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Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats

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World Journal of Gastroenterology 2013年第38期19卷 6416-6426页

作者： Paulo Emilio Botura Ferreira Cláudia Regina Pinheiro Lopes Angela Maria Pereira alves der Paulo Belato alves David Robert Linden Jacqueline Nelisis Zanoni Nilza Cristina Buttow Department of Morphological Sciences Universidade Estadual de MaringáMaringáPR. CEP 87020-900Brazil Department of Physiology and Biomedical Engineering and Enteric NeuroScience Program Mayo Clinic College of MedicineRochesterMN 55905United States

AIM:To investigate the effect of quercetin supplementation on the myenteric neurons and glia in the cecum of diabetic ***:Total preparations of the muscular tunic were prepared from the ceca of twenty-four rats divided into the following groups:control(C),control supplemented with quercetin(200 mg/kg quercetin body weight)(CQ),diabetic(D)and diabetic supplemented with quercetin(DQ).Immunohistochemical double staining technique was performed with HuC/D(general population)/nitric oxide synthase(nNOS),HuC-D/S-100and *** analysis of the general neuronal population HuC/D-IR,the nNOS-IR(nitrergic subpopulation)and the enteric glial cells(S-100)was performed,and the morphometry and the reduction in varicosity population(VIP-IR)in these populations were ***:Diabetes promoted a significant reduction(25%)in the neuronal density of the HuC/D-IR(general population)and the nNOS-IR(nitrergic subpopulation)compared with the C *** also significantly increased the areas of neurons,glial cells and VIP-IR *** with quercetin in the DQ group prevented neuronal loss in the general population and increased its area(P<0.001)and the area of nitrergic subpopulation(P<0.001),when compared to C *** induced a VIP-IR and glial cells areas(P<0.001)in DQ group when compared to C,CQ and D ***:In diabetes,quercetin exhibited a neuroprotective effect by maintaining the density of the general neuronal population but did not affect the density of the nNOS subpopulation.

关键词： Diabetes Myenteric plexus Neuroprotection Neuronal nitric oxide synthase Vasoactive intestinal polypeptide Enteric glia

Detection of functional diversity gradients and their geoclimatic filters is sensitive to data types(occurrence ***)and spatial scales(sites ***)

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Plant Diversity 2024年第6期46卷 732-743页

作者： JoséLuiz alves Silva Alexandre Souza Angela Pierre Vitória Laboratório de Ciências Ambientais Universidade Estadual do Norte Fluminense Darcy RibeiroCampos dos GoytacazesRio de JaneiroBrazil Departamento de Ecologia Universidade Federal do Rio Grande do NorteRio Grande do NorteBrazil

Functional diversity(FD)reflects within-and between-site variation of species traits(α-and β-FD,respectively).Understanding how much data types(occurrence-based ***-weighted)and spatial scales(sites ***)change FD and ultimately interfere with the detection of underlying geoclimatic filters is still *** contribute to this debate,we explored the occurrence of 1690 species in 690 sites,abundances of 1198 species in 343 sites,and seven functional traits of the Atlantic Forest woody flora in South *** FD indices were sensitive and dependent on the data type at both scales,with occurrence particularly increasing a richness and dispersion(occurrence>abundance in 80%of the sites)while abundance increased β total,β replacement,and α evenness(abundance>occurrence in 60%of the sites).Furthermore,detecting the effect of geoclimatic filters depended on the data type and was *** the site scale,precipitation seasonality and soil depth had weak effects on α-and β-FD(max.R^(2)=0.11).However,regional-scale patterns of a richness,dispersion,and evenness strongly mirrored the variation in precipitation seasonality,soil depth,forest stability over the last 120 kyr,and cation exchange capacity(correlations>0.80),suggesting that geoclimatic filters manifest stronger effects at the regional ***,the role of edaphic gradients expands the idea of biogeographical filters beyond *** findings caution functional biogeographic studies to consider the effect of data type and spatial scale before designing and reaching ecological conclusions about the complex nature of FD.

关键词： Environmental filtering Historical events Human pressure n-dimensional hypervolume Biodiversity hotspot Tropical forest

The Characteristics of the Violence against Women in Mozambique

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Health 2014年第13期6卷 1589-1601页

作者： Germano Vera Cruz Lidia domingos Aniceto Sabune Education Faculty Eduardo Mondlane University Maputo Mozambique Psychology Faculty University of Toulouse II Toulouse France

The purpose of this study is to identify the main characteristics of violence against women in the context of a) intimate partner relationships and b) non-partner relationships in Mozambique, using the Revised Conflict Tactics Scale (CTS2);measure the occurrence during lifetime or the past 12 months, and examine the association between intimate partner violence (IPV)/non-partner violence (NPV) types and predictor variables (demographic, socio-economic and lifestyle factors). A total of 1200 women (aged 15 - 45?years) were recruited to participate in this study. Results show that in Mozambique, generally, the rates of IPV and NPV are higher compared to those of other Sub-Saharan Africa countries (except when it comes to sexual assault). It seems that there is more violence against women within intimate partner relationship than in non-partner relationship. Adolescent, single young adults and women who experience the financial strain or use frequently alcohol are more vulnerable to be abused.

关键词： Mozambique Relationship Violence against Women

Integrated Design Fabrication and Control of a Bioinspired Multimaterial Soft Robotic Hand

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Cyborg and Bionic Systems 2023年第1期4卷 156-165页

作者： Samuel alves Mihail Babcinschi Afonso Silva Diogo Neto Diogo Fonseca Pedro Neto University of Coimbra CEMMPREARISEDepartment of Mechanical Engineering3030-788 CoimbraPortugal

Machines that mimic humans have inspired scientists for *** soft robotic hands are a good example of such an endeavor,featuring intrinsic material compliance and continuous motion to deal with uncertainty and adapt to unstructured *** research led to impactful achievements in functional designs,modeling,fabrication,and control of soft ***,the full realization of life-like movements is still challenging to achieve,often based on trial-and-error considerations from design to fabrication,consuming time and *** this study,a soft robotic hand is proposed,composed of soft actuator cores and an exoskeleton,featuring a multimaterial design aided by finite element analysis(FEA)to define the hand geometry and promote finger’s *** actuators are fabricated using molding,and the exoskeleton is 3D-printed in a single *** ON-OFF controller keeps the set fingers’inner pressures related to specific bending angles,even in the presence of *** FEA numerical results were validated by experimental tests,as well as the ability of the hand to grasp objects with different shapes,weights,and *** integrated solution will make soft robotic hands more available to people,at a reduced cost,avoiding the time-consuming design-fabrication trial-and-error processes.

关键词： consuming skeleton realization

Chronic hepatitis C genotype 1 virus:Who should wait for treatment?

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World Journal of Gastroenterology 2014年第11期20卷 2867-2875页

作者： Cristiane Valle Tovo Angelo alves de Mattos Paulo Roberto Lerias de Almeida Department of Gastroenterology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90430-080Brasil Department of Gastroenterology Hospital Nossa Senhora da Concei??oPorto Alegre 91350-200Brasil

Elucidation of the natural history of chronic hepatitis C (CHC) and the identification of risk factors for its progression to advanced liver disease have allowed many physicians to recommend deferral treatment (triple therapy) in favour of waiting for new drug availability for patients who are at low risk of progression to significant liver disease. Newer generation drugs are currently under development, and are expected to feature improved efficacy and safety profiles, as well as less complex and shorter duration delivery regimens, compared to the current standards of care. In addition, patients with cirrhosis and prior null responders have a low rate (around 15%) of achieving sustained virological response (SVR) with triple therapy, and physicians must also consider the decision to wait for new treatments in the future for these patients as well. Naïve patients are the most likely to achieve a close to 100% SVR rate; therefore, it may be advisable to recommend that patients with mild to moderate CHC should wait for the newer therapy options. In contrast, patients with advanced fibrosis and cirrhosis will be those with the greatest need for expedited therapeutic intervention. There remains a need, however, for establishing definitive clinical management guidelines to maximize the benefit of waiting for new drugs and minimize risk of side effects and non-response to the current triple therapy.

关键词： Hepatitis C virus Chronic hepatitis C Treatment of hepatitis C Cirrhosis Protease inhibitors

Implant surface features as key role on cell behavior

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BIOCELL 2022年第5期46卷 1151-1156页

作者： RAFAEL SCAF DE MOLON MARTA MARIA alves PEREIRA ERICA DORIGATTI DE AVILA Federal University of Rio de Janeiro Rio de Janeiro21941-617Brazil São Paulo State University Araraquara14801-930Brazil

It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix(ECM)that may affect cell *** nature,ECM is a heterogeneous three-dimensional superstructure formed by three major components,glycosaminoglycan,glycoconjugate,and protein,that anchors cellular compartments in tissues and regulates the function and the behavior of *** in the biointerface alter the quality of ECM and morphology through cell surface receptors,which,in turn,enable it to trigger specific cell signaling and different cellular *** fact,a number of strategies have been used to improve the functionality of surfaces and direct cell behavior through precisely designed ***,we aimed to discuss,through a science-based viewpoint,the biomaterial surface features on cell behavior and analyze the impact of cell physical modification on dental implant development.

关键词： Biomaterial Cell adhesion Surface chemistry Surface topography

Genotoxic Effect of Phenol on the Cells of Onion (Allium cepa) Roots

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生态毒理学报 2013年第4期8卷 609-615页

作者： Gisele Pigatto Regildo Marcio Gonalves da Silva Gian Luigi Mariottini Vanessa Marques de Oliveira Mauri Sergio alves Palma Attilio Converti Department of Pharmaceutical and Biochemical Technology Universidade de So PauloSao Paulo SP Brasil Department of Civil Chemical and Environmental Engineering University of GenoaGenova Italy Department of Biology Universidade Estadual PaulistaAssis SP Brasil Department of Earth Environment and Life Sciences University of GenoaGenova Italy

The roots of onion (Allium cepa) stand out for having cells with large size and small number of *** characteristics make them useful in bioassays for the measurement of a variety of cytogenetic and morphological parameters , in which they can be used as toxicity indicators of the induction and formation of micronuclei and chromosomal *** on this background , the potential genotoxic effect of phenol concentration on cells of *** was investigated either in terms of induced aberrations or micronuclei *** results demonstrated that the higher the concentration of phenol , the higher the incidence of abnormalities , thus confirming the genotoxicity of this pollutant.

关键词：摘要编辑部编辑工作读者

Hydrocarbons in particulate samples from wildfire events in central Portugal in summer 2010

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Journal of Environmental Sciences 2017年第3期29卷 122-131页

作者： Ana Vicente Ana Calvo Ana P.Fernandes Teresa Nunes Cristina Monteiro Casimiro Pio Célia alves Centre for Environmental and Marine Studies (CESAM) Department of EnvironmentUniversity of Aveiro Department of Physics IMARENABUniversity of León

In summer 2010, twenty eight （14 PM=2.5 samples plus 14 samples PM2.5-10） smoke samples were collected during wildfires that occurred in central Portugal. A portable high-volume sampler was used to perform the sampling, on quartz fibre filters of coarse （PM=2.5-10） and fine （PM2.5） smoke samples. The carbonaceous content （elemental and organic carbon） of particulate matter was analysed by a thermal-optical technique. Subsequently, the particulate samples were solvent extracted and fractionated by vacuum flash chromatog- raphy into three different classes of organic compounds （aliphatics, polycyclic aromatic hydrocarbons （PAHs） and carbonyl compounds）. The organic speciation was performed by gas chromatography-mass spectrometry （GC-MS）. Emissions were dominated by the fine particles, which represented around 92% of the PM10. A clear predominance of carbonaceous constituents was observed, with organic to elemental carbon （OC/EC） ratios ranging between 1.69 and 245 in both size fractions. The isoprenoid ketone 6,10,14-trimethyl-2-pentadecanone, a tracer for secondary organic aerosol formation, was one of the dominant constituents in both fine and coarse particles. Retene was the most abundant compound in all samples. Good correlations were obtained between OC and both aliphatic and PAH compounds. Pyrogenic processes, thermal release of biogenic com- pounds and secondary processing accounted for 97% of the apportioned PM2.5 levels.

关键词： WildfiresOrganic carbonOrganic compoundsBiomarkersParticulate matterPortugal

Partition coefficient prediction of Baker's yeast invertase in aqueous two phase systems using hybrid group method data handling neural network

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Chinese Journal of Chemical Engineering 2017年第5期25卷 652-657页

作者： Carlos Eduardo de Araújo Padilha Sérgio Dantas de Oliveira Júnior domingos Fabiano de Santana Souza Jackson Araújo de Oliveira Gorete Ribeiro de Macedo Everaldo Silvino dos Santos Laboratory of Biochemical Engineering Chemical Engineering DepartmentFederal University of Rio Grande do Norte (UFRN)

A hybrid GMDH neural network model has been developed in order to predict the partition coefficients of invertase from Baker's yeast. ATPS experiments were carried out changing the molar average mass of PEG(1500–6000 Da), p H(4.0–7.0), percentage of PEG(10.0–20.0 w/w), percentage of MgSO_4(8.0–16.0 w/w), percentage of the cell homogenate(10.0–20.0 w/w) and the percentage of MnSO_4(0–5.0 w/w) added as cosolute. The network evaluation was carried out comparing the partition coefficients obtained from the hybrid GMDH neural network with the experimental data using different statistical metrics. The hybrid GMDH neural network model showed better fitting(AARD = 32.752%) as well as good generalization capacity of the partition coefficients of the ATPS than the original GMDH network approach and a BPANN model. Therefore hybrid GMDH neural network model appears as a powerful tool for predicting partition coefficients during downstream processing of biomolecules.

关键词： Partitioning Invertase Aqueous Two Phase System GMDH Neural network