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Primary Mode of Action of <i>Cistus ladaniferus</i>L. Essential Oil Active Fractions on <i>staphylococcus aureus</i>strain

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Advances in Microbiology 2015年第13期5卷 881-890页

作者： Elodie Guinoiseau Anne Luciani dominique de rocca s.rra Yann Quilichini Liliane Berti Vannina Lorenzi Laboratoire de Biochimie et de Biologie Moléculaire du Végétal Université de Corse Campus Grimaldi Corte France Laboratoire de Chimie et Biomasse Université de Corse Route des Sanguinaires Ajaccio France Laboratoire Parasites et Ecosystèmes Méditerranéens Université de Corse Campus Grimaldi Corte France

The purpose of this study was to investigate the primary mode of action of Cistus ladaniferus essential oil active fractions on staphylococcus aureus strain ATCC6538P (CIP 53.156). The mode of inhibition of the active fractions was assessed by determining the minimum inhibitory concentration (MIC). The effects of time on cell integrity were determined by time-kill, bacteriolysis and loss of 260 and 280-nm-absorbing material assays. Measurement of intra- and extracellular ATP was used to evaluate the energy remaining in the cells after treatment. A bacteriostatic and a bactericidal mode of inhibition were established respectively for acetate and alcohol fractions at their MIC. No intracellular material leakage and no lysis occurred after treatments with these fractions. In both cases, we observed a decrease of the ATP level within s. aureus cells whilst there was no proportional increase outside the cells. However, the effects induced by alcohols are more pronounced than those provoked by acetates. Indeed, marked structural changes were observed by transmission electron microscopy (TEM). The septal material of cells undergoing division became thicker and stained more lightly. The proportion of septa is also markedly increased and defective with respect to placement. These observations suggest a blocking in cell division, probably caused by the inhibition of ATPase or a disturbance in proton motrice force by the hydrophobic molecules viridiflorol and ledol, mainly present in alcohol fraction.

关键词： staphylococcus aureus Cistus ladaniferus Essential Oil MIC ATP Cell Division Blocking TEM

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Helping the Consumers and Producers of standards,Repositories and Policies to Enable FAIR Data

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Data Intelligence 2020年第1期2卷 151-157,312页

作者： Peter McQuilton dominique Batista Oya Beyan Ramon Granell simon Coles Massimiliano Izzo Allyson L.Lister Robert Pergl Philippe rocca-s.rra Ben schaap Hugh shanahan Milo Thurston susanna-Assunta sansone Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK Fraunhofer Institute for Applied Information Technology(FIT) 53754 Sankt AugustinGermany school of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic Wageningen University Wagengen 6700 HBThe Netherlands Royal Holloway University of LondonLondon Surrey TW200EXUK

Thousands of community-developed(meta)data guidelines,models,ontologies,schemas and formats have been created and implemented by several thousand data repositories and knowledge-bases,across all *** resources are necessary to meet government,funder and publisher expectations of greater transparency and access to and preservation of data related to research *** obligates researchers to ensure their data is FAIR,share their data using the appropriate standards,store their data in sustainable and community-adopted repositories,and to conform to funder and publisher data *** data sharing also plays a key role in enabling researchers to evaluate,re-analyse and reproduce each other’s *** can map the landscape of relationships between community-adopted standards and repositories,and the journal publisher and funder data policies that recommend their *** this paper,we show how the work of the GO-FAIR FAIR standards,Repositories and Policies(stRePo)Implementation Network serves as a central integration and cross-fertilisation point for the reuse of FAIR standards,repositories and data policies in *** to this effort,the FAIRsharing,an endorsed flagship resource of the Research Data Alliance that maps the landscape of relationships between community-adopted standards and repositories,and the journal publisher and funder data policies that recommend their ***,we highlight a number of activities around FAIR tools,services and educational efforts to raise awareness and encourage participation.

关键词： Convergence Data repositories Data policies Data standards FAIR data FAIR enabling community standards

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FAIR Principles:Interpretations and Implementation Considerations

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Data Intelligence 2020年第1期2卷 10-29,293-302,322页

作者： Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty dominique Batista simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe rocca-s.rra Robert Pergl susanna-Assunta sansone Luiz Olavo Bonino da silva santos Juliane schneider George strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik schultes Leiden University Medical Center Leiden2333 ZAThe Netherlands Institute of Data science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands department of Computer science The University of ManchesterOxford RoadManchester M139PLUK Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK school of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK Amsterdam UMC University of AmsterdamAmsterdam 1000 GGThe Netherlands European Bioinformatics Institute(EMBL-EBI) HinxtonCambridgeCB101SDUK Harvard University CambridgeMassachusetts 02138USA department of Bioinformatics–BiGCaT NUTRIMMaastricht UniversityMaastricht 6229 ERThe Netherlands Conceptual and Cognitive Modeling Research Group(CORE) Free University of Bozen-BolzanoBolzano 39100Italy Aalborg University Aalborg DK-9220Denmark Insight Centre for Data Analytics National University of Ireland GalwayH91 TK33Ireland Centre for Digital scholarship Leiden University LibrariesLeiden2333 ZAThe Netherlands department of Computer science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Dutch Techcentre for Life sciences(DTL) UtrechtThe Netherlands sURF Utrecht 3511 EPThe Netherlands Keith G Jeffery Consultants FaringdonUK Castor EDC Paasheuvelweg 25Wing 5D1105 BPAmsterdamThe Netherlands san Diego supercomputer Center University of California San DiegoLa JollaCalifornia 92093USA Learning and Research Resources Centre(CRAI) Universitat de Barcelona08007 BarcelonaSpain Environment Agency Austria A-1090 ViennaAustria University of Notre Dame 75004 ParisFrance Health Research Board(HRB) Dublin 2DO2 H638Ireland Liacs Institute of Advanced Computer science Leiden University2311 GJ LeidenThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic GO FAIR International support&Coordination Office(GFIsCO) LeidenThe Netherlands Harvard Catalys

The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in *** intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital *** has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR ***,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible ***,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-*** introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR *** self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the ***,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.

关键词： FAIR guiding principles FAIR implementation FAIR convergence FAIR communities choices and challenges

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