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Real-time detection of influenza A virus using semiconductor nanophotonics

Light(Science & Applications) 2013年第1期2卷 184-191页

作者： dominic lepage Alvaro Jimenez Jacques Beauvais Jan J Dubowski Laboratory for Quantum Semiconductors and Photon-based BioNanotechnology Interdisciplinary Institute for Technological Innovation(3IT)Department of Electrical and Computer EngineeringUniversite´de SherbrookeSherbrookeQC J1K 2R1Canada

Modern miniaturization and the digitalization of characterization instruments greatly facilitate the diffusion of technological advances in new fields and generate innovative *** concept of a portable,inexpensive and semi-automated biosensing platform,or lab-on-a-chip,is a vision shared by many researchers and venture *** this scope,we present a semiconductor monolithic integration approach to conduct surface plasmon resonance *** technology is already commonly used for biochemical characterization in pharmaceutical industries,but we have reduced the technological platform to a few nanometers in scale on a semiconductor *** evaluate the signal quality of this nanophotonic device using hyperspectral-imaging technology,and we compare its performance with that of a standard prism-based commercial *** standard biochemical agents are employed for this characterization study:bovine serum albumin and inactivated influenza A *** resolutions of data acquisition varying between 360 and 2.2 s are presented,yielding 2.731025–1.531026 RIU resolutions,respectively.

关键词： GaAs/AlGaAs quantum well device hyperspectral imaging technology influenza A virus integrated surface plasmon resonance biosensor

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Conic hyperspectral dispersion mapping applied to semiconductor plasmonics

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Light(Science & Applications) 2012年第1期1卷 48-55页

作者： dominic lepage Alvaro Jimenez Jacques Beauvais Jan J Dubowski Department of Electrical and Computer Engineering Interdisciplinary Institute for Technological Innovation(3IT)Universite´de SherbrookeSherbrookeQue´.Canada

The surface plasmon resonance tracking over metal surfaces is a well-established,commercially available,biochemical quantification tool primarily applied in *** utilization of such a tool is,however,constrained to highly specialized industries,capable of justifying the human and instrumental resource investments required by the characterization *** have proposed to expand the field of application of this biosensing approach by redesigning this method through the integration and miniaturization within a semiconductor *** and broadband emission from a light-emitting semiconductor is employed to couple a continuum of surface plasmon modes over a metal–dielectric architecture interfaced with a GaAs–AlGaAs substrate.A tensor version of rigorous coupled wave theory is employed to optimize the various fabrication specifications and to predict the light scatterings over a wide range of *** then present a hyperspectral characterization microscope capable of directly mapping the dispersion relation of scattered light,including diffracted surface plasmons,as an intensity distribution versus photon energy and surface *** carried out in a buffered solution demonstrate the accurate description of the uncollimated and broadband surface plasmon ***,we introduce a simplified method of dispersion mapping,in which quasi-conic cross-sections of the light’s scattering can be acquired directly,thus monitoring surficial responses in as fast as 1.2 *** is over 300 times faster than required by implementing full dispersion *** compromising on the volume of collected information,this method,combined with the solid-state integration of the platform,shows great promise for the fast detection of biochemical agents.

关键词： biosensors light scattering optical devices semiconductors surface plasmon resonance

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