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Non-substituted fused bis-tetracene based thin-film transistor with self-assembled monolayer hybrid dielectrics

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Frontiers of Materials Science 2020年第3期14卷 314-322页

作者： Baolin Zhao Mikhail Feofanov dominik Lungerich Hyoungwon Park Tobias Rejek Judith Wittmann Marco Sarcletti Konstantin Amsharov Marcus Halik Organic Materials and Devices Institute of Polymer MaterialsDepartment of Materials ScienceFriedrich-Alexander-Universität Erlangen-NürnbergIZNF BuildingCauerstraße 391058ErlangenGermany Chair of Organic Chemistry II Friedrich-Alexander-Universität Erlangen-NürnbergNikolaus-Fiebiger-Str.1091058ErlangenGermany Molecular Technology Innovation Presidential Endowed Chair The University of Tokyo7-3-1 HongoBunkyo-ku113-0033TokyoJapan

Polycyclic aromatic hydrocarbons with zigzag peripheries are high perspective candidates for organic ***,large fused acenes are still poorly studied due to the tedious *** we report a non-substituted fused bistetracene DBATT(2.3,8.9-dibenzanthanthrene)as the semiconductor on low-voltage-driven organic thin-film *** systematic studies of thin-film growth on various self-assembled monolayer(SAM)modified gate dielectrics and the electrical performances were carried *** sub-monolayer of the semiconductor film shows larger island domains on the alkyl chain *** device exhibits the hole mobility of 0.011 cm2·V−1·s−1 with a current ratio of IonIIoff above 105.

关键词： fused bis-tetracene organic field-effect transistor contact resistance self-assembled monolayer

A dahlia flower extract has antidiabetic properties by improving insulin function in the brain

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Life Metabolism 2023年第4期2卷 39-50页

作者： dominik Pretz Philip M.Heyward Jeremy Krebs Joel Gruchot Charles Barter Pat Silcock nerida Downes Mohammed Zubair Rizwan Alisa Boucsein Julia Bender Elaine J.Burgess Geke Aline Boer Pramuk Keerthisinghe Nigel B.Perry alexander Tups Centre for neuroendocrinology School of Biomedical SciencesUniversity of OtagoDunedin 9054New Zealand Department of Physiology School of Biomedical SciencesUniversity of OtagoDunedin 9054New Zealand Maurice Wilkins Centre for Molecular Biodiscovery University of AucklandAuckland 1010New Zealand Department of Medicine University of OtagoWellingtonWellington South 6242New Zealand Centre for Endocrine Diabetes and Obesity Research Wellington Regional HospitalNewtownWellington 6021New Zealand Product Development Research Centre University of OtagoDunedin 9054New Zealand Department of Chemistry The New Zealand Institute for Plant and Food ResearchUniversity of OtagoDunedin 9054New Zealand

Butein,a rare chalcone found in the toxic plant Toxicodendron vernicifluum,has been shown to regulate glucose homeostasis via inhibition of the nuclear factor kappa-B kinase subunit beta(IKKβ)/nuclear factor kappa B(NF-κB)pathway in the ***,we investigated whether the nonpoisonous plant Dahlia pinnata could be a source of butein as a potential treatment for type 2 diabetes(T2D).In mice fed a high-fat diet(HFD)to induce glucose intolerance,an oral *** petal extract improved glucose tolerance at doses of 3.3 mg/kg body weight and 10 mg/kg body ***,this effect was not mediated by butein alone but by butein combined with the closely related flavonoids,sulfuretin and/or ***,the extract improved systemic insulin *** of phosphatidylinositol 3-kinase to block insulin signaling in the brain abrogated the glucoregulatory effect of the orally administered *** extract reinstated central insulin signaling and normalized astrogliosis in the hypothalamus of HFD-fed *** NF-κB reporter zebrafish to determine IKKβ/NF-κB activity,a potent anti-inflammatory action of the extract was found.A randomized controlled crossover clinical trial on participants with predia-betes or T2D confirmed the safety and efficacy of the extract in *** conclusion,we identified an extract from the flower petals of *** as a novel treatment option for T2D,potentially targeting the central regulation of glucose homeostasis as a root cause of the disease.

关键词： inflammation hypothalamus signal transduction neuroendocrine arcuate nucleus

Cerebral processing of auditory stimuli in patients with irritable bowel syndrome

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World Journal of Gastroenterology 2006年第11期12卷 1723-1729页

作者： Viola Andresen alexander Poellinger Chedwa Tsrouya dominik Bach Albrecht Stroh Annette Foerschler Petra Georgiewa Marco Schmidtmann Ivo R van der Voort Peter Kobelt Claus Zimmer Bertram Wiedenmann Burghard F Klapp Hubert Monnikes Department of Medicine Division of Psychosomatic Medicine and Psychotherapy Charité-Universi-t(a|¨)tsmedizin BerlinBerlinGermany Department of Radiology Charité-Universit(a|¨)tsmedizin Berlin BerlinGermany Department of Medicine Division of Hepatology Gastroenterologyand Endocrinology Department of neuroradiology University of Leipzig LeipzigGermany Department of Medicine Division of Psychosomatic Medicine and Psychotherapy Charité-Universit(a|¨)tsmedizin BerlinBerlinGermany Department of neuroradiology Klinikum rechts der Isar Technische Universit(a|¨)t MünchenMunichGermany

AIM： To determine by brain functional magnetic resonance imaging （fMRI） whether cerebral processing of non-visceral stimuli is altered in irritable bowel syndrome （IBS） patients compared with healthy subjects. To circumvent spinal viscerosomatic convergence mechanisms, we used auditory stimulation, and to identify a possible influence of psychological factors the stimuli differed in their emotional quality. METHODS： In 8 IBS patients and 8 controls, fMRI measurements were performed using a block design of 4 auditory stimuli of different emotional quality （pleasant sounds of chimes, unpleasant peep （2000 Hz）, neutral words, and emotional words）. A gradient echo T2＊weighted sequence was used for the functional scans. Statistical maps were constructed using the general linear model. RESULTS： To emotional auditory stimuli, IBS patients relative to controls responded with stronger deactivations in a greater variety of emotional processing regions, while the response patterns, unlike in controls, did not differentiate between distressing or pleasant sounds. To neutral auditory stimuli, by contrast, only IBS patients responded with large significant activations. CONCLUSION： Altered cerebral response patterns to auditory stimuli in emotional stimulus-processing regions suggest that altered sensory processing in IBS may not be specific for visceral sensation, but might reflect generalized changes in emotional sensitivity and affectire reactivity, possibly associated with the psychological comorbidity often found in IBS patients.

关键词： Visceral hypersensitivity Irritable bowel syndrome Brain processing fMRI Auditory stimulation Emotion

Friction and Deformation Behavior of Elastomers

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Research and developments of laser assisted methods for translation into clinical application

Materials Sciences and Applications（材料科学与应用期刊） 2019年第8期

作者： alexander Adam dominik Paulkowski Bernd Mayer

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Frontiers of Optoelectronics 2017年第3期10卷 239-254页

作者： Ronald SROKA Nikolas dominik Max EISEL Anna ESIPOVA Christian FREYMULLER Christian HECKL Georg HENNIG Christian HOMANN Nicolas HOEHne Robert KAMMERER Thomas KELLERER alexander LANG Niklas MARKWARDT Heike POHLA Thomas PONGRATZ Claus-Georg SCHMEDT Herbert STEPP Stephan STROBL Keerthanan ULAGANATHAN Wolfgang ZIMMERMANN Adrian RUEHM Laser-Forschungslabor LIFE-Center Hospital of University Ludwig-Maximilians University Munich Munich Germany Department of Urology Hospital of University Ludwig-Maximilians University Munich Munich Germany Department of Vascular Surgery Diakonie Klinikum Schwaibisch Hall Germany Labor fur Tumorimmunologie LIFE-Center Hospital of University Ludwig-Maximilians University Munich Munich Germany Friedrich-Loeftter-Institute Federal Research Institute for Animal-Health Greifswald- Insel Riems Germany

Biophotonics and laser medicine are very dynamic and continuously increasing fields ecologically as well as economically. Direct communication with medical doctors is necessary to identify specific requests and unmet needs. Information on innovative, new or renewed techniques is necessary to design medical devices for introduction into clinical application and finally to become established after positive clinical trials as well as medical approval. The long-term endurance in developing light based innovative clinical concepts and devices are described based on the Munich experience. Fluorescence technologies for laboratory medicine to improve non- invasive diagnosis or for online monitoring are described according with new approaches in improving photody- namic therapeutic aspects related to immunology. Regard- ing clinically related thermal laser applications, the introduction of new laser wavelengths and laser parameters showed potential in the treatment of varicose veins as well as in lithotripsy. Such directly linked research and development are possible when researchers and medical doctors perform their daily work in immediate vicinity, thus have the possibility to share their ideas in meetings by day.

关键词： translational biophotonics thermal laser appli-cation fluorescence diagnosis on-line monitoring litho-tripsy phlebology photodynamic therapy (PDT),laboratory medicine

Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 306-319页

作者： dominik D alexander Lauren C Bylsma Laura Elkayam Douglas L Nguyen Epid Stat Institute Exponent Inc. Health Sciences Department of Medicine Irvine School of Medicine University of California

AIM:To critically review and summarize the literature on nutritional and health outcomes of semi-elemental formulations on various nutritionally vulnerable patient populations who are unable to achieve adequate nutrition from standard oral ***:We conducted a comprehensive literature search of Pubmed and Embase *** manually screened articles that examined nutritional and health outcomes(e.g.,growth,disease activity,gastrointestinal impairment,mortality,and economic impact)among various patient groups receiving semi-elemental *** review focused on full-text articles of randomized controlled clinical trials and other intervention studies,but pertinent abstracts and case studies were also *** pertaining primarily to tolerance,digestion,and absorption were summarized for each patient population in this systematic ***:Results pertaining primarily to tolerance,digestion,and absorption were summarized for each patient *** efficacy of semi-elemental whey hydrolyzed protein(WHP)diet have been reported in various nutritionally high risk patient populations including-Crohn’s disease,short bowel syndrome,acute and chronic pancreatitis,cerebral palsy,cystic fibrosis,cerebrovascular accidents,human immunodeficiency virus,critically ill,and ***,the evidence from the medical literature indicates that feeding with a semi-elemental diet performs as well or better than parenteral or amino acid based diets in terms of toler-ance,digestion,and nutrient assimilation measures across various disease ***:Based on this comprehensive review of the literature,patient populations who have difficulty digesting or absorbing standard diets may be able to achieve improved health and nutritional outcomes through the use of semi-elemental WHP diets.

关键词： Semi-elemental diet Malnutrition 100% hydrolyzed whey protein Nutrition Malabsorption

Optical prediction of single muscle fiber force production using a combined biomechatronics and second harmonic generation imaging approach

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Light(Science & Applications) 2018年第1期7卷 289-302页

作者： dominik Schneidereit Stefanie Nübler Gerhard Prölß Barbara Reischl Sebastian Schürmann Oliver J Müller Oliver Friedrich Institute of Medical Biotechnology Friedrich-Alexander-University(FAU)Erlangen-NürnbergPaul-Gordan-Str.391052 ErlangenGermany Erlangen Graduate School in Advanced Optical Technologies(SAOT) FAU Erlangen-NürnbergPaul-Gordan-Str.791052 ErlangenGermany Muscle Research Center Erlangen(MURCE) Friedrich-Alexander-University Erlangen-NürnbergErlangenGermany Department of Internal Medicine III University of KielArnold-Heller-Str.324105 KielGermany DZHK(German Center for Cardiovascular Research)Partner Site Hamburg/Kiel/Lübeck KielGermany

Skeletal muscle is an archetypal organ whose structure is tuned to match *** magnitude of order in muscle fibers and myofibrils containing motor protein polymers determines the directed force output of the summed force vectors and,therefore,the muscle’s power performance on the structural *** and function can change dramatically during disease states involving chronic *** remodeling of the cytoarchitecture has been pursued using noninvasive and label-free multiphoton second harmonic generation(SHG)***,structure parameters can be extracted as a measure of myofibrillar order and thus are suggestive of the force output that a remodeled structure can still ***,to date,the parameters have only been an indirect measure,and a precise calibration of optical SHG assessment for an exerted force has been elusive as no technology in existence correlates these *** engineered a novel,automated,high-precision biomechatronics system into a multiphoton microscope allows simultaneous isometric Ca2+-graded force or passive viscoelasticity measurements and SHG *** this MechaMorph system,we studied force and SHG in single EDL muscle fibers from wt and mdx mice;the latter serves as a model for compromised force and abnormal myofibrillar *** present Ca2+-graded isometric force,pCa-force curves,passive viscoelastic parameters and 3D structure in the same fiber for the first ***,we provide a direct calibration of isometric force to morphology,which allows noninvasive prediction of the force output of single fibers from only multiphoton images,suggesting a potential application in the diagnosis of myopathies.

关键词： structure harmonic fibers

不同方法获得的脂肪来源干细胞再生能力比较：超声辅助吸脂与传统脂肪抽吸对比

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中国美容整形外科杂志 2015年第8期26卷 J0011-J0011页

作者： David Atashroo dominik Duscher Zeshaan N. Maan Elizabeth R. Zielins Kevin Paik alexander Whittam Michelle Lin Adrian McArdle Christopher Duldulao t Graham G. Walmsley Michael S.Hu Ruth Tevlin Derrick C. Wan Geoffrey C. Gurtner Michael T. Longaker 朱利娜高景恒张晨袁继龙不详《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科辽宁省人民医院整形外科

背景与目的超声辅助吸脂（ultrasound assisted liposuction，UAL）因其获取脂肪容易，且可让创伤和失血最小化，受到整形外科医师的青睐。但是，很少有研究报道这种方法获取的脂肪来源干细胞（adipose derived stromal cells，ADSCs）... 详细信息

背景与目的超声辅助吸脂（ultrasound assisted liposuction，UAL）因其获取脂肪容易，且可让创伤和失血最小化，受到整形外科医师的青睐。但是，很少有研究报道这种方法获取的脂肪来源干细胞（adipose derived stromal cells，ADSCs）的质量。ADSCs在基于细胞的治疗方法中的作用也在急剧增长。因此，本研究比较了传统脂肪抽吸（suctionassistedliposuction，SAL）方法获得的ADSCs与UAL方法获得的ADSCs之间再生能力的差异。方法分别采用SAL和UAL方法，从健康人中获取脂肪并培养ADSCs；采用荧光辅助细胞分选（fluorescent assisted cell sorting，FACS）方法，分析ADSCs的产量。利用MTT比色法分析ADSCs的增殖能力，并在培养基中进行成脂和成骨分化诱导。将基因表达谱与qPCR进行对比。利用细胞染色比较成脂和成骨分化标记物。建立小鼠创伤愈合模型，在水凝胶支架上，分别播种采用SAL方法获取的ADSCs（SAL组）和采用UAL方法获取的ADSCs（UAL组），水凝胶组只加入水凝胶作为对照，同时比较3组的组织再生能力。结果UAL与SAL方法获得的ADSCs相比，在细胞数量和增殖能力方面的差异无统计学意义。油红O染色显示两者成脂分化能力没有差异，分化7d时，PPAR-γ受体和LPL的表达差异无统计学意义也证实了这一点（P〉0．05）。同样，碱性磷酸酶和茜素红染色也显示了两者相似的成骨分化能力，而且成骨标志物Runx-2、骨桥蛋白和骨钙蛋白的表达差异也无统计学意义（P〉0．05）。SAL组和UAL组的愈合速度明显大于水凝胶组（P〈0．05），SAL和UAL两组之间差异无统计学意义（P〉0．05）。结论与传统SAL方法相比，UAL方法可获得相等增殖能力的ADSCs，并用于以细胞疗法为基础的治疗。

关键词：细胞再生能力脂肪抽吸吸脂超声 ADSCs 脂肪来源干细胞成骨分化整形外科医师

Cell:新分子或可有效清除肝脏和血液中的脂肪

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现代生物医学进展 2017年第4期17卷 I0004-I0004页

作者： Brian Finan Christoffer Clemmensen Zhimeng Zhu Kerstin Stemmer Karine Gauthier Luisa M uuml ller Meri De Angelis Kristin Moreth Frauke neff Diego Perez-Tilve Katrin Fischer dominik Lutter Miguel A. S aacute nchez-Garrido Peng Liu Jan Tuckermann Mohsen Malehmir Marc E. Healy Achim Weber Mathias Heikenwalder Martin Jastroch Maximilian Kleinert Sigrid Jall Sara Brandt Fr eacute d eacute ric Flamant Karl-Werner Schramm Heike Biebermann Yvonne D ouml ring Christian Weber Kirk M. Habegger Michaela Keuper Vasily Gelfanov Fa Liu Josef K ouml hrle Jan Rozman Helmut Fuchs Valerie Gailus-Durner Martin Hrabě de Angelis Susanna M. Hofmann Bin Yang Matthias H. Tsch ouml p Richard DiMarchi Timo D. M uuml ller Institute for Diabetes and Obesity Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany Department of Chemistry Indiana University Bloomington IN 47405 USA Institut de Génomique Fonctionnelle de Lyon Université de Lyon Centre National de la Recherche Scientifique (CNRS) Institut National de la Recherche Agronomique (INRA) École Normale Supérieure de Lyon 69364 Lyon France Molecular EXposomics Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany German Mouse Clinic Institute of Experimental Genetics Helmholtz Zentrum München German Research Center for Environmental Health 85764 Neuherberg Germany Division of Endocrinology Department of Internal Medicine Metabolic Diseases Institute University of Cincinnati College of Medicine Cincinnati OH 45237 USA Institute of Comparative Molecular Endocrinology University of Ulm 89081 Ulm Germany Department of Pathology and Molecular Pathology University Zurich and University Hospital Zurich 8091 Zurich Switzerland Institute of Virology Technische Universität München 81675 Munich Germany Institute of Experimental Pediatric Endocrinology Charité-Universitätsmedizin Berlin Berlin 13353 Germany Department of Medicine Institute for Cardiovascular Prevention Ludwig-Maximilians-Universität München 80336 Munich Germany Comprehensive Diabetes Center and Department of Medicine-Endocrinology Diabetes & Metabolism University of Alabama at Birmingham Birmingham AL 35294 USA Institute for Diabetes and Regeneration Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) Neuherberg 85764 Germany Calibrium LLC Carmel IN 46032 USA Institute for Experimental Endocrinology Charité-Universitätsmedizin Berlin Berlin 13353 Germany German Center for Diabetes Research (DZD) 85764 Neuherberg Germany

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学... 详细信息

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学挑战。

关键词：脂肪肝 Cell 动脉粥样硬化血液肝脏清除分子代谢疾病