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Visual function alterations in essential tremor: A case report

Journal of Innovative Optical Health Sciences 2015年第5期8卷 94-98页

作者： David P.Pinero Begona Monllor Vicenta Moncho Vicent J.Camps dolores de fez Grupo de Optica y Percepcion Visual(GOPV)department of Optics Pharmacology and Anatomy University of AlicanteSpain department of Ophthalmology(OFTALMAR)Medimar International Hospital AlicanteSpain Foundation for the Visual Quality(Fundacion para la Calidad Visual FUNCAVIS)

Our purpose is to report alterations in contrast sensitivity function(CSF)and in the magno,parvo and koniocellular visual pathways by means of a multichannel perimeter in case of an essential tremor(ET).A complete evaluation of the visual function was performed in a 69-year old patient,including the analysis of the chromatic discrimination by the Fansworth–Munsell 100 hue test,the measurement of the CSF by the CSV-1000E test,and the detection of potential alteration patterns in the magno,parvo and koniocellular visual pathways by means of a multichannel *** acuity and intraocular pressure(IOP)were within the ranges of normality in both *** abnormalities were detected in the fundoscopic examination and in the optical coherence tomography(OCT)*** results of the color vision examination were also within the ranges of normality.A signi¯cant decrease in the achromatic CSFs for right eye(RE)and left eye(LE)was detected for all spatial *** statistical global values provided by the multichannel perimeter confirms that there were significant absolute sensitivity losses compared to the normal pattern in *** the LE,only a statistically significant decrease in sensitivity was detected for the blue-yellow(BY)*** pattern standard deviation(PSD)values obtained in our patient indicated that there were significant localized losses compared to the normality pattern in the achromatic channel of the RE and in the red-green(RG)channel of the *** color vision alterations may be present in ET that cannot be detected with conventional color vision tests,such as the FM 100 Hue.

关键词： Multichannel perimetry essential tremor color vision visual pathways contrast sensitivity

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Visual perception alterations in COVID-19:a preliminary study

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 1-9页

作者： María Begoña Coco-Martín Luis Leal-Vega Irene Alcoceba-Herrero Ainhoa Molina-Martín dolores de-fez María JoséLuque Carlos Dueñas-Gutiérrez Juan Francisco Arenillas-Lara David PPiñero Group of Applied Clinical Neurosciences and Advanced Data Analysis Department of MedicineDermatology and ToxicologyUniversity of ValladolidValladolid 47005Spain Group of Optics and Visual Perception Department of OpticsPharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain department of Optics and Optometry and Vision SciencesUniversity of ValenciaValencia 46100Spain COVID-19 Unit Department of Internal MedicineUniversity Clinical Hospital of ValladolidValladolid 47003Spain Stroke Unit Department of NeurologyUniversity Clinical Hospital of ValladolidValladolid 47003Spain Clinical Optometry Unit Department of OphthalmologyVithas Medimar International HospitalAlicante 03016Spain

AIM:To compare the visual perception(color and chromatic-achromatic contrast vision)of a small cohort of COVID-19 patients at the time of infection and after 6mo with that of a healthy population matched for sex and ***:A total of 25 patients(9 females,16 males,mean age:54±10y)with COVID-19 hospitalized in the COVID-19 Unit of the University Clinical Hospital of Valladolid were recruited for this preliminary *** perception,as determined by monocular measurement of contrast sensitivity function(CSF)and color vision was assessed in each patient using the Optopad *** results obtained were then compared with those of a sample of 16 age-and sex-matched healthy controls(5 females,11 males,mean age:50±6y)in which the same measurement procedure was *** significant differences between groups were assessed using the Mann-Whitney U *** were repeated after a minimum follow-up period of 6mo and statistically significant differences between the two time points in each group were assessed using the Wilcoxon signed rank ***:Discrimination thresholds(color and chromatic-achromatic contrast vision)and their corresponding sensitivity,calculated as the inverse of the discrimination threshold,were *** of the data revealed higher contrast threshold results(i.e.,worse contrast sensitivity)in the COVID-19 group than in the control group for all spatial frequencies studied in the Optopad-CSF achromatic test and most of the spatial frequencies studied in the Optopad-CSF chromatic test for the red-green and blue-yellow *** addition,color threshold results in the COVID-19 group were also significantly higher(i.e.,worse color sensitivity)for almost all color mechanisms studied in the Optopad-Color *** 6mo,most of the differences found between the groups were maintained despite COVID-19 ***:The present results provide preliminary evidence that visual perception may be impaired in COVID-19

关键词： SARS-CoV-2 COVID-19 visual perception contrast sensitivity function color vision

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普通用户电子设备使用距离的特征分析

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国际眼科杂志 2021年第9期21卷 1508-1514页

作者： Fernando Soler Alicia Sánchez-García Ainhoa Molina-Martín dolores de fez Valentín Díaz David P Piñero Innova Ocular Clinica Dr Soler 西班牙埃尔切03202 Dr Soler Foundation of the Valencian Community 西班牙埃尔03202 阿里坎特大学药理学、解剖学与光学系西班牙阿里坎特03690

目的:分析普通用户使用电子设备/电脑的工作距离(WD)及移动电话使用距离(MPUD)的特征。方法:横向描述性研究。经过筛选后,纳入每天使用电子设备/电脑超过2h的专业人员100例,年龄20-62(平均41.2)岁,测量每位受试者工作环境中使用电子设备... 详细信息

目的:分析普通用户使用电子设备/电脑的工作距离(WD)及移动电话使用距离(MPUD)的特征。方法:横向描述性研究。经过筛选后,纳入每天使用电子设备/电脑超过2h的专业人员100例,年龄20-62(平均41.2)岁,测量每位受试者工作环境中使用电子设备/电脑的工作距离(WD)、手臂长度和MPUD。结果:纳入受检者WD明显长于MPUD(61.22±12.35 vs 32.22±6.35 cm;P<0.001),MPUD明显短于臂长(74.44±4.65 cm;P<0.001)。4%和91%的受检者WD和MPUD分别小于或等于40 cm。WD与MPUD、手臂长度均呈弱相关性(r=0.387,P<0.001;r=0.260,P<0.001)。不同职业受试者WD有显著差异(P=0.021),军队人员相比大学研究人员和讲师的WD更长(P=0.025)。结论:普通用户使用电子设备/电脑的工作距离与移动电话使用距离差别较大,移动电话使用距离较近,这对于矫正老视具有一定的参考意义。

关键词：老视工作距离移动电话使用距离电子设备

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dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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Semen analysis in 21st century medicine： the need for sperm function testing

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Asian Journal of Andrology 2010年第1期12卷 64-70页

作者： dolores J. Lamb Scott department of Urology and the department of Molecular and Cellular Biology Baylor College of MedicineHouston TX 77030 USA

Sperm function testing, once commonly performed for the infertile couple before employing assisted reproductive technology （ART）, has fallen out of favour in many reproductive medicine centers throughout the world. Indeed, the most recent addition of the ＇World Health Organisation （WHO） Laboratory Manual for the Examination and Processing of Hu- man Semen＇ now groups many of these procedures into a section termed Research Procedures. In large part, this reflects the current clinical practice of bypassing the in-depth evaluation of the male partner, while assuming that if a spermatozoon can be found for intracytoplasmic sperm injection （ICSI）, it must be a healthy cell capable of achieving fertilization. Never- theless, sperm function testing can provide valuable clinical insights into defects causing male infertility. Admittedly, in some cases, functional sperm deficiencies can be overcome using an ART. In other cases, couples will be empowered by the knowledge of the cause of their infertility, and for some couples, perhaps even the likelihood of ICSI success （relative to the spermatozoa）. The knowledge allows them to make truly informed reproductive decisions, including （perhaps） the de- cision to seek donor insemination, to adopt or to remain childless. Knowledge of the cause of their infertility may provide closure for couples and a sense of confidence regarding their choice of reproductive treatment.

关键词： semen analysis sperm function tests

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Molecular aspects of mammalian fertilization

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Asian Journal of Andrology 2001年第4期3卷 243-249页

作者： Hector Serrano dolores Garcia-Suarez dept. Health Sciences Dept. Biology Universidad Autonoma Metropoliana-Iztapalapa Ave. Michoacan and Purisima Mexico City DF 09340 Mexico

Mammalian fertilization is a highly regulated process, much of which are not clearly understood. Here we presentsome information in order to elaborate a working hypothesis for this process, beginning with the sperm modifications inthe epidydimis up to sperm and egg plasmalemma interaction and fusion. We also discuss the still poorly understood ca-pacitation process, the phenomenon of sperm chemo-attraction that brings the capacitated sperm to interact with theoocyte vestments and certain aspects of the acrosome reaction. (Asian J Androl 2001 dec; 3 : 243 - 249)

关键词： fertilization sperm maturation sperm capacitation sperm-ovum interactions membrane fusion

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Functional traits:the pathways to riverine plant resistance in times of hydropeaking

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Ecological Processes 2023年第1期12卷 884-915页

作者： Alejandro Baladrón María dolores Bejarano Isabel Boavida CERIS Civil Engineering Research and Innovation for SustainabilityInstituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais1049-001 LisbonPortugal Natural Resources department Universidad Politécnica de Madrid(UPM)Calle JoséAntonio Novais1028040 MadridSpain

Hydropeaking,which refers to rising or falling discharges caused by the turning on or off of hydro-turbines to generate electricity,is a topic of growing interest due to its impact on fluvial *** date,most hydropeaking studies have focused on the impact of peak fluctuations on invertebrate and fish communities,but little attention has been paid to its impact on riverine plants and how functional traits may make them resistant to *** performed a review to assess how a set of 32 plant functional traits can be expressed in riverine plant species,and found evidence of how such expression affects their capacity to cope with common sources of hydropeaking disturbance(i.e.,inundation,fast water drawdown,and rapid water fluctuations linked to up-ramping and down-ramping hydropeaking operations).The information here presented can simplify the evaluation of impacts on riverine plant communities worldwide,as well as to detect suitable species to successfully restore rivers affected by hydropower production.

关键词： Drought Flooding Waterlogging Hydropeaking Plant trait Riverine vegetation

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Performance evaluation of Cuckoo filters as an enhancement tool for password cracking

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Cybersecurity 2024年第4期7卷 62-72页

作者： Maria-dolores Cano Antonio Vilfranca Igor Tasic department of Information and Communication Technologies Universidad Politecnica de Cartagena30202 CartagenaSpain

Cyberthreats continue their expansion,becoming more and more complex and ***,credentials and passwords are still a critical point in *** cracking can be a powerful tool to fight against cyber criminals if used by cybersecurity professionals and red teams,for instance,to evaluate compliance with security policies or in forensic *** particular systems,one crucial step in the password-cracking process is comparison or matchmaking between password-guess hashes and real *** hypothesize that using newer data structures such as Cuckoo filters could optimize this *** results show that,with a proper configuration,this data structure is two orders of magnitude more efficient in terms of size/usage compared to other data structures while keeping a comparable performance in terms of time.

关键词： Authentication Passwords Password cracking Cybersecurity Cuckoo filters

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In vivo exploration of the functional activity of the non-coding 8q24 prostate cancer risk locus

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Asian Journal of Andrology 2010年第6期12卷 787-789页

作者： dolores J. Lamb Mounia Tannour-Louet Scott department of Urology Baylor College of Medicine Houston TX 77030 USA department of Molecular and Cellular Biology Baylor College of Medicine Houston TX 77030 USA

Genome-wide association studies （GWAS） have successfully identified a substantial number of risk variants for prostate cancer [1-10]. In total, more than 20 single nucleotide polymorphisms （SNPs） that predispose to prostate malignancy have been found scattered throughout the genome in coding and non-coding regions. The 8q24 chromosomal region is an intriguing locus as it harbors five independent susceptibility variants （rs10086908; rs16901979; rs620861; rs6983267; rs1447295） that span a 440-kb genomic interval devoid of genes or protein-coding transcripts.

关键词： Genomes Cancer (genus) Neoplasms Variants Prostate Genes Andean region

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In vitro production of functional sperm in mice

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Asian Journal of Andrology 2011年第6期13卷 791-792页

作者： Kathleen Hwang dolores J Lamb Scott department of Urology Baylor College of Medicine Houston TX 77030 USA Scott department of Urology and Molecular and Cellular Biology Baylor College of Medicine Houston TX 77030 USA Laboratory for Male Reproductive Research and Testing Baylor College of Medicine Houston TX 77030 USA

Spermatogenesis refers to the process by which the production and development of the spermatozoa （the mature male gamete of most sexually reproducing species） occurs. It is a complex, stepwise process of sperm development, taking more than a month depending upon the species involving three specific functional phases： spermatogonial proliferation, meiosis and metamorphosis.1 Investigators have been successful in recreating this process in some species of fish; however, this whole process has never been reproduced in vitro in mammals.

关键词： Spermatogenesis refers production the spermatozoa

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