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Does Surgery Benefit Postmenopausal Overweight Women with Pelvic Floor Dysfunction?

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Open Journal of Therapy and Rehabilitation 2014年第3期2卷 114-119页

作者： márta Hock Balázs domány József Bódis János Garai Department of Obstetrics and Gynaecology Faculty of Medicine University of Pécs Pécs Hungary Institute of Pathophysiology and Gerontology Faculty of Medicine University of Pécs Pécs Hungary Institute of Physiotherapy and Sport Sciences Faculty of Health Sciences University of Pécs Pécs Hungary mTA-PTE Human Reproduction Scientific Research Group Pécs Hungary

Introduction: Pelvic floor muscle function of 30 overweight postmenopausal women prior to and after colporrhahpy was monitored in this study. material and methods: Patients diagnosed with cystokele or combined cystorectokele was involved. 1 mg oral estriol and local estriol cream were administered for 30 days preoperatively. Pelvic floor muscle function was monitored by surface electromyography 1 month before (1st) 1 day prior to surgery (2nd), and six weeks after the surgery (3rd measurement). Body composition parameters (intra- and extracellular water and body fat) were also measured. Results: The ability to relax significantly improved (p = 0.03) in the preoperative period (between 1st and 2nd occasions). Six weeks after surgery a non-significant (p = 0.054) decrease in average muscle activity was detected when compared with values obtained before the surgery. muscle-activity declined significantly from the first to the last measurements (p = 0.005). Conclusion: Our results confirm that postmenopausal obese women who undergo anterior or posterior colporrhaphy need a follow-up concerning pelvic floor muscle function and suggest that physiotherapy started the earliest possible may aid in preserving postoperative functionality on the long run.

关键词： Pelvic Floor muscle Function Operative Period Body Composition Postmenopause Obesity

Graphene quantum dots: From efficient preparation to safe renal excretion

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Nano Research 2021年第3期14卷 674-683页

作者： Caroline Hadad Josémiguel González-domínguez Silvia Armelloni Deborah mattinzoli masami Ikehata Akcan Istif Adrian Ostric Francesco Cellesi Carlo maria Alfieri Piergiorgio messa Belén Ballesteros Tatiana Da Ros Centre of Excellence for Nanostructured materials(CENmAT) INSTMDepartment of Chemical and Pharmaceutical SciencesUniversity of TriesteVia L.Giorgieri 134127TriesteItaly Laboratoire LG2A-CNRS UmR 7378 Universitéde Picardie Jules Verne33 rue Saint Leu-UFR des Sciences80039AmiensFrance Instituto de Carboquímica(CSIC) C/Miguel Luesma Castán 4E-50018ZaragozaSpain Renal Research Laboratory-Fondazione IRCCS Ca’Granda Ospedale maggiore Policlinico via Pace 920122MilanItaly Dipartimento di Chimica Materiali ed Ingegneria Chimica“G.Natta”Politecnico di MilanoVia Mancinelli 720131MilanItaly Unit of Nephrology Dialysis and Renal Transplant Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinicovia della commenda 420122MilanItaly Department of Clinical Sciences and Community Health University of Milan20122MilanItaly Catalan Institute of Nanoscience and Nanotechnology(ICN2) CSIC and the Barcelona Institute of Science and TechnologyCampus UABBellaterra08193BarcelonaSpain

Carbon nanomaterials offer excellent prospects as therapeutic agents,and among them,graphene quantum dots(GQDs)have gained considerable interest thanks to their aqueous solubility and intrinsic fluorescence,which enable their possible use in theranostic approaches,if their biocompatibility and favorable pharmacokinetic are *** prepared ultra-small GQDs using an alternative,reproducible,top-down synthesis starting from graphene oxide with a nearly 100%*** materials were tested to assess their safety,demonstrating good biocompatibility and ability in passing the ultrafiltration barrier using an in vitro *** leads to renal excretion without affecting the ***,we studied the GQDs in vivo biodistribution confirming their efficient renal clearance,and we demonstrated that the internalization mechanism into podocytes is ***,considering the reported characteristics,it appears possible to vehiculate compounds to kidneys by means of GQDs,overcoming problems related to lysosomal degradation.

关键词： graphene quantum dots podocytes biodistribution uptake pathway renal clearance nanocarrier

Efficient antibody evasion but reduced ACE2 binding by the emerging SARS-CoV-2 variant B.1.640.2

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Cellular & molecular Immunology 2022年第9期19卷 1067-1069页

作者： Prerna Arora Amy Kempf Inga Nehlmeier Luise Graichen Sebastian Schulz Anne Cossmann Alexandra Dopfer-Jablonka martin S.Winkler Hans-martin Jäck Georg m.N.Behrens Stefan Pöhlmann markus Hoffmann Infection Biology Unit German Primate CenterKellnerweg 437077GöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenWilhelmsplatz 137073GöttingenGermany Division of molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergGlückstraße 691054ErlangenGermany Department for Rheumatology and Immunology Hannover Medical SchoolCarl-Neuberg-Straße 130625HannoverGermany German Centre for Infection Research(DZIF) Partner Site Hannover-BraunschweigHannoverGermany Centre for Individualised Infection medicine(Ciim) HannoverGermany Department of Anesthesiology University of Göttingen Medical CenterGöttingenGeorg-August University of GöttingenRobert-Koch-Straße 4037075GöttingenGermany

The SARS-CoV-2 spike(S)protein engages ACE2 for cell entry,and the S protein/ACE2 interface is an important target for neutralizing *** the course of the COVID-19 pandemic,SARS-CoV-2 variants have emerged that harbor mutations in the S protein,which confer neutralization resistance and allow viral spread in immunologically nonnaive *** most prominent example is the highly mutated Omicron variant,which infects convalescent or vaccinated individuals with unprecedented efficiency[1,2].

关键词： ACE2 harbor neutral

WJD 5^(th) Anniversary Special Issues(2): Type 2 diabetes Inflammation in diabetic kidney disease

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World Journal of Diabetes 2014年第4期5卷 431-443页

作者： Patricia m García-García maría A Getino-melian Virginia domínguez-Pimentel Juan F Navarro-Gonzalez Nephrology Service and Research Unit University Hospital Nuestra Se?ora de Candelaria 38010 Santa Cruz de Tenerife Spain Spanish National Coordinator of GEENDIAB (Grupo Espa ol para el Estudio de la Nefropatía Di-abética) (RedInRen 12/0021/0019 Instituto de Salud Carlos IIIMinisterio de Economía y Competitividad) 38010 Santa Cruz de Tenerife Spain

Diabetes mellitus entails significant health problems *** pathogenesis of diabetes is multifactorial,resulting from interactions of both genetic and environmental factors that trigger a complex network of pathophysiological events,with metabolic and hemodynamic *** this context,inflammation has emerged as a key pathophysiology *** pathogenic pathways will provide targets for prevention or future *** review will focus on the implications of inflammation in diabetes mellitus,with special attention to inflammatory cytokines.

关键词： Diabetes Diabetic nephropathy Diabetic kidney disease Inflammation Cytokines Oxidative stress

microscopic Characterization of Ecological Concrete Polymeric

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microscopy Research 2014年第1期2卷 13-17页

作者： A. D. Rodríguez m. L. domínguez R. m. melgoza Centro de Investigación en Ingeniería y Ciencias Aplicadas Universidad Autónoma del Estado de Morelos Cuernavaca México Facultad de Ciencias Químicas e Ingeniería Universidad Autónoma del Estado de Morelos Cuernavaca México.

The Scanning Electron microscopy (SEm) and Optical microscopy (Om) with integrated digital camera are techniques that are used in the present investigation, for the morphological characterization of a new composite material called “organic polymer concrete” in which microparticles added fibers and polyethylene terephthalate (PET) recycling mechanically (Rm). Polymer concrete (PC) is a new composite material (mC) in the application considered as an alternative material of construction in which reinforcement particles are recycled polymers which have approximately the same dimensions in all directions. Therefore, the particles can be rods, spheres, chips and many other shapes whose appearance reasons are about 10 microns. These mC, the size, shape and distribution and the ratio and the modulus of the particles affect the properties of the material.

关键词： Polymer Concrete Polymer Blend

Effect of Antimony Additions on Corrosion and mechanical Properties of Sn-Bi Eutectic Lead-Free Solder Alloy

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materials Sciences and Applications 2012年第6期3卷 355-362页

作者： Alberto Torres Luis Hernández Octavio domínguez Instituto de metalurgia-UASLP San Luis Potosí México

The goal of the present work is to investigate the effects of the addition of Sb (0, 3 and 6 wt%) on structure, melting, corrosion and mechanical properties of Sn-Bi eutectic solder alloys. The mechanical properties of the bulk Sn-Bi-Sb solders were higher as the amount of antimony increases, making compressive strength augment from 65 mPa to 100 mPa when 6 wt% Sb was incorporated to the Sn-Bi eutectic alloy. The three alloys presented a melting temperature that is smaller to the one exhibited by the eutectic alloy Sn-38Pb (Tm = 183°C). According to the electrochemical results, the addition of higher contents of Sb to the Sn-Bi eutectic alloy had a positive effect: it ennobled the Ecorr values.

关键词： Lead Free Solder Alloys Sn-Bi-Sb mechanical Properties Corrosion Properties

Bisacodyl and Sodium Picosulfate Improve Bowel Function and Quality of Life in Patients with Chronic Constipation—Analysis of Pooled Data from Two Randomized Controlled Trials

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Open Journal of Gastroenterology 2017年第1期7卷 32-43页

作者： Stefan müller-Lissner Erika Richter marion Eberlin Harald Weigmann Tobias m.ck michael A. Kamm Department of Internal medicine Park-Klinik Weissensee Berlin Germany Sanofi-Aventis GmbH Frankfurt-Hoechst Germany St Vincent’s Hospital University of Melbourne Melbourne Australia

Background: Quality of life (QoL) is impaired in chronic constipation. Among nonprescription laxatives QoL data out of randomized controlled trials are available only for bisacodyl and sodium picosulfate (SPS). methods: In two randomized, double-blind, placebo-controlled, parallel-group trials, the efficacy and safety of treatment with either bisacodyl or SPS, respectively, were assessed. After a 2-week baseline period patients with functional constipation were randomized to a 4-week treatment with either bisacodyl (2 tablets = 10 mg), SPS (18 drops = 10 mg), or matching placebo in a ratio of active drug to placebo of 2:1. Dose reduction as well as resuming the original dose was permitted. Patients who did not experience a bowel movement for more than 72 h were allowed to use a bisacodyl suppository. The primary endpoint was the mean number of Complete Spontaneous Bowel movements (CSBms) per week during the trial. QoL was assessed using the Patient Assessment of Constipation (PAC)-QoL questionnaire. Results: Active treatment led to a greater improvement of PAC-QoL scores for every domain. Active treatment was also superior to placebo for all individual questions of the questionnaire. Of note, SPS or bisacodyl not only improved satisfaction with stool patterns (“quite a bit/extremely satisfied” in 12.8% of patients on placebo and 50.3% on active treatment) but bloating was also considerably ameliorated (“not at all feeling bloated” in 24.5% on placebo and 41.4% on active treatment). Conclusion: Bisacodyl and SPS not only improve stool variables but also quality of life in patients with chronic functional constipation. (EudraCT Nos. 2007-001991-34 and 2007-002087-10).

关键词： Constipation Laxative Bisacodyl Sodium Picosulfate Quality of Life

Recycling of Electronic Waste, Using Basic and Acid Leaching

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Open Journal of Applied Sciences 2016年第3期6卷 169-176页

作者： miguel Aguilar Cortes martha Lilia domínguez Patiño Graduate Engineering and Applied Science Universidad Autónoma del Estado de Morelos Cuernavaca México Faculty of Chemical and Engineering Sciences Universidad Autónoma del Estado de Morelos Cuernavaca México

This recycling of printed circuit board (TCI) for the production of metals, given the environmental degradation that can cause toxic substances of these, is the reuse of valuable materials recovered from the TCI, this being an economic engine that promotes the recycling of this waste. This paper presents a methodology for evaluating the reaction kinetics and leaching of metals that form the metal substrate, which have environmental and energy advantages, so the generation of new recovery techniques metals from the TCI low environmental and energy impact is increasingly necessary, for it is essential to establish the parameters affecting the reaction rate and identify design alternatives to determine whether or not sustainable, economically viable and that does not pollute. The method adopted was a leaching acid samples, where the full factorial method employed two experimental levels to evaluate the influence of: leaching time, temperature of the aqueous leach solution, reaction kinetics and solid/liquid, on the percentage of metal extraction. Subsequently, the metals are obtained by calcining and smelting the resulting salts by addition of acid liquor.

关键词： TCI Acidic and Basic Leaching and Electronic Waste

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贵族休闲方式 G1俱乐部赛道日

汽车与运动 2007年第6期 164-165页

作者： nic

中国人口基数非常之巨大,因此,要找到一群有着雄厚财力的人并不难,而且,这群人的数目还相当之大。于是我们可以看到越来越多的世界顶级奢侈品品牌正在大举开拓中国市场,汽车业如是,珠宝业如是,电子产品业如是,酒店业如是……当然,象征... 详细信息

中国人口基数非常之巨大,因此,要找到一群有着雄厚财力的人并不难,而且,这群人的数目还相当之大。于是我们可以看到越来越多的世界顶级奢侈品品牌正在大举开拓中国市场,汽车业如是,珠宝业如是,电子产品业如是,酒店业如是……当然,象征财富的私人俱乐部也开始新兴起来,就像G1俱乐部,它可以全程安排任何一种私人或公务活动,包括机票预订、酒店预订在内的一切事务,都可交由俱乐部处理,服务范围遍及全球。当然,源自格鲁艾姆赛车队(Gruppe m Racing)

关键词： G1 休闲方式