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Closing the gap of children’s surgery in Pakistan

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World Journal of Pediatric Surgery 2019年第1期2卷 20-20页

作者： Simra Siddiqui dominique Vervoort Alexander W Peters Haitham Shoman Nabeel M Ashraf Irum Fatima Lubna Samad Center for Essential Surgical and Acute Care Indus Health NetworkKarachiPakistan Program in Global Surgery and Social Change Department of Global Health and Social MedicineHarvard Medical SchoolBostonMassachusettsUSA Department of Surgery Weill Cornell Medical CollegeNew York CityNew YorkUSA

Two billion children worldwide lack access to safe surgical and anesthesia care when needed.1 The global pediatric surgical work-force is limited,and children and adolescents with surgical conditions often get absorbed into adult surgical services as pediatric surgeons are absent or *** an estimated population of 68.5 million chil-dren younger than 15 years(35%of the total population),Pakistan also faces similar chal-lenges in delivering adequate surgical care to *** investments in maternal and child health in recent years,Pakistan was unable to attain the Millennium Development Goals in *** death rate from congenital anomalies before the age of 5 years is still 77.2 children per 100000 live births,and a quarter of all deaths among children ages 5 and 14 years are a result of injuries.2 Despite this high burden,pediatric surgical care remains limited throughout Pakistan,with 0.4 pedi-atric surgeons per million population in the entire country,in contrast to upper-middle and high-income countries which have more than two pediatric surgeons per million popu-lation.

关键词： anesthesia injuries spite

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应用糖皮质激素治疗咽喉痛：临床实践指南

英国医学杂志中文版 2018年第6期21卷 346-352页

作者：卫红齐(译) 苏州大学附属第二医院耳鼻咽喉科

单剂量口服糖皮质激素在治疗急性咽喉痛中扮演着怎样的角色？依据bMJ快速推荐程序，使用GRADE框架。专家小组对糖皮质激素的使用做出了弱推荐。专家组根据2017年4月发表的一项大型随机试验所引发的相关系统性综述做出了这些推荐。该试... 详细信息

单剂量口服糖皮质激素在治疗急性咽喉痛中扮演着怎样的角色？依据bMJ快速推荐程序，使用GRADE框架。专家小组对糖皮质激素的使用做出了弱推荐。专家组根据2017年4月发表的一项大型随机试验所引发的相关系统性综述做出了这些推荐。该试验报告称，糖皮质激素提高了48小时疼痛完全缓解患者的比例。

关键词：糖皮质激素急性咽喉痛激素治疗临床实践指南应用单剂量口服系统性综述专家小组

不同文化传统的国家中饮酒模式与缺血性心脏病的关系：心肌梗死前瞻性流行病学研究（PRIME研究）

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英国医学杂志中文版 2011年第2期14卷 114-115页

作者： Jean-bernard Ruidavets Pierre Ducimetiere Alun Evans Michele Montaye bernadette Haas Annie bingham John Yamell Philippe Amouyel dominique Arveiler Frank Kee Vanina bongard Jean Ferrieres 齐文安(译) Department of Epidemiology INSERM U558 Toulouse University School of Medicine Toulouse France INSERM-Paris XI University Villejuif France UK Clinical Research Collaboration Centre of Excellence for Public Health Queen's University Belfast Belfast UK Department of Epidemiology and Public Health INSERM U744 Pasteur Institute of Lille Lille France Department of Epidemiology and Public Health EA 3430 Medical Faculty University of Stmsbourg Strasbourg France INSERM U970 Paul Brousse Hospital Villejuif France Department of Cardiology b and Depamnent of Epldemiology INSERM U558 Toulouse University Hospital Toulouse France 《中华病理学杂志》编辑部

目的探讨在两个生活方式不同的国家（北爱尔兰和法国）中，饮酒方式对缺血性心脏病发生的影响。

关键词：缺血性心脏病心肌梗死前流行病学饮酒模式文化传统北爱尔兰生活方式饮酒方式

中国与OECD成员国对化学农药原药登记中毒理数据和试验指南要求的比较

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中国与OECD成员国对化学农药原药登记中毒理数据和试验指南要求的...

局灶性皮质发育不良和神经发育肿瘤的癫痫发作模式与手术预后和神经病理亚型的联系

中国毒理学会第十次全国毒理学大会

作者： Nan Zhang dominique Renault-billault Alessa Ignarski Lirong Chen birgit Neumann Jing Ma Zi Liu Vickie Shang Katrin bender Li Zhang Jens Peter Lampe Venoe 拜耳作物科学(中国)有限公司

2017年11月1日起,农业部开始实施2569号公告《农药登记资料要求》,其中对化学农药原药登记的毒理学数据(包括试验种类和试验物种)都进行了清晰的要求,相对应试验指南的国家标准《农药登记毒理学试验方法》也于2018年2月1日起开始实施。... 详细信息

2017年11月1日起,农业部开始实施2569号公告《农药登记资料要求》,其中对化学农药原药登记的毒理学数据(包括试验种类和试验物种)都进行了清晰的要求,相对应试验指南的国家标准《农药登记毒理学试验方法》也于2018年2月1日起开始实施。为了保证人体健康安全和环境安全,实现中国与OECD成员国数据互认(MAD)并将中国创新化学农药原药推向全球市场,本研究对中国与OECD成员国的毒理数据和试验指南要求进行了全面系统的比较。在毒理学数据要求方面,中国与OECD监管框架的要求基本一致,其中包括急性毒性、遗传毒性、慢性毒性和致癌性(大鼠和小鼠)、生殖毒性(大鼠和兔子)、致畸性和迟发性神经毒性等。某些毒理终点和毒理方法存在差异,例如中国要求进行亚急性吸入试验,并由此得到吸入途径的可接受操作暴露水平(AOEL)进行施药人员健康风险评估,而OECD成员国通常不要求此试验(除非有可预见的吸入毒性);OECD成员国要求在亚慢性试验中使用大鼠、小鼠和狗三个物种,以确定最敏感物种,而中国针对此试验并未进行物种要求;OECD成员国对代谢物毒性的试验基于QSAR/分组/交叉参照,且对无预测结论的代谢物要求急性、亚急性(28天)和遗传毒性试验,而中国尚无指南,当前也一般要求亚慢性(90天)试验;其他差别也可以见于急性神经毒性、代谢和毒物动力学试验或内分泌干扰作用评价方法等。在毒理学试验指南中方面,中国试验指南的起草在很大程度上参照OECD试验指南,但具体的试验方法和观察指标也有差异,比如基于更为保守的毒性分类标准,中国急性毒性的试验指南一般要求更高的限量剂量和每组动物数量;吸入试验的试验指南参考旧版OECD试验指南,因此测试物的颗粒物理化学和观察指标均存在较大差别;其他差别也可以见于致癌性、生殖毒性、代谢和毒动试验或内分泌干扰作用等。尽管中国与OECD成员国对化学农药原药登记在毒理方面的要求仍存在差异,但通过全面系统的比较,在对毒理数据和试验指南方面均可以认为其功能性是相当的,均涵盖了相似的评估方法指标及健全的评估能力。当然,为了中国与OECD成员国MAD问题的解决,目前的评估仍需要扩展,包括环境方面数据及实验指南的要求等。此外,具体的数据质量仍然要基于各个实验室对试验指南的理解和执行水平。

关键词：毒理 OECD MAD 试验指南化学农药原药登记要求

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癫痫杂志 2017年第2期3卷 158-166页

作者： Stanislas Lagarde Francesca bonini Aileen McGonigal Patrick Chauvel Martine Gavaret Didier Scavarda Romain Carron Jean Regis Sandrine Aubert Nathalie Villeneuve bernard Giusiano dominique Figarella-branger Agnes Trebuchon Fabrice bartolomei 张颖颖慕洁

颅内脑电图对癫痫发作模式的研究对癫痫灶的精确定位和指导成功切除有重要作用。它也引出了癫痫发生机制相关的重要病理生理问题。目前,植入硬膜下和深部电极等记录方式已经描述了几种癫痫发作模式(主要是颞叶癫痫和伴有异质新皮层病变... 详细信息

颅内脑电图对癫痫发作模式的研究对癫痫灶的精确定位和指导成功切除有重要作用。它也引出了癫痫发生机制相关的重要病理生理问题。目前,植入硬膜下和深部电极等记录方式已经描述了几种癫痫发作模式(主要是颞叶癫痫和伴有异质新皮层病变的癫痫)。研究分析了53例患者的连续性队列资料,所有患者均行立体定向脑电图(SEEG)监测,且病理证实为皮质发育畸形(Malformation of cortical development,MCD)——局灶性皮质发育不良(Focal cortical dysplasia,FCD)和神经发育肿瘤(Neurodevelopmental tumors,NDTs)。通过对视觉和时间-频率的分析,证实了存在6种癫痫发作模式:低压快波活动(Low-voltage fast activity,LVFA);发作前棘波继之LVFA;爆发性多棘波继之LVFA;慢波/直流电漂移继之LVFA;θ或α尖波;节律性棘波/棘波。结果表明包含LVFA的模式(83%)普遍性较高,但是LVFA并不是癫痫发作的一个固定特征。癫痫发作模式和组织学类型具有相关性(P=0.01)。更加普遍的模式如下:(1)FCDⅠ型:LVFA占23.1%,慢波/基线漂移继之LVFA占15.4%;(2)FCDⅡ型:爆发性多棘波继之LVFA占31%,LVFA占27.6%;发作前棘波继之LVFA占27.6%;(3)NDTs:LVFA占54.5%。发现包含LVFA的癫痫发作模式与较好的手术预后具有相关性,但癫痫灶切除的完整性是一个独立预测因子;FCD和NDTs有6种不同的癫痫发作模式;包含LVFA的癫痫发作模式的患者手术预后更好。

关键词：癫痫局灶性皮质发育不良神经发育肿瘤皮质发育畸形立体定向脑电图癫痫发作癫痫手术癫痫灶

WHV/myc转基因小鼠肝癌发生过程中的基因异常

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南京医科大学学报(自然科学版) 2000年第5期20卷 394-394页

作者：刘平,赵志泉,dominique bernuau,Gerard Feldmann 南京医科大学第一附属医院消化科南京医科大学第一附属医院消化科南京医科大学第一附属医院消化科南京医科大学第一附属医院消化科

目的　探测WHV/myc转基因小鼠肝癌发生过程中有关基因在肝脏中的异常表达。方法　用原位杂交方法检测WHV/myc转基因小鼠肝肿瘤形成的不同阶段 ,c myc转染基因、胰岛素样生长因子Ⅱ (IGF Ⅱ )基因c jun、c fos和c H ras等基因的表达。结... 详细信息

目的　探测WHV/myc转基因小鼠肝癌发生过程中有关基因在肝脏中的异常表达。方法　用原位杂交方法检测WHV/myc转基因小鼠肝肿瘤形成的不同阶段 ,c myc转染基因、胰岛素样生长因子Ⅱ (IGF Ⅱ )基因c jun、c fos和c H ras等基因的表达。结果　c myc转染基因IGF Ⅱ基因在转基因小鼠出生后早期的肝脏中异常表达 ,随后表达水平即降低至不能测出。上述两基因的表达在肝肿瘤形成期重新出现。c jun、c fos和c H ras基因在转基因小鼠肝癌发生前肝脏中的表达强度明显高于正常小鼠。结论　c myc转染基因和IGF Ⅱ基因在小鼠出生后早期和肿瘤形成期的异常表达对肝肿瘤的发生和瘤细胞转化表型的维持可能具有重要意义 ;在c myc转染基因表达的“沉默”期 ,一些癌基因在肝脏中的异常表达对日后肝脏肿瘤的形成可能也具有一定作用。

关键词：小鼠肝癌肝脏 WHV/myc 转基因基因转移

Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults:big Data from Seven Randomized Controlled Trials Worldwide

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Health Data Science 2021年第1期2021卷 174-183页

作者： Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana C.Del Gobbo Jordi Salas-Salvadó Miguel A.Martínez-González Jan Polak Markku Laakso Arne Astrup dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf Pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat Cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen Christopher D.Gardner Joan Sabaté Dolores Corella J.Alfredo Martinez Lu Qi Department of Epidemiology&biostatistics School of Public HealthPeking UniversityChina Department of Global Health School of Public HealthPeking UniversityChina Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education China Global Health Institute Peking University China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLAUSA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMAUSA Department of Endocrinology&Nutrition Institut d’Investigacions Biomèdiques August Pi SunyerHospital ClínicBarcelonaSpain CIbER Fisiopatologia de la Obesidad y Nutrición(CIbERobn) Instituto de Salud Carlos III(ISCIII)MadridSpain Stanford Prevention Research Center Stanford UniversityStanford CAUSA Human Nutrition Unit Faculty of Medicine and Health SciencesPere Virgili Health Research InstituteRovira i Virgili UniversityReusSpain University of Navarra Department of Preventive Medicine and Public HealthMedical School&IDISNAPamplonaSpain Department for the Study of Obesity and Diabetes Third Faculty of MedicineCharles UniversityPragueCzech Republic Department of Medicine University of Eastern FinlandKuopioFinland University of Copenhagen Department of NutritionExercise and SportsFaculty of ScienceCopenhagenDenmark Institut National de la Santéet de la Recherche Médicale(Inserm) UMR1048Institute of Metabolic and Cardiovascular DiseasesUniversity of Toulouse and Paul Sabatier UniversityToulouseFrance NestléInstitute of Health Sciences LausanneSwitzerland Department of Human biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical Centre+MaastrichtNetherlands Section of Metabolic Genetics Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Sorbonne Université Institute of Cardiometabolism and Nutrition(ICAN)Department of NutritionPitié-Salpêtrière HospitalAssistance Publique-

*** strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RCTs).*** October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 *** RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese *** treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all *** the joint analysis,a total of 7 eligible RCTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting *** with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,pbenefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.

关键词： TCF7L2 weight finding

FAIR Principles:Interpretations and Implementation Considerations

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Data Intelligence 2020年第1期2卷 10-29,293-302,322页

作者： Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty dominique batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos barend Mons Erik Schultes Leiden University Medical Center Leiden2333 ZAThe Netherlands Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK Amsterdam UMC University of AmsterdamAmsterdam 1000 GGThe Netherlands European bioinformatics Institute(EMbL-EbI) HinxtonCambridgeCB101SDUK Harvard University CambridgeMassachusetts 02138USA Department of bioinformatics–biGCaT NUTRIMMaastricht UniversityMaastricht 6229 ERThe Netherlands Conceptual and Cognitive Modeling Research Group(CORE) Free University of Bozen-BolzanoBolzano 39100Italy Aalborg University Aalborg DK-9220Denmark Insight Centre for Data Analytics National University of Ireland GalwayH91 TK33Ireland Centre for Digital Scholarship Leiden University LibrariesLeiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Dutch Techcentre for Life Sciences(DTL) UtrechtThe Netherlands SURF Utrecht 3511 EPThe Netherlands Keith G Jeffery Consultants FaringdonUK Castor EDC Paasheuvelweg 25Wing 5D1105 BPAmsterdamThe Netherlands San Diego Supercomputer Center University of California San DiegoLa JollaCalifornia 92093USA Learning and Research Resources Centre(CRAI) Universitat de Barcelona08007 BarcelonaSpain Environment Agency Austria A-1090 ViennaAustria University of Notre Dame 75004 ParisFrance Health Research board(HRb) Dublin 2DO2 H638Ireland Liacs Institute of Advanced Computer Science Leiden University2311 GJ LeidenThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic GO FAIR International Support&Coordination Office(GFISCO) LeidenThe Netherlands Harvard Catalys

The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in *** intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital *** has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR ***,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible ***,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-*** introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR *** self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the ***,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.

关键词： FAIR guiding principles FAIR implementation FAIR convergence FAIR communities choices and challenges

婴儿配方粉成分的全球标准:欧洲儿科胃肠病、肝病和营养学会牵头的国际专家组建议

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中国循证儿科杂志 2006年第4期1卷 307-319页

作者： berthold Koletzko Susan baker Geoff Cleghorn Ulysses Fagundes Neto Sarath Gopalan Olle Hernell Quak Seng Hock Pipop Jirapinyo bo Lonnerdal Paul Pencharz Hildegard Pzyrembel Jaime Ramirez-Mayans Raanan Shamir dominique Turck Yuichiro Yamashiro 丁宗一(译) 无德国慕尼黑大学冯豪内儿童医院国际专家组美国纽约州布法罗大学儿科系澳大利亚布里斯班昆士兰大学儿科与儿童健康系巴西圣保罗联邦大学儿科系印度新德里营养支持系统研究中心瑞典Umea大学儿科系临床科学部新加坡国立大学儿科系泰国曼谷大学儿科系美国加州大学营养与内科系加拿大多伦多儿童医院胃肠病与营养系德国柏林联邦风险评估研究所墨西哥国家儿科研究所胃肠病与营养系以色列海法Meyer儿童医院儿科胃肠病与营养系法国里尔胃肠病肝病与营养系日本东京顺天堂大学儿科系中国北京市儿童医院欧洲儿科胃肠病肝病和营养学会牵头的国际专家组

联合国粮食及农业组织(FAO)和WHO的食品法典委员会提出的食品标准、指南和其他相关文件旨在保护消费者健康以及全球的公平贸易.

关键词：全球标准婴儿配方营养学会胃肠病专家组食品法典委员会儿科欧洲