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Environmental Data Acquisition, Elaboration and Integration： Preliminary Application to a Vulnerable Mountain Landscape and Village （Novalesa, NW Italy）

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Engineering 2018年第5期4卷 635-642页

作者： Massimiliano Lega Marco Casazza Laura Turconi Fabio Luino domenico Tropeano Gabriele Savio Sergio Ulgiati Theodore Endreny Department of Engineering Parthenope University of Napoli Naples 80143 Italy Institute for Hydro-Geological Protection Research National Research Council (CNR-IRPI) Turin 10135 Italy Department of Science and Technology Parthenope University of Napoli Naples 80143 Italy Department of Environmental Resources Engineering College of Environmental Science and Forestry State University of New York Syracuse NY 13210 USA

Climate conditions play a crucial role in the survival of mountain communities, whose survival already critically depends on socioeconomic factors. In the case of montane areas that are prone to natural haz-ards, such as alpine slope failure and debris flows, climatic factors exert a major influence that should be considered when creating appropriate sustainable scenarios. In fact, it has been shown that climate change alters the availability of ecosystem services （ES）, thus increasing the risks of declining soil fertility and reduced water availability, as well as the loss of grassland, potential shifts in regulatory services （e.g., protection from natural hazards）, and cultural services. This study offers a preliminary discussion on a case study of a region in the Italian Alps that is experiencing increased extreme precipitation and erosion, and where an isolated and historically resilient community directly depends on a natural resource econ- omy. Preliminary results show that economic factors have influenced past population trends of the Novalesa community in the Piemonte Region in northwest Italy. However, the increasing number of rock fall and debris flow events, which are triggered by meteo-climatic factors, may further influence the livelihood and weflbeing of this community, and of other similar communities around the world, Therefore, environmental monitoring and data analysis will be important means of detecting trends in landscape and climate change and choosing appropriate planning options. Such analysis, in turn, would ensure the survival of about 10% of the global population, and would also represent a possibility for future economic development in critical areas prone to poverty conditions.

关键词： Environmental data elaboration Climate change Mountain community Italy Resilience Socioecological system Hydrogeological risk

Acute biliary pancreatitis and cholecystolithiasis in a child: one time treatment with laparoendoscopic "Rendez-vous" procedure

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World Journal of Gastroenterology 2006年第11期12卷 1782-1785页

作者： Gaetano La Greca Michele Di Blasi Francesco Barbagallo Manuela Di Stefano Saverio Latteri domenico Russello Department of Surgical Sciences Transplantation and Advanced Technologies University of Catania Cannizzaro HospitalVia Messina 829-95100CataniaItaly

Acute biliary pancreatitis （ABP） is rare in childhood and endoscopic sphincterotomy should be avoided in the child due to the risk of both early and late complications but, when necessary, the optimal timing between endoscopic procedure and cholecystectomy is still uncertain, A nine years old child with acute biliary pancreatitis underwent successfull laparo-endoscopic ＂Rendez-Vous＂ procedure in which endoscopic drainage of the common bile duct and laparoscopic cholecystectomy were performed simultaneously. This is the first case reported of laparo-endoscopic RendezoVous in a child. The excellent outcome of this patient and the review of the literature concerning other available options for the treatment of such cases suggest that this procedure offers great advantages, especially in children, of reducing the required number of treatments, the risk of ineffectiveness, the number of anaesthesia, the length of hospital stay and the risk of iatrogenic morbidity.

关键词： Acute biiiary pancreatitis Gallstones ERCP Laparoscopic cholecystectomy Endoscopic sphyncterotomy

International visibility of Armenian domestic journals:the role of scientific diaspora

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数据与情报科学学报:英文版 2023年第2期8卷 93-117页

作者： Edita Gzoyan Aram Mirzoyan Anush Sargsyan Mariam Yeghikyan domenico AMaisano Shushanik Sargsyan Center for Scientific Information Analysis and Monitoring(CSIAM) Institute for Informatics and Automation ProblemsNational Academy of Sciences of the Republic of Armenia(IIAP NAS RA).1 Paruyr Sevak str.0014 YerevanArmenia Department of Management and Production Engineering(DIGEP) Politecnico di Torino(Italy)TurinItaly

Purpose:Nearly 122 scientific journals are currently being published in Armenia-of which only six are indexed by WoS and/or Scopus *** majority of the national journals are published in the Armenian language,solely possessing abstracts written in English,although there are also English-language and multi-language journals with articles not only in Armenian but also in other foreign *** aim of this article is to study the visibility of the(non-indexed)national Armenian journals in the WoS database through citation analy*** consideration of the existence of a relevant Armenian“diaspora”in the world,this article also attempts to estimate its impact in terms of citation ***/methodology/approach:For this end,we have identified citations to the national/domestic Armenian journals in the WoS database in comparison with the share of citations received from“diaspora”researchers(researchers of Armenian origin born in foreign countries and those originally from Armenia who have emigrated to foreign countries).Findings:Among the 116 Armenian domestic journals analyzed(not indexed by WoS),only 47 were found to be cited in *** these journals,almost 12%are citations by“diaspora”researchers,most of which concern Social Science and Humanities *** limitations:Although the surnames of Armenians end with-i(y)an,sometimes,the Diaspora Armenians,surnames are changed or modified or they are not ending with-i(y)an,in this case we may fail to identify *** implications:This study can help to build new,more deep and comprehensive relations with scientific ***/value:This study offers a new understanding of multifaced research collaboration with scientific diasporas and their role in internationalization of domestic journals.

关键词： Citation analysis National/domestic journal Armenian diaspora Scientific diaspora

Dynamical changes in hydration water accompanying lysozyme thermal denaturation

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Frontiers of physics 2015年第5期10卷 35-41页

作者： Francesco Mallamace Carmelo Corsaro domenico Mallamace Nicola Cicero Sebastiano Vasi Giacomo Dugo H. Eugene Stanley CNR-IPCF Messina Istituto per i Processi Chimico-Fisici Viale F. Stagno D'Alcontres 37 98158 Messina Italy Dipartimento di Fisica e Scienze della Terra Universitd di Messina Viale F. Stagno D'Alcontres 31 98166 Messina Italy Center for Polymer Studies and Department of Physics Boston University Boston MA 02215 USA Dipartimento di Scienze dell'Ambiente della Sicurezza del Territorio degli Alimenti e della Salute Universita di Messina Viale F. Stagno d'Alcontres 31 98166 Messina Italy

We study the dynanfics of the first hydration shell of lysozyme to determine the role of hydra- tion water that accompanies lysozyme thermal denaturation. We use nuclear magnetic resonance spectroscopy to investigate both the translational and rotational contributions. Data on proton self-diffusion and reorentational correlation time indicate that the kinetics of the lysozyme fold- ing/unfolding process is controlled by the dynamics of the water molecules in the first hydration shell. When the hydration water dynamics change, because of the weakening of the hydrogen bond network, the three-dimensional structure of the lysozyme is lost and denaturation is triggered. Our data indicates that at temperatures above approximately 315 K, water behaves as a simple liquid and is no longer a good solvent.

关键词： lysozyme unfolding hydration water NMR correlation time solvent dynamics

Diagnostic accuracy of enhanced liver fibrosis test to assess liver fibrosis in patients with chronic hepatitis C

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Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 500-507页

作者： Roberto Catanzaro Michele Milazzo Silvia Arona Chiara Sapienza Dario Vasta domenico Arcoria Francesco Marotta Department of Medical and Pediatric Sciences Institute of Internal Medicine "A. Francaviglia"Section of Gastro-enterologyUniversity of Catania"G. Rodolico" Hospital Laboratory analysis "MedLab-Analisi Cliniche" Specialist in diabetes and metabolic diseases ReGenera Research Group for Aging Intervention

BACKGROUND:The prognosis and clinical management of patients with chronic liver diseases are closely related to the severity of liver *** biopsy is considered the gold standard for the staging of liver ***,it is an invasive test sometimes related to *** study aimed to assess the diagnostic value of enhanced liver fibrosis(ELF) test to predict liver fibrosis in patients with chronic hepatitis ***:This study included 162 patients with liver disease and 67 healthy *** acid,tissue inhibitor of matrix metalloproteinase type 1,and amino-terminal propeptide type III procollagen were measured by enzymelinked immunosorbent assay with the ELF test ADVIA Centaur(Siemens Healthcare Diagnostics Inc.).Fibrosis stage was determined using the Metavir scoring ***:In our study,for the diagnosis of significant fibrosis(Metavir F≥2) a cut-off value >7.72 provides a sensitivity of 93.0% and a specificity of 83.0%.The areas under the receiver operator characteristic curve,sensitivity,specificity,and positive and negative predictive values were 0.94,93.3%,81.0%,93.3%,and 81.0%,respectively(P9.3 provides a sensitivity of 93.0% and a specificity of 86.0%.The areas under the receiver operator characteristic curve,sensitivity,specificity,and positive and negative predictive values were 0.94,79.1%,90.8%,75.6%,and 92.3%,respectively(P<0.001).CONCLUSIONS:The ELF test is a promising non-invasive method for assessing liver fibrosis in patients with chronic hepatitis *** is effective in the diagnosis of both fibrosis and cirrhosis.

关键词： enhanced liver fibrosis test non-invasive diagnosis liver fibrosis blood marker

Optical coherence tomography angiography in retinal cavernous hemangioma

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1945-1946页

作者： Gilda Cennamo Francesca Amoroso domenico Solari Mariacristina Alfier Giuseppe de Crecchio Eye Clinic Department of Public HealthUniversity of Naples Fedefico IINaples 80100Italy Eye Clinic Department of NeurosciencesReproductive Sciences and DentistryUniversity of Naples Federico IINaples 80100Italy Division of Neurosurgery Department of NeurosciencesReproductive Sciences and DentistryUniversity of Naples Federico IINaples 80100Italy UOC Ophthalmology Pellegrini Hospital Naples 80100Italy

Citation： Cennamo G, Amoroso F, Solari D, Alfieri MC, de Crecchio G. Optical coherence tomography angiography in retinal cavernous hernangioma, lnt J Ophthalmol 2017; 10（12）： 1945-1946

关键词： Figure Optical coherence tomography angiography in retinal cavernous hemangioma

Estrogens and the pathophysiology of the biliary tree

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World Journal of Gastroenterology 2006年第22期12卷 3537-3545页

作者： domenico Alvaro Maria Grazia Mancino Paolo Onori Antonio Franchitto Gianfranco Alpini Heather Francis Shannon Glaset Eugenio Gaudio Division of Gastroenterology University of Rome "La Sapienza"RomeItaly University of Rome "La Sapienza"Polo PontinoLatinaItaly Division of Gastroenterology University of Rome "La Sapienza"RomeItaly Department of Experimental Medicine Section of Human and Clinical Anatomy State University of L'AquilaL'AquilaItaly Department of Anatomy University of Rome "La Sapienza" RomeItaly Department of Medicine The Texas A&M University System Health Science Center College of Medicine Scott & White HospitalTempleTX 76504United States ResearchCentral Texas Veterans Health Care SystemScott & White HospitalTempleTX 76504United States Systems Biology and Translational MedicineThe Texas A&M University System Health Science Center College of MedicineTX 76504United States Division of R&E Scott & White Hospital TempleTX 76504United States Eugenio Gaudio Department of Anatomy University of Rome "La Sapienza"RomeItaly

The scientific framework concerning estrogen effects on different tissues has expanded enormously during the last decades, when estrogen receptor （ER） subtypes were identified. Estrogens are not only essential for the female reproductive system, but they also control fundamental functions in other tissues including the cardiovascular system, bone, brain and liver. Recently, estrogens have been shown to target the biliary tree, where they modulate the proliferative and secretory activities of cholangiocytes, the epithelial cells lining bile ducts. By acting on both estrogen receptors （ER-α） and （ER-β） subtypes, and by activating either genomic or non-genomic pathways, estrogens play a key role in the complex loop of growth factors and cytokines, which modulates the proliferative response of cholangiocytes to damage. Specifically, estrogens activate intracellular signalling cascades JERK1/2 （extracellular regulated　kinases 1/2, PI3-kinase/AKT （phosphatidylinositol-3＇ kinase/AKT）] typical of growth factors such as insulin like growth factor （IGF1）, nerve growth factor （NGF） and vascular endothelial growth factor （VEGF）, thus potentiating their action. In addition, estrogens stimulate the secretion of different growth factors in proliferating cholangiocytes. This review specifically deals with the recent advances related to the role and mechanisms by which estrogens modulate cholangiocyte functions in normal and pathological conditions.

关键词： Estrogens Cholangiocytes IGF1 Proliferation APDKD PBC Cholangiocarcinoma SERMs

Sympathetic nervous system activation and heart failure:Current state of evidence and the pathophysiology in the light of novel biomarkers

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World Journal of Cardiology 2020年第8期12卷 373-408页

作者： Josip Anđelo Borovac domenico D'Amario Josko Bozic Duska Glavas Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Working Group on Heart Failure of Croatian Cardiac Society Zagreb 10000Croatia Department of Cardiovascular and Thoracic Sciences IRCCS Fondazione Policlinico A.GemelliUniversita Cattolica Sacro CuoreRome 00168Italy Clinic for Cardiovascular Diseases University Hospital of SplitSplit 21000Croatia

Heart failure(HF)is a complex clinical syndrome characterized by the activation of at least several neurohumoral pathways that have a common role in maintaining cardiac output and adequate perfusion pressure of target organs and *** sympathetic nervous system(SNS)is upregulated in HF as evident in dysfunctional baroreceptor and chemoreceptor reflexes,circulating and neuronal catecholamine spillover,attenuated parasympathetic response,and augmented sympathetic outflow to the heart,kidneys and skeletal *** these sympathoexcitatory effects on the cardiovascular system are sustained chronically they initiate the vicious circle of HF progression and become associated with cardiomyocyte apoptosis,maladaptive ventricular and vascular remodeling,arrhythmogenesis,and poor prognosis in patients with *** detrimental effects of SNS activity on outcomes in HF warrant adequate diagnostic and treatment ***,this review summarizes basic physiological concepts about the interaction of SNS with the cardiovascular system and highlights key pathophysiological mechanisms of SNS derangement in ***,special emphasis in this review is placed on the integrative and up-to-date overview of diagnostic modalities such as SNS imaging methods and novel laboratory biomarkers that could aid in the assessment of the degree of SNS activation and provide reliable prognostic information among patients with HF.

关键词： Autonomic nervous system Biomarkers Catecholamines Catestatin Chromaffin system Epinephrine Heart failure Myocardial failure Norepinephrine Sympathetic nervous system

Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction

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Journal of Geriatric Cardiology 2015年第4期12卷 346-352页

作者： Flora Pirozzi AntoneUa Paglia Laura Sasso Pasquale Abete Angelo Carlomagno Carlo G Tocchetti domenico Bonaduce Mario Petretta Department of Translational Medical Sciences Section of Internal Medicine Federico Ⅱ University Naples ltaly

Objective Doppler derived mitral peak early diastolic filling velocity to deceleration time ratio （E/DT） has been proposed as parameter for predicting prognosis in general population. This study prospectively investigates the incremental prognostic value of E/DT over clinical, conven- tional eehocardiographic and mitral-Doppler variables in patients hospitalized for decompensated heart failure （HF）. Methods We analyzed 95 HF patients （mean age 64.8 ± 12.2 years） hospitalized at our institution from January 2010 to March 2012. The primary end-point was cardiac death or hospitalization, whichever occurred first. Cox regression analysis was performed to identify significant predictors of outcomes. Results During follow-up （median 37.7 months） 13 patients died and 44 were hospitalized for a cardiac event. At univariable analysis, New York Heart Association （NYHA） functional class, furosemide dosage, lateral tricuspidal annular plane systolic excursion, deceleration lime and E/DT were predictive of outcome. At multivariable analysis, E/DT was the only predictor of prognosis （hazard ratio = 1.02, P = 0.018）, giving incremental prognostic information to clinical and other echocardio-graphic measures （global chi-square from 15.4 to 25.2; P = 0.032）. Conclusions FJDT gives independent and incremental prognostic information in HF patients.

关键词： Echocardiographic evaluation Left venlricular function Risk stratification