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应用糖皮质激素治疗咽喉痛：临床实践指南

英国医学杂志中文版 2018年第6期21卷 346-352页

作者：卫红齐(译) 苏州大学附属第二医院耳鼻咽喉科

单剂量口服糖皮质激素在治疗急性咽喉痛中扮演着怎样的角色？依据BMJ快速推荐程序，使用GRADE框架。专家小组对糖皮质激素的使用做出了弱推荐。专家组根据2017年4月发表的一项大型随机试验所引发的相关系统性综述做出了这些推荐。该试... 详细信息

单剂量口服糖皮质激素在治疗急性咽喉痛中扮演着怎样的角色？依据BMJ快速推荐程序，使用GRADE框架。专家小组对糖皮质激素的使用做出了弱推荐。专家组根据2017年4月发表的一项大型随机试验所引发的相关系统性综述做出了这些推荐。该试验报告称，糖皮质激素提高了48小时疼痛完全缓解患者的比例。

关键词：糖皮质激素急性咽喉痛激素治疗临床实践指南应用单剂量口服系统性综述专家小组

四川省藏族牧区感染多房棘球绦虫犬只空间聚集性研究(英文)

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预防医学情报杂志 2012年第5期28卷 323-328页

作者：王谦克莉丝汀.布德克黄亮帕崔克.热合度弗兰西斯.豪尔多米尼克.维通菲利普.克瑞格邱东川 Sichuan Center for Disease Control and Prevention College of Veterinary Medicine and Biomedical Sciences Texas A&M University WHO Collaborating Centre for the Prevention and Treatment of Human Echinococcosis Research Unit "Chrono-environment " UMR CNRS 6249 usc INRAUniversity of Franche-ComtéPlace Leclerc25030 Besancon cedexFrance University of Franche-Comté and Besanon University Hospital 25030-BesanconFrance Cestode Zoonoses Research Group Biomedical sciences Research Institute and School of Environment and Life SciencesUniversity of SalfordSalford MS4WTUnited Kingdom

目的泡型包虫病(AE)是中国西部的一个重大公共卫生问题,在四川和青海2省藏族地区更为突出。多房棘球绦虫(***)是泡型包虫病的病原体。流行病学调查表明,犬是是泡型包虫病的显著流行风险因素,一些牧区犬只多房棘球绦虫感染率较高。这些... 详细信息

目的泡型包虫病(AE)是中国西部的一个重大公共卫生问题,在四川和青海2省藏族地区更为突出。多房棘球绦虫(***)是泡型包虫病的病原体。流行病学调查表明,犬是是泡型包虫病的显著流行风险因素,一些牧区犬只多房棘球绦虫感染率较高。这些研究表明犬可能作为终末宿主,在环境中维持多房棘球绦虫的生活史。但是普遍认为狐狸是环境中支撑多房棘球绦虫生活史的终末宿主。该研究旨在通过研究感染多房棘球绦虫犬只的空间聚集性,来进一步了解犬在环境中维持多房棘球绦虫生活史的证据。方法在中国四川省西部青藏高原石渠县的牧区,通过氢溴酸槟榔碱驱虫的方法,收集家牧犬感染多房棘球绦虫感染状态,并用GPS测量这些犬只的地理位置数据。通过BB join-count test分析,了解感染多房棘球绦虫犬只是否存在空间聚集性。结果在300～600、800、1600和1800～3900 m的距离,感染多房棘球绦虫犬只存在空间聚集性。结论感染多房棘球绦虫犬只存在空间聚集性,表明环境中犬可能在多房棘球绦虫生活史中发挥作用。

关键词：多房棘球绦虫泡型包虫病犬空间聚集性藏族牧区

肝脏切除术治疗非结直肠癌、非内分泌肿瘤来源的转移性肝癌：1452例患者的资料分析和预后模型的建立

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医学信息（手术学分册） 2007年第9期20卷 802-802页

作者： Adam, Rene Chiche, Laurence Aloia, Thomas Elias, dominique Salmon, Remy Rivoire, Michel Jaeck, Daniel Saric, Jean Le Treut,Yves Patrice Belghiti, Jacques Mantion, Georges Mentha, Gilles the Association Francaise de Chirurgie

研究目的：明确肝脏切除术（HR）在非结直肠、非内分泌肿瘤来源的转移性肝癌（NCNELM）患者中的治疗作用。背景资料总结：HR在NCNELM患者中的治疗地位仍有争议，主要原因在于先前发表的报道有限，同时肿瘤原发部位与组织学存在异质性。... 详细信息

研究目的：明确肝脏切除术（HR）在非结直肠、非内分泌肿瘤来源的转移性肝癌（NCNELM）患者中的治疗作用。背景资料总结：HR在NCNELM患者中的治疗地位仍有争议，主要原因在于先前发表的报道有限，同时肿瘤原发部位与组织学存在异质性。方法：在1983—2004年间，对1452例接受HR的NCNELM患者进行预后因素和长期疗效分析，在此基础上建立多变量风险模型。研究结果：56％患者为肝脏孤立转移灶；71％为单侧（平均直径50．5mm）。

关键词：非内分泌肿瘤肝脏切除术转移性肝癌治疗作用结直肠癌预后模型原发部位疗效分析

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应用以织物为基础的光通信二极管纤维

家电科技 2018年第8期 8-8页

作者： Michael Rein Valentine dominique Favrod Chong Hou Tural Khudiyev Alexander Stolyarov Jason Cox Chia-Chun Chung Chhea Chhav Marry Ellis John Joannopoulos Yoel Fink 李巧红(编译)

半导体二极管是现代计算、通信和传感的基本构件。因此，将其纳入纺织品级纤维可以提高纤维的性能和功能，例如基于纺织品的通信或生理学监测。然而由于加工技术方面的局限，到目前为止仍无法在热拉伸纤维中实现高质量的半导体二极管。

关键词：半导体二极管光通信高纤维基础织物应用加工技术拉伸纤维

Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized Controlled Trials Worldwide

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Health Data Science 2021年第1期2021卷 174-183页

作者： Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana C.Del Gobbo Jordi Salas-Salvadó Miguel A.Martínez-González Jan Polak Markku Laakso Arne Astrup dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf Pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat Cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen Christopher D.Gardner Joan Sabaté Dolores Corella J.Alfredo Martinez Lu Qi Department of Epidemiology&Biostatistics School of Public HealthPeking UniversityChina Department of Global Health School of Public HealthPeking UniversityChina Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education China Global Health Institute Peking University China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLAUSA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMAUSA Department of Endocrinology&Nutrition Institut d’Investigacions Biomèdiques August Pi SunyerHospital ClínicBarcelonaSpain CIBER Fisiopatologia de la Obesidad y Nutrición(CIBERobn) Instituto de Salud Carlos III(ISCIII)MadridSpain Stanford Prevention Research Center Stanford UniversityStanford CAUSA Human Nutrition Unit Faculty of Medicine and Health SciencesPere Virgili Health Research InstituteRovira i Virgili UniversityReusSpain University of Navarra Department of Preventive Medicine and Public HealthMedical School&IDISNAPamplonaSpain Department for the Study of Obesity and Diabetes Third Faculty of MedicineCharles UniversityPragueCzech Republic Department of Medicine University of Eastern FinlandKuopioFinland University of Copenhagen Department of NutritionExercise and SportsFaculty of ScienceCopenhagenDenmark Institut National de la Santéet de la Recherche Médicale(Inserm) UMR1048Institute of Metabolic and Cardiovascular DiseasesUniversity of Toulouse and Paul Sabatier UniversityToulouseFrance NestléInstitute of Health Sciences LausanneSwitzerland Department of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical Centre+MaastrichtNetherlands Section of Metabolic Genetics Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Sorbonne Université Institute of Cardiometabolism and Nutrition(ICAN)Department of NutritionPitié-Salpêtrière HospitalAssistance Publique-

*** strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RCTs).*** October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 *** RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese *** treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all *** the joint analysis,a total of 7 eligible RCTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting *** with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,p<0:05;z=2:20,p=0:028)per one copy of the TCF7L2 T risk ***,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist ***,there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk *** findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.

关键词： TCF7L2 weight finding

阿克森费尔德-里格尔畸形：在一个四代的家系中Forkhead Box C1（FOXC1）基因的一个异常突变

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美国医学会眼科杂志（中文版） 2005年第3期17卷 144-144页

作者： Bruno Morternousque Patrizia Amati-Bonueau Francois Couture Rodolphe Graffan Stephaue Dubois Joseph Colin dominique Bonueau Jean Morissette Didier Lacombe Vincent Rayrnond 冯云（译）雷嘉启（校）

目的：为了描述阿克森费尔德-里格尔畸形（ARA）（人类盂德尔遗传601631）谱系中DNA突变的特点。这是一种临床和遗传非均质伴有前房异常和青光眼常染色体显性遗传的疾病。方案：可观察的病例对照和DNA连锁和基因筛查。

关键词： DNA突变基因筛查常染色体显性遗传畸形异常 Box 家系四代病例对照

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如何设计面向整体任务的学习(上)

数字教育 2017年第5期3卷 86-92页

作者：麦基·范尼特维尔特尔多米尼克·曼合夫伯特·艾尔赫尔斯杰拉尔丁·克拉勒布杰伦·范梅里恩伯尔安·洛克斯陆琦向佐军盛群力鲁汶大学马斯特里赫特大学浙江大学浙江杭州310028

为了促进综合学习,教学设计应将重点放在设计一个真实或模拟的任务环境上,让学习者完成各类基于现实情境的学习任务。基于"四元教学设计模式",我们引入了"综合学习十步骤"贯穿于项目设计、开发和实施的全过程,其中涉及五大学习模块的内... 详细信息

为了促进综合学习,教学设计应将重点放在设计一个真实或模拟的任务环境上,让学习者完成各类基于现实情境的学习任务。基于"四元教学设计模式",我们引入了"综合学习十步骤"贯穿于项目设计、开发和实施的全过程,其中涉及五大学习模块的内容。这些模块内容均与加拿大开发的"医学教育指导专家模型"中综合能力的要求相契合。另外,我们还引入了引导教育革新的模型,旨在应对实践挑战,预防不同用户之间合作产生的问题,试图解决从传统的、碎片化课堂教学到基于良好教学设计原则所开发的综合的混合式学习环境的转变问题。

关键词：四元教学设计模式综合学习设计整体任务

第二届中国江苏·扬子江作家周“文学:稳定与变化”主旨发言

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钟山 2020年第1期 195-205页

作者：张大春多米妮克西戈阿来毕飞宇西蒙范布伊李修文不详四川省作协南京大学江苏省作协江苏文学院湖北省作协

2015年夏,我到三亚去参加了一个“三亚财经国际论坛”附属的“文化艺术论坛”。与会讨论的陈平原先生、徐冰先生等等,都是一时俊雅,我的确是抱着当老学生的心情参与和学习的。其中,最令我印象深刻的是许多显然来自商界的生面孔,他们往... 详细信息

2015年夏,我到三亚去参加了一个“三亚财经国际论坛”附属的“文化艺术论坛”。与会讨论的陈平原先生、徐冰先生等等,都是一时俊雅,我的确是抱着当老学生的心情参与和学习的。其中,最令我印象深刻的是许多显然来自商界的生面孔,他们往往在极短的时间之内——甚至只是端着一杯咖啡错身点头的瞬间,就彼此热络起来,这种交游的效率,在我看来,简直不可思议。

关键词：陈平原交游扬子江不可思议三亚第二届

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO