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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： VICTOR Abiola Adepoju OKECHUKWU Innocent Onyezue SAFAYET Jamil OLALEKAN John Okesanya don eliseo lucero-prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

Occupational,physical,sexual and mental health and violence among migrant and trafficked commercial fishers and seafarers from the Greater Mekong Subregion(GMS):systematic review

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Global Health Research and Policy 2018年第1期3卷 89-101页

作者： Nicola S.Pocock Long Hoang Nguyen don eliseo lucero-prisno iii Cathy Zimmerman SiânOram Department of Global Health and Development Faculty of Public Health and Policy15-17 Tavistock PlaceLondon WC1H 9SHUK United Nations University International Institute of Global Health UKM Medical CentreJalan Yaacob LatifBandar Tun Razak56000 CherasKuala LumpurMalaysia School of Medicine and Pharmacy Vietnam National UniversityNo.144 Xuan Thuy StreetCau Giay districtHanoiVietnam Department of Public Health Emerging and Interdisciplinary Sciences Building(ES)South CampusXi′an Jiaotong-Liverpool University111 Ren′ai RoadSuzhou Dushu Lake Science and Education Innovation DistrictSuzhou Industrial ParkSuzhou 215123People’s Republic of China Section of Women’s Mental Health Institute of PsychiatryPsychology and Neuroscience16 De Crespigny ParkKings College LondonLondon SE58AFUK

Background:Little is known about the health of GMS commercial fishers and seafarers,many of whom are migrants and some *** systematic review summarizes evidence on occupational,physical,sexual and mental health and violence among GMS commercial fishers/***:We searched 5 electronic databases and purposively searched grey *** or qualitative studies reporting prevalence or risk of relevant outcomes were *** reviewers independently screened *** were extracted on nationality and long/short-haul fishing where ***:We identified 33 eligible papers from 27 *** fishers/seafarers were included in n=12/13 grey literature and n=1/20 peer-reviewed *** peer-reviewed papers:11 focused on HIV/AIDS/sexual health;nine on occupational/physical health;one study included mental health of trafficked *** was quantitatively measured in eight papers with prevalence of:11-26%in port convenience samples;68-100%in post-trafficking service *** fishers/seafarers whether trafficked or not worked extremely long hours;trafficked long-haul fishers had very limited access to care following injuries or ***-known risks reported among fishers included penile oil injections and *** found just one work safety intervention study and inconclusive evidence for differences in the outcomes by *** are limited by methodological weaknesses of primary ***:Results show an absence of high-quality epidemiological studies beyond sexual *** and pilot intervention research on occupational,physical and mental health among GMS commercial fishers and seafarers is *** studies should include questions about violence and *** and reporting standards of grey literature should be improved.

关键词： Migrant fishermen Human trafficking Seafarers Migrant workers

A mixed method analysis of the Botswana schistosomiasis control policy and plans using the policy triangle framework

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Global Health Research and Policy 2023年第1期8卷 147-159页

作者： Kebabonye P.Gabaake don eliseo lucero-prisno iii Olekae T.Thakadu Nthabiseng A.Phaladze Department of Medical Sciences School of Allied Health ProfessionsUniversity of BotswanaGaboroneBotswana Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUK Faculty of Management and Development Studies University of the Philippines Open UniversityLos BanosLagunaPhilippines Okavango Research Institute University of BotswanaMaunBotswana School of Nursing University of BotswanaGaboroneBotswana

Background The present goal of the World Health Organization(WHO)2021-2030 roadmap for Neglected Tropical Diseases is to eliminate schistosomiasis as a public health problem,and reduce its prevalence of heavy infections to less than 1%.Given the evolution and impact of schistosomiasis in the Ngamiland district of Botswana,the aim of this study was to analyze the control policies for the district using the Policy Triangle *** The study used a mixed method approaches of an analysis of policy documents and interviews with 12 informants who were purposively *** the informants were recruited from all levels of the NTD sector,the analysis of the program was predominantly from the Ngamiland *** were analyzed using Braun and Clarke’s approach to content *** The study highlights the presence of clear,objectives and targets for the Ngamiland control *** theme was the success in morbidity control,which was realized primarily through cycles of MDA in *** contextual background for the policy was high morbidity and lack of programming *** implementation process of the policy was centralized at the Ministry of Health(MOH)and WHO,and there was minimal involvement of the communities and other *** policy implementation process was impeded by a lack of domestic resources and lack of comprehensive policy content on snail control and no expansion of the policy content beyond *** actors were predominately MOH headquarters and WHO,with little representation of the district,local level settings,NGOs,and private *** The lack of resources and content in the control of environmental determinants and exclusion of other at-risk groups in the policy,impeded sustained elimination of the *** is a need to guide the treatment of preschool-aged children and develop national guidelines on treating foci of intense ***,the dynamic of the environmental transmissions and

关键词： Schistosomiasis Control policy Ngamiland Botswana and health policy triangle

Assessment of awareness and knowledge of schistosomiasis among school-aged children(6-13 years)in the Okavango Delta,Botswana

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Global Health Research and Policy 2022年第1期7卷 151-161页

作者： Kebabonye P.Gabaake Nthabiseng A.Phaladze don eliseo lucero-prisno iii Olekae T.Thakadu School of Allied Health Professions University of BotswanaGaboroneBotswana School of Nursing University of BotswanaGaboroneBotswana Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUK Faculty of Management and Development Studies University of the Philippines Open UniversityLos BañosLagunaPhilippines Okavango Research Institute University of BotswanaMaunBotswana

Background:Schistosomiasis is a global health problem affecting 250 million people,with 90%in Sub-Saharan *** Botswana,the burden is high in the Okavango delta because of the water *** recommends integrated measures,including access to clean water,sanitation,health education,and drugs to control and eliminate *** knowledge and awareness of schistosomiasis for School-Aged Children(SAC)is *** study aimed at assessing knowledge and awareness of schistosomiasis among SAC in the Okavango ***:A cross-sectional survey assessing awareness and knowledge of schistosomiasis in schools was conducted.480 questionnaires were administered to gather demographic profiles,awareness,and knowledge of risky ***-square and descriptive analysis determined the differences in SAC`s awareness and knowledge levels based on localities,gender,age,and health ***:The results showed a low awareness level,with only(42%)of respondents having heard about the disease and(52%)knowing its local *** children from Sekondomboro(83%)and Samochima lacked awareness,while children from Mohembo(77%)and those who had health education(70%)demonstrated significant awareness levels(P≤0.001).Seventy-two percent(72%)lacked knowledge of the cause and(95%)did not know the disease *** from Xakao(91%),(85%)Sepopa,and(75%)of younger children did not know haematuria is a symptom of the *** and SAC with health education were more likely to know that swimming is a risk factor(P≤0.001)and(P≤0.05)***:Although respondents from four schools demonstrated some level of awareness of the disease,and knowledge of risky behaviors,the study showed a lack of in-depth knowledge on the life-cycle and cause of the ***,therefore,recommend the implementation of an integrated approach to health education and improvement in access to clean water and sanitation in all study areas.

关键词： Awareness Knowledge Schistosomiasis

Can Africa achieve herd immunity?

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Global Health Research and Policy 2021年第1期6卷 26-31页

作者： don eliseo lucero-prisno iii Isaac Olushola Ogunkola Ekpereonne Babatunde Esu Yusuff Adebayo Adebisi Xu Lin Hao Li Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUK Faculty of Management and Development Studies University of the Philippines Open UniversityLos BañosLagunaPhilippines Department of Public Health University of CalabarCalabarNigeria Faculty of Pharmacy University of IbadanIbadanNigeria Department of Thoracic Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina Global Health Institute Wuhan UniversityWuhanHubeiChina

The World Health Organization described herd immunity,also known as population immunity,as the indirect fortification from an infectious disease that happens when a population is immune either through vaccination or immunity developed through previous exposure to *** emergence of COVID-19 vaccine is a step towards the achievement of herd *** one billion people across the globe have been vaccinated and Africa recorded only 2%.The objective of this article was to develop a forecast of the number of people to be vaccinated to achieve herd immunity in the 13 WHO-identified priority African countries for *** immunity is achieved when one infected person in a population causes less than one secondary case on average,corresponding to the effective basic reproduction number(R_(0)).Vaccine delivery and distribution infrastructure including the cold chain remains *** hesitancy is also one of the limiting factors that may hinder herd immunity in *** order to achieve herd immunity globally,African countries should not be excluded in fair and equal distribution of *** stakeholders should foster commitment as well as community sensitization on COVID-19 vaccines and integration of COVID-19 vaccines in existing healthcare services.

关键词： Africa COVID-19 Herd immunity Vaccine

Current efforts and challenges facing responses to 2019-nCoV in Africa

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Global Health Research and Policy 2020年第1期5卷 238-240页

作者： don eliseo lucero-prisno iii Yusuff Adebayo Adebisi Xu Lin Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUK Faculty of Pharmacy University of IbadanIbadanNigeria Department of Thoracic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003P.R.China

The novel coronavirus is a pandemic that has started to creep into Africa thus making the virus a truly global,health security *** number of new 2019-nCoV cases has been rising in Africa,though currently lower than the cases reported outside the *** countries have activated their Emergency Operations Centres to coordinate responses and preparedness activities to the pandemic.A series of measures such as restricting travel,case detection and contact tracing,mandatory quarantine,guidance and information to the public among other efforts are being implemented across ***,the presence of porous borders,the double burden of communicable and noncommunicable diseases,poverty,poor health literacy,infodemic and family clustering,and most of all,weak health systems,may make containment *** is important for African countries to continue to intensify efforts and address the challenges to effectively respond to the uncertainty the pandemic poses.

关键词： 2019-nCoV SARS-CoV-2 COVID-19 Coronavirus Africa Outbreak Global Health Pandemic

Achieving herd immunity in South America

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Global Health Research and Policy 2023年第1期8卷 541-547页

作者： don eliseo lucero-prisno iii Deborah Oluwaseun Shomuyiwa Creuza Rachel Vicente María JoséGonzález Méndez Shohra Qaderi Jaifred Christian Lopez Yidnekachew Girma Mogessie Jason Alacapa Lila Chamlagai Remy Ndayizeye Pelin Kinay Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUK Faculty of Management and Development Studies University of the Philippines Open UniversityLos BanosLagunaPhilippines Faculty of Public Health Mahidol UniversityBangkokThailand Faculty of Pharmacy University of LagosLagosNigeria Department of Social Medicine Federal University of Espírito SantoVitóriaBrazil Postgraduate Program in Infectious Diseases Federal University of Espírito SantoVitóriaBrazil Global Health Focus South America SantiagoChile Maternal Fetal Care Center Boston Children’s HospitalHarvard Medical SchoolBostonMAUSA Department of Population Health Sciences School of MedicineDuke UniversityDurhamNCUSA Johns Hopkins Bloomberg School of Public Health BaltimoreMDUSA Johns Hopkins Carey Business School BaltimoreMDUSA School of Public Health Brown UniversityProvidenceRIUSA George Washington University WashingtonDCUSA School of Climate Change and Adaptation University of Prince Edward IslandCharlottetownCanada

South America,once an epicenter of COVID-19,has stayed on the road of continued management of the *** region initially struggled to cope with the pandemic as it experienced spiraling numbers of infections and overwhelmed public health *** America has risen in its pandemic response to be the region with the highest global vaccination *** region posed a strong vaccination drive,with over 76%of its population fully vaccinated with the initial *** America leveraged its deeply rooted vaccination culture and public health confidence among its *** immunity is an integral concept in population infectious disease *** herd immunity is presently not feasible with available vaccines,but the high vaccination rate in the region depicts the acceptance of vaccination as a strategy for population *** availability of effective transmission-blocking vaccines,the continuous implementation of strategies that will enable the undisrupted supply of the vaccines,equity in access to the vaccines,improved vaccine acceptance,and trust in the vaccination and public health systems will help shepherd the region towards herd *** vaccine production backed with investment in infrastructure and international collaboration for research and knowledge development will also drive population safety.

关键词： Herd immunity COVID-19 Vaccination Population health South America Pandemic

What is global health?Key concepts and clarification of misperceptions Report of the 2019 GHRP editorial meeting

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Global Health Research and Policy 2020年第1期5卷 310-317页

作者： Xinguang Chen Hao Li don eliseo lucero-prisno iii Abu S.Abdullah Jiayan Huang Charlotte Laurence Xiaohui Liang Zhenyu Ma Zongfu Mao Ran Ren Shaolong Wu Nan Wang Peigang Wang Tingting Wang Hong Yan Yuliang Zou Global Health Institute Wuhan UniversityWuhanChina Department of Epidemiology University of FloridaFloridaUSA School of Health Sciences Wuhan UniversityWuhanChina Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUK Global Health Research Center Duke Kunshan UniversityKunshanChina Duke Global Health Institute Duke UniversityDurhamNorth CarolinaUSA School of Public Health Fudan UniversityShanghaiChina Consultant in Global Health LondonUK School of Public Health Guangxi Medical UniversityGuangxiChina Global Health Research Center Dalian Medical UniversityDalianChina School of Public Health Sun Yat-sen UniversityGuangzhouChina

The call for“Working Together to Build a Community of Shared Future for Mankind”requires us to improve people’s health across the globe,while global health development entails a satisfactory answer to a fundamental question:“What is global health?”To promote research,teaching,policymaking,and practice in global health,we summarize the main points on the definition of global health from the Editorial Board Meeting of Global Health Research and Policy,convened in July 2019 in Wuhan,*** meeting functioned as a platform for free brainstorming,indepth discussion,and post-meeting *** the meeting,we have reached a consensus that global health can be considered as a general guiding principle,an organizing framework for thinking and action,a new branch of sciences and specialized discipline in the large family of public health and *** word“global”in global health can be subjective or objective,depending on the context and *** addition to dual-,multicountry and global,a project or a study conducted at a local area can be global if it(1)is framed with a global perspective,(2)intends to address an issue with global impact,and/or(3)seeks global solutions to an issue,such as frameworks,strategies,policies,laws,and *** this regard,global health is eventually an extension of“international health”by borrowing related knowledge,theories,technologies and methodologies from public health and *** global health is a concept that will continue to evolve,our conceptualization through group effort provides,to date,a comprehensive *** report helps to inform individuals in the global health community to advance global health science and practice,and recommend to take advantage of the Belt and Road Initiative proposed by China.

关键词： Global health Definition Global impact Global solution Global health sciences Global health theory global health education Global health development

Addressing schistosomiasis in the Philippines:Need for a coordinated intersectoral effort

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Asian Pacific Journal of Tropical Medicine 2024年第11期17卷 479-480页

作者： Alvin I.Abeleda don eliseo lucero-prisnoⅢ Jerico B.Ogaya College of Public Health University of the Philippines ManilaPhilippines Department of Global Health and Development Faculty of Public Health and PolicyLondon School of Hygiene and Tropical MedicineLondonUnited Kingdom Faculty of Management and Development Studies University of the Philippines(Open University)Los BañosLagunaPhilippines Department of Medical Technology Institute of Health Sciences and NursingFar Eastern UniversityManilaPhilippines

The World Health Organization(WHO)recognized schistosomiasis as one of the neglected tropical diseases(NTDs)caused by parasitic blood *** a 4.68%national prevalence in 2017,schistosomiasis is endemic in 28 provinces in the Philippines[1,2].Having agriculture as a common source of livelihood,the country is vulnerable to schistosomiasis as this disease is transmitted when a larva,released by freshwater snails,penetrates the skin of a susceptible *** fact,it was estimated that 12.4 million Filipinos are at risk,while 2.7 million are directly exposed to the parasite[2].This remains to be a major public health concern as it contributes to a considerable morbidity and *** children,this disease causes malnutrition and impaired cognitive ***,schistosomiasis as an NTD puts the burden on poverty-stricken areas,especially in low-and middle-income countries,exacerbating the health inequality within a country and across the globe.

关键词： schistosomiasis impaired income

Reduction of Linear Systems of ODEs with Optimal Replacement Variables

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Communications in Computational Physics 2011年第3期9卷 756-779页

作者： Alex Solomonoff Wai Sun don Camberville Research Institute SomervilleMAUSA Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong Kong

In this exploratory study,we present a new method of approximating a large system of ODEs by one with fewer equations,while attempting to preserve the essential dynamics of a reduced set of variables of *** method has the following key elements:(i)put a(simple,ad-hoc)probability distribution on the phase space of the ODE;(ii)assert that a small set of replacement variables are to be unknown linear combinations of the not-of-interest variables,and let the variables of the reduced system consist of the variables-of-interest together with the replacement variables;(iii)find the linear combinations that minimize the difference between the dynamics of the original system and the reduced *** describe this approach in detail for linear systems of *** techniques and issues for carrying out the required minimization are *** of systems of linear ODEs and variable-coefficient linear PDEs are used to demonstrate the *** show that the resulting approximate reduced system of ODEs gives good approximations to the original ***,some directions for further work are outlined.

关键词： System reduction optimal replacement variables resolved variables optimal prediction