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World Journal of Gastroenterology 2012年第39期18卷 5635-5639页

作者： Fabrice Airaud Sébastien Küry Isabelle Valo Ingrid Maury dominique bonneau Olivier Ingster Stéphane Bezieau CHU Nantes Service de Génétique Médicale9 quai Moncousu44093 Nantes Cedex 1France Institut de Cancérologie de l'Ouest Service d'Anatomie et Cytologie Pathologique2 rue Moll49933 Angers Cedex 9France CHU Angers Service de Génétique Médicale4 rue Larrey49933 AngersFrance

We describe a patient with a Homo sapiens mutL homolog 1 (MLH1)-associated Lynch syndrome with previous diagnoses of two distinct primary cancers:a sigmoid colon cancer at the age of 39 years, and a right colon cancer at the age of 50 years. The mutation identified in his blood and buccal cells, c.1771delG, ***591Ilefs*25, appears to be a de novo event, as it was not transmitted by either of his parents. This type of de novo event is rare in MLH1 as only three cases have been reported in the literature so far. Further-more, the discordant results observed between repli-cation error phenotyping and immunohistochemistry highlight the importance of the systematic use of both pre-screening tests in the molecular diagnosis of Lynch syndrome.

关键词：免疫组织化学综合征生物学试验分子和谐突变患者生殖

Going straight for the gut:gut-brain axis pathology and treatment of Parkinson's disease

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Neural Regeneration Research 2024年第10期19卷 2111-2112页

作者： dominique Ebedes Cesar V.Borlongan University of South Florida Morsani College of Medicine TampaFLUSA Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain RepairUniversity of South Florida Morsani College of MedicineTampaFLUSA

This perspective focuses on the recent literature regarding the role of the gut-brain axis(GBA) in fecal microbiota transplantation(FMT) and stem cell therapy(SCT) in Parkinson's disease(PD).PD is the second most common neurodegenerative disease in the United States,yet therapies remain *** research suggests that the GBA may play a role in the pathogenesis of *** FMT as well as SCT offer promising new avenues for PD *** bing the interactions between FMT and SCT with the GBA may reveal novel therapeutics for PD.

关键词： straight pathology pathogenesis

Numerical study of convective heat transfer in static arrangements of particles with arbitrary shapes:A monolithic hybrid lattice Boltzmann-finite difference-phase field solver

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Particuology 2024年第2期85卷 186-197页

作者： Reza Namdar Mohammadhassan Khodsiani Hesameddin Safari Tanya Neeraj Seyed Ali Hosseini Frank Beyrau Benoit Fond dominique Thevenin Fathollah Varnik Interdisciplinary Centre for Advanced Materials Simulation(ICAMS) Ruhr-University BochumBochum44801Germany Laboratory of Technical Thermodynamics University of Magdeburg"Otto von Guericke"Magdeburg39106Germany Laboratory of Fluid Dynamics and Technical Flows University of Magdeburg"Otto von Guericke"MagdeburgD-39106Germany Department of Mechanical and Process Engineering ETH ZurichZurich8092Switzerland ONERA The French Aerospace Lab Department of AerodynamicsAeroelasticity and Acoustics(DAAA)Paris-Saclay UniversityMeudon92190France

A compressible lattice Boltzmann-finite difference method is extended by the phase-field approach into a monolithic scheme to study fluid flow and heat transfer through regular arrangements of solid bodies of circular,elliptical and irregular *** advantage of using the phase-field method is demon-strated both in its simplicity of accounting for flow and thermal boundary conditions at solid surfaces with irregular shapes and in the capability of generating such complex-shaped *** an array of discs,numerical results for the overall solid-to-gas heat transfer rate are validated via experiments on flow through arrays of hot *** thus validated compressible LB-FD-PF hybrid scheme is used to study the dependence of heat transfer on flow and thermal boundary conditions(Reynolds number,temperature difference between the hot solid bodies and the inlet gas),porosity as well as on the shape of solid *** are rationalized in terms of the residence time of the gas close to the solid body and downstream variations of gas velocity and *** for further applications of the proposed methodology are also discussed.

关键词： Lattice Boltzmann method Finite difference scheme Convective heat transfer Diffuse interface Thermal compressible flow

Health Systems Strengthening to Tackle the Global Burden of Pediatric and Congenital Heart Disease: A Diagonal Approach

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Congenital Heart Disease 2024年第2期19卷 131-138页

作者： dominique Vervoort Amy Verstappen Sreehari Madhavankutty Nair Chong Chin Eu Bistra Zheleva Institute of Health Policy Management and EvaluationUniversity of TorontoTorontoCanada Division of Cardiac Surgery University of TorontoTorontoCanada Global Alliance for Rheumatic and Congenital Hearts PhiladelphiaUSA Department of Health Services Government of KeralaKeralaIndia Ministry of Health PutrajayaMalaysia Children’s HeartLink MinneapolisUSA

1 Background Congenital heart disease(CHD)is the most common major congenital anomaly,affecting approximately one in every 100 live births[1].Among congenital anomalies,66%of preventable deaths are due to CHD,and 58%of the avertable morbidity and mortality due to congenital anomalies would result from scaling congenital heart surgery services[2].Every year,nearly 300,000 children and adults die from CHD,the majority of whom live in low-and middle-income countries(LMICs)[3].Approximately 49%of all individuals with CHD will require surgical or interventional care at some point in their lifetime[4];as a result of advances in access to and the delivery of such services,over 95%of children born with CHD in high-income countries now live into adulthood[3].Here,adults have surpassed children in the number of CHD cases at a ratio of 2:1[5].

关键词： Congenital heart disease pediatric heart disease global health health systems health policy

Protein-S-100-beta is increased in patients with decompensated cirrhosis admitted to ICU

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Journal of Intensive Medicine 2024年第2期4卷 222-230页

作者： Nicolas Weiss Simona Tripon Maxime Mallet Françoise Imbert-Bismut Mehdi Sakka dominique Bonnefont-Rousselot Philippe Sultanik Sarah Mouri Marika Rudler dominique Thabut Sorbonne Université AP-HP.Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreDépartement de NeurologieUnitéde Médecine Intensive RéanimationàOrientation NeurologiqueParisFrance Brain Liver Pitié-Salpêtrière(BLIPS)Study Group INSERM UMR_S 938Centre de recherche Saint-AntoineMaladies métaboliquesBiliaires et Fibro-Inflammatoire du FoieInstitute of Cardiometabolism and Nutrition(ICAN)ParisFrance Groupe de Recherche Clinique en REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aiguE(GRC-RESPIRE)Sorbonne Université ParisFrance Assistance Publique-Hôpitaux de Paris AP-HP.Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreService d'hépato-GastroentérologieUnitéde Soins Intensifs d'HépatologieParisFrance Assistance Publique-Hôpitaux de Paris AP-HP.Sorbonne UniversitéService de Biochimie MétaboliqueHôpitaux Universitaires Pitié-Salpêtrière-Charles FoixDMU BioGeMParis F-75013France UniversitéParis Cité UFR de PharmacieCNRSInsermUTCBSParisFrance

Background Hepatic encephalopathy(HE)is highly prevalent in patients with liver *** pathophysiology of HE is centered on the synergic role of hyperammonemia and systemic ***,some data suggest altered functioning of the blood–brain barrier(BBB).Assessing BBB function is challenging in clinical practice and at the ***-S-100 Beta(PS100-Beta)could be a useful peripheral marker of BBB permeability in *** study aimed to assess plasmatic PS100-Beta levels in a prospective cohort of patients admitted to the intensive care unit(ICU)with decompensated cirrhosis with and without overt *** We retrospectively evaluated a prospective cohort of cirrhotic patients admitted to the ICU from October 2013 to September 2015 that had an available plasmatic PS100-Beta *** with previous neurological impairment or limitation of intensive or resuscitative measures were *** HE was defined as West-Haven grades 2 to *** patients were compared to a control cohort of outpatient clinic cirrhotic and non-cirrhotic patients explored for isolated elevation of liver *** ICU discharge,the patients were followed for at least 3 months for the occurrence of overt *** outcomes(liver transplantation or death)were *** ability of PS100-Beta–in combination with other factors–to predict overt HE was evaluated in a multivariate analysis using logistic *** ratios were used to determine the effects and calculate odds ratios(OR).Survival analysis was performed by using the Kaplan–Meier method and survival between groups was compared using a Log-rank *** A total of 194 ICU patients and 207 outpatients were included in the *** levels of plasmatic PS100-Beta were detected in the ICU decompensated cirrhotic patients compared with the outpatients([0.15±0.01]mg/L vs.[0.08±0]mg/L,P<0.001).ICU patients with overt HE had higher levels of PS100-Beta([0.19±0.03]mg/L)compared with the

关键词： Cirrhosis Hepatic encephalopathy Blood-brain barrier PS100-Beta Liver disease

The Impact of the Inclusion of MgO Nano-Fillers in a Polyethylene Matrix on Dielectric Strength and Resistance to Partial Discharges

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Open Journal of Applied Sciences 2024年第3期14卷 626-634页

作者： Virginie Griseri dominique Mary David Malec Eric David Laboratoire Plasma et Conversion d’énergie Université de Toulouse CNRS UPS INPT Route de Narbonne Toulouse France É cole de Technologie Supérieure de Montréal Rue Notre-Dame Ouest Montréal Canada

One commonly used strategy to enhance polymers specific properties such as the resistance to partial discharges erosion is the incorporation into the polymeric matrix of inorganic micro or nanoparticles. This study focused on the dielectric properties of Low-Density Polyethylene (LDPE) filled with nano-sized Magnesium Oxide (MgO) particles compounded by thermo-mechanical process and one of the purposes was to establish appropriate processing parameters in order to reach the desired dielectric properties. LDPE was used as a matrix and was reinforced by MgO particles having a nominal average size of 30 nm. The MgO nanoparticles were treated with a silane coupling agent (3-Glycidyloxypropyl Trimethoxysilane). The samples were initially prepared in a melt-mixing chamber with a MgO content of 1% wt. These pre-mixed samples were further treated by the means of thermo-mechanical mixing in a conical co-rotating twin-screw extruder in order to improve the dispersion and distribution of the MgO particles. In this report, both lifetime under a PD activity and AC dielectric strength of pure and nano-filled LDPE samples have been measured and compared. Nano-filled LDPE samples were found to exhibit an improve lifetime, without any detrimental impact on their short-term dielectric strength. This suggests that nano-filled LDPE may be for electric applications for which the dielectric materials may be exposed to partial discharge activities. This is significant result for the use of MgO-reinforced PE as an insulating material for HV cables since the resistance to PD is closely related to treeing resistance which is the main electrical degradation mechanism that leads to failure for shielded extruded power cables.

关键词： Low Density Polyethylene MgO Nanofillers Dielectric Strength Partial Discharges Resistance

Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles

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World Journal of Gastroenterology 2014年第1期20卷 204-213页

作者： Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao dominique bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau CHU Nantes Service de Génétique Médicale44093 Nantes CEDEX 1France Public Health Sciences Division Fred Hutchinson Cancer Research CenterSeattleWA 98109United States CHU Angers Service de Génétique Médicale4 rue Larrey49933 AngersFrance Centre de Lutte contre le Cancer Fran?ois Baclesse 3 avenue du Général Harris14076 Caen Cedex 5France Université de Nantes Faculté de Médecine de NantesEA 4273 NantesFrance CHU Nantes Institut des Maladies de l’Appareil Digestif et Service d’Hépato-Gastroentérologie44093 Nantes Cedex 1France

AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic *** a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial ***:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation ***603Cys(R603C)and another exhibited the unreported variant of unknown significance ***617Ile(T617I).The ***628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes.

关键词： Colorectal cancer UNC5C Genetic predisposition Fam

Finding biomarkers of experience in animals

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Journal of Animal Science and Biotechnology 2024年第3期15卷 925-944页

作者： Sarah Babington Alan J.Tilbrook Shane K.Maloney Jill N.Fernandes Tamsyn M.Crowley Luoyang Ding Archa H.Fox Song Zhang Elise A.Kho Daniel Cozzolino Timothy J.Mahony dominique Blache School of Agriculture and Environment The University of Western AustraliaCrawleyWA 6009Australia Centre for Animal Science The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia School of Veterinary Science The University of QueenslandGattonQLD 4343Australia School of Human Sciences The University of Western AustraliaCrawleyWA 6009Australia School of Medicine Deakin UniversityGeelongVIC 3217Australia Poultry Hub Australia University of New EnglandArmidaleNSW 2350Australia College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China Centre for Nutrition and Food Sciences The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia

At a time when there is a growing public interest in animal welfare,it is critical to have objective means to assess the way that an animal experiences a *** is critical to ensure appropriate animal welfare *** behavioural,physiological,and neurobiological indicators that are used to assess animal welfare can verify the absence of extremely negative *** welfare is more than an absence of negative outcomes and an appropriate indicator should reflect the full spectrum of experience of an animal,from negative to *** this review,we draw from the knowledge of human biomedical science to propose a list of candidate biological markers(biomarkers)that should reflect the experiential state of non-human *** proposed biomarkers can be classified on their main function as endocrine,oxidative stress,non-coding molecular,and thermobiological *** also discuss practical challenges that must be addressed before any of these biomarkers can become useful to assess the experience of an animal in real-life.

关键词： Animal experience Animal welfare Biomarker Stress Welfare assessment

Accidental Ingestion of Nitric Acid in an Agricultural Company: A Case Study and Literature Review

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Occupational Diseases and Environmental Medicine 2024年第1期12卷 21-27页

作者： Asséga Sylvain Sagna Mame Thioro Aïssatou Fall Mossane dominique Ndour Sidy Diallo Société de Cultures Légumières (SCL) Saint-Louis Sénégal West Africa Farms (WAF) Yamane Louga Sénégal International Committee of The Red Cross Dakar Sénégal Saint-Louis Regional Hospital Center Saint-Louis Sénégal

Introduction: Though common in society, caustic accidental ingestion is rare in the agricultural industry. This study describes a case of ingestion of nitric acid used as an agricultural fertilizer by an ordinary worker at the Société de Cultures Légumières. Clinical Case: This is a 33-year-old unschooled woman who ingested a sip of nitric acid from an abandoned labelled acid canister near a farming plot of land. She showed a burn of the oral cavity with a bleeding tablecloth and an intense retrosternal pain. The duodenal oesophagus fibroscopy screening that was carried out 18 hours after the accident, revealed an esophagitis class 2b. The tests revealed no anomalies. Fifteen (15) days after the accident, the FOGD was normal. Following an 8-month-follow up, no signs of stenosis or degeneration were noted. Conclusion: The accidental ingestion of nitric acid is rare in adult. Its treatment is mainly symptomatic and aims at preserving vital functions without directly fighting the ingested substance off. The right actions must be integrated into the 15-minute Health and Safety awarenesssessions for optimum pre-hospital management. The hospital evaluation is mandatory and is carried out thanks to the digestive endoscopy, which is still relevant in this indication, but is completed by the thoraco-abdominal CT. The latter is very sensitive the transmural necrosis diagnosis.

关键词： Accident Agriculture Caustic Fibroscopy Senegal

Estimating the Input Power of a Power Plant Using the Efficiency of the Inverter

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Smart Grid and Renewable Energy 2024年第3期15卷 99-106页

作者： Toussaint Tilado Guingane Sosthène Tassembedo Eric Korsaga dominique Bonkoungou Zacharie Koalaga François Zougmore Physics UFR/SEA Materials and Environment Laboratory (LAME) Pr. Joseph Ki ZERBO University Ouagadougou Burkina Faso Physics UFR/ST Science and Technology Laboratory (LaST) Thomas SANKARA University Ouagadougou Burkina Faso

The study focuses on estimating the input power of a power plant from available data, using the theoretical inverter efficiency as the key parameter. The paper addresses the problem of missing data in power generation systems and proposes an approach based on the efficiency formula widely documented in the literature. In the absence of input data, this method makes it possible to estimate the plant’s input power using data extracted from the site, in particular that provided by the Ministry of the Environment. The importance of this study lies in the need to accurately determine the input power in order to assess the overall performance of the energy system.

关键词： Estimation Data Missing Input Power Efficiency Inverter