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E-Health Telecommunication Systems and Networks 2022年第3期11卷 101-108页

作者： Lídia Maria Lourençön Rodrigues Agia Cristina Broilo Rui Pedro Charters Lopes Rijo domingos alves Department of Social Medicine Ribeir&#227 o Preto Medical School University of S&#227 o Paulo Ribeir&#227 o Preto Brazil TopMed Healthcare and Telemedicine LTDA Florianópolis Brazil School of Technology and Management Polytechnic Institute of Leiria Leiria Portugal

With the advent of the pandemic, the Brazilian Ministry of Health structured in record time the Telehealth Service of the Unified Health System called TeleSUS, an ecosystem based on the intensive use of information technology involving automated mechanisms and a personalized health care center at distance. In addition to constant evaluations carried out in the service as a public health strategy, at clinical and epidemiological levels, the team involved in the project was also concerned with evaluating the system developed to enable the operation of remote care, from the conception of the organization of health actions to the technological development of the digital health tool. The objective of this study was to carry out an evaluation of a telehealth system, measuring the degree of satisfaction of users of health professionals regarding its usability and identifying factors that positively and/or negatively influence the evaluation.

关键词： System Evaluation Health Information Systems Telehealth

SACI Protocol: Preliminary Guidelines for the Development of Digital Health Technologies for Clinical Trials in Brazil

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E-Health Telecommunication Systems and Networks 2022年第3期11卷 85-100页

作者： Lídia Maria Lourençön Rodrigues Agia Jorge Luiz Dias Agia Rui Pedro Charters Lopes Rijo Valdes Roberto Bollela domingos alves Department of Social Medicine Ribeir&#227 o Preto Medical School University of S&#227 o Paulo Ribeir&#227 o Preto Brazil Postgraduate Program in Production Engineering UNIP S&#227 o Paulo Brazil Polytechnic Institute of Leiria Leiria Portugal Department of Internal Medicine Ribeir&#227 o Preto Medical School University of S&#227 o Paulo Ribeir&#227 o Preto Brazil

In the last decade, evidence-based medical practice has been supported on a large scale by computerized decision support tools, aiming to reduce diagnostic and therapeutic uncertainty, complementing the actions of the health professional. With technological developments, it is now possible to consider these systems as part of clinical intervention, both for the diagnosis and treatment of diseases. The literature has described the implementation of e-health tools, that is, technological innovations in the health area such as software, applications, serious games, among others, as a strategy to improve the process and adherence to treatment. However, there is still no standardized instrument in Brazil that can be used to guide the development, from the research phase, and the implementation of these tools as a health intervention, also impacting patient outcomes. With the objective of investigating a new therapeutic and preventive form, based on intervention with a computerized system, this work proposes the creation of guidelines for the registration and implementation of e-health tools as a clinical intervention. The proposal aims to be able to assist in the reporting standardization from the development stage to the application of the e-health tool helping in the treatment of diseases, registering all the experience lived in the research and applying it in different contexts of health.

关键词： Reporting Guidelines Clinical Trials Digital Health E-Health

Landesman–Lazer Type Conditions and Multiplicity Results for Nonlinear Elliptic Problems with Neumann Boundary Values

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Acta Mathematica Sinica,English Series 2014年第2期30卷 229-250页

作者： Edcarlos domingos DA SILVA Francisco Odair DE PAIVA Universidade Federal de Gois Departamento de Matemtica Universidade Federal de So Carlos Departamento de Matemtica

We establish the existence and multiplicity of solutions for Steklov problems under non- resonance or resonance conditions using variational methods. In our main theorems, we consider a weighted eigenvalue problem of ... 详细信息

关键词： Neumann-Steklov eigenvalue problems resonance Landesman-Lazer conditions

Quantitative Progress Evaluation of Post-stroke Patients Using a Novel Bimanual Cable-driven Robot

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Journal of Bionic Engineering 2021年第6期18卷 1331-1343页

作者： Thiago alves Rogério Sales Gonçalves Giuseppe Carbone Laboratory of Automation and Robotics School of Mechanical EngineeringFederal University of UberlândiaUberlândia38400-902Brazil Department of Mechanical Energy and Management EngineeringUniversity of Calabria87036RendeItaly

Rehabilitation is the most effective way to reduce motor impairments in post-stroke *** process demands several hours with a specialized *** resources and personnel shortages,the literature reports a high interest in robotic assisted rehabilitation ***,cable-driven robotic architectures are attracting significant research interest for post-stroke ***,the existing cable-driven robots are mostly unilateral devices allowing the rehabilitation only of the most affected *** leaves unaddressed the rehabilitation of bimanual activities,which are predominant within the common Activities of Daily Living(ADL).Thus,this paper presents a specific novel design to achieve bimanual rehabilitation tasks that has been named as BiCAR ***,this paper provides a full insight on the BiCAR system as well as on its dedicated developed software *** particular,BiEval software has been developed as based on a serious game strategy and a virtual reality environment to track the patient exercising duration,motion ranges,speeds,and forces over time for achieving a quantitative assessment of the rehabilitation ***,the paper presents the BiCAR/BiEval capabilities by referring to a pilot Randomized Controlled Trial(RCT).The clinical trials have been used to validate the BiCAR/BiEval in terms of engineering feasibility and user acceptance to achieve an innovative cost-oriented integrated hardware/software device for the bimanual assistive rehabilitation of post-stroke patients.

关键词： Cable-driven robots Low cost Stroke rehabilitation Bimanual Progress tracking Serious games

Degradative solvent extraction of subbituminous coal with deep eutectic solvent and effect of reaction conditions on products

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Carbon Resources Conversion 2023年第1期6卷 43-50页

作者： Pedro domingos Dauce Ryo Suzuki Ayano Nakamura Kenji Murakami Department of Material Science Graduate School of Engineering ScienceAkita University1-1 Tegata Gakuen-tyoAkita-shiAkita 010-8502Japan

A degradative solvent extraction method for upgrading low-rank coal was performed at 200-350◦C for 90 min to obtain a substance dissolved in the solvent at room temperature(Soluble).Because the resulting mixture exhibited a high carbon content without ash,it could be readily used as a ***,deep eutectic solvents(DESs)have attracted attention for improving the Soluble yield and decreasing the oxygen content in *** is known to cleave oxygen-containing functional groups in biomass and is considered effective for deoxidizing low-rank ***,DES was prepared by mixing choline chloride,FeCl3⋅6H2O,and Adaro subbituminous coal(AD)and then added to 1-methylnaphthalene(1-MN)in a non-polar solvent,followed by degradative solvent extraction in the range of 200-350◦*** effects of reaction temperature and added DES amount on the product yield and the composition were *** the reaction temperature and amount of DES added increased,the Soluble yield and carbon content *** was also found that the thermal decomposition temperature and oxygen content decreased with the increasing DES *** decrease indicates that DES promotes the deoxygenation and decomposition of AD and increases the soluble yield of the fuel source.

关键词： Low-rank coal Degradative solvent extraction Deep eutectic solvent Reaction temperature Upgrading

Nitric Oxide： A Multitasked Signaling Gas in Plants

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Molecular Plant 2015年第4期8卷 506-520页

作者： Patricia domingos Ana Margarida Prado Aloysius Wong Christoph Gehring Jose A. Feijo Instituto Gulbenkian de Ciencia P-2780-156 Oeiras Portugal Division of Biological and Environmental Sciences and Engineering 4700 King Abdullah University of Science and Technology Thuwa123955-6900 Kingdom of Saudi Arabia Department of Cell Biology and Molecular Genetics University of Maryland 0118 BioScience Research Building College Park MD 20742-5815 USA

Nitric oxide （NO） is a gaseous reactive oxygen species （ROS） that has evolved as a signaling hormone in many physiological processes in animals. In plants it has been demonstrated to be a crucial regulator of development, acting as a signaling molecule present at each step of the plant life cycle. NO has also been implicated as a signal in biotic and abiotic responses of plants to the environment. Remarkably, despite this plethora of effects and functional relationships, the fundamental knowledge of NO production, sensing, and transduction in plants remains largely unknown or inadequately characterized. In this review we cover the current understanding of NO production, perception, and action in different physiological sce- narios. We especially address the issues of enzymatic and chemical generation of NO in plants, NO sensing and downstream signaling, namely the putative cGMP and Ca^2＋ pathways, ion-channel activity modulation, gene expression regulation, and the interface with other ROS, which can have a profound effect on both NO accumulation and function. We also focus on the importance of NO in cell-cell communication during developmental processes and sexual reproduction, namely in pollen tube guidance and embryo sac fertilization, pathogen defense, and responses to abiotic stress.

关键词： nitric oxide (NO) reactive oxygen species (ROS) plant sexual reproduction cell communication pollen

Coincidence Wecken Property for Nilmanifolds

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Acta Mathematica Sinica,English Series 2019年第2期35卷 239-244页

作者： Daciberg GON?alves Peter WONG Departamento de Matemática-IME-Universidade de S?o Paulo Rua do Mat?o Department of Mathematics Bates College

Let f, g: X → Y be maps from a compact infra-nilmanifold X to a compact nilmanifold Y with dim X ≥ dim Y. In this note, we show that a certain Wecken type property holds, i.e., if the Nielsen number N(f, g) vanishes then f and g are deformable to be coincidence free. We also show that if X is a connected finite complex X and the Reidemeister coincidence number R(f, g) = ∞ then f ～ f' so that C(f', g) = {x ∈ X | f'(x) = g(x)} is empty.

关键词： Nielsen coincidence theory nilmanifolds

Using Extreme Value Theory to Assess the Mortality Risk of Tornado Outbreaks

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International Journal of Disaster Risk Science 2023年第1期14卷 14-25页

作者： Vilane Gonçalves Sales Eric Strobl Department of Economics University of Bern3012BernSwitzerland Oeschger Centre for Climate Change Research University of Bern3012BernSwitzerland World Trade Institute University of Bern3012BernSwitzerland

The majority of tornado fatalities occur during severe thunderstorm occurrences that produce a large number of tornadoes,termed tornado *** study used extreme value theory to estimate the impact of tornado outbreaks on fatalities while accounting for climate and demographic *** findings indicate that the number of fatalities increases with the increase of tornado ***,this study undertook a counterfactual analysis to determine what would have been the probability of a tornado outbreak under various climatic and demographic *** results of the counterfactual study indicate that the likelihood of increased mortality increases as the population forecast *** El Niño events,on the other hand,reduce the likelihood of further *** Niña events are expected to increase probability of fatalities.

关键词： Climate change Demography Extreme value theory Fatalities Tornado outbreaks

Multi-bump positive solutions for a logarithmic Schrödinger equation with deepening potential well

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Science China Mathematics 2022年第8期65卷 1577-1598页

作者： Claudianor O.alves Chao Ji Unidade Acadêmica de Matemática Universidade Federal de Campina GrandeCampina Grande 58429-900Brazil Department of Mathematics East China University of Science and TechnologyShanghai 200237China

This article concerns the existence of multi-bump positive solutions for the following logarithmic Schrödinger equation:{−Δu+λV(x)u=ulogu^(2)inRN,u∈H^(1)(R^(N)),where N≥1,⋋>0 is a parameter and the nonnegative continuous function V:ℝ^(N)→ℝhas potential wellΩ:=int V^(−1)(0)which possesses k disjoint bounded componentsΩ=∪^(k)_(j)=1Ω_(j).Using the variational methods,we prove that if the parameter⋋>0 is large enough,then the equation has at least 2^(k)−1 multi-bump positive solutions.

关键词： variational methods logarithmic Schrödinger equation multi-bump solutions deepening potential well

Effect of caffeine in the intraventricular hemorrhage of the preterm newborn

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Neural Regeneration Research 2023年第9期18卷 1942-1943页

作者： Pilar alves-Martinez Monica Garcia-Alloza Division of Physiology School of MedicineUniversidad de CadizCadizSpain Biomedical Research and Innovation Institute of Cádiz(INiBICA)Research Unit Puerta del Mar University Hospital University of CadizCadizSpain

There are around 15 million preterm newborns(PT) eve ry year(Atienza-Navarro et al., 2020).With these figures in mind,prematurity represents a major health problem worldwide and it is a leading cause of infant mortality,accounting for up to 35%of all deaths among newborns(Atienza-Navarro et al.,2020) and up to 18% of the deaths among children under 5 years of age.

关键词： newborn infant deaths