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Diagnostic accuracy of enhanced liver fibrosis test to assess liver fibrosis in patients with chronic hepatitis C

Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 500-507页

作者： Roberto Catanzaro Michele Milazzo Silvia Arona Chiara Sapienza Dario Vasta domenico arcoria Francesco Marotta Department of Medical and Pediatric Sciences Institute of Internal Medicine "A. Francaviglia"Section of Gastro-enterologyUniversity of Catania"G. Rodolico" Hospital Laboratory analysis "MedLab-Analisi Cliniche" Specialist in diabetes and metabolic diseases ReGenera Research Group for Aging Intervention

BACKGROUND:The prognosis and clinical management of patients with chronic liver diseases are closely related to the severity of liver *** biopsy is considered the gold standard for the staging of liver ***,it is an invasive test sometimes related to *** study aimed to assess the diagnostic value of enhanced liver fibrosis(ELF) test to predict liver fibrosis in patients with chronic hepatitis ***:This study included 162 patients with liver disease and 67 healthy *** acid,tissue inhibitor of matrix metalloproteinase type 1,and amino-terminal propeptide type III procollagen were measured by enzymelinked immunosorbent assay with the ELF test ADVIA Centaur(Siemens Healthcare Diagnostics Inc.).Fibrosis stage was determined using the Metavir scoring ***:In our study,for the diagnosis of significant fibrosis(Metavir F≥2) a cut-off value >7.72 provides a sensitivity of 93.0% and a specificity of 83.0%.The areas under the receiver operator characteristic curve,sensitivity,specificity,and positive and negative predictive values were 0.94,93.3%,81.0%,93.3%,and 81.0%,respectively(P9.3 provides a sensitivity of 93.0% and a specificity of 86.0%.The areas under the receiver operator characteristic curve,sensitivity,specificity,and positive and negative predictive values were 0.94,79.1%,90.8%,75.6%,and 92.3%,respectively(P<0.001).CONCLUSIONS:The ELF test is a promising non-invasive method for assessing liver fibrosis in patients with chronic hepatitis *** is effective in the diagnosis of both fibrosis and cirrhosis.

关键词： enhanced liver fibrosis test non-invasive diagnosis liver fibrosis blood marker

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Resilience Against Replay Attacks:A Distributed Model Predictive Control Scheme for Networked Multi-Agent Systems

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IEEE/CAA Journal of Automatica Sinica 2021年第3期8卷 628-640页

作者： Giuseppe Franzè Francesco Tedesco domenico Famularo DIMES Department University of CalabriaArcavacata di Rende 87036Italy

In this paper,a resilient distributed control scheme against replay attacks for multi-agent networked systems subject to input and state constraints is *** methodological starting point relies on a smart use of predictive arguments with a twofold aim:1)Promptly detect malicious agent behaviors affecting normal system operations;2)Apply specific control actions,based on predictive ideas,for mitigating as much as possible undesirable domino effects resulting from adversary ***,the multi-agent system is topologically described by a leader-follower digraph characterized by a unique leader and set-theoretic receding horizon control ideas are exploited to develop a distributed algorithm capable to instantaneously recognize the attacked ***,numerical simulations are carried out to show benefits and effectiveness of the proposed approach.

关键词： Distributed model predictive control leader-follower networks multi-agent systems replay attacks resilient control

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Biofabrication of nanovesicles for brain diseases

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Neural Regeneration Research 2023年第3期18卷 525-526页

作者： Pasquale Picone domenico Nuzzo Istituto per la Ricerca e l’Innovazione Biomedica CNRDipartimento di Scienze e Tecnologie Biologiche Chimiche e FarmaceuticheUniversitàdi PalermoPalermoItaly

Background:Nanotechnologies promise to improve disease diagnosis and treatment,overcoming the limitations of conventional *** particular,extracellular vesicles(EVs)and artificial vesicles(AVs)are strongly emerging tools in nanomedicine(Leggio et al.,2020).EVs are cell-derived membrane structures secreted after the fusion of endosomes with the plasma membrane(exosomes)or shed from the plasma membrane(microvesicles).EVs are released by different brain cells(neurons,oligodendrocytes,astrocytes,and microglia)and constitute a physiological intercellular communication ***,EVs can deliver different types of molecules(nucleic acids and proteins),which often influence the phenotype of the recipient *** play a physiological role in the central nervous system(CNS),such as development,myelination,regeneration,and synaptic activity(Lai et al.,2012).Due to their content,EVs could therefore constitute an important biomarker for neurodegenerative diseases,represent candidates for therapeutic use,enclosing regulatory molecules,or be considered as vectors for brain drug delivery(Croese et al.,2018).

关键词： diseases diagnosis constitute

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Between plaza and peak: a montological perspective on verticality and urbanization in highland Peru

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Journal of Mountain Science 2023年第10期20卷 2783-2803页

作者： Andreas HALLER domenico BRANCA Deyvis CANO Institute for Interdisciplinary Mountain Research Austrian Academy of SciencesInnsbruck 6020Austria Department of Humanities and Social Sciences University of SassariSassari 07100Italy Programa Académico de Ingeniería Ambiental Universidad de HuánucoHudnuco 10001Peru

Under the influence of concentrated and extended urbanization,Andean cities and the different altitudinal zones of their“hinterlands”are experiencing profound changes in land cover—from the central plazas up to the highest *** complex regional-geographic characteristics of these socioecological systems,such as the vertical complementarity of land use,require a montological perspective on verticality and urbanization:it transcends disciplinary approaches and can be crucial to properly interpret the trajectories of land cover change and formulate hypotheses for future practiceoriented *** trajectories of land cover change characterized altitudinal zones of Andean cities and their surroundings over the last three decades?Are there similarities that allow for the formulation of more general hypotheses?Using the Peruvian cases of Cusco and Huaraz,and combining a traditional altitudinal zonation model of land use in Peru with direct field observations and GIS-based analyses of remotely sensed data from 1991,2001,2011,and 2021,this study identifies the main trajectories of land cover change in the Quechua(>2300–3500 m),Suni(>3500–4000 m),and Puna(>4000–4800 m)regions—and finds insightful similarities between Cusco and Huaraz:(1)an impressive area of built-up land substitutes grassland in the Quechua,which,following regional altitudinal zonation models,is characterized by irrigated and rain-fed cropland;(2)an unexpected expansion of irrigated cropland takes place in the Suni,which,in theory,often lacks irrigation infrastructure and is mostly used for rain-fed tuber cultivation;and(3)a clear change from“other land”to grassland occurs in the Puna—where grassland is thought to predominate,anyway,since pre-Hispanic *** that these changes reflect the interplay between speculative fallow,agricultural intensification,and ecological restoration,the results can be read as vertically complementary,local manifestations of concentrated and extended urba

关键词： Mountain cities Mountain agriculture Land use change Land cover change Rural-urban linkages Montology

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A Resilient Control Strategy for Cyber-Physical Systems Subject to Denial of Service Attacks:A Leader-Follower Set-Theoretic Approach

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IEEE/CAA Journal of Automatica Sinica 2020年第5期7卷 1204-1214页

作者： Giuseppe Franzè domenico Famularo Walter Lucia Francesco Tedesco DIMES Department Universitàdella CalabriaVia Pietro Bucci 87036Italy CIISE Department Concordia UniversityMontrealQuebec H3G-1M8Canada IEEE

Multi-agent systems are usually equipped with open communication infrastructures to improve interactions efficiency,reliability and *** technologically costeffective,this makes them vulnerable to cyber-attacks with potentially catastrophic *** this end,we present a novel control architecture capable to deal with the distributed constrained regulation problem in the presence of time-delay attacks on the agents’communication *** basic idea consists of orchestrating the interconnected cyber-physical system as a leader-follower configuration so that adequate control actions are computed to isolate the attacked unit before it compromises the system *** on a multi-area power system confirm that the proposed control scheme can reconfigure the leader-follower structure in response to denial ofservice(DoS)attacks.

关键词： Denial-of-service(DoS)attacks distributed model predictive control leader-follower paradigm resilient control

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Systemic therapy of hepatocellular carcinoma:Current status and future perspectives

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World Journal of Gastroenterology 2014年第12期20卷 3087-3099页

作者： domenico Germano Bruno Daniele Oncology Unit A.O. "G.Rummo"

The management of hepatocellular carcinoma (HCC) has substantially changed in the past few decades, the introduction of novel therapies (such as sorafenib) have improved patient survival. Nevertheless, HCC remains the third most common cause of cancer-related deaths worldwide. Decision-making largely relies on evidence-based criteria, as showed in the US and European clinical practice guidelines, which endorse five therapeutic recommendations:resection; transplantation; radiofrequency ablation; chemoembolization; and sorafenib. Many molecularly targeted agents that inhibit angiogenesis, epidermal growth factor receptor, and mammalian target of rapamycin are at different stages of clinical development in advanced HCC. Future research should continue to unravel the mechanism of hepatocarcinogenesis and to identify key relevant molecular targets for therapeutic intervention. Identification and validation of potential surrogate and predictive biomarkers hold promise to individualize patient’s treatment to maximize clinical benefit and minimize the toxicity and cost of targeted agents.

关键词： Hepatocellular Carcinoma Molecular agents Targheted therapy Sorafenib

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Three Dimensional Coupling between Elastic and Thermal Fields in the Static Analysis of Multilayered Composite Shells

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Computer Modeling in Engineering & Sciences 2023年第9期136卷 2551-2594页

作者： Salvatore Brischetto Roberto Torre domenico Cesare Department of Mechanical and Aerospace Engineering.Politecnico di Torino Torino10129Italy

This new work aims to develop a full coupled thermomechanical method including both the temperature profile and displacements as primary unknowns of the *** generic full coupled 3D exact shell model permits the thermal stress investigation of laminated isotropic,composite and sandwich *** and spherical panels,cylinders and plates are analyzed in orthogonal mixed curved reference *** 3D equilibrium relations and the 3D Fourier heat conduction equation for spherical shells are coupled and they trivially can be simplified in those for plates and cylindrical *** exponential matrix methodology is used to find the solutions of a full coupled model based on coupled differential relations with respect to the thickness *** analytical solution is based on theories of simply supported edges and harmonic relations for displacement components and *** sovra-temperature magnitudes are directly applied at the outer faces through static state *** a consequence,the sovra-temperature description is assumed to be an unknown variable of themodel and it is calculated in the sameway as the three *** final systemis based on a set of coupled homogeneous differential relations of second order in the thickness *** system is reduced in a first order differential relation system by redoubling the number of ***,the exponential matrix methodology is applied to calculate the *** temperature field effects are evaluated in the static investigation of shells and plates in terms of displacement and stress *** an appropriate preliminary validation,new benchmarks are discussed for several thickness ratios,geometrical data,lamination sequences,materials and sovra-temperature values imposed at the outer *** make evident the accordance between the uncoupled thermo-mechanical model and this new full coupled thermo-mechanical model without the need to se

关键词： Three-dimensional exact thermo-elastic shellmodel full coupled thermoelasticity three-dimensional fourier heat conduction relation plate and shell geometries laminated and sandwich configurations

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Comparison of Hydrodynamic Performances Between Single Pontoon and Double Pontoon Floating Breakwaters Through the SPH Method

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China Ocean Engineering 2022年第6期36卷 894-910页

作者： CHEN Yong-kun LIU Yong domenico D.Meringolo Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China Dipartimento D.I.C.E.A.M. Universitàdegli Studi Mediterranea di Reggio CalabriaVia Salita Melissari89124Reggio CalabriaItaly

A numerical study adopting the 2Dδ-SPH model is performed to compare the hydrodynamic characteristics of a single pontoon floating breakwater and a double pontoon floating *** simulations are performed using theδ-SPH model and experimental tests are conducted to validate the numerical *** numerical results of both the free surface elevations and motions of the floating breakwater are in good agreement with the experimental *** results show that when the pontoon drafts are larger,the double pontoon floating breakwater performs better in wave attenuations compared with the single pontoon floating breakwater,and for all the drafts,the amplitudes of motions including sway,heave and roll of the double pontoon floating breakwater is always *** addition,increasing the spacing between the two pontoons can further reduce the amplitudes of pontoon motions and improve the wave attenuation ability of the double pontoon floating breakwater.

关键词： smoothed particle hydrodynamics floating pontoon breakwater hydrodynamic characteristics experimental test

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Numerical Simulations of Wave Impact Forces on the Open-Type Sea Access Road Using A Two-Phase SPH Model

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China Ocean Engineering 2024年第5期38卷 755-770页

作者： CHEN Yong-kun domenico D.MERINGOLO LIU Yong Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China Dipartimento D.I.C.E.A.M. Universitàdegli Studi Mediterranea di Reggio CalabriaVia Salita Melissari89124Reggio CalabriaItaly

A numerical study based on a two-dimensional two-phase SPH(Smoothed Particle Hydrodynamics)model to analyze the action of water waves on open-type sea access roads is *** study is a continuation of the analyses presented by Chen et al.(2022),in which the sea access roads are *** this new configuration,the sea access roads are placed above the still water level,therefore the presence of the air phase becomes a relevant issue in the determination of the wave forces acting on the ***,the comparison of wave forces on the open-type sea access roads obtained from the single and two-phase SPH models with the experimental results shows that the latter are in much better *** in the numerical simulations,a two-phaseδ-SPH model is adopted to investigate the dynamical *** on the numerical results,the maximum horizontal and uplifting wave forces acting on the sea access roads are analyzed by considering different wave conditions and geometries of the *** particular,the presence of the girder is analyzed and the differences in the wave forces due to the air cushion effects which are created below the structure are highlighted.

关键词： Smoothed Particle Hydrodynamics two-phase SPH wave impact forces experimental test sea access road

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Experimental tests for a liquid-liquid critical point in water

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Science China(Physics,Mechanics & Astronomy) 2020年第12期63卷 30-71页

作者： domenico Mallamace Carmelo Corsaro Francesco Mallamace H.Eugene Stanley Department ChiBioFarAm(Industrial Chemistry) University of MessinaERIC and CASPE/INSTMMessina 98166Italy Dipartimento MIFT Universitàdi MessinaMessina 98166Italy Department of Nuclear Science and Engineering Massachusetts Institute of TechnologyCambridge MA 02139USA Istituto dei Sistemi Complessi(ISC)-CNR Rome 00185Italy Center for Polymer Studies and Department of Physics Boston UniversityBoston MA 02215USA

Water is a fascinating *** composition is simple—one oxygen and two hydrogen atoms—but its chemistry and physics are extremely complex and exhibit 75 documented *** these anomalies and their molecular origin are not completely understood,we know that hydrogen bonds play key roles in all of the phases of ***,there is experimental evidence that the polymorphism of the ice structure extends into the liquid phase and is associated with a liquid-liquid coexistence *** is currently a topic of great interest in water research because there are indications that the end point of the coexistence line corresponds to a second critical point inside the supercooled liquid *** examine the recent progress in understanding water anomalies and the liquid-liquid phase transition hypothesis,including the results of recent experimental work and molecular simulations of both bulk and confined *** examine experimental results that test whether the behavior of liquid water is consistent with the"liquid polymorphism"hypothesis that liquid water can exist in two distinct phases of differing *** also examine recent research on the anomalies of nanoconfined water and,in particular,on water in biological *** find that the concept of liquid polymorphism can also describe the properties of other liquids that have two characteristic length scales.

关键词： hydrophobic-hydrophilic interactions water systems thermal properties

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