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Resilience Against Replay Attacks:A Distributed Model Predictive Control Scheme for Networked Multi-Agent Systems

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IEEE/CAA Journal of Automatica Sinica 2021年第3期8卷 628-640页

作者： Giuseppe Franzè Francesco Tedesco domenico Famularo DIMES Department University of CalabriaArcavacata di Rende 87036Italy

In this paper,a resilient distributed control scheme against replay attacks for multi-agent networked systems subject to input and state constraints is *** methodological starting point relies on a smart use of predictive arguments with a twofold aim:1)Promptly detect malicious agent behaviors affecting normal system operations;2)Apply specific control actions,based on predictive ideas,for mitigating as much as possible undesirable domino effects resulting from adversary ***,the multi-agent system is topologically described by a leader-follower digraph characterized by a unique leader and set-theoretic receding horizon control ideas are exploited to develop a distributed algorithm capable to instantaneously recognize the attacked ***,numerical simulations are carried out to show benefits and effectiveness of the proposed approach.

关键词： Distributed model predictive control leader-follower networks multi-agent systems replay attacks resilient control

Biofabrication of nanovesicles for brain diseases

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Neural Regeneration Research 2023年第3期18卷 525-526页

作者： Pasquale Picone domenico Nuzzo Istituto per la Ricerca e l’Innovazione Biomedica CNRDipartimento di Scienze e Tecnologie Biologiche Chimiche e FarmaceuticheUniversitàdi PalermoPalermoItaly

Background:Nanotechnologies promise to improve disease diagnosis and treatment,overcoming the limitations of conventional *** particular,extracellular vesicles(EVs)and artificial vesicles(AVs)are strongly emerging tools in nanomedicine(Leggio et al.,2020).EVs are cell-derived membrane structures secreted after the fusion of endosomes with the plasma membrane(exosomes)or shed from the plasma membrane(microvesicles).EVs are released by different brain cells(neurons,oligodendrocytes,astrocytes,and microglia)and constitute a physiological intercellular communication ***,EVs can deliver different types of molecules(nucleic acids and proteins),which often influence the phenotype of the recipient *** play a physiological role in the central nervous system(CNS),such as development,myelination,regeneration,and synaptic activity(Lai et al.,2012).Due to their content,EVs could therefore constitute an important biomarker for neurodegenerative diseases,represent candidates for therapeutic use,enclosing regulatory molecules,or be considered as vectors for brain drug delivery(Croese et al.,2018).

关键词： diseases diagnosis constitute

Role of chemotherapy and novel biological agents in the treatment of elderly patients with colorectal cancer

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World Journal of Gastroenterology 2008年第12期14卷 1812-1822页

作者： Gerardo Rosati domenico Bilancia Medical Oncology Unit S. Carlo Hospital Potenza 85100 Italy

Patients older than 65 years are the fastest growing segment of the cancer population. It is estimated that within 20 years over 75% of cases and 85% of deaths from colorectal cancer (CRC) will be in this setting. Concerns about cancer treatment in the elderly relate to comorbidities, which increase proportionally with age, physiological changes associated with aging which may influence drug metabolism and toxicity, and diminishing life expectancy, which particularly impacts decisions surrounding the benefits of adjuvant therapies. Over the last 10 years, significant improvements in the treatment of advanced CRC with combination therapy have been made. The randomized trials which have defined these improvements did not exclude elderly patients. However, the median age of patients in these trials has generally been approximately 60 years. Thus, it appears that some degree of selection is involved with younger and presumably fitter patients being the subjects in most of the pivotal trials. The availability of new molecularly targeted agents and newly improved existing agents has expanded the range of treatment options available. This variety gives greater flexibility in dealing with different subsets of patients, such as the elderly. However, some fit elderly patients seem to tolerate combination therapy reasonably well, while studies on unfit elderly subjects are needed.

关键词： Bevacizumab Chemotherapy Cetuximab Colorectal cancer Elderly patients

Between plaza and peak: a montological perspective on verticality and urbanization in highland Peru

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Journal of Mountain Science 2023年第10期20卷 2783-2803页

作者： Andreas HALLER domenico BRANCA Deyvis CANO Institute for Interdisciplinary Mountain Research Austrian Academy of SciencesInnsbruck 6020Austria Department of Humanities and Social Sciences University of SassariSassari 07100Italy Programa Académico de Ingeniería Ambiental Universidad de HuánucoHudnuco 10001Peru

Under the influence of concentrated and extended urbanization,Andean cities and the different altitudinal zones of their“hinterlands”are experiencing profound changes in land cover—from the central plazas up to the highest *** complex regional-geographic characteristics of these socioecological systems,such as the vertical complementarity of land use,require a montological perspective on verticality and urbanization:it transcends disciplinary approaches and can be crucial to properly interpret the trajectories of land cover change and formulate hypotheses for future practiceoriented *** trajectories of land cover change characterized altitudinal zones of Andean cities and their surroundings over the last three decades?Are there similarities that allow for the formulation of more general hypotheses?Using the Peruvian cases of Cusco and Huaraz,and combining a traditional altitudinal zonation model of land use in Peru with direct field observations and GIS-based analyses of remotely sensed data from 1991,2001,2011,and 2021,this study identifies the main trajectories of land cover change in the Quechua(>2300–3500 m),Suni(>3500–4000 m),and Puna(>4000–4800 m)regions—and finds insightful similarities between Cusco and Huaraz:(1)an impressive area of built-up land substitutes grassland in the Quechua,which,following regional altitudinal zonation models,is characterized by irrigated and rain-fed cropland;(2)an unexpected expansion of irrigated cropland takes place in the Suni,which,in theory,often lacks irrigation infrastructure and is mostly used for rain-fed tuber cultivation;and(3)a clear change from“other land”to grassland occurs in the Puna—where grassland is thought to predominate,anyway,since pre-Hispanic *** that these changes reflect the interplay between speculative fallow,agricultural intensification,and ecological restoration,the results can be read as vertically complementary,local manifestations of concentrated and extended urba

关键词： Mountain cities Mountain agriculture Land use change Land cover change Rural-urban linkages Montology

A Resilient Control Strategy for Cyber-Physical Systems Subject to Denial of Service Attacks:A Leader-Follower Set-Theoretic Approach

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IEEE/CAA Journal of Automatica Sinica 2020年第5期7卷 1204-1214页

作者： Giuseppe Franzè domenico Famularo Walter Lucia Francesco Tedesco DIMES Department Universitàdella CalabriaVia Pietro Bucci 87036Italy CIISE Department Concordia UniversityMontrealQuebec H3G-1M8Canada IEEE

Multi-agent systems are usually equipped with open communication infrastructures to improve interactions efficiency,reliability and *** technologically costeffective,this makes them vulnerable to cyber-attacks with potentially catastrophic *** this end,we present a novel control architecture capable to deal with the distributed constrained regulation problem in the presence of time-delay attacks on the agents’communication *** basic idea consists of orchestrating the interconnected cyber-physical system as a leader-follower configuration so that adequate control actions are computed to isolate the attacked unit before it compromises the system *** on a multi-area power system confirm that the proposed control scheme can reconfigure the leader-follower structure in response to denial ofservice(DoS)attacks.

关键词： Denial-of-service(DoS)attacks distributed model predictive control leader-follower paradigm resilient control

Systemic therapy of hepatocellular carcinoma:Current status and future perspectives

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World Journal of Gastroenterology 2014年第12期20卷 3087-3099页

作者： domenico Germano Bruno Daniele Oncology Unit A.O. "G.Rummo"

The management of hepatocellular carcinoma (HCC) has substantially changed in the past few decades, the introduction of novel therapies (such as sorafenib) have improved patient survival. Nevertheless, HCC remains the third most common cause of cancer-related deaths worldwide. Decision-making largely relies on evidence-based criteria, as showed in the US and European clinical practice guidelines, which endorse five therapeutic recommendations:resection; transplantation; radiofrequency ablation; chemoembolization; and sorafenib. Many molecularly targeted agents that inhibit angiogenesis, epidermal growth factor receptor, and mammalian target of rapamycin are at different stages of clinical development in advanced HCC. Future research should continue to unravel the mechanism of hepatocarcinogenesis and to identify key relevant molecular targets for therapeutic intervention. Identification and validation of potential surrogate and predictive biomarkers hold promise to individualize patient’s treatment to maximize clinical benefit and minimize the toxicity and cost of targeted agents.

关键词： Hepatocellular Carcinoma Molecular agents Targheted therapy Sorafenib

Three Dimensional Coupling between Elastic and Thermal Fields in the Static Analysis of Multilayered Composite Shells

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Computer Modeling in Engineering & Sciences 2023年第9期136卷 2551-2594页

作者： Salvatore Brischetto Roberto Torre domenico Cesare Department of Mechanical and Aerospace Engineering.Politecnico di Torino Torino10129Italy

This new work aims to develop a full coupled thermomechanical method including both the temperature profile and displacements as primary unknowns of the *** generic full coupled 3D exact shell model permits the thermal stress investigation of laminated isotropic,composite and sandwich *** and spherical panels,cylinders and plates are analyzed in orthogonal mixed curved reference *** 3D equilibrium relations and the 3D Fourier heat conduction equation for spherical shells are coupled and they trivially can be simplified in those for plates and cylindrical *** exponential matrix methodology is used to find the solutions of a full coupled model based on coupled differential relations with respect to the thickness *** analytical solution is based on theories of simply supported edges and harmonic relations for displacement components and *** sovra-temperature magnitudes are directly applied at the outer faces through static state *** a consequence,the sovra-temperature description is assumed to be an unknown variable of themodel and it is calculated in the sameway as the three *** final systemis based on a set of coupled homogeneous differential relations of second order in the thickness *** system is reduced in a first order differential relation system by redoubling the number of ***,the exponential matrix methodology is applied to calculate the *** temperature field effects are evaluated in the static investigation of shells and plates in terms of displacement and stress *** an appropriate preliminary validation,new benchmarks are discussed for several thickness ratios,geometrical data,lamination sequences,materials and sovra-temperature values imposed at the outer *** make evident the accordance between the uncoupled thermo-mechanical model and this new full coupled thermo-mechanical model without the need to se

关键词： Three-dimensional exact thermo-elastic shellmodel full coupled thermoelasticity three-dimensional fourier heat conduction relation plate and shell geometries laminated and sandwich configurations

CHK2 kinase in the DNA damage response and beyond

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Journal of Molecular Cell Biology 2014年第6期8卷 442-457页

作者： Laura Zannini domenico Delia Giacomo Buscemi Department of Experimental Oncology Fondazione IRCCS Istituto Nazionale dei Tumori Via Amadeo 42 20133 Milan Italy

The serine/threonine kinase CHK2 is a keycomponent of the DNA damage response. In human cells, following genotoxic stress, CHK2 is activated and phosphorylates 〉20 proteins to induce the appropriate cellular response, which, depending on the extent of damage, the cell type, and other factors, could be cell cycle checkpoint activation, induction of apoptosis or senescence, DNA repair, or tolerance of the damage. Recently, CHK2 has also been found to have cellular functions independent of the presence of nuclear DNA lesions. In par- ticular, CHK2 participates in several molecular processes involved in DNA structure modification and cell cycle progression. In this review, we discuss the activity of CHK2 in response to DNA damage and in the maintenance of the biological functions in unstressed cells. These activities are also considered in relation to a possible role of CHK2 in tumorigenesis and, as a consequence, as a target of cancer therapy.

关键词： DNA damage checkpoints apoptosis genomic stability

Comparison of Hydrodynamic Performances Between Single Pontoon and Double Pontoon Floating Breakwaters Through the SPH Method

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China Ocean Engineering 2022年第6期36卷 894-910页

作者： CHEN Yong-kun LIU Yong domenico D.Meringolo Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China Dipartimento D.I.C.E.A.M. Universitàdegli Studi Mediterranea di Reggio CalabriaVia Salita Melissari89124Reggio CalabriaItaly

A numerical study adopting the 2Dδ-SPH model is performed to compare the hydrodynamic characteristics of a single pontoon floating breakwater and a double pontoon floating *** simulations are performed using theδ-SPH model and experimental tests are conducted to validate the numerical *** numerical results of both the free surface elevations and motions of the floating breakwater are in good agreement with the experimental *** results show that when the pontoon drafts are larger,the double pontoon floating breakwater performs better in wave attenuations compared with the single pontoon floating breakwater,and for all the drafts,the amplitudes of motions including sway,heave and roll of the double pontoon floating breakwater is always *** addition,increasing the spacing between the two pontoons can further reduce the amplitudes of pontoon motions and improve the wave attenuation ability of the double pontoon floating breakwater.

关键词： smoothed particle hydrodynamics floating pontoon breakwater hydrodynamic characteristics experimental test