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Journal of Energy Chemistry 2024年第7期94卷 357-359页

作者： Xu Dong dominic Bresser Helmholtz Institute Ulm(HIU) Helmholtzstrasse 1189081 UlmGermany karlsruhe Institute of Technology(kIT) P.O.Box 364076021 KarlsruheGermany

The continuously growing importance of batteries for powering(hybrid)electric vehicles and storing renewable energy has prompted a renewed focus on lithium-metal batteries(LMBs)in recent years,as its high theoretical specific capacity of about 3860 ma h g^(-1) and very low redox potential(-3.04 V *** standard hydrogen electrode)promise substantially higher energy densities compared to current lithium-ion batteries(LIBs)[1].However,lithium metal electrodes face severe challenges associated with the risk of dendritic lithium deposition and the high reactivity with traditional organic liquid electrolytes,resulting in a continuous loss of electrochemically active lithium and a relatively low Coulombic efficiency[2].To address these challenges,solid inorganic and polymer electrolytes have emerged as a potentially saferalternative.

关键词： lithium polymer prompt

Adeno-associated virus as a delivery vector for gene therapy of human diseases

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1808-1840页

作者： Jiang-Hui Wang dominic J.Gessler Wei Zhan Thomas L.Gallagher Guangping Gao Horae Gene Therapy Center University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Department of Microbiology and Physiological Systems University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVIC3002Australia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVIC3002Australia Department of Neurological Surgery University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Department of Neurosurgery University of MinnesotaMinneapolisMN55455USA Department of Medicine University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Li Weibo Institute for Rare Diseases Research University of Massachusetts Chan Medical SchoolWorcesterMA01605USA

Adeno-associated virus(AAV)has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different *** AAV(rAAV)has been engineered for enhanced specificity and developed as a tool for treating various ***,as rAAV is being more widely used as a therapy,the increased demand has created challenges for the existing manufacturing *** rAAV-based gene therapy products have received regulatory approval,but there continue to be concerns about safely using high-dose viral therapies in humans,including immune responses and adverse effects such as genotoxicity,hepatotoxicity,thrombotic microangiopathy,and *** this review,we explore AAV biology with an emphasis on current vector engineering strategies and manufacturing *** discuss how rAAVs are being employed in ongoing clinical trials for ocular,neurological,metabolic,hematological,neuromuscular,and cardiovascular diseases as well as *** outline immune responses triggered by rAAV,address associated side effects,and discuss strategies to mitigate these *** hope that discussing recent advancements and current challenges in the field will be a helpful guide for researchers and clinicians navigating the ever-evolving landscape of rAAV-based gene therapy.

关键词： diseases specificity approval

Integrated Stratigraphy and Mineralogy of the Doushantuo Formation in Weng’an,South China,and Implications for Ediacaran Phosphogenesis

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Journal of Earth Science 2024年第2期35卷 476-503页

作者： Liangxuan Jiao Zhenbing She dominic Papineau Yaguan Zhang matthew S.Dodd kenan Cao Qun Chen Guoyong Chen State key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan430078China School of Earth Sciences China University of GeosciencesWuhan430047China London Centre for Nanotechnology University College London17-19 Gordon StreetLondonWC1E 6BTUK Department of Earth Sciences University College LondonLondonWC1E 6BTUK Centre for Planetary Science University College London and Birkbeck CollegeLondonWC1E 7HXUK Innovation Center of Ore Resources Exploration Technology in the Region of Bedrock Ministry of Natural Resources of People’s Republic of China’Guiyang550000China Guizhou Bureau of Geology and Mineral Exploration and Development Guiyang550000China

The Ediacaran–Cambrian Phosphogenic Episode is the Earth’s first true phosphogenic event and resulted in worldwide phosphate deposits,which occurred during the processes of the Neoproterozoic Oxygenation *** Ediacaran Doushantuo Formation(ca.635–551 ma)of Weng’an area in central Guizhou,South China,contains two economic phosphorite beds(the Lower and Upper Phosphorite Beds).This paper presents a detailed stratigraphic,sedimentological and mineralogical study of multiple outcrop and drill core sections of the Doushantuo Formation across the Weng’an area,and identified 11 lithofacies and 4 types of phosphatic *** differences in lithofacies and grain types between the upper and lower phosphate deposits are observed,indicating that the two sets of phosphate deposits are the products of two distinct phosphogenic *** Lower Phosphorite Bed mainly consists of banded and laminated phosphorites,contains micro-oncoids formed by microbially-mediated precipitation and peloids formed by in-situ chemically oscillating reactions,indicating a biochemical and chemical enrichment of phosphorus to sediments during the Early Ediacaran *** Upper Phosphorite Bed is mainly composed of carbonaceous,massive,and stromatolitic phosphorites,contains bioclasts(phosphatized spheroidal fossils),and intraclasts formed by hydrodynamic agitation,suggesting that the major accesses of phosphorus to sediments were the remineralization of organic *** of the two economic phosphorite beds was controlled by two sea-level *** differences have also been documented in contemporaneous phosphate-bearing successions in Brazil and mangolia,indicating a significant shift in global phosphogenic mechanism during the early and middle Ediacaran,which may be due to the changes in redox conditions in seawater,associated with the Neoproterozoic Oxygenation *** regional active P-cycle processes could produce more free oxygen,which may have contributed to the up

关键词： phosphorite lithofacies phosphatic grains phosphogenic paragenesis phosphorus cycle mineralogy

A natural model of behavioral depression in postpartum adult female cynomolgus monkeys (macaca fascicularis)

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Zoological Research 2014年第3期35卷 174-181页

作者： Xun-Xun CHU Joshua dominic Rizak Shang-Chuan YANG Jian-Hong WANG Yuan-Ye ma Xin-Tian HU Laboratory of Primate Neuroscience Research and key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences& Yunnan Province Kunming Institute of Zoology University of the Chinese Academy of Sciences kunming Primate Research Center Kunming Institute of Zoology Chinese Academy of Sciences

Postpartum depression （PPD） is a modified form of major depressive disorders （MDD） that can exert profound negative effects on both mothers and infants than MDD. Within the postpartum period, both mothers and infants are susceptible; but because PPD typically occurs for short durations and has moderate symptoms, there exists challenges in exploring and addressing the underlying cause of the depression. This fact highlights the need for relevant animal models. In the present study, postpartum adult female cynomolgus monkeys （macaca fascicularis） living in breeding groups were observed for typical depressive behavior. The huddle posture behavior was utilized as an indicator of behavioral depression postpartum （BDP） as it has been established as the core depressive-like behavior in primates. Monkeys were divided into two groups： A t3DP group （n=6）, which were found to spend more time huddling over the first two weeks postpartum than other individuals that formed a non-depression control group （n=4）. The two groups were then further analyzed for locomotive activity, stressful events, hair cortisol levels and for maternal interactive behaviors. No differences were found between the BDP and control groups in locomotive activity, in the frequencies of stressful events experienced and in hair cortisol levels. These findings suggested that the postpartum depression witnessed in the monkeys was not related to external factors other than puerperium period. Interestingly, the BDP monkeys displayed an abnormal maternal relationship consisting of increased infant grooming. Taken together, these findings suggest that the adult female cynomolgus monkeys provide a natural model of behavioral postpartum depression that holds a number of advantages over commonly used rodent systems in PPD modeling. The cynomolgus monkeys have a highly-organized social hierarchy and reproductive characteristics without seasonal restriction--similar to humans--as well as much greater homology to humans

关键词： Postpartum depression Cynomolgus monkeys Huddle behavior Locomotion activity Stressful events Hair cortisol maternal relationship

High-performance mid-wavelength InAs avalanche photodiode using AlAs0.13Sb0.87as the multiplication layer

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Photonics Research 2020年第5期8卷 755-759页

作者： JIANLIANG HUANG CHENGCHENG ZHAO BIYING NIE SHIYU XIE dominic C.M.kWAN XIAO MENG YANHUA ZHANG DIANA L.HUFFAkER WENQUAN ma key Laboratory of Semiconductor materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Physics and Astronomy Cardiff UniversityCardiffUK

We report on a high-performance mid-wavelength infrared avalanche photodetector(APD)with separate absorption and multiplication *** is used as the absorber material and high-bandgap AlAs0.13Sb0.87 is used as the multiplication *** room temperature,the APD’s peak response wavelength is 3.27μm,and the 50%cutoff wavelength is 3.5μ*** avalanche gain reaches 13.1 and the responsivity is 8.09 A/W at 3.27μm when the applied reverse bias voltage is 14.6 *** measured peak detectivity D*of the device is 2.05×10^9 cm·Hz^0.5/W at 3.27μm.

关键词： avalanche material. performance

Social rank and cortisol among female rhesus macaques(macaca mulatta)

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Zoological Research 2013年第2期34卷 42-49页

作者： Dong-Dong QIN Joshua dominic Rizak Xiao-Li FENG Xun-Xun CHU Shang-Chuan YANG Chun-Lu LI Long-Bao LV Yuan-Ye ma Xin-Tian HU key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China University of Chinese Academy of Sciences Beijing 100049China Institute of Psychology Chinese Academy of SciencesBeijing 100101China kunming Primate Research Center Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State key Laboratory of Brain and Cognitive Sciences Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

In animal societies,some stressful events can lead to higher levels of physiological *** stressors,like social rank,also predict an increased vulnerability to an array of ***,the physiological relationship between social rank and stress varies between different species,as well as within groups of a single *** example,dominant individuals are more socially stressed at times,while at other times it is the subordinate ones who experience this ***,these variations make it difficult to assess disease vulnerability as connected to social *** order to learn more about how physiological rank relationships vary between groups of a single species,cortisol measurements from hair samples were used to evaluate the effects of dominance rank on long-term stress levels in despotic and less stringent female rhesus macaque hierarchal *** despotic groups,cortisol levels were found not to be correlated with social rank,but a negative correlation was found between social rank and cortisol levels in less stringent *** ranking monkeys in less stringent groups secreted elevated levels of cortisol compared to higher ranking *** data suggest that variations in the strictness of the dominance hierarchy are determining factors in rank related stress *** further consideration of nonhuman primate social system diversity and the linear degree of their hierarchies may allow for the development of valid rank-related stress models that will help increase our understanding and guide the development of new therapeutics for diseases related to human socioeconomic status.

关键词： Social rank Hypothalamus-pituitary-adrenal axis Cortisol Female Rhesus macaques

二甲双胍与吡格列酮两种2型糖尿病药物在亲水作用色谱上的保留机理研究（英文）

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分析科学学报 2019年第6期35卷 790-796页

作者：鲁肖飞 Caroline martin 戚忠林 Pari Samani Zemen Berhe dominic B Siaw Shyam k Pahari 左跃钢 University of massachusetts Dartmouth Chemistry and Biochemistry DepartmentMA 02747USA 湖北省鄂州市武汉大学人民医院鄂州医院湖北鄂州436000

二甲双胍和吡格列酮是治疗2型糖尿病的常见药物,经常用于同一复方制剂。制药和临床领域常要求同时测定这两种药物。亲水作用色谱近来在医药分析领域展现出良好的前景。本文通过研究流动相的有机溶剂含量、pH值和缓冲盐浓度等参数对色谱... 详细信息

二甲双胍和吡格列酮是治疗2型糖尿病的常见药物,经常用于同一复方制剂。制药和临床领域常要求同时测定这两种药物。亲水作用色谱近来在医药分析领域展现出良好的前景。本文通过研究流动相的有机溶剂含量、pH值和缓冲盐浓度等参数对色谱保留的影响,从而尝试揭示两种药物在亲水性硅胶柱上的分离机理。流动相中甲醇的增加会导致二甲双胍的保留因子的增加。流动相pH值比较低时,二甲双胍的保留因子会随着pH值升高而增加,而当pH值>6.09,其反而会随着pH值的升高而下降。吡格列酮的保留因子几乎不受甲醇比例和pH值的影响。缓冲盐浓度对两种药物的保留因子几乎都没有影响。因此,对于二甲双胍,亲水作用是主要的保留机理,静电作用和氢键也起到了重要作用。对于吡格列酮,亲水作用是支配性的。经过优化的亲水作用色谱方法可成功地应用到分离测定两种药物在2型糖尿病复方药物中的含量。

关键词：二甲双胍吡格列酮糖尿病亲水作用色谱硅胶色谱柱

MUSHROOM SONG Designer&Founder of WMWM

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城市漫步（GBA版） 2017年第12期 19-19页

作者： dominic Ngai 不详

Shortly after graduating from the ma program at the London College of Fashion in 2015,Mushroom Song emerged onto the fashion scene with the launch of her label,*** the start,her unique take on creating an understated androgynous look with oversized proportions,monochromatic colors,as well as the creative use of draping to create interesting shapes and layers.

关键词： Designer stated sized

MUSHROOM SONG Designer & Founder of WMWM

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城市漫步（上海版、英文） 2017年第12期 19-19页

作者： dominic Ngai 不详

Shortly after graduating from the ma program at the London College of Fashion in 2015,Mushroom Song emerged onto the fashion scene with the launch of her label,WMWM.

关键词： Designer emerged scene

FIONA ma Founder and Head Designer of kunmanma

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城市漫步（上海版、英文） 2017年第1期 15-15页

作者： dominic Ngai 不详

At the age of 27,Shanghai-based fashion designer Fiona ma has had her womenswear label kunmanma featured in one of the most well-respected showrooms of Paris Fashion Week since *** a background in architectural design,ma considers her clothingto be"the architecture for the human body:Here,she tells us about how her studies have influenced her work in fashion.

关键词： Designer architectural fashion