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A Study of Zole.ronic Acid as Ne.-Adjuvant, Pe.iope.ative.The.apy in Patie.ts with Re.e.table.Pancre.tic Ductal Ade.ocarcinoma

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Journal of Cance. The.apy 2013年第3期4卷 797-803页

作者： dominic e. sanford Matthe. R. Pore.bka Rohe.na Z. Panni Jonathan B. Mitche. Brian A. Be.t Stace. M. Plambe.k-Sue.s Goldie.Lin David G. De.ardo Ryan C. Fie.ds William G. Hawkins Ste.e. M. Strasbe.g Craig Lockhart Andre. Wang-Gillam Simon Pe.e. Goe.e.e.uure.David C. Line.an Alvin J. Site.an Cance. Ce.te. St. Louis USA De.artme.t of Me.icine School of Medicine Washington University St. Louis USA De.artme.t of Surge.y School of Medicine Washington University St. Louis USA

Background: Pancre.tic ductal ade.ocarcinoma (PDAC) is an aggre.sive.malignancy characte.ize. by abundant granulocytic mye.oid-de.ive. suppre.sor ce.ls (G-MDSC = CD45+/Lin﹣/CD33+/CD11b+/CD15+), which infiltrate.tumors and suppre.s anti-tumor immunity. We.have.pre.iously de.onstrate. in a murine.mode. of PDAC that zole.ronic acid (ZA) de.le.e. G-MDSC re.ulting in de.re.se. tumor growth and improve. survival. We.re.ort he.e.the.re.ults of a phase.1 clinical trial (NCT00892242) using ZA as ne.-adjuvant, pe.iope.ative.the.apy in patie.ts with non-me.astatic, re.e.table.pancre.tic ade.ocarcinoma. Me.hods: e.igible.PDAC patie.ts re.e.ve. ZA (4 mg) IV 2 we.ks prior to surge.y. Patie.ts the. re.e.ve. 2 additional dose. of ZA 4 we.ks apart. Blood and bone.marrow we.e.obtaine. from patie.ts prior to tre.tme.t with ZA and 3 months afte. surge.y for analysis of G-MDSC by flow cytome.ry. Re.ults: Twe.ty-thre. patie.ts re.e.ve. pre.ope.ative.ZA with at le.st 6 months of follow-up. Only 15 PDAC patie.ts had nonme.astatic PDAC, which was ame.able.to re.e.tion. ZA was we.l tole.ate., and all adve.se.e.e.ts we.e.grade.1 or 2. The.most common adve.se.e.e.ts we.e.fatigue. abdominal pain/discomfort, anore.ia, and arthralgia. Of re.e.te. PDAC patie.ts tre.te. with ZA, 1- and 2-ye.r ove.all survival (OS) was 85.7% and 33.3%, re.pe.tive.y, with a me.ian OS of 18 months. This group had a 1- and 2-ye.r progre.sion-fre. survival (PFS) of 26.9% and 8.9%, re.pe.tive.y, with a me.ian PFS of 12 months. The.pre.ale.ce.of G-MDSC was unchange. in the.blood and bone.marrow of PDAC patie.ts pre. and post-tre.tme.t with ZA. Conclusion: ZA is safe.and we.l tole.ate. as ne.-adjuvant, pe.i-ope.ative.the.apy in PDAC patie.ts. In this small study, we.did not obse.ve.a diffe.e.ce.in OS or PFS compare. to historical controls. Also, the.e.was no diffe.e.ce.in the.pre.ale.ce.of G-MDSC in the.blood and bone.marrow of PDAC patie.ts pre. and post-tre.tme.t with ZA.

关键词： Pancre.tic Cance. Zole.ronic Acid Mye.oid-De.ive. Suppre.sor Ce.ls

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Towards an e.hance. unde.standing of the.particle.size.e.fe.t on conve.sion/alloying lithium-ion anode.

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Mate.ials Future. 2024年第1期3卷 150-164页

作者： Jakob Ase.baue. Dominik Horny Mayokun Olutogun Katrin Schulz dominic Bre.se. He.mholtz Institute.Ulm(HIU) 89081 UlmGermany Karlsruhe.Institute.of Te.hnology(KIT) 76021 KarlsruheGermany Institute.for Applie. Mate.ials(IAM) Karlsruhe Institute of Technology(KIT)76131 KarlsruheGermany Karlsruhe.Unive.sity of Applie. Scie.ce. 76133 KarlsruheGermany

Conve.sion/alloying mate.ials(CAMs)re.re.e.t a pote.tial alte.native.to graphite.as a Li-ion anode.active.mate.ial,e.pe.ially for high-powe. *** far,howe.e.,e.se.tially all studie. on CAMs have.be.n de.ling with nano-size. particle.,le.ving the.que.tion of how the.pe.formance.and the.de./lithiation me.hanism in ge.e.al)is affe.te. by the.particle.***,we.comparative.y inve.tigate.four diffe.e.t sample. of Zn_(0.9)Co_(0.1)O with a particle.size.ranging from about 30 nm to a fe. *** re.ults show that e.e.trode. made.of large. particle. are.more.susce.tible.to fading due.to particle.displace.e.t and particle.*** re.ults also show that the.conve.sion-type.re.ction in particular is affe.te. by an incre.sing particle.size.be.oming le.s re.e.sible.due.to the.formation of re.ative.y large.transition me.al(TM)and alloying me.al nanograins upon lithiation,thus hinde.ing an e.ficie.t e.e.tron transport within the.initial particle.while.the.alloying contribution re.ains e.se.tially *** ge.e.ality of the.e.findings is confirme. by also inve.tigating Sn_(0.9)Fe.(0.1)O_(2) as a se.ond CAM with a substantially gre.te. contribution of the.alloying re.ction and e.ploying Fe.inste.d of Co as a TM dopant.

关键词： particle.size conve.sion alloying anode lithium-ion batte.y

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Inte.rate. Stratigraphy and Mine.alogy of the.Doushantuo Formation in We.g’an,South China,and Implications for e.iacaran Phosphoge.e.is

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Journal of e.rth Scie.ce 2024年第2期35卷 476-503页

作者： Liangxuan Jiao Zhe.bing She.dominic Papine.u Yaguan Zhang Matthe. S.Dodd Ke.an Cao Qun Che. Guoyong Che. State.Ke. Laboratory of Bioge.logy and e.vironme.tal Ge.logy China University of GeosciencesWuhan430078China School of e.rth Scie.ce. China University of GeosciencesWuhan430047China London Ce.tre.for Nanote.hnology University College London17-19 Gordon StreetLondonWC1E 6BTUK De.artme.t of e.rth Scie.ce. University College LondonLondonWC1E 6BTUK Ce.tre.for Plane.ary Scie.ce University College London and Birkbeck CollegeLondonWC1E 7HXUK Innovation Ce.te. of Ore.Re.ource. e.ploration Te.hnology in the.Re.ion of Be.rock Ministry of Natural Resources of People’s Republic of China’Guiyang550000China Guizhou Bure.u of Ge.logy and Mine.al e.ploration and De.e.opme.t Guiyang550000China

The.e.iacaran–Cambrian Phosphoge.ic e.isode.is the.e.rth’s first true.phosphoge.ic e.e.t and re.ulte. in worldwide.phosphate.de.osits,which occurre. during the.proce.se. of the.Ne.prote.ozoic Oxyge.ation *** e.iacaran Doushantuo Formation(ca.635–551 Ma)of We.g’an are. in ce.tral Guizhou,South China,contains two e.onomic phosphorite.be.s(the.Lowe. and Uppe. Phosphorite.Be.s).This pape. pre.e.ts a de.aile. stratigraphic,se.ime.tological and mine.alogical study of multiple.outcrop and drill core.se.tions of the.Doushantuo Formation across the.We.g’an are.,and ide.tifie. 11 lithofacie. and 4 type. of phosphatic *** diffe.e.ce. in lithofacie. and grain type. be.we.n the.uppe. and lowe. phosphate.de.osits are.obse.ve.,indicating that the.two se.s of phosphate.de.osits are.the.products of two distinct phosphoge.ic *** Lowe. Phosphorite.Be. mainly consists of bande. and laminate. phosphorite.,contains micro-oncoids forme. by microbially-me.iate. pre.ipitation and pe.oids forme. by in-situ che.ically oscillating re.ctions,indicating a bioche.ical and che.ical e.richme.t of phosphorus to se.ime.ts during the.e.rly e.iacaran *** Uppe. Phosphorite.Be. is mainly compose. of carbonace.us,massive.and stromatolitic phosphorite.,contains bioclasts(phosphatize. sphe.oidal fossils),and intraclasts forme. by hydrodynamic agitation,sugge.ting that the.major acce.se. of phosphorus to se.ime.ts we.e.the.re.ine.alization of organic *** of the.two e.onomic phosphorite.be.s was controlle. by two se.-le.e. *** diffe.e.ce. have.also be.n docume.te. in conte.porane.us phosphate.be.ring succe.sions in Brazil and Mangolia,indicating a significant shift in global phosphoge.ic me.hanism during the.e.rly and middle.e.iacaran,which may be.due.to the.change. in re.ox conditions in se.wate.,associate. with the.Ne.prote.ozoic Oxyge.ation *** re.ional active.P-cycle.proce.se. could produce.more.fre. oxyge.,which may have.contribute. to the.up

关键词： phosphorite lithofacie. phosphatic grains phosphoge.ic parage.e.is phosphorus cycle mine.alogy

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Microbially-me.iate. formation of Ca-Fe.carbonate. during dissimilatory fe.rihydrite.re.uction:Implications for the.origin of se.ime.tary anke.ite

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Scie.ce.China e.rth Scie.ce. 2024年第1期67卷 208-221页

作者： De.g LIU Jinpe.g CAO Shanshan YANG Yating YIN Pe.gcong WANG dominic PAPINe.U Hongme. WANG Xuan QIU Ge.ming LUO Zongmin ZHU Fe.gping WANG State.Ke. Laboratory of Bioge.logy and e.vironme.tal Ge.logy China University of GeosciencesWuhan 430074China School of e.vironme.tal Studie. China University of GeosciencesWuhan 430074China London Ce.tre.for Nanote.hnology University College LondonLondon WC1H 0AHUK De.artme.t of e.rth Scie.ce. University College LondonLondon WC1E 6BTUK Ce.te. for Plane.ary Scie.ce. University College London and Birkbeck College LondonLondon WC1E 6BTUK State.Ke. Laboratory of Microbial Me.abolism State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The.origin of se.ime.tary dolomite.has be.ome.a long-standing proble. in the.e.rth *** carbonate.mine.als like.anke.ite.have.the.same.crystal structure.as dolomite.he.ce.the.r ge.e.is may provide.clue. to he.p solving the.dolomite.*** purpose.of this study was to probe.whe.he. microbial activity can be.involve. in the.formation of ***-carbonation e.pe.ime.ts associate. with microbial iron re.uction we.e.pe.forme. in batch syste.s with various conce.trations of Ca^(2+)(0–20 mmol/L),with a marine.iron-re.ucing bacte.ium She.ane.la pie.otole.ans WP3 as the.re.ction me.iator,and with lactate.and fe.rihydrite.as the.re.pe.tive.e.e.tron donor and *** biomine.alization data showe. that Ca-ame.dme.ts e.pe.ite. microbially-me.iate. fe.rihydrite.re.uction by e.hancing the.adhe.ion be.we.n WP3 ce.ls and fe.rihydrite.*** biore.uction,side.ite.occurre. as the.principal se.ondary mine.al in the.Ca-fre. ***,Ca-Fe.carbonate. we.e.forme. whe. Ca^(2+)ions we.e.*** CaCO_(3) conte.t of microbially-induce. Ca-Fe.carbonate. was positive.y corre.ate. with the.initial Ca2+*** Ca-Fe.carbonate.phase.produce. in the.20 mmol/L Ca-ame.de. biosyste.s had a che.ical formula of Ca_(0.8)Fe.(1.2)(CO_(3))_(2),which is close.to the.the.re.ical composition of *** anke.ite.ike.phase.was nanome.ric in size.and sphe.ical,Ca-Fe.disorde.e.,and structurally *** simulate. diage.e.is e.pe.ime.ts furthe. de.onstrate. that the.re.ulting anke.ite.like.phase.could be.conve.te. into orde.e. anke.ite.unde. hydrothe.mal *** introduce. the.te.m“proto-anke.ite.to de.ine.the.Ca-Fe.phase. that posse.s ne.r-anke.ite.stoichiome.ry but disorde.e. cation *** the.basis of the.pre.e.t study,we.propose. he.e.n that microbial activity is an important contributor to the.ge.e.is of se.ime.tary anke.ite.by providing the.me.astable.Ca-Fe.carbonate.pre.ursors.

关键词： Anke.ite Proto-anke.ite Microbial iron re.uction Dolomite.proble. Mine.al transformation

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Fre.-surface.long wave.propagation ove. line.r and parabolic transition she.ve.

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Wate. Scie.ce.and e.gine.ring 2018年第4期11卷 318-327页

作者： Ikha Magdale.a Iryanto dominic e.Re.ve Faculty of Mathe.atics and Natural Scie.ce. Bandung Institute of Technology Informatics De.artme.t Indramayu State Polytechnic Colle.e.of e.gine.ring Swansea UniversityBay Campus

Long-pe.iod wave. pose.a thre.t to coastal communitie. as the. propagate.from de.p oce.n to shallow coastal wate.s. At the.coastline. such wave. have.a gre.te. he.ght and longe. pe.iod in comparison with local storm wave., and can cause.se.e.e.inundation and damage. In this study,we.conside.e. line.r long wave. in a two-dime.sional(ve.tical-horizontal) domain propagating towards a shore.ine.ove. a shallowing *** solutions to the.line.r shallow wate. e.uations we.e.found, through the.se.aration of variable., for two forms of transition she.f morphology: de.p wate. and shallow coastal wate. horizontal she.ve. conne.te. by line.r and parabolic transition, re.pe.tive.y. e.pre.sions for the.transmission and re.le.tion coe.ficie.ts are.pre.e.te. for e.ch case. The.analytical solutions we.e.use. to te.t the.re.ults from a nove. computational sche.e. which was the. applie. to e.te.ding the.e.isting re.ults re.ating to the.re.le.te. and transmitte. compone.ts of an incide.t wave. The.solutions and computational package.provide.ne. tools for coastal manage.s to formulate.improve. de.e.ce.and riskmitigation strate.ie..

关键词： Shallow wate. e.uation Long-pe.iod wave Shoaling Analytical solution Nume.ical solution Re.le.tion coe.ficie.t Transmission coe.ficie.t

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微生物异化还原水铁矿介导的Ca-Fe.酸盐矿物形成:对铁白云石成因的启示

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中国科学：地球科学 2024年第1期54卷 216-230页

作者：刘邓曹锦鹏杨珊珊殷雅婷王鹏聪 dominic PAPINe.U 王红梅邱轩罗根明朱宗敏王风平中国地质大学(武汉)生物地质与环境地质国家重点实验室武汉430074 中国地质大学(武汉)环境学院武汉430074 London Ce.tre.for Nanote.hnology University College LondonLondon WC1H 0AHUK De.artme.t of e.rth Scie.ce. University College LondonLondon WC1E 6BTUK Ce.te. for Plane.ary Scie.ce. University College London and Birkbeck College LondonLondon WC1E 6BTUK 上海交通大学微生物代谢国家重点实验室海洋工程国家重点实验室上海200240

白云石的成因机制至今仍是地球科学领域的一个谜题(“白云石问题”).铁白云石等碳酸盐矿物具有类白云石晶体结构,因此研究这些矿物的形成机制可为解答“白云石问题”提供新线索.本研究利用一株海洋异化铁还原菌(She.ane.la pie.otole.an... 详细信息

白云石的成因机制至今仍是地球科学领域的一个谜题(“白云石问题”).铁白云石等碳酸盐矿物具有类白云石晶体结构,因此研究这些矿物的形成机制可为解答“白云石问题”提供新线索.本研究利用一株海洋异化铁还原菌(She.ane.la pie.otole.ans WP3),在不同钙离子浓度(0~20mmol/L)条件下,通过氧化乳酸盐诱导水铁矿还原转化为次生碳酸盐矿物,以此评估微生物在铁白云石形成过程中的作用.实验结果表明,加入Ca^(2+)可以增强*** WP3细胞与水铁矿颗粒之间的黏附作用,从而提高反应体系中Fe.Ⅲ)还原速率.在不同Ca^(2+)浓度条件下,菌株WP3诱导生成的次生碳酸盐矿物类别有所差异:在0mmol/L Ca^(2+)体系中生成菱铁矿,而含钙体系中则为Ca-Fe.酸盐固溶体,且这些固溶体的钙离子含量与反应体系中初始的Ca^(2+)浓度呈正相关关系.值得注意的是,在20mmol/L Ca^(2+)体系中生成的Ca-Fe.酸盐固溶体化学组成为Ca0.8Fe..2(CO3)2,与铁白云石类似.此外,这些微生物成因的“类铁白云石”具有纳米晶粒的形态,晶体结构中钙和铁元素呈无序分布,并且发育较多晶体缺陷.进一步成岩模拟实验证明,“类铁白云石”可以在水热条件下转化为有序铁白云石.基于成分类比性和转化规律,微生物成因的“类铁白云石”可能是沉积物(岩)中铁白云石的重要前驱体,可以被定义为“原铁白云石”.以上新发现对理解微生物在铁白云石乃至白云石形成中的贡献具有重要的启示意义.

关键词：铁白云石原铁白云石微生物铁还原白云石问题矿物转化

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Computational inve.tigation of hydraulic pe.formance.variation with ge.me.ry in gabion ste.pe. spillways

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Wate. Scie.ce.and e.gine.ring 2019年第1期12卷 62-72页

作者： dominic e.Re.ve.Ali Ade. Zuhaira Harshinie.Karunarathna Colle.e.of e.gine.ring Swansea University

Ove. re.e.t ye.rs, the.e.has be.n a cle.r incre.se.in the.fre.ue.cy of re.orte. flooding e.e.ts around the.world. Gabion structure. offe. one.me.ns of flood mitigation in dam spillways. The.e.type. of structure. provide.an additional challe.ge.to the.computational mode.le. in that flow through the.porous gabions must be.simulate.. We.have.use. a computational mode. to inve.tigate.the.flow ove. gabion ste.pe. spillways. The.mode. was first validate. against publishe. e.pe.ime.tal re.ults. The., gabion ste.pe. spillways with four diffe.e.t ste. ge.me.rie. we.e.te.te. unde. the.same.conditions in orde. to facilitate.inte.-comparisons and to choose.the.be.t option in te.ms of e.e.gy dissipation. The.re.ults show that normal gabion ste.s can dissipate.more.e.e.gy than ove.lap, incline., and poole. ste.s. An inte.sive.se. of te.ts with varying slope. stone.size. and porosity we.e.unde.take.. The.location of the.ince.tion point and the.wate. de.th at this point obtaine. from this study we.e.compare. with those.from e.isting formulae. Two ne. e.pirical e.uations have.be.n de.ive., on the.basis of a re.re.sion analysis, to provide.improve. re.ults for gabion ste.pe. spillways.

关键词： Computational mode.ling e.e.gy dissipation Gabion ste.pe. spillways Ince.tion point location Skimming flow

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Nove. e.doscopic manage.e.t of burie. bumpe. syndrome.in pe.cutane.us e.doscopic gastrostomy: The.Olympus Hook Knife

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World Journal of Gastroe.te.ology 2017年第35期23卷 6546-6548页

作者： Laura e.Wolpe.t dominic M Summe.s Andre. Tsang De.artme.t of Ge.e.al Surge.y Peterborough City HospitalEdith Cavell Campus

Burie. bumpe. syndrome.BBS) is an uncommon but se.ious complication of pe.cutane.us e.doscopic gastrostomy. It involve. the.inte.nal fixation de.ice. or "bumpe.", migrating into the.gastric wall and subse.ue.t mucosal ove.growth. We.de.cribe. a case.se.ie. of four patie.ts with BBS tre.te. with a nove. e.doscopic te.hnique.using a Hook Knife.be.we.n June.2016 and Fe.ruary 2017. The.Hook Knife.is a rotating L-shape. cutting wire.de.igne. for hooking tissue.and pulling it away from the.gastric wall towards the.lume.. The.te.hnique.was succe.sful in all four case. with no complications. e.ch patie.t was discharge. on the.day of tre.tme.t. The.Hook Knife.is a manoe.vrable. safe.and e.fe.tive.de.ice.for e.doscopic re.oval of burie. bumpe.s and could avoid surge.y in a high risk group of patie.ts. To our knowle.ge.this te.hnique.has not be.n de.cribe. pre.iously. We.sugge.t that this te.hnique.should be.adde. to the.tre.tme.t algorithms for managing BBS.

关键词： Burie. bumpe. syndrome Pe.cutane.us e.doscopic gastrostomy Hook Knife

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Philippine.re.inoblastoma initiative.multi-e.e.ce.te. study 2010-2020

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Inte.national Journal of Ophthalmology(e.glish e.ition) 2024年第1期17卷 144-156页

作者： Roland Jose.h D.Tan Gary John V.Me.cado Patricia e.Cabre.a Paulita Pame.a P.Astudillo Rolando e.rique.D.Domingo Jose.t Mari S.Poble.e.Charmaine.Grace.M.Cabe.e.Adrie. Vince.t R.Te.Me.issa Anne.S.Gonzale. Joce.yn G.Sy Be.tran Ale.is A.Aclan Jayson T.So Fatima G.Re.ala Kimbe.le. Amanda K.Comia Jose.aria M.Castro Mara Augustine.S.Galang Aldous dominic C.Cabanlas Be.e.icto Juan e.Aguilar Gabrie.le.S.e.ange.ista Jo Michae. Maniwan Andre. P.Martin Calvin Y.Martine. John Alfre. H.Lim Re.a Ivy Bascuna Rache. M.Ng Ke.in B.Agsaoay Kris Zanna A.Acluba-Arao e.laine.Rose.V.Apostol Be.triz M.Prie.o De.artme.t of Ophthalmology and Visual Scie.ce. Philippine General HospitalManila 1000Philippines De.artme.t of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines De.artme.t of Ophthalmology Manila Doctors HospitalManila 1000Philippines De.artme.t of Ophthalmology Rizal Medical CenterPasig City 1600Philippines De.artme.t of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines De.artme.t of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines De.artme.t of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines De.artme.t of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines De.artme.t of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Le.azpi e.e.Ce.te. Legazpi City 4500Philippines De.artme.t of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide.a compre.e.sive.and more.re.re.e.tative.national data on the.dise.se.e.pe.ially on tre.tme.t options and outcome.,and to de.e.mine.acce.s of re.inoblastoma patie.ts from Luzon,Visayas and Mindanao to e.e.care.and de.e.mine.if acce.s is associate. with de.ay in consultation,staging and ***:Cohort study of re.inoblastoma patie.ts se.n in e.e.e. institutions locate. in the.thre. major are.s of the.Philippine. name.y Luzon,Vizayas and Mindanao from ***:Totally 636 patie.ts,involving 821 e.e.,we.e.***(57%)we.e.from Luzon and we.e.se.n in institutions in Luzon(72%).Annually,58±10 ne. case. we.e.se.n with 71%having unilate.al *** de.ay of consultation re.aine. long at 9(3,17)mo,longe.t in patie.ts with unilate.al dise.se.Pe.from the.Visayas(Pe. on the.Inte.national Re.inoblastoma Staging Syste.,only 35%of patie.ts had Stage.1 while.47%alre.dy had e.traocular *** was the.most common tre.tme.t re.e.ve. by 484 patie.ts while.intrave.ous che.othe.apy was re.e.ve. by *** we.e.250(39%)patie.ts alive.195(31%)de.d,85(13%)abandone.,17(3%)re.use. and 89(14%)with no ***:This study pre.e.ts the.large.t cohort of re.inoblastoma patie.ts in the.Philippine. in te.ms of patie.ts’and participating institutions’numbe. and ge.graphical location and type.of institution(private.and public).It also pre.e.ts more.compre.e.sive.data on the.tre.tme.ts use. and outcome.(survival,globe.salvage.and vision re.e.tion rate.).De.ay in consultation was still long among patie.ts le.ding to advance. dise.se.stage.and lowe. survival *** incre.sing capacity to diagnose.and manage.re.inoblastoma in the.country,the.de.ay of consultation re.ains long primarily due.to acce.sibility issue. to e.e.care.institutions e.pe.ially in the.Visayas and financial *** de.ay was still significant that ove.all survival rate.re.ain low.

关键词： re.inoblastoma Philippine. clinical profile

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e.amining the.intrinsic foot muscle.'capacity to modulate.plantar fle.or ge.ring and ankle.joint contributions to propulsion in ve.tical jumping

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Journal of Sport and He.lth Scie.ce 2023年第5期12卷 639-647,F0003页

作者： Ross Smith Gle. Lichtwark dominic Farris Luke.Ke.ly School of Human Move.e.t and Nutrition Scie.ce. The University of QueenslandBrisbaneQLD 4072Australia Sport and He.lth Scie.ce. College of Life and Environmental SciencesThe University of ExeterExeterEX12LUUnited Kingdom

Background:During human locomotion,a sufficie.tly stiff foot allows the.ankle.plantar fle.ors to ge.e.ate.large.propulsive.*** foot stiffne.s(e.g.,via a carbon plate.incre.se. the.ankle.s e.te.nal mome.t arm in re.ation to the.inte.nal mome.t arm(i.e.,incre.sing ge.r ratio),re.uce. plantar fle.or muscle.’shorte.ing ve.ocity,and e.hance. muscle.force.*** contrast,whe. activation of the.foot’s intrinsic muscle. is impaire.,the.e.is a re.uction in foot and ankle.work and me.atarsophalange.l joint *** spe.ulate. that the.re.uce. capacity to active.y control me.atarsophalange.l joint stiffne.s may impair the.ge.ring function of the.foot at the.***:We.use. a tibial ne.ve.block to e.amine.the.dire.t e.fe.ts of the.intrinsic foot muscle. on ankle.joint kine.ics,in vivo me.ial gastrocne.ius’musculote.dinous dynamics,and ankle.ge.r ratio on 14 participants during maximal ve.tical ***:Unde. the.ne.ve.block,the.inte.nal ankle.plantar fle.ion mome.t de.re.se.(p=0.004)alongside.a re.uction in e.te.nal mome.t arm le.gth(p=0.021)and ankle.joint ge.r ratio(p=0.049)whe. compare. to the.non-blocke. *** me.ial gastrocne.ius muscle.te.don unit and fascicle.ve.ocity we.e.not diffe.e.t be.we.n conditions,the.Achille. te.don was shorte. during propulsion in the.ne.ve.block condition(pe.r known role.of re.ulating the.e.e.ge.ic function of the.foot,our data indicate.that the.intrinsic foot muscle. also act to optimize.ankle.joint torque.production and le.e.age.during the.propulsion phase.of ve.tical jumping.

关键词： Ankle.biome.hanics Ankle.ge.ring Foot biome.hanicsTage.e.d

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