Theoretical Determination of Infusion Times and Toxicity Conditions

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Journal of Biosciences and Medicines 2024年第9期12卷 251-265页

作者： Clare B. Lipscombe Trevor C. Lipscombe don S. Lemons Division of General Surgery Vanderbilt University Medical Center Nashville TN USA Catholic University of America Press Washington DC USA Department of Physics Bethel College North Newton KS USA

Background: Elastomeric pumps (elastic balls into which analgesics or antibiotics can be inserted) push medicines through a catheter to a nerve or blood vessel. Since elastomeric pumps are small and need no power source, they fit easily into a pocket during infusion, allowing patient mobility. Elastomeric pumps are widely used and widely studied experimentally, but they have well-known problems, such as maintaining reliable flow rates and avoiding toxicity or other peak-and-trough effects. Objectives: Our research objective is to develop a realistic theoretical model of an elastomeric pump, analyze its flow rates, determine its toxicity conditions, and otherwise improve its operation. We believe this is the first such theoretical model of an elastomeric pump consisting of an elastic, medicine-filled ball attached to a horizontal catheter. Method: Our method is to model the system as a quasi-Poiseuille flow driven by the pressure drop generated by the elastic sphere. We construct an engineering model of the pressure exerted by an elastic sphere and match it to a solution of the one-dimensional radial Navier-Stokes equation that describes flow through a horizontal, cylindrical tube. Results: Our results are that the model accurately reproduces flow rates obtained in clinical studies. We also discover that the flow rate has an unavoidable maximum, which we call the “toxicity bump”, when the radius of the sphere approaches its terminal, unstretched value—an effect that has been observed experimentally. Conclusions: We conclude that by choosing the properties of an elastomeric pump, the toxicity bump can be restricted to less than 10% of the earlier, relatively constant flow rate. Our model also produces a relation between the length of time that the analgesic fluid infuses and the physical properties of the fluid, of the elastomeric sphere and the tube, and of the blood vessel into which the analgesic infuses. From these, we conclude that elastomeric pumps can be design

关键词： Elastomeric Pump Infusion Therapy Bio-Fluids Medical Devices Antibiotic Delivery Analgesic Delivery

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小老鼠、红草莓和大饿熊

阅读 2024年第44期 14-19页

作者： don Audrey Wood

绘本导读：欢乐的“六一”儿童节，你打算和伙伴们一起做点什么呢？不如跟着绘本来玩一场有意思的游戏吧！你看，有一只小老鼠，他一大早就跑去摘了一颗熟透了的红草莓，辛苦地扛回了家。可是，竟然有个声音一直对他说：有一只饥饿的大...

绘本导读：欢乐的“六一”儿童节，你打算和伙伴们一起做点什么呢？不如跟着绘本来玩一场有意思的游戏吧！你看，有一只小老鼠，他一大早就跑去摘了一颗熟透了的红草莓，辛苦地扛回了家。可是，竟然有个声音一直对他说：有一只饥饿的大坏熊，离得老远就能闻到草莓的香气，正准备冲过来抢走红草莓呢！于是，一场关于红草莓的“保卫战”开始了……

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远程工作是否可行?

空中英语教室（高级版．彭蒙惠英语） 2024年第1期 16-17,42页

作者： don Lee 不详

10经历过疫情之后,巴特·瓦尔德兹有着和许多传统老板一样的心态。他认为远程工作是一种反常现象,希望所有人都能尽快回到办公桌前。“在我成长的环境里,人们都穿西装打领带,早上8点就出现在公司——没有任何借口。”这位60岁的Ingenovi... 详细信息

10经历过疫情之后,巴特·瓦尔德兹有着和许多传统老板一样的心态。他认为远程工作是一种反常现象,希望所有人都能尽快回到办公桌前。“在我成长的环境里,人们都穿西装打领带,早上8点就出现在公司——没有任何借口。”这位60岁的Ingenovis公司首席执行官说。

关键词：反常现象首席执行官瓦尔德远程办公桌老板

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北美机车车队的更新

国外铁道机车与动车 2024年第2期 5-7页

作者： [美]don Graab 焦国超(译) 不详

2016年以来,北美电传动内燃机车制造业务持续下滑;2021年购置5台内燃机车后,至今未购入一台新造机车。这种情况可能还将持续:相较于购置新车,铁路公司更倾向于对现有机车进行翻新改造。何时能够恢复对新型机车的需求仍是未知,这主要取... 详细信息

2016年以来,北美电传动内燃机车制造业务持续下滑;2021年购置5台内燃机车后,至今未购入一台新造机车。这种情况可能还将持续:相较于购置新车,铁路公司更倾向于对现有机车进行翻新改造。何时能够恢复对新型机车的需求仍是未知,这主要取决于机车改后使用寿命的延长情况。现状持续时间越久,铁路制造企业面临的困难和挑战就越大。

关键词：北美电传动内燃机车铁路公司机车改造

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土体性质对地铁振动传播与衰减的影响

噪声与振动控制 2024年第5期44卷 210-217页

作者：黄浩陈启阳孔凡兵庞玲赵坪锐西南交通大学土木工程学院成都610031 西南交通大学高速铁路线路工程教育部重点实验室成都610031 中铁第一勘察设计院集团有限公司西安710043 中铁二院工程集团有限责任公司成都610031

地铁沿线地质构造复杂多变,车致振动在不同路基土中的传播衰减规律也因土体性质的不同而变化。为研究土体性质对车致振动在土体水平和建筑物竖直方向上传播和衰减规律的影响,分别建立车辆-轨道耦合动力学模型和轨道-隧道-土体-建筑物三... 详细信息

地铁沿线地质构造复杂多变,车致振动在不同路基土中的传播衰减规律也因土体性质的不同而变化。为研究土体性质对车致振动在土体水平和建筑物竖直方向上传播和衰减规律的影响,分别建立车辆-轨道耦合动力学模型和轨道-隧道-土体-建筑物三维动力学有限元模型,然后分别取路基土为坚硬土、中硬土、中软土和软弱土,分析比较地铁运行所引起的线路周围土体和建筑物的振动情况。结果表明:相比较于硬土,软土路基的土体振动强度更大;路基土越软,振动在由土体传到建筑物过程中的衰减幅度越大;随着与线路中心距离的增加,4种土体振动响应在整体上均呈现出随之减弱的趋势,但在局部区域会出现振动放大效应,此现象需格外关注;随楼层升高,在4种路基土条件下建筑物对16Hz以下的振动响应基本不变,对16Hz以上的振动响应呈减弱趋势。研究成果可为不同路基土条件下地铁线路的减振降噪提供理论指导。

关键词：振动与波地铁振动传播数值计算环境振动土体性质车致振动

全球最危险城市什么样？加拉加斯的暴力、选美与街头锐舞

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环球人文地理 2024年第17期 56-65页

作者： Zoe Alexander Sánchez ZERYO Paolo Pietro Roccasalva don Perucho Zatletic anecaroline unsplash

近日，福布斯顾问（Forbes Advisor）发布了2024年最危险城市排行榜，委内瑞拉首都—加拉加斯，以满分100分的成绩居于榜首。评分主要参考五个指标：犯罪风险、个人安全风险、健康安全风险、基础设施风险和数字安全风险。

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