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Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children

World Journal of Gastroenterology 2012年第40期18卷 5729-5733页

作者： Salvatore Leonardi Andrea domenico Praticò Elena Lionetti Massimo Spina Giovanna Vitaliti Mario La Rosa Department of Pediatrics University of Catania

AIM： To compare intradermal （ID） and intramuscular （IM） booster doses, which have been used in healthy and high risk subjects, such as healthcare workers, haemodialysis patients, human immunodeficiency virus patients, and renal transplant recipients unresponsive to initial hepatitis B vaccination, in celiac individuals. METHODS： We conducted our study on 58 celiac pa- tients, vaccinated in the first year of life, whose blood analysis had showed the absence of protective hepati- tis B virus （HBV） antibodies. All patients had received the last vaccine injection at least one year before study enrolment and they had been on a gluten free diet for at least 1 year. In all patients we randomly performed an HBV vaccine booster dose by ID or IM route. Thirty celiac patients were revaccinated with recombinant hepatitis B vaccine （Engerix B） 2 μg by the ID route, while 28 celiac patients were revaccinated with Engerix B 10 μg by the IM route. Four weeks after every boost- er dose, the anti-hepatitis B surface （HBs） antibody titer was measured by an enzyme-linked immune- adsorbent assay. We performed a maximum of three booster doses in patients with no anti-HBs antibodies after the first or the second vaccine dose. The cut off value for a negative anti-HBs antibody titer was 10 IU/*** with values between 10 and 100 IU/L were considered ＂low responders＂ while patients with an antibody titer higher than 1000 IU/L were considered ＂high responders＂. RESULTS： No significant difference in age, gender, du- ration of illness, and years of gluten intake was found between the two groups. We found a high percent- age of ＂responders＂ after the first booster dose （ID = 76.7%, IM = 78.6%） and a greater increase after the third dose （ID = 90%, IM = 96.4%） of vaccine in both groups. Mloreover we found a significantly higher num- ber of high responders （with an anti-HBs antibody titer 〉 1000 IU/L） in the ID （40%） than in the IM （7.1%） group, and this difference was evident after the firs

关键词： Hepatitis B virus Non responders Intradermal route Intramuscular route Celiac disease

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Assessment of compost and three biochars associated with Ailanthus altissima(Miller)Swingle for lead and arsenic stabilization in a post-mining Technosol

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Pedosphere 2021年第6期31卷 944-953页

作者： Ibrahim ALIDOU-ARZIKA Manhattan LEBRUN Florie MIARD Romain NANDILLON Gulriz BAYCU Sylvain BOURGERIE domenico MORABITO University of Orleans INRA USC1328LBLGC EA1207Orleans 45067(France) Division of Botany Department of BiologyFaculty of ScienceIstanbul UniversityIstanbul 34134(Turkey) Department of Bioscience and Territory University of MolisePesche 86090(Italy)

The elevated presence of metal(loid)s in the environment significantly impacts ecosystems and human health and is generally largely due to industrial and mining ***,in the current study,we investigated and proposed an environmentally friendly method(phytomanagement)aimed at reducing the negative impacts associated with metal(loid)pollution through the use of soil amendments(biochar and compost)to permit Ailanthus altissima growth on a highly contaminated mining Technosol,with arsenic(As)and lead(Pb)contents of 539.06 and 11453 mg kg^(-1),*** objective was to examine the impacts of three biochars and compost on i)the physicochemical characteristics of soil,ii)metal(loid)immobilization in soil,and iii)*** *** revealed that the application of biochar as a soil amendment improved soil conditions by increasing soil electrical conductivity,pH,and water-holding ***,concomitantly,we observed a large reduction(99%)in Pb mobility and availability following application of the hardwood biochar in combination with compost(HBCP).Thus,this combined soil amendment was most effective in promoting *** *** addition,the HBCP treatment prevented As translocation in the upper parts of plants,although soil pore water As concentration was not diminished by amendment application.

关键词： amendment metal(loid) mining soil phytomanagement soil pore water

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Predictors of early and late hepatocellular carcinoma recurrence

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World Journal of Gastroenterology 2023年第8期29卷 1243-1260页

作者： Riccardo Nevola Rachele Ruocco Livio Criscuolo Angela Villani Maria Alfano domenico Beccia Simona Imbriani Ernesto Claar domenico Cozzolino Ferdinando Carlo Sasso Aldo Marrone Luigi Elio Adinolfi Luca Rinaldi Department of Advanced Medical and Surgical Sciences University of Campania“Luigi Vanvitelli”Naples 80138Italy Internal Medicine and Hepatology Unit Ospedale Evangelico BetaniaNaples 80147Italy

Hepatocellular carcinoma(HCC)is the most frequent liver neoplasm,and its incidence rates are constantly *** the availability of potentially curative treatments(liver transplantation,surgical resection,thermal ablation),long-term outcomes are affected by a high recurrence rate(up to 70%of cases 5 years after treatment).HCC recurrence within 2 years of treatment is defined as“early”and is generally caused by the occult intrahepatic spread of the primary neoplasm and related to the tumor burden.A recurrence that occurs after 2 years of treatment is defined as“late”and is related to de novo HCC,independent of the primary *** HCC recurrence has a significantly poorer prognosis and outcome than late *** pathogenesis corresponds to different predictors of the risk of early or late *** adequate knowledge of predictive factors and recurrence risk stratification guides the therapeutic strategy and post-treatment *** at high risk of HCC recurrence should be referred to treatments with the lowest recurrence rate and when standardized to combined or adjuvant therapy *** review aimed to expose the recurrence predictors and examine the differences between predictors of early and late recurrence.

关键词： Hepatocellular carcinoma Early recurrence Late recurrence Predictors Liver transplant Liver resection Thermal ablation

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Contrasting microscopic interactions determine the properties of water/methanol solutions

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Frontiers of physics 2018年第1期13卷 51-56页

作者： Carmelo Corsaro Francesco Mallamace Sebastiano Vasi Sow-Hsin Chen H. Eugene Stanley domenico Mallamace CNR-IPCF Messina Istituto per i Processi Chimico-Fisici Viale F. Stagno D'Alcontres 37 98158 Messina Italy Dipartimento MIFT Sezione di Fisica Universita di Messina Viale F. Stagno D'Alcontres 31 98166 Messina Italy Department of Nuclear Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA Center for Polymer Studies and Department of Physics Boston University Boston MA 02215 USA Consorzio interuniversitario per lo sviluppo dei Sistemi a Grande Interfase - CSGI Via della Lastruccia 3 50019 Sesto Fiorentino Firenze Italy

Herein we study the different microscopic interactions occurring in water/methanol solutions at dif- ferent methanol molar fractions, using NMR spctroscopy. Temperature was found to determine which interaction dominates. It was found that the mixing between water and methanol is non-ideal because of the presence of interactions like hydrophobicity and hydrophilicity. These results indicate that the competition between hydrophilic and hydrophobic interactions is different in different thermal regions, and that the physical properties of the solution are determined by the character of the solution itself, which in turn depends on the mole fraction of methanol and on the temperature.

关键词： aqueous solutions hydrophobicity NMR hydrophilicity

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Adjusting CA19-9 values to predict malignancy in obstructive jaundice:Influence of bilirubin and C-reactive protein

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World Journal of Gastroenterology 2012年第31期18卷 4150-4155页

作者： Gaetano La Greca Maria Sofia Rosario Lombardo Saverio Latteri Agostino Ricotta Stefano Puleo domenico Russello Department of Surgical Sciences Organ Transplantation and Advanced TechnologiesUniversity of Catania95125 CataniaItaly

AIM:To find a possible relationship between inflammation and CA19-9 tumor marker by analyzing data from patients with benign jaundice(BJ) and malignant jaundice(MJ).METHODS:All patients admitted for obstructive jaundice,in the period 2005-2009,were prospectively enrolled in the study,obtaining a total of 102 *** admission,all patients underwent complete standard blood test examinations including C-reactive protein(CRP),bilirubin,*** were considered eligible for the study when they presented obstructive jaundice confirmed by instrumental examinations and increased serum bilirubin levels(total bilirubin > 2.0 mg/dL).The standard cut-off level for CA19-9 was 32 U/mL,whereas for CRP this was 1.5 mg/*** CA19-9 level was adjusted by dividing it by the value of serum bilirubin or by the CRP *** patients were divided into 2 groups,MJ and BJ,and after the adjustment a comparison between the 2 groups of patients was ***,specificity and positive predictive values were calculated before and after the ***:Of the 102 patients,51 were affected by BJ and 51 by *** CA19-9 levels were found in 71.7% of the *** the group of 51 BJ patients there were 29(56.9%) males and 22(43.1%) females with a median age of 66 years(range 24-96 years),whereas in the MJ group there were 24(47%) males and 27(53%) females,with a mean age of 70 years(range 30-92 years).Pathologic CA19-9 serum level was found in 82.3% of *** levels were pathologic in 66.6% of the patients with BJ and in 49% with *** and CA19-9 average levels were significantly higher in MJ compared with BJ(P = 0.000 and P = 0.02),while the CRP level was significantly higher in BJ(P = 0.000).Considering a CA19-9 cut-off level of 32 U/mL,82.3% in the MJ group and 54.9% in the BJ group were positive for CA19-9(P = 0.002).A CA19-9 cut-off of 100 U/mL increases the difference between the two groups:35.3% in BJ and 68.6% in MJ(P = 0.0007).Adjusting the CA1

关键词： Tumor marker CA19-9 C-reactive protein Bilirubin Pancreato-biliary malignancy Biliary stones

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Localization of Seed Oil Body Proteins in Tobacco Protoplasts Reveals Specific Mechanisms of Protein Targeting to Leaf Lipid Droplets

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Journal of Integrative Plant Biology 2011年第11期53卷 858-868页

作者： Stefania De domenico Stefania Bonsegna Marcello Salvatore Lenucci Palmiro Poltronieri Gian Pietro Di Sansebastiano Angelo Santino Institute of Sciences of Food Production C.N.R. Unit of Lecce via Monteroni Lecce 73100 Italy Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali Universita` del Salento via Monteroni Lecce 73100 Italy

Oleosin, caleosin and steroleosin are normally expressed in developing seed cells and are targeted to oil bodies. In the present work, the cDNA of each gene tagged with fluorescent proteins was transiently expressed into tobacco protoplasts and the fluorescent patterns observed by confocal laser scanning microscopy. Our results indicated clear differences in the endocellular localization of the three proteins. Oleosin and caleosin both share a common structure consisting of a central hydrophobic domain flanked by two hydrophilic domains and were correctly targeted to lipid droplets （LD）, whereas steroleosin, characterized by an N-terminal oil body anchoring domain, was mainly retained in the endoplasmic reticulum （ER）. Protoplast fractionation on sucrose gradients indicated that both oleosin and caleosin- green fluorescent protein （GFP） peaked at different fractions than where steroleosin-GFP or the ER marker binding immunoglobulin protein （BiP）, were recovered. Chemical analysis confirmed the presence of triacylglycerols in one of the fractions where oleosin-GFP was recovered. Finally, only oleosin- and caleosin-GFP were able to reconstitute artificial oil bodies in the presence of triacylglycerols and phospholipids. Taken together, our results pointed out for the first time that leaf LDs can be separated by the ER and both oleosin or caleosin are selectively targeted due to the existence of selective mechanisms controlling protein association with these organelles.

关键词： artificial oil bodies caleosin endoplasmic reticulum lipid droplets oleosin protein sorting steroleosin.

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钢中夹杂物的常规定性分析(英文)

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冶金分析 2007年第4期27卷 1-6页

作者： TORTORETO Giampietro SCIABOLETTA domenico ROTICIANI Silvio ThyssenKrupp Acciai Speciali Terni TerniItaly

对于钢中夹杂物的研究,目前大多数工作是采用光学显微镜测量抛光的钢样表面的方法实现的。今后若干年里,脉冲分布解析原子发射光谱法(PDA-OES)的分辩率有望得到提高,可以获得夹杂物的尺寸、颗粒数以及空间分布的信息。在应用电子探针微... 详细信息

对于钢中夹杂物的研究,目前大多数工作是采用光学显微镜测量抛光的钢样表面的方法实现的。今后若干年里,脉冲分布解析原子发射光谱法(PDA-OES)的分辩率有望得到提高,可以获得夹杂物的尺寸、颗粒数以及空间分布的信息。在应用电子探针微区分析(EPMA)或PDA-OES技术的自动监控过程中,是对抛光的钢表面进行扫描分析。虽然可以获得夹杂物的截面面积及其边界信息,但是这些夹杂物形状的成因却不明显。由于夹杂物的形状和表面特性可以揭示出某类夹杂物的形成过程,因此获知夹杂物的形成过程就可以得到夹杂物的形成、生长和演变等相关信息。本文的目的就是研究钢中夹杂物分析中SEM/EDS技术和OES/PDA技术的相关性。应用PDA-OES技术对不锈钢及碳钢中夹杂物进行了定性分析。在此基础上,通过峰高和峰强度与参考物质的比较,将有望实现对夹杂物的半定量或定量分析。

关键词：不锈钢脉冲分布解析原子发射光谱非金属夹杂物

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Legacy of neuropsychiatric symptoms associated with past COVID-19 infection:A cause of concern

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World Journal of Psychiatry 2022年第6期12卷 773-778页

作者： domenico De Berardis Francesco Di Carlo Massimo Di Giannantonio Mauro Pettorruso Mental Health NHSASL 4 TeramoTeramo 64100Italy Neurosciences and Imaging and Clinical Sciences University"G.D'Annunzio"Chieti 66100Italy

Although primarily affecting the respiratory system,growing attention is being paid to the neuropsychiatric consequences of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** and sub-acute neuropsychiatric manifestations of coronavirus disease 2019(COVID-19)disease and their mechanisms are better studied and understood currently than they had been when the pandemic began;however,many months or years will be necessary to fully comprehend how significant the consequences of such complications will *** this editorial,we discuss the possible long-term sequelae of the COVID-19 pandemic,deriving our considerations on experiences drawn from past coronaviruses’outbreaks,such as the SARS and the middle east respiratory syndrome,and from the knowledge of the mechanisms of neurotropism and invasiveness of *** the global spread of COVID-19 and the vast number of people affected,to date amounting to many millions,the matter of this pandemic’s neuropsychiatric legacy appears *** health monitoring strategies and early interventions seem to be necessary to manage the possible emergence of a severe wave of neuropsychiatric distress among the survivors.

关键词： COVID-19 Neuropsychiatric symptoms Neuropsychiatric sequelae Mental health Post-traumatic stress disorder Depression

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Digital assets rights management through smart legal contracts and smart contracts

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Blockchain(Research and Applications) 2023年第3期4卷 64-73页

作者： Enrico Ferro Marco Saltarella domenico Rotondi Marco Giovanelli Giacomo Corrias roberto Moncada Andrea Cavallaro Alfredo Favenza Links Foundation 10138 TurinItaly FINCONS SpA 70132 BariItaly freelance consultant FINCONS GROUP AG Lugano6900 Switzerland

Intellectual property rights(IPR)management needs to evolve in a digital world where not only companies but also many independent content creators contribute to our culture with their art,music,and *** this respect,blockchain has recently emerged as a promising infrastructure,providing a trustworthy and immutable environment through the use of smart contracts,which may enable more agile management of digital rights and streamline royalty ***,no widespread consensus has been reached on the ability of this technology to adequately manage and transfer *** paper presents an innovative approach to digital rights management developed within the scope of an international research endeavour co-financed by the European Commission named *** approach proposes the combined usage of smart legal contracts and blockchain smart contracts to take care of the legally binding contractual aspects of IPR and,at the same time,the need for notarization,rights transfer,and royalty *** work being conducted represents a contribution to advancing the current literature on IPR management that may lead to an improved and fairer monetization process for content creators as a means of individual empowerment.

关键词： Blockchain Consumer protection Contract law Copyright protection Intellectual property Intellectual property rights(IPR) Non-fungible token(NFT) Smart legal contract Smart contract Tokenomics

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molecular pathology of intraductal papillary mucinous neoplasms of the pancreas

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World Journal of Gastroenterology 2014年第29期20卷 10008-10023页

作者： Marina Paini Stefano Crippa Stefano Partelli Filippo Scopelliti domenico Tamburrino Andrea Baldoni Massimo Falconi Department of Surgery University of Verona Division of Pancreatic Surgery Ospedali RiunitiUniversità Politecnica delle Marche Division of Pancreatic Surgery Casa di Cura Dott.Pederzoli37019 Peschiera del Garda (VR)Italy

Since the first description of intraductal papillary mucinous neoplasms(IPMNs)of the pancreas in the eighties,their identification has dramatically increased in the last decades,hand to hand with the improvements in diagnostic imaging and sampling techniques for the study of pancreatic ***,the heterogeneity of IPMNs and their malignant potential make difficult the management of these *** objective of this review is to identify the molecular characteristics of IPMNs in order to recognize potential markers for the discrimination of more aggressive IPMNs requiring surgical resection from benign IPMNs that could be *** briefly summarize recent research findings on the genetics and epigenetics of intraductal papillary mucinous neoplasms,identifying some genes,molecular mechanisms and cellular signaling pathways correlated to the pathogenesis of IPMNs and their progression to *** knowledge of molecular biology of IPMNs has impressively developed over the last few years.A great amount of genes functioning as oncogenes or tumor suppressor genes have been identified,in pancreatic juice or in blood or in the samples from the pancreatic resections,but further researches are required to use these informations for clinical intent,in order to better define the natural history of these diseases and to improve their management.

关键词： Intraductal papillary mucinous neoplasm Pancreas Pancreatic cancer Molecular pathology Oncogene Tumor suppressor gene Dysplasia Malignant transformation

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