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Sensitive capacitive pressure sensors based on graphene membrane arrays

中国化学会第十四届全国氟化学会议

作者： dominique cAHARD cNRS UMR 6014 C.O.B.R.A. Normandy University

＜正＞The synthesis of enantiopure molecules featuring a fluorine atom or a fluorinated motif at a stereogenic carbon centre has stimulated considerable *** subtle effects of fluorine atom（s）on the course of asymmet...

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Microsystems & Nanoengineering 2020年第1期6卷 176-184页

作者： Makars Siskins Martin Lee dominique Wehenkel Richard van Rijn Tijmen W.de Jong Johannes R.Renshof Berend c.Hopman Willemijn S.J.M.Peters Dejan Davidovikj Herre S.J.van der Zant Peter G.Steeneken Kavli Institute of Nanoscience Delft University of TechnologyLorentzweg 12628 CJ DelftThe Netherlands Applied Nanolayers B.V. Feldmannweg 172628 CT DelftThe Netherlands Department of Precision and Microsystems Engineering Delft University of TechnologyMekelweg 22628 CD DelftThe Netherlands

The high flexibility,impermeability and strength of graphene membranes are key properties that can enable the next generation of nanomechanical ***,for capacitive pressure sensors,the sensitivity offered by a single suspended graphene membrane is too small to compete with commercial ***,we realize highly sensitive capacitive pressure sensors consisting of arrays of nearly ten thousand small,freestanding double-layer graphene *** fabricate large arrays of small-diameter membranes using a procedure that maintains the superior material and mechanical properties of graphene,even after high-temperature *** sensors are readout using a low-cost battery-powered circuit board,with a responsivity of up to 47:8aF Pa^(−1) mm^(−2),thereby outperforming the commercial sensors.

关键词： graphene arrays thereby

chemical characterization of fine and ultrafine PM, direct and indirect genotoxicity of PM and their organic extracts on pulmonary cells

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Journal of Environmental Sciences 2018年第9期30卷 168-178页

作者： Sylvain Billet Yann Landkocz Perrine J. Martin Anthony Verdin Frederic Ledoux capucine Lepers Veronique Andre Fabrice cazier Francois Sichel Pirouz Shirali Pierre Gosset dominique courcot University of the Littoral Opal coast Unit of Environmental Chmistry and Interactions with Liuing Organisms UCEIV EA4492 SFR Condorcet FR CNRS 3417 Dunkerque France Normandy Uniu UNICAEN ABTE EA4651 Caen France University of the Littoral Opal coast Common Centre of Measurements CCM Dunkerque France centre Francois Baclesse Caen France Department of Anatomy and Pathological cytologly Saint-Vincent Hospital Catholic Hospital Lille France

Particulate matter in ambient air constitutes a complex mixture of fine and ultrafine particles composed of various chemical compounds including metals, ions, and organics. A multidisciplinary approach was developed by studying physico-chemical characteristics and mechanisms involved in the toxicity of particulate atmospheric pollution. PM0.3-2.s and PM2.5 including ultrafine particles were sampled in Dunkerque, a French industrialized seaside city. PM samples were characterized from a chemical and toxicological point of view. Physico-chemical characterization evidenced that PM2.5 comes from several sources： natural ones, such as soil resuspension and marine sea-salt emissions, as well as anthropogenic ones, such as shipping traffic, road traffic, and industrial activities. Human BEAS-2B tung cells were exposed to PM0.3-2.5, or to the Extractable Organic Matter （EOM） of PM0.3-2.5 and PM2.s. These exposures induced several mechanisms of action implied in the genotoxicity, such as oxidative DNA adducts and DNA Damage Response. The toxicity of PM-EOM was higher for the sample including the ultrafine fraction （PM2.5） containing also higher concentrations of polycyclic aromatic hydrocarbons. These results evidenced the major role of organic compounds in the toxicity of PM.

关键词： Air pollution particulate matter PM2.5 Ultrafine particles Physico-chemical characterization Biotransformation Genotoxicity

chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance

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Journal of Sport and Health Science 2023年第2期12卷 194-201页

作者： Wouter M.A.Franssen charly Keytsman Nastasia Marinus Kenneth Verboven Bert O.Eijnde Lisa van Ryckeghem Paul Dendale Renate Zeevaert Guy Massa dominique Hansen Rehabilitation Research centre(REVAL) Faculty of Rehabilitation SciencesHasselt UniversityHasselt 3500Belgium Biomedical Research Institute(BIOMED) Faculty of Medicine and Life SciencesHasselt UniversityHasselt 3500Belgium ADLON Sports Medical center Hasselt 3500Belgium Heart centre Hasselt Jessa HospitalHasselt 3500Belgium Department of Pediatric Endocrinology and Diabetology Jessa HospitalHasselt 3500Belgium

Background:Adults with obesity may display disturbed cardiac chronotropic responses during cardiopulmonary exercise testing,which relates to poor cardiometabolic health and an increased risk for adverse cardiovascular *** is unknown whether cardiac chronotropic incompetence(cI)during maximal exercise is already present in obese adolescents and,if so,how that relates to cardiometabolic ***:Sixty-nine obese adolescents(body mass index standard deviation score=2.23±0.32,age=14.1±1.2 years;mean±SD)and 29lean adolescents(body mass index standard deviation score=-0.16±0.84,age=14.0±1.5 years)performed a maximal cardiopulmonary exercise testing from which indicators for peak performance were *** resting heart rate and peak heart rate were used to calculate the maximal chronotropic response ***(lipid profile,glycemic control,inflammation,and leptin)was studied in fasted blood samples and during an oral glucose tolerance test within obese *** analyses were applied to examine associations between the presence of cI and blood or exercise capacity parameters,respectively,within obese ***:cI was prevalent in 32 out of 69 obese adolescents(46%)and 3 out of 29 lean adolescents(10%).c-reactive protein was significantly higher in obese adolescents with cI compared to obese adolescents without cI(p=0.012).Furthermore,peak oxygen uptake and peak cycling power output were significantly reduced(pcents with cI *** adolescents without *** chronotropic index was independently related to blood total cholesterol(standardized coefficientβ=-0.332;p=0.012)and c-reactive protein concentration(standardized coefficientβ=-0.269;p=0.039).conclusion:cI is more common in the current cohort of obese adolescents,and is related to systemic inflammation and exercise intolerance.

关键词： Adolescents cardiometabolic health Exercise tolerance Heart rate Obesity

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肝癌发生过程中转录因子AP-1活化的研究

南京医科大学学报（自然科学版） 2004年第1期24卷 28-30,37页

作者：刘平 Bernau dominique 南京医科大学第一附属医院消化科江苏南京210029 Bichat医学院细胞生物学实验室

目的:检测肝癌及其癌周组织中AP-1活化状态,探索该转录因子在肝癌发生过程中可能的作用。方法:用电泳迁移率转移试验、免疫印迹和RNA酶保护性分析等方法,测定15例原发性肝癌及其癌周组织中AP-1与DNA的结合活性、AP-1复合物的蛋白组成以... 详细信息

目的:检测肝癌及其癌周组织中AP-1活化状态,探索该转录因子在肝癌发生过程中可能的作用。方法:用电泳迁移率转移试验、免疫印迹和RNA酶保护性分析等方法,测定15例原发性肝癌及其癌周组织中AP-1与DNA的结合活性、AP-1复合物的蛋白组成以及细胞增殖状况。结果:与正常肝组织相比,AP-1与DNA结合活性在73%的癌周组织中增高;60%的肝癌组织中AP-1结合活性比癌周组织进一步增高;其AP-1二聚体主要由JunD、c-Jun和c-Fos蛋白参与组成,AP-1结合活性与JunD和c-Jun蛋白表达水平呈正相关。结论:AP-1的激活是肝癌发生过程中的早期频发事件,可能有助于肝细胞恶性转化表型的获得,在肝癌的形成中具有重要作用。

关键词：肝癌 AP-1 Jun蛋白 Fos基因

c-myc基因和IGF-Ⅱ基因在WHV/myc转基因小鼠肝癌发生过程中的双相性表达

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肿瘤 1998年第5期18卷 343-345页

作者：刘平 dominique bernuau gerard feldmann 南京医科大学第一附属医院消化科法国巴黎第七大学ＢＩＣＨＡＴ医学院

肝癌的发生机理尚未阐明，流行病学调查的资料表明，肝癌的发生与乙型、丙型肝炎病毒（ＨＢＶ、ＨＣＶ）的感染有密切的联系。用土拨鼠肝炎病毒（ＷＨＶ）ＤＮＡ操纵下的ｃ－ｍｙｃ基因建成的转基因小鼠模型，其肝脏肿瘤自然形成率高达... 详细信息

肝癌的发生机理尚未阐明，流行病学调查的资料表明，肝癌的发生与乙型、丙型肝炎病毒（ＨＢＶ、ＨＣＶ）的感染有密切的联系。用土拨鼠肝炎病毒（ＷＨＶ）ＤＮＡ操纵下的ｃ－ｍｙｃ基因建成的转基因小鼠模型，其肝脏肿瘤自然形成率高达９０％～１００％［１］，可用于研究...

关键词：基因表达 c-myc 肝肿瘤原位杂交转基因动物

characterisation and seasonal variations of particles in the atmosphere of rural, urban and industrial areas：Organic compounds

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Journal of Environmental Sciences 2016年第6期28卷 45-56页

作者： Fabrice cazier Paul Genevray Dorothée Dewaele Habiba Nouali Anthony Verdin Frédéric Ledoux Adam Hachimi Lucie courcot Sylvain Billet Saad Bouhsina Pirouz Shirali Guillaume Garcon dominique courcot common center of Measurements (ccM) Univ. Littoral Cote d'Opale F-59140 Dunkirk France Unit of Environmental chemistry and Interactions with Life UCEIV-EA4492 Univ. Littoral Cote d'Opale F-59140 Dunkirk France MicroPolluants Technologie SA 4 Rue de Bort Les Orgues F-57070 Saint Julien Les Metz France Oceanology and Geosciences Laboratory LOG UMR 8187 Univ. Littoral C6te d'Opale F-62230 Wimereux France Impact of chemical Environment on Human Health Univ. Lille CHU Lille Institut Pasteur de Lille EA4483-IMPECS 59000 LILLE France

Atmospheric aerosol samples（PM2.5–0.3, i.e., atmospheric particles ranging from 0.3 to2.5 μm） were collected during two periods： spring–summer 2008 and autumn–winter 2008–2009, using high volume samplers equipped with cascade impactors. Two sites located in the Northern France were compared in this study： a highly industrialised city（Dunkirk） and a rural site（Rubrouck）. Physicochemical analysis of particulate matter（PM） was undertaken to propose parameters that could be used to distinguish the various sources and to exhibit seasonal variations but also to provide knowledge of chemical element composition for the interpretation of future toxicological studies. The study showed that PM2.5–0.3concentration in the atmosphere of the rural area remains stable along the year and was significantly lower than in the urban or industrial ones, for which concentrations increase during *** concentrations of polycyclic aromatic hydrocarbons（PAHs）, dioxins, furans and dioxin like polychlorinated biphenyls（DL-PcBs）, generated by industrial activities, traffic and municipal wastes incineration were detected in the samples. Specific criteria like carbon Preference Index（cPI） and combustion PAHs/Total PAHs ratio（cPAHs/TPAHs） were used to identify the possible sources of atmospheric pollution. They revealed that paraffins are mainly emitted by biogenic sources in spring–summer whereas as in the case of PAHs, they have numerous anthropogenic emission sources in autumn-winter（mainly from traffic and domestic heating）.

关键词： Environmental monitoring Airborne particles PAHs Paraffins Dioxins

运用生物能量学模型预测草鱼生长、饲料需求和污染排放

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水产学报 2018年第6期42卷 950-967页

作者：刘晓娟罗伟王春芳李大鹏 dominique BUREAU 华中农业大学水产学院淡水水产健康养殖湖北省协同创新中心池塘健康养殖湖北省工程实验室 Fish Nutrition Research Laboratory Department of Animal Bioscience University of Guelph

为预测不同生长阶段草鱼生长性能、饲料需求量和污染排放量,提高草鱼投喂管理水平,本研究运用特定增长率(SGR)、日增长率(DGc)、日均增重(ADG)和热积温系数(TGc)等生长模型计算草鱼在不同生长阶段的生长速率,并通过计算定期采样中实际... 详细信息

为预测不同生长阶段草鱼生长性能、饲料需求量和污染排放量,提高草鱼投喂管理水平,本研究运用特定增长率(SGR)、日增长率(DGc)、日均增重(ADG)和热积温系数(TGc)等生长模型计算草鱼在不同生长阶段的生长速率,并通过计算定期采样中实际观测值和预测值最小残差平方和法选出最优生长模型。饲料需求模型通过估算鱼类消化能需求量决定,根据能量收支原理,通过计算鱼体储积能(RE)、基础代谢能(He E)、摄食热增能(Hi E)以及尿液和鳃的代谢能(UE+ZE),来估算草鱼的消化能,再根据所用饲料的消化能含量来确定草鱼对饲料的需求量。草鱼污染物排放主要采用营养物质平衡法计算。在模型验证时,以粗蛋白分别为33%、28%、23%的饲料投喂不同生长阶段的草鱼,将草鱼体质量和饲料系数(FcR)的模型预测值与实际观测值进行比较。结果显示,与其他生长模型(SGR、ADG、DGc)相比,调整后的TGc模型能更精确预测草鱼的生长情况;草鱼体质量和FcR预测值与观测值之间显著相关;每生产1 t鱼(体质量为0.52500 g),其消化能需求量约为1.55×107 k J,消耗1 t饲料或生产1 t鱼所排放的总固态污染物分别为440和623 kg。研究表明,该复合性营养模型可以有效地估计实际养殖中草鱼生长、饲料需求量和污染物排放量,有望为草鱼差异化上市、节省饲料成本、减少饲料浪费以及养殖场的污染评价提供有效的预判工具。

关键词：草鱼生物能量学模型污染排放饲料需求

Degradation of PAI/PEI Enamel under High Temperature (Up to 400°c)

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Materials Sciences and Applications 2022年第1期13卷 1-21页

作者： Fabrice Aymonino Thierry Lebey David Malec dominique Mary LAboratoire PlAsma et conversion d’Energie (LAPLAcE) Université de Toulouse Toulouse France

This work deals with the understanding of the degradation of the primary insulation (PEI/PAI) of rotating machines working temporarily under high-temperature. The main domain of application of these motors is the smoke extraction either from tunnels or underground parking when a fire occurs. In such a critical situation, the internal temperature of the motor winding may reach temperatures up to 400°c. Under such very high thermal stresses, the behaviour of the electrical insulation is not well understood. This work proposes an analysis of the decomposition gases under very high temperatures and the corresponding degradation pathway. A simple method is proposed to identify whether the insulation of such motors has been strongly damaged during the working time at very high temperatures, thus allowing estimating if it can still continue to operate.

关键词： Polyesterimide (PEI) Polyamide-Imide (PAI) Enamel Electrical Insulation Rotating Machine High Temperature Thermal Degradation