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Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells

World Journal of Gastroenterology 2020年第33期26卷 4900-4918页

作者： Michela Anna Polidoro Joanna Mikulak Valentina Cazzetta Ana Lleo domenico mavilio Guido Torzilli Matteo Donadon Hepatobiliary Immunopathology Laboratory Humanitas Clinical and Research Center–IRCCSRozzano 20089MilanItaly Laboratory of Clinical and Experimental Immunology Humanitas Clinical and Research Center-IRCCSRozzano 20089MilanItaly Department of Medical Biotechnologies and Translational Medicine(BioMeTra) University of MilanRozzano 20089MilanItaly Department of Biomedical Science Humanitas UniversityPieve Emanuele 20090MilanItaly Department of Internal Medicine Humanitas Clinical and Research Center–IRCCSRozzano 20089MilanItaly Department of Hepatobiliary and General Surgery Humanitas Clinical and Research Center-IRCCSRozzano 20089MilanItaly

In the last years,several studies have been focused on elucidate the role of tumor microenvironment(TME)in cancer development and *** TME,cells from adaptive and innate immune system are one of the main abundant *** dynamic interactions between immune and cancer cells lead to the activation of complex molecular mechanisms that sustain tumor *** important cross-talk has been elucidate for several kind of tumors and occurs also in patients with liver cancer,such as hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA).Liver is well-known to be an important immunological organ with unique ***,in normal conditions,the rich immune-infiltrating cells cooperate with non-parenchymal cells,such as liver sinusoidal endothelial cells and Kupffer cells,favoring self-tolerance against gut *** presence of underling liver immunosuppressive microenvironment highlights the importance to dissect the interaction between HCC and iCCA cells with immune infiltrating cells,in order to understand how this cross-talk promotes tumor *** attention is,in fact,focused on immune-based therapy for these tumors,as promising approach to counteract the intrinsic anti-tumor activity of this *** this review,we will examine the key pathways underlying TME cell-cell communications,with deeper focus on the role of natural killer cells in primary liver tumors,such as HCC and iCCA,as new opportunities for immune-based therapeutic strategies.

关键词： Primary liver cancer Natural killer cells Tumor microenvironment Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Immune cells

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