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Copper-uptake mediated by an ecofriendly zwitterionic ionic liquid: A new challenge for a cleaner bioeconomy

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Journal of Environmental Sciences 2023年第8期130卷 92-101页

作者： Marie E.Vuillemin Christophe Waterlot Anthony Verdin Sylvain Laclef Christine Cézard David Lesur Catherine Sarazin dominique Courcot Caroline Hadad Eric Husson Albert Nguyen Van Nhien Enzyme and Cell Engineering UMR 7025 CNRSUniversity of Picardie Jules Verne-Faculty of Sciences33 rue Saint Leu80039 Amiens CedexFrance University of Lille Mines-Télécom InstituteUniversity of ArtoisJUNIAULR 4515-LGCgELaboratory of Civil Engineering and Geo-EnvironmentF-59000 LilleFrance Environmental Chemistry and Life Interactions Unit UCEIV UR4492FR CNRS 3417University of Littoral Cote d’Opale(ULCO)DunkerqueFrance Laboratory of Glycochemistry Antimicrobials and AgroresourcesUMR CNRS 7378University of Picardie Jules Verne-Faculty of Sciences33 rue Saint Leu80039 Amiens CedexFrance Institute of Chemistry of Picardie FR CNRS 3085 80039 AmiensFrance

This study aims to investigate the ability of an imidazolium biobased Zwitterionic Ionic Liquids(ZILs)in enhancing the phytoavailability of copper from garden(G)and vineyard(V)soils using the model plant *** and artificially contaminated CuSO_(4) soils,unamended and ZIL-amended soil modalities were *** copper/ZIL molar ratio(1/4)introduced was rationally established based on molecular modeling and on the maximal copper concentration in artificially contaminated *** accumulation of copper in the shoots was detected for the uncontaminated and copper contaminated ZIL amended V soils(18.9 and 23.3 mg/kg,respectively)contrary to G soils together with a ZIL concentration of around 3%(W/W)detected by LC-MS *** data evidenced a Cu-accumulation improvement of 38%and 66%compared to non-amended V soils(13.6 and 13.9 mg/kg respectively).ZIL would be mainly present under Cu(II)-ZIL_(4) complexes in the *** impact on the chemical composition of shoot was also *** results show that depending on the soils modalitity,the presence of free copper and/or ZIL led to different chemical compositions in lignin and monomeric sugar *** the biorefinery context,performances of enzymatic hydrolysis of shoots were also related to the presence of both ZIL and copper under free or complex *** assessment of the vineyard soil samples indicated that the quantity of copper and ZIL remaining in the soils had no significant *** amendment in a copper-contaminated soil was demonstrated as being a promising way to promote the valorization of phytoremediation plants.

关键词： Cu-accumulation Biobased Zwitterionic Ionic Liquid (ZIL) Enzymatic hydrolysis Ecotoxicity

Antiplasmodial activity of traditional polyherbal remedy from Odisha, India:Their potential for prophylactic use

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Asian Pacific Journal of Tropical Biomedicine 2015年第12期5卷 982-986页

作者： Prakash Bangalore Nagendrappa Jean-Francois Franetich Frederick Gay Audrey Lorthiois Padma Venkatasubramanian dominique Mazier Institute of Trans-Disciplinary Health Sciences and Technology Foundation for Revitalisation of Local Health Traditions Manipal University Cimi-Paris (UPMC UMRS CR7 Inserm U1135 CNRS ERL 8255) AP-HP Pitié-Salpêtrière Hospital Group

Objective:To evaluate the potential prophylactic activity of traditional polyherbal remedy against ***:A traditional polyherbal remedy against malaria from Odisha,India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malaria system Plasmodium yoelii yoelii/Anopheles ***:The polyherbal extract inhibited the Plasmodium yoelii hepatic stages in vitro(IC500.74 mg/m L),a therapeutic index of *** mice treated with the aqueous extract(2 000 mg/kg/day),peak parasitaemia values were 81%lower in the experimental2.35%±0.14%as compared to controls 12.62%±0.52%(P<0.001),suggesting significant prophylactic ***:The observations provide a proof of concept for a traditional malaria prophylactic remedy used by tribal populations in India.

关键词： Polyherbal remedy Plasmodium Malaria prophylaxis Antiplasmodial activity

Quality of life, physical performance and nutritional status in older patients hospitalized in a cardiology department

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Journal of Geriatric Cardiology 2020年第7期17卷 410-416页

作者： Matthieu Lilamand Mariannick Saintout Marie Vigan Astrid Bichon Laure Tourame Aurélie Brembilla Diet Bernard Iung dominique Himbert Cédric Laouenan Agathe Raynaud-Simon Assistance Publique Hôpitaux de Paris Nord Department of GeriatricsBichat University HospitalFrance University of Paris France Assistance Publique Hôpitaux de Paris Nord Department of EpidemiologyBiostatistics and Clinical ResearchBichat University HospitalFrance Assistance Publique Hôpitaux de Paris Nord Department of CardiologyBichat University HospitalFrance

Objectives Quality of life(QoL) is a priority outcome in older adults suffering from cardiovascular diseases. Frailty and poor nutritional status may affect the QoL through mobility disorders and exhaustion. The objective of this study was to determine if physical frailty and nutritional status were associated with QoL, in older cardiology patients. Methods Cross sectional, observational study conducted in a cardiology department from a university hospital. Participants(n = 100) were aged 70 and older. Collected data included age, sex, cardiac diseases, New York Heart Association(NYHA) classification, comorbidities(Charlson Index) and disability. A Short Physical Performance Battery(SPPB), including walking speed assessment was performed;handgrip strength were measured as well as Fried’s frailty phenotype. Nutritional status was assessed using the Mini Nutritional Assessment(MNA) and Body Mass Index(BMI), inflammation by C-reactive protein(CRP). QoL was assessed using the EORTC–QLQ questionnaire. Univariate and multivariate analyses were performed to study the associations between all recorded parameters and QoL. Results In participants(mean age: 79.3 ± 6.7 years;male: 59%), Charlson index, arrhythmia, heart failure, NYHA class III-IV, MNA, disability, walking speed, SPPB score, frailty and CRP were significantly associated with QoL in univariate analysis. Multivariate analysis showed that NYHA class III-IV(P < 0.001), lower MNA score(P = 0.03), frailty(P < 0.0001), and higher CRP(P < 0.001) were independently associated with decreased QoL. Conclusions Frailty, nutritional status and inflammation were independently associated with poor QoL. Further studies are needed to assess the efficacy of nutritional and physical interventions on QoL in this population.

关键词： Cardiovascular diseases Frailty Muscle strength Nutrition Older adults Quality of life

Kinetical Inflation and Quintessence by F-Harmonic Map

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Journal of Modern Physics 2012年第11期3卷 1727-1731页

作者： Antonin Kanfon dominique Lambert Lambert Faculté des Sciences et Techniques Université d'Abomey-Calavi Cotonou Bénin University of Namur Namur Belgium

We were interested, along this work, in the phenomena of the quintessence and the inflation due to the F-harmonic maps, in other words, in the functions of the scalar field such as the exponential and trigo-harmonic maps. We showed that some F-harmonic map such as the trigonometric functions instead of the scalar field in the lagrangian, allow, in the absence of term of potential, reproduce the inflation. However, there are other F-harmonic maps such as exponential maps which can’t produce the inflation;the pressure and the density of this exponential harmonic field being both of the same sign. On the other hand, these exponential harmonic fields redraw well the phenomenon of the quintessence when the variation of these fields remains weak. The problem of coincidence, however remains.

关键词： F-Harmonic Maps Kinetical Inflation Kinetical Quintessence

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肝癌发生过程中转录因子AP-1活化的研究

南京医科大学学报（自然科学版） 2004年第1期24卷 28-30,37页

作者：刘平 Bernau dominique 南京医科大学第一附属医院消化科江苏南京210029 Bichat医学院细胞生物学实验室

目的:检测肝癌及其癌周组织中AP-1活化状态,探索该转录因子在肝癌发生过程中可能的作用。方法:用电泳迁移率转移试验、免疫印迹和RNA酶保护性分析等方法,测定15例原发性肝癌及其癌周组织中AP-1与DNA的结合活性、AP-1复合物的蛋白组成以... 详细信息

目的:检测肝癌及其癌周组织中AP-1活化状态,探索该转录因子在肝癌发生过程中可能的作用。方法:用电泳迁移率转移试验、免疫印迹和RNA酶保护性分析等方法,测定15例原发性肝癌及其癌周组织中AP-1与DNA的结合活性、AP-1复合物的蛋白组成以及细胞增殖状况。结果:与正常肝组织相比,AP-1与DNA结合活性在73%的癌周组织中增高;60%的肝癌组织中AP-1结合活性比癌周组织进一步增高;其AP-1二聚体主要由JunD、c-Jun和c-Fos蛋白参与组成,AP-1结合活性与JunD和c-Jun蛋白表达水平呈正相关。结论:AP-1的激活是肝癌发生过程中的早期频发事件,可能有助于肝细胞恶性转化表型的获得,在肝癌的形成中具有重要作用。

关键词：肝癌 AP-1 Jun蛋白 Fos基因

Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance

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Journal of Sport and Health Science 2023年第2期12卷 194-201页

作者： Wouter M.A.Franssen Charly Keytsman Nastasia Marinus Kenneth Verboven Bert O.Eijnde Lisa van Ryckeghem Paul Dendale Renate Zeevaert Guy Massa dominique Hansen Rehabilitation Research Centre(REVAL) Faculty of Rehabilitation SciencesHasselt UniversityHasselt 3500Belgium Biomedical Research Institute(BIOMED) Faculty of Medicine and Life SciencesHasselt UniversityHasselt 3500Belgium ADLON Sports Medical Center Hasselt 3500Belgium Heart Centre Hasselt Jessa HospitalHasselt 3500Belgium Department of Pediatric Endocrinology and Diabetology Jessa HospitalHasselt 3500Belgium

Background:Adults with obesity may display disturbed cardiac chronotropic responses during cardiopulmonary exercise testing,which relates to poor cardiometabolic health and an increased risk for adverse cardiovascular *** is unknown whether cardiac chronotropic incompetence(CI)during maximal exercise is already present in obese adolescents and,if so,how that relates to cardiometabolic ***:Sixty-nine obese adolescents(body mass index standard deviation score=2.23±0.32,age=14.1±1.2 years;mean±SD)and 29lean adolescents(body mass index standard deviation score=-0.16±0.84,age=14.0±1.5 years)performed a maximal cardiopulmonary exercise testing from which indicators for peak performance were *** resting heart rate and peak heart rate were used to calculate the maximal chronotropic response ***(lipid profile,glycemic control,inflammation,and leptin)was studied in fasted blood samples and during an oral glucose tolerance test within obese *** analyses were applied to examine associations between the presence of CI and blood or exercise capacity parameters,respectively,within obese ***:CI was prevalent in 32 out of 69 obese adolescents(46%)and 3 out of 29 lean adolescents(10%).C-reactive protein was significantly higher in obese adolescents with CI compared to obese adolescents without CI(p=0.012).Furthermore,peak oxygen uptake and peak cycling power output were significantly reduced(p<0.05)in obese adolescents with CI *** adolescents without *** chronotropic index was independently related to blood total cholesterol(standardized coefficientβ=-0.332;p=0.012)and C-reactive protein concentration(standardized coefficientβ=-0.269;p=0.039).Conclusion:CI is more common in the current cohort of obese adolescents,and is related to systemic inflammation and exercise intolerance.

关键词： Adolescents Cardiometabolic health Exercise tolerance Heart rate Obesity

Effect of alcohol consumption on liver stiffness measured by transient elastography

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World Journal of Gastroenterology 2013年第4期19卷 516-522页

作者： Edouard Bardou-Jacquet Ludivine Legros Draman Soro Marianne Latournerie Anne Guillygomarc'h Caroline Le Lan Pierre Brissot dominique Guyader Romain Moirand Hepatology and Addictology Department University Hospital PontchaillouF35000 RennesFrance Institut National de la Santé et de la Recherche Médicale U991 Institut Fédératif de Recherche 140University of Rennes 1F35000 RennesFrance

AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or ***:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver *** was performed at least one week apart by senior *** examinations with less than ten successful measures or with an interquartile range above 30% were *** retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was *** biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were *** fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis *** and final putative fibrosis score were compared according to alcohol consumption during ***:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two ***-seven patients met our criteria with a median follow-up of 32.5 *** the end of the study,13(35%) were abstinent,and 24(65%) *** patients had liver biopsy during *** decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off *** relapsers TE increased in 45% and decreased in 54% of *** was no statistical difference between initial and final TE in *** the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final ***

关键词： Alcohol Transient elastography Cirrhosis Fibrosis Liver biopsy Liver stiffness

c-myc基因和IGF-Ⅱ基因在WHV/myc转基因小鼠肝癌发生过程中的双相性表达

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肿瘤 1998年第5期18卷 343-345页

作者：刘平 dominique bernuau gerard feldmann 南京医科大学第一附属医院消化科法国巴黎第七大学ＢＩＣＨＡＴ医学院

肝癌的发生机理尚未阐明，流行病学调查的资料表明，肝癌的发生与乙型、丙型肝炎病毒（ＨＢＶ、ＨＣＶ）的感染有密切的联系。用土拨鼠肝炎病毒（ＷＨＶ）ＤＮＡ操纵下的ｃ－ｍｙｃ基因建成的转基因小鼠模型，其肝脏肿瘤自然形成率高达... 详细信息

肝癌的发生机理尚未阐明，流行病学调查的资料表明，肝癌的发生与乙型、丙型肝炎病毒（ＨＢＶ、ＨＣＶ）的感染有密切的联系。用土拨鼠肝炎病毒（ＷＨＶ）ＤＮＡ操纵下的ｃ－ｍｙｃ基因建成的转基因小鼠模型，其肝脏肿瘤自然形成率高达９０％～１００％［１］，可用于研究...

关键词：基因表达 c-myc 肝肿瘤原位杂交转基因动物

Top-down assembly design using assembly features

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Journal of Chongqing University 2002年第2期1卷 5-11页

作者：石万凯 DENEUX dominique 等 StateKeyLaboratoryofMechanicalTransmission ChongqingUniversityChongqing400044P.R.China LAMIH-SP(UMRCNRSno8530) UniversityofValenciennesValenciennes59313France

The primary task of top-down assembly design is to define a product抯 detailed physical description satisfying its functional requirements identified during the functional design phase. The implementation of this design process requires two things, that is, product functional representation and a general assembly model. Product functions are not only the formulation of a customer抯 needs, but also the input data of assembly design. A general assembly model is to support the evolving process of the elaboration of a product structure. The assembly feature of extended concept is taken as a functional carrier, which is a generic relation among assembly-modeled entities. The model of assembly features describes the link between product functions and form features of parts. On the basis of this link, the propagation of design modifications is discussed so as to preserve the functionality and the coherence of the assembly model. The formal model of assembly design process describes the top-down process of creating an assembly model. This formal model is represented by the combination of assembly feature operations, the assembly model and the evaluation process. A design case study is conducted to verify the applicability of the presented approaches.

关键词： product function assembly feature assembly model top-down assembly design design process model