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Science Bulletin 2022年第22期67卷 2336-2344页

作者： Ulf Büntgen Alan crivellaro dominique Arseneault Mike Baillie David Barclay Mauro Bernabei Jarno Bontadi Gretel Boswijk David Brown Duncan Achristie Olga Vchurakova Edward Rcook Rosanne D’Arrigo Nicole Davi Jan Esper Patrick Fonti ciara Greaves Rashit MHantemirov Malcolm KHughes Alexander VKirdyanov Paul JKrusic carlos Le Quesne Fredrik cLjungqvist Michael Mccormick Vladimir SMyglan Kurt Nicolussi clive Oppenheimer Jonathan Palmer 秦春 Frederick Reinig Matthew Salzer Markus Stoffel Max Torbenson Mirek Trnka Ricardo Villalba Nick Wiesenberg Greg Wiles 杨保 Alma Piermattei Department of Geography University of CambridgeCambridge CB23ENUK Swiss Federal Research Institute(WSL) Birmensdorf 8903Switzerland Global change Research centre(czechGlobe) Brno 60300Czech Republic Department of Geography Faculty of ScienceMasaryk UniversityBrno 61300Czech Republic Forest Biometrics Laboratory Faculty of Forestry“Stefan cel Mare”University of SuceavaSuceava 720229Romania Department of Biology Chemistry and GeographyUniversity of Quebec in RimouskiRimouski Qc.G5L 3A1Canada Archaeology&Palaeoecology School of Natural and Built EnvironmentQueen’s University BelfastBelfast BT71NNUK Department of Geology State University of New York at CortlandCortland NY 13045USA cNR-IBE Institute of BioEconomyNational Research CouncilTrento 38121Italy School of Environment The University of AucklandAuckland 1010New Zealand Laboratorio de Dendrocronología y cambio Global Universidad Austral de ChileValdivia 509000Chile center for climate and Resilience Research(cR) Santiago 8370449Chile cape Horn International center(cHIc) Punta Arenas 6200000Chile Institute of Ecology and Geography Siberian Federal UniversityKrasnoyarsk 660041Russia Tree-Ring Laboratory Lamont-Doherty Earth ObservatoryColumbia UniversityPalisades NY 10964USA Department of Environmental Science William Paterson UniversityWayne NJ 07470USA Department of Geography Johannes Gutenberg UniversityMainz 55099Germany Institute of Plant and Animal Ecology Ural BranchRussian Academy of SciencesYekaterinburg 620144Russia Ural Institute of Humanities Ural Federal UniversityYekaterinburg 620002Russia Laboratory of Tree-Ring Research University of ArizonaTucson AZ 85721USA Sukachev Institute of Forest SB RAS Krasnoyarsk 660036Russia Department of Physical Geography Bolin Centre for Climate ResearchStockholm UniversityStockholm 10691Sweden Department of History Stockholm UniversityStockholm 10691Sweden Bolin centre for climate Research Stockholm UniversityStockholm 10691Sweden Swedish collegium for Advanced Study

公元536~540年间的大规模火山喷发使得晚古小冰期成为过去两千年最为寒冷的时期.然而,受限于现有气候代用资料的时间分辨率和空间覆盖度,晚古小冰期的开始时间和空间范围仍存有争议.本文分析了全球23个森林样点、20个树种的106个树轮样... 详细信息

公元536~540年间的大规模火山喷发使得晚古小冰期成为过去两千年最为寒冷的时期.然而,受限于现有气候代用资料的时间分辨率和空间覆盖度,晚古小冰期的开始时间和空间范围仍存有争议.本文分析了全球23个森林样点、20个树种的106个树轮样本资料,从细胞尺度揭示了公元530~550年间北半球发生的短暂夏季冷却现象.经过交叉定年和染色处理后,在北半球的树轮样品中共识别出89个蓝轮(缺失细胞壁木质化过程)、9个霜轮(细胞分裂受阻)和93个浅轮(细胞壁增厚减弱).研究结果表明,公元536年7月中旬至8月初期间整个北美和欧亚大陆均发生了最剧烈的温度下降,而更多的区域性“冷夏”出现于公元532年、540~543年和548年.然而,本研究在南半球的树轮资料中并未发现异常的解剖结构,其原因可能与南半球的海洋热惯性减缓了火山降温效应有关,也或与南半球其时正值非生长季有关.相较于传统的树轮年代学方法,本研究的木材解剖学的方法能为地球系统模式提供更为精细的参考标准,有望服务于气候与人类历史交叉学科研究,同时对“全球气候平均”概念的使用提出质疑.

关键词：地球系统模式小冰期火山喷发树轮年代学全球气候欧亚大陆冷夏染色处理

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单脉冲膨胀波激波管用于同质核化率的实验研究

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流体力学实验与测量 1998年第2期12卷 44-50页

作者：傅云飞杨基明韩肇元 c.c.M.Luijten O.D.E.baas M.E.H.vanDongen 中国科学技术大学艾恩德霍芬技术大学

以单脉冲膨胀波激波管为工具，利用激光散射、透射测试方法，研究了戊醇在总压为１００ｋＰａ，温度为２４０Ｋ、２５０Ｋ和２６０Ｋ状态附近同质核化率量值、以及它同饱和度之间的关系，并同经典同质核化理论计算结果进行了比较。结果... 详细信息

以单脉冲膨胀波激波管为工具，利用激光散射、透射测试方法，研究了戊醇在总压为１００ｋＰａ，温度为２４０Ｋ、２５０Ｋ和２６０Ｋ状态附近同质核化率量值、以及它同饱和度之间的关系，并同经典同质核化理论计算结果进行了比较。结果表明：戊醇在携带气体氦气中的同质核化率量级范围为１０１３～１０１７／ｍ３ｓ；相应的过饱和度为１１～２６；在相同的饱和度条件下，实验所得同质核化率比经典同质核化理论计算的结果大。

关键词：激波管单脉冲膨胀波戊醇同质核化率

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clinical Aspects and Precipitating Factors of Hepatic Encephalopathy Associated with cirrhosis in a cameroonian Population

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Open Journal of Gastroenterology 2019年第11期9卷 228-238页

作者： Mathurin Pierre Kowo Edgar Kenne Yimagou Firmin Ankouane Andoulo Antonin Wilson Ndjitoyap Ndam Bonaventure Jemea Servais Albert Fiacre Eloumou Bagnaka Patricia Ouamba Guekam Larissa Pessidjo Eric Tchoumi Leuwat dominique Noah Noah Oudou Njoya Faculty of Medicine and Biomedical Sciences The University of Yaoundé I Yaoundé Cameroon Research Laboratory on Viral Hepatitis and Health communication Yaoundé Cameroon Internal Medicine Unit Yaounde University Teaching Hospital Yaoundé Cameroon Gastroenterology Unit Central Hospital Yaoundé Cameroon Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon

Background: Hepatic Encephalopathy (HE), a common complication of cirrhosis, is associated with a pejorative prognosis. This study aims to describe the clinical presentation, precipitating factors and outcome of HE. Methods: This was a cross-sectional multicenter inpatient study in cirrhotic patients admitted for HE in four tertiary hospitals in Yaoundé (cameroon) from December 2016 to May 2017. The diagnosis of HE was based on West Haven clinical criteria. The diagnosis of cirrhosis was made using clinical and/or biological, endoscopic and/or ultrasonography signs. Results: A total of 53 patients with HE (mean age: 49.9 ± 18.9 years, 35 Males) were included. The frequency of hospital admission for HE was 4.9%. HE grade III was the most common (37.7%), followed by grades I and II (26.4% and 26.4%, respectively). Grade IV was present in 9.4% of cases. According to the child-Pugh score, 72.1% of the patients were at stage c and 27.9% at stage B. The main precipitating factors found were: constipation (38.5%), hyponatremia (35.9%), hepatocellular carcinoma (Hcc) (31.7%), herbal medicine (28.3%), hypokalemia (25.6%), gastrointestinal bleeding (22.6%) and ascitic fluid infection (spontaneous bacterial peritonitis) (13.8%). In 5.7% of cases, no factor was identified. Mortality rate during hospitalization was 45.3% and was significantly associated with stage III (RR = 11.1;95% cI: 1.9 - 64.5;p = 0.003) and IV (RR = 24;95% cI: 1.6 - 40.9;p = 0.01) of HE;child-Pugh c score (RR = 15.2;95% cI: 1.7 - 30.1;p = 0.003) and hypokalemia (RR = 12.2;95% cI: 1.3 - 19;p = 0.01). conclusion: HE is a common complication during cirrhosis with a poor prognosis. In the majority of cases, a precipitating factor could be determined.

关键词： Hepatic Encephalopathy Liver cirrhosis West Haven criteria child-Pugh cameroon

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Factors associated with DAA virological treatment failure and resistance-associated substitutions description in HIV/HcV coinfected patients

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World Journal of Hepatology 2018年第11期10卷 856-866页

作者： dominique Salmon Pascale Trimoulet camille Gilbert caroline Solas Eva Lafourcade Julie chas Lionel Piroth Karine Lacombe christine Katlama Gilles Peytavin Hugues Aumaitre Laurent Alric Franoois Boué Philippe Morlat Isabelle Poizot-Martin Eric Billaud Eric Rosenthal Alissa Naqvi Patrick Miailhes Firouzé Bani-Sadr Laure Esterle Patrizia carrieri Franoois Dabis Philippe Sogni Linda Wittkop 无 Assistance Publique des Hopitaux de Paris Hopitaux Universitaires Paris CentreHopital Hotel DieuUnitédes Maladies infectieuses et tropicalesParis 75004France Université Paris Descartes Sorbonne Paris CitéParis 75006France Trimoulet CHU de BordeauxHopital PellegrinLaboratoire de VirologieBordeaux 33000France Trimoulet CNRS-UMR 5234Microbiologie fondamentale et PathogénicitéUniversitéde BordeauxBordeaux 3000France Philippe Morlat Laure EsterleFrancois DabisLinda WittkopUniv.BordeauxISPEDInsermBordeaux Population Health Research Centerteam MORPH3EUSUMR 1219CIC-EC 1401Bordeaux F-33000France APHM Hopital La TimoneLaboratoire de Pharmacocinétique et ToxicologieMarseille 13005France centre Hospitalier Universitaire de Dijon Département d'InfectiologieDijon cedex 21079France INSERM-cIc 1342 Universitéde Bourgogne Dijon 21000France Assistance Publique des Hopitaux de Paris GHUEP site Saint-AntoineServices Maladies infectieuses et tropicalesParis 75011France UniversitéPierre et Marie curie UMR S1136Institut Pierre Louis d' Epidémiologie et de SantéPubliqueParis 75646France UniversitéParis-Sorbonne Paris 75005France Assistance Publique des Hopitaux de Paris Hopital PitiéSalpêtrière Services Maladies infectieuses et tropicalesParis 75013France Assistance Publique des Hopitaux de Paris Hopital Bichat-Claude BernardLaboratoire de PharmacologieParis 75877France IAME UMR 1137Sorbonne Paris CitéINSERMUniversitéParis DiderotParis 75890France centre Hospitalier de Perpignan Service Maladies infectieuses et tropicalesPerpignan 66000Franc centre Hospitalier Universitaire de Toulouse Hopital PurpanService Médecine interne-Pole DigestifToulouse 31300France UMR 152 IRD UniversitéToulouseⅢ Paul SabatierToulouse 31330France Hopital Antoine-Béclère Assistance Publique des Hopitaux de ParisUniversitéParis SudService Médecine interne et immunologieClamart 92140France centre Hospitalier Universitaire de Bordeaux Service de médecine interneHopital Saint-AndréBordeaux 33000France Uni

AIM To describe factors associated with treatment failure and frequency of resistance-associated substitutions(RAS).METHODS Human immunodeficiency virus(HIV)/hepatitis c virus(HcV) coinfected patients starting a first direct-acting antiviral(DAA) regimen before February 2016 and included in the French ANRS cO13 HEPAVIH cohort were eligible. Failure was defined as:(1) non-response [HcV-RNA remained detectable during treatment, at end of treatment(EOT)]; and(2) relapse(HcVRNA suppressed at EOT but detectable thereafter). Sequencing analysis was performed to describe prevalence of drug class-specific RAS. Factors associated with failure were determined using logistic regression *** Among 559 patients, 77% had suppressed plasma HIV-RNA copies/mL at DAA treatment initiation, 41% were cirrhotic, and 68% were HcV treatmentexperienced. Virological treatment failures occurred in 22 patients and were mainly relapses(17, 77%) then undefined failures(3, 14%) and non-responses(2, 9%). Mean treatment duration was 16 wk overall. Posttreatment NS3, NS5 A or NS5 B RAS were detected in 10/14 patients with samples available for sequencing analysis. After adjustment for age, sex, ribavirin use, HcV genotype and treatment duration, low platelet count was the only factor significantly associated with a higher risk of failure(OR: 6.5; 95%cI: 1.8-22.6). cONcLUSION Only 3.9% HIV-HcV coinfected patients failed DAA regimens and RAS were found in 70% of those failing. Low platelet count was independently associated with virological failure.

关键词：耐药性治疗方法患者肝病

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The clinical Features and Outcomes of Four Neonates Born to Mothers with a Severe Form of cOVID-19 and a Positive RT-PcR for SARS co-V2 in Douala Gynaeco-Obstetric and Pediatric Hospital in cameroon

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Open Journal of Pediatrics 2020年第4期10卷 642-651页

作者： dominique Enyama D. Noukeu Njinkui I. Rakya D. Djomo Tamchom R. Tiokeng Nenzeko c. Mbakop Tchogna M. c. Bissa S. R. Wekang Tcheuffa D. Kamdem A. Ngalame H. Neng D. Mwadjie Ndongo Eteme F. Kemta Lekpa S. R. Simeni Njonnou S. P. choukem G. P. Ngaba E. T. Mboudou Douala Gynaeco-Obstetric and Pediatric Hospital Douala Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon The University of Dschang Taskforce for the Elimination of cOVID-19 (UNITED#cOVID-19) Dschang Cameroon Faculty of Medicine and Biomedical Sciences University of Garoua Garoua Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaounde Cameroon

Background: A novel viral respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-coV-2), is responsible for a worldwide pandemic. The effects of this new disease in pregnant women and ... 详细信息

Background: A novel viral respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for a worldwide pandemic. The effects of this new disease in pregnant women and newborns are actually not well known. Methods: We investigated the clinical features and outcomes of four neonates born to mothers with a severe form of COVID-19 and a positive RT-PCR for SARS Co-V2 in Douala Gynaeco-Obstetric and Pediatric Hospital (Cameroon) from April 20 to June 5, 2020. Results: All four mothers were symptomatic and had a positive RT-PcR for SARS coV-2 from nasopharyngeal swab on admission. All of them delivered prematurely through cesarean section because of severe respiratory distress and one died shortly after delivery. The four premature male infants were born between 30 weeks and 35 weeks 2 days of gestation and had birth weights ranging from 1090 g to 2950 g. All infants had 1-minute Apgar scores that ranged from 7 to 8 and 5-minute Apgar scores varying between 8 and 9. They were isolated from their mothers immediately after birth and received formula feeding. Three of the four infants were tested using nasopharyngeal swab specimens for RT-PcR 24 to 48 hours after birth and were negative for cOVID-19. All the infants were treated in a dedicated area at the neonatal care unit and presented with mild respiratory distress on admission with a Silverman score that varied between 2 and 4/10. During their hospitalization, all the infants also presented with jaundice and underwent phototherapy. Three of the

关键词： cOVID-19 Infected Mothers Premature Newborns Severe Respiratory Distress Outcome cameroon

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2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography initial staging impacts on survival in Hodgkin lymphoma

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World Journal of Radiology 2013年第12期5卷 484-490页

作者： Juliano J cerci camila c G Linardi Luís F Pracchia José Soares Junior Evelinda Trindade dominique Delbeke Rodrigo J cerci Robert carr José c Meneghetti Valeria Buccheri Department of Nuclear Medicine Heart Institute (InCor) University of Sāo Paulo Medical School Division of PET/cT Quanta-Diagnóstico Nuclear Division of Hematology Clinical Hospital of the University of Sāo Paulo Medical School Health Technology Assessment/Executive Direction Heart Institute (InCor) University of Sāo Paulo Medical School Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Department of Haematology St Thomas’ Hospital

AIM:To assess the prognostic value and risk classification improvement of metabolic staging(MS)with Initial2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography(FDG-PET)in initial staging of Hodgkin’s Lymphoma(HL)patients to predict 5 years overall survival(5y-OS)and event free survival(EFS).METHODS:A total of 275 patients were included in this retrospective study,155 patients were staged with conventional anatomical staging(AS),and 120 also submitted to MS(FDG-PET).Prognostic analysis compared 5y-OS and 5y-EFS of patients staged with AS and ***-adjusted models incorporated clinical risk factors,computed tomography and FDG-PET ***:During the follow up of 267 evaluated patients,220(122 AS and 98 MS)achieved complete remission after first-line therapy(median follow-up:70±29 mo),treatment failure occurred in 79 patients and 34 *** 5y-EFS for early vs advanced disease in AS patients was 79.3%and 66.7%,and 85.6%and53.6%in MS patients,respectively(Pced disease with AS was91.3%and 81.5%,and 97.5%and 80.7%for patients staged with MS,*** proportional hazards analysis demonstrated that FDG-PET added signifcant prognostic information and improved risk prediction(P=0.02).cONcLUSION:Initial staging FDG-PET could be used as an accurate and independent predictor of OS and EFS in HL,with impact in 5y-EFS and OS.

关键词： Hodgkin disease Positron-emission tomography 2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography Neoplasm staging Prognosis

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欧洲呼吸学会和欧洲胸外科医师学会恶性胸膜间皮瘤诊疗指南

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中国肺癌杂志 2010年第10期13卷 999-1021页

作者： A. Scherpereel P. Astoul P. baas T. Berghmans H. clayson P. de Vuyst H. Dienemann F. Galateau-Salle c. Hennequin G. Hillerdal c. Le Pe'choux L. Mutti J-c. Pairon R. Stahel P. van Houtte J. van Meerbeeck D. Waller W. Weder 宋作庆徐萧洪 For a full list of affiliations please see the Acknowledgements section 天津医科大学总医院天津市肺癌研究所天津市肺癌转移与肿瘤微环境重点实验室

恶性胸膜间皮瘤(malignant pleural mesothelioma,MPM)是一种罕见肿瘤,但发病率正逐渐上升,且预后较差。2008年,欧洲呼吸学会(European Respiratory Society,ERS)和欧洲胸外科医师学会(European Society of Tho-racic Surgeons,ESTS)特别工作组召集各方专家计划制定MPM诊治经验及更新指南。为了使MPM得到及时准确的诊断,专家推荐对患者实施胸腔镜检查,有手术禁忌和胸腔粘连的病例除外。约10%的病例采用标准染色方法无法获得满意的结果。因此我们推荐在胸膜活检的基础上,采用特异性免疫组化标志物。由于目前缺乏一个统一的、切实有效的分期系统,我们推荐应用最新的TNM分期,并且提出三个阶段的治疗前评估。在MPM的治疗中,患者的体力状态评分和组织亚型是目前唯一的、具有重要临床价值的预后因素。在临床试验中,应对其它潜在因素进行初步探讨并予以报道。MPM对化疗高度耐受,仅有少数患者可接受根治性手术。本文对新的治疗方法和策略进行了综述。目前由于最佳综合治疗的资料有限,适合采用多种方案联合治疗策略的患者应被纳入专业机构的前瞻性试验中。

关键词：石棉肿瘤指南间皮瘤,胸膜治疗

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WHV/myc转基因小鼠肝癌发生过程中c-jun,c-fos和c-H-ras基因的表达

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南京医科大学学报（自然科学版） 1997年第4期17卷 305-308页

作者：刘平 dominique Bernuau Gerard Feldmann 南京医科大学第一附属医院消化科巴黎第七大学ＢＩＣＨＡＴ医学院

用核酸分子原位杂交的方法，检测了ＷＨＶ／ｍｙｃ转基因小鼠肝癌发生过程中ｃ－ｊｕｎ、ｃ－ｆｏｓ和ｃ－Ｈ－ｒａｓ基因的表达情况。正常小鼠（１０天龄和４月龄）肝脏中可检测出上述三种基因呈低水平的表达。１０天龄转基因小鼠肝脏... 详细信息

用核酸分子原位杂交的方法，检测了ＷＨＶ／ｍｙｃ转基因小鼠肝癌发生过程中ｃ－ｊｕｎ、ｃ－ｆｏｓ和ｃ－Ｈ－ｒａｓ基因的表达情况。正常小鼠（１０天龄和４月龄）肝脏中可检测出上述三种基因呈低水平的表达。１０天龄转基因小鼠肝脏中这三种基因的表达与正常同龄小鼠相似，而４月龄转基因小鼠肝脏中三种基因的表达强度明显高于正常小鼠，且杂交信号的分布范围广。肿瘤形成阶段，仍可在肝肿瘤结节中检测到这三种癌基因较弱的表达信号。结果表明，在ＷＨＶ／ｍｙｃ转基因小鼠肝肿瘤发生前ｃ－ｍｙｃ转染基因表达的“沉默”期，存在一些癌基因在肝脏中异常表达的现象。

关键词：基因表达肝肿瘤原位杂交转基因动物小鼠

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Daclatasvir vs telaprevir plus peginterferon alfa/ribavirin for hepatitis c virus genotype 1

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World Journal of Gastroenterology 2016年第12期22卷 3418-3431页

作者： Ira Jacobson Stefan Zeuzem Robert Flisiak Brygida Knysz Stefan Lueth Dorota Zarebska-Michaluk Ewa Janczewska Peter Ferenci Moises Diago Anna Linda Zignego Rifaat Safadi Yaacov Baruch Dzhamal Abdurakhmanov Stephen Shafran dominique Thabut Rafael Bruck Adrian Gadano Alexander James Thompson Justin Kopit Fiona Mc Phee Tracy Michener Eric A Hughes Philip D Yin Stephanie Noviello Weill cornell Medical college New YorkNY 10029United States Icahn School of Medicine at Mount Sinai New YorkNY 10029United States JW Goethe University Hospital 60323 FrankfurtGermany Uniwersytet Medyczny w Bialymstoku 15-089 BialystokPoland EMc and Medical University 50-220 WroclawPoland Universitatsklinikum Hamburg-Eppendorf 20246 HamburgGermany Wojewodzki Szpital Zespolony w Kielcach 25-736 KielcePoland ID clinic 41-400 MyslowicePoland Medizinische Universitat Wien 1090 ViennaAustria clinica Quiron 46010 ValenciaSpain Universita degli Studi di Firenze 50121 FlorenceItaly Holy Family Hospital Nazareth 6004Israel Rambam Medical center Haifa 31096Israel 1st Moscow State Medical University N.A.I.M.Sechenov 119991 MoscowRussia University of Alberta Hospital EdmontonAlberta T6G 2B7Canada Groupe Hospitalier Pitie-Salpetriere 75013 ParisFrance Tel Aviv Sourasky Medical center and Tel Aviv University Tel Aviv 64239Israel Hospital Italiano de Buenos Aires Buenos Aires C1181ACHArgentina St.Vincents Hospital and the University of Melbourne Melbourne 3065Australia Fiona McPhee Bristol-Myers Squibb Research and DevelopmentWallingfordCT 06492United States Bristol-Myers Squibb Research and Development PrincetonNJ 08450United States

AIM: To evaluate daclatasvir vs telaprevir, each combined with peginterferon alfa-2a/ribavirin(peg IFN/RBV), in treatment-naive hepatitis c virus(HcV) genotype(GT) 1-infected ***: In this phase 3, randomized, open-label, noninferiority study, 602 patients were randomly assigned(2:1) to daclatasvir vs telaprevir, stratified by IL28 B rs12979860 host genotype(cc vs non-cc), cirrhosis status(compensated cirrhosis vs no cirrhosis), and HcV GT1 subtype(GT1a vs GT1b). Patients were selected by study inclusion criteria from a total of 793 enrolled patients. Patients received daclatasvir 60 mg once daily or telaprevir 750 mg 3 times daily plus peg IFN/RBV. Daclatasvir recipients received 24 wk of daclatasvir plus peg IFN/RBV; those without an extended rapid virologic response(e RVR; undetectable HcV-RNA at weeks 4 and 12) received an additional 24 wk of peg IFN/RBV. Telaprevir-treated patients received 12 wk of telaprevir plus peg IFN/RBV followed by 12(with e RVR) or 36(no e RVR) wk of peg IFN/RBV. The primary objective was to compare for noninferiority of sustained virologic response rates at posttreatment week 12(SVR12) in GT1b-infected patients. Key secondary objectives were to demonstrate that the rates of anemia(hemoglobin clatasvir + peg IFN/RBV than with telaprevir + peg IFN/RBV among GT1b-infected patients. Resistance testing was performed using population-based sequencing of the NS5 A region for all patients at baseline, and for patients with virologic failure or relapse and HcV-RNA ≥ 1000 IU/m L, to investigate any link between NS5 A polymorphisms associated with daclatasvir resistance and virologic outcome. RESULTS: Patient demographics and disease characteristics were generally balanced across treatment arms; however, there was a higher proportion of black/African Americans in the daclatasvir groups(6.0% and 8.2% in the GT1 b and GT1 a groups, respectively) than in the telaprevi

关键词： Direct-acting antiviral chronic hepatitis c Daclatasvir Genotype 1b NS5A inhibitor Liver disease

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WHV/myc转基因小鼠肝癌发生过程中的基因异常

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南京医科大学学报(自然科学版) 2000年第5期20卷 394-394页

作者：刘平,赵志泉,dominique Bernuau,Gerard Feldmann 南京医科大学第一附属医院消化科南京医科大学第一附属医院消化科南京医科大学第一附属医院消化科南京医科大学第一附属医院消化科

目的　探测WHV/myc转基因小鼠肝癌发生过程中有关基因在肝脏中的异常表达。方法　用原位杂交方法检测WHV/myc转基因小鼠肝肿瘤形成的不同阶段 ,c myc转染基因、胰岛素样生长因子Ⅱ (IGF Ⅱ )基因c jun、c fos和c H ras等基因的表达。结... 详细信息

目的　探测WHV/myc转基因小鼠肝癌发生过程中有关基因在肝脏中的异常表达。方法　用原位杂交方法检测WHV/myc转基因小鼠肝肿瘤形成的不同阶段 ,c myc转染基因、胰岛素样生长因子Ⅱ (IGF Ⅱ )基因c jun、c fos和c H ras等基因的表达。结果　c myc转染基因IGF Ⅱ基因在转基因小鼠出生后早期的肝脏中异常表达 ,随后表达水平即降低至不能测出。上述两基因的表达在肝肿瘤形成期重新出现。c jun、c fos和c H ras基因在转基因小鼠肝癌发生前肝脏中的表达强度明显高于正常小鼠。结论　c myc转染基因和IGF Ⅱ基因在小鼠出生后早期和肿瘤形成期的异常表达对肝肿瘤的发生和瘤细胞转化表型的维持可能具有重要意义 ;在c myc转染基因表达的“沉默”期 ,一些癌基因在肝脏中的异常表达对日后肝脏肿瘤的形成可能也具有一定作用。

关键词：小鼠肝癌肝脏 WHV/myc 转基因基因转移

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