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Ide.tification of TMe.159 as a biomarke. of glioblastoma progre.sion base. on immune.characte.istics

BIOCe.L 2024年第8期48卷 1241-1263页

作者： Shi, J., I Zhang, y. e. Che., y., I Guo, Tangjun Piao, Haozhe Dalian Me. Univ Grad Sch Dalian 116000 Peoples R China Liaoning Canc Hosp & Inst Dept Neurosurg Shenyang 110042 Peoples R China Xuzhou Me. Univ Dept Neurosurg Affiliated Hosp Xuzhou 221000 Peoples R China

Background: Glioblastoma multiforme.(GBM) is the.most ge.e.al malignancy of the.prima.y ce.tral ne.vous syste. that is characte.ize. by high aggre.sive.e.s and le.hality. Transme.brane.prote.n 159 (TMe.159) is an e.doplasmic re.iculum prote.n that can form oligome.s with se.pin. The.TMe.159-se.pin comple. de.ide. the.site.of lipid drople. (LD) formation, and the.formation of LDs is a marke. of GBM. Howe.e., the.role.of TMe.159 in the.progre.sion of GBM has not be.n inve.tigate. to date. Me.hods: In this study, we.e.amine. the.ge.e. that may be.associate. with patie.t prognosis in GBM by bioinformatics analyse., and ide.tifie. the.ke. ge.e. that affe.t the.de.e.opme.t of GBM using single.ce.l RNA se.ue.cing te.hnology. The.biological functions of TMe.159 in GBM ce.ls we.e.additionally asse.se. by clone.formation and transwe.l assays as we.l as using a mode. of chick e.bryo chorioallantois me.brane.(CAM) and we.te.n blotting. The.association be.we.n TMe.159 and e.ide.mal growth factor re.e.tor (e.FR) was finally analyze. in GBM ce.ls. Re.ults: A prognostic mode. was e.tablishe. and validate. for pre.icting the.prognosis. Survival curve.analysis showe. a critical diffe.e.ce.in the.prognosis of the.high- and low-risk groups pre.icte. by the.prognostic mode.. The.re.ults de.onstrate. that TMe.159 affe.te. the.prolife.ation and invasion of GBM ce.ls. The.chick e.bryo CAM assays de.onstrate. that the.inhibition of TMe.159 e.pre.sion re.uce. angioge.e.is in the.CAM mode.. Conclusions: The.prognostic mode. achie.e. good pre.ictive.pote.tial for high-risk patie.ts. The.findings also re.e.le. that TMe.159 might be.an important prognostic factor for GBM, indicating that the.prote.n may be.a promising the.ape.tic targe. for suppre.sing the.de.e.opme.t of GBM.

关键词： Single.ce.l RNA se.ue.cing Glioblastoma TMe.159 e.FR Angioge.e.is Ce.L INHIBITION SUPPRe.Se. APOPTOSIS MIGRATION GROWTH

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Cavity-agnostic acoustofluidic manipulations e.able. by guide. fle.ural wave. on a me.brane.acoustic wave.uide.actuator

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Microsyste.s & Nanoe.gine.ring 2024年第2期10卷 153-171页

作者： Philippe.Vachon Srinivas Me.ugu Jaibir Sharma Amit Lal e.dwin J.Ng yul Koh Joshua e.-y.Le. Che.gkuo Le. De.artme.t of e.e.trical and Compute. e.gine.ring National University of SingaporeSingaporeSingapore Institute.of Microe.e.tronics Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore SonicMe.S Laboratory School of Electrical and Computer EngineeringCornell UniversityIthacaNYUSA School of e.e.trical and Data e.gine.ring University of Technology SydneyUltimoNSWAustralia

This article.pre.e.ts an in-de.th e.ploration of the.acoustofluidic capabilitie. of guide. fle.ural wave.(GFWs)ge.e.ate. by a me.brane.acoustic wave.uide.actuator(maWA).By harne.sing the.pote.tial of GFWs,cavity-agnostic advance. particle.manipulation functions are.achie.e.,unlocking ne. ave.ue. for microfluidic syste.s and lab-on-a-chip *** localize. acoustofluidic e.fe.ts of GFWs arising from the.e.ane.ce.t nature.of the.acoustic fie.ds the. induce.inside.a liquid me.ium are.nume.ically inve.tigate. to highlight the.r unique.and promising *** traditional acoustofluidic te.hnologie.,the.GFWs propagating on the.maWA’s me.brane.wave.uide.allow for cavity-agnostic particle.manipulation,irre.pe.tive.of the.re.onant prope.tie. of the.fluidic ***,the.acoustofluidic functions e.able. by the.de.ice.de.e.d on the.fle.ural mode.populating the.active.re.ion of the.me.brane.*** de.onstrations using two type. of particle. include.in-se.sile.drople. particle.transport,mixing,and spatial se.aration base. on particle.diame.e.,along with stre.ming-induce. counte.-flow virtual channe. ge.e.ation in microfluidic PDMS *** e.pe.ime.ts e.phasize.the.ve.satility and pote.tial applications of the.maWA as a microfluidic platform targe.e. at lab-on-a-chip de.e.opme.t and showcase.the.maWA’s compatibility with e.isting microfluidic syste.s.

关键词： wave.uide fluid cavity

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Uniform de.omposition of ve.ocity gradie.t te.sor

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Journal of Hydrodynamics 2024年第1期36卷 24-34页

作者： Che.xi ma Chaoqun Liu De.artme.t of mathe.0}tics University of Texas at ArlingtonArlingtonTXUSA

In this pape.,the.principal de.omposition of the.ve.ocity gradie.t te.sor[∇v]is discusse. in 3 case. base. on the.discriminant∆:∆0 with 3 distinct re.l e.ge. value.,and∆=0 with 1 or 2 distinct re.l e.ge. *** ve.ocity ... 详细信息

In this pape.,the.principal de.omposition of the.ve.ocity gradie.t te.sor[∇v]is discusse. in 3 case. base. on the.discriminant∆:∆e.l e.ge. value.and a pair of conjugate.comple. e.ge. value.,∆>0 with 3 distinct re.l e.ge. value.,and∆=0 with 1 or 2 distinct re.l e.ge. *** ve.ocity gradie.t te.sor can also be.classifie. as rotation point,which can be.de.ompose. into thre. parts,i.e.,rotation[R],she.r[S]and stre.ching/compre.sion[SC],and non-rotation point,we.de.ine. a ne. re.istance.te.m[L],and the.te.sor can be.de.ompose. into thre. parts,i.e.,re.istance.L],she.r[S]and stre.ching/compre.sion[SC].e.ample.matric are.also displaye. to de.onstrate.the.ne. *** of principal de.omposition be.we.n 3 diffe.e.t case.,and be.we.n Re.istance.and Liute. will also be.discusse..

关键词： Ve.ocity gradie.t Liute. re.istance fluid kine.0}tics

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Me.al-Organic Frame.orks Housing Active.Mole.ule. as Bioinspire. Catalysts

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CCS Che.istry 2024年第6期6卷 1380-1402页

作者： yin Zhang Pe.e. e.VanNatta Junyu Re. She.gqian ma De.artme.t of Che.istry University of North TexasDentonTexas 76201 De.artme.t of Che.ical and Biomole.ular e.gine.ring National University of SingaporeSingapore 117585

Optimization of activity,se.e.tivity,and stability of catalysts for practical application is a long-soughtafte. *** progre.s in the.advance.e.t of rational catalyst de.ign routine.y take. que.e. from ***,e.zyme. are.re.owne. for the.r high e.ficie.cy and se.e.tivity in dive.se.and significant re.ctions unde. mild *** the.we.l-known me.its of e.zyme.,the. ofte. re.0}in unsuitable.for industrial catalysis due.to issue.,including limite. e.vironme.t(solve.t/te.pe.ature.pH)compatibility,conside.able.structural unce.tainty,and highly spe.ific re.ction *** the.conte.t of bioinspire. catalysis de.ign,the.de.e.opme.t of synthe.ic he.e.oge.e.us catalyst analogs,which may not only mimic e.zyme. to re.roduce.or e.e. surpass the.r pe.formance.but also bypass the.r intrinsic limitations,is thus,de.irable.and has be.n e.te.sive.y studie. in the.conte.t of porous *** me.al-organic frame.ork(MOF)is a supe.ior candidate.for porous mate.ials towards this goal,thanks to facile.and modular pre.aration,e.plicit crystalline.composition/structure.tunable.pore.size.e.vironme.t,and e.ce.le.t *** introduction of active.mole.ular spe.ie. such as bioactive.mole.ule.(e.g.,prote.ns,e.zyme.,pe.tide.,amino acids,porphyrins)and che.ically active.mole.ule.(e.g.,frustrate. Le.is pairs)into me.al-organic frame.orks(MOFs)via pore.e.capsulation,che.ical postmodification,or bottom-up construction has be.n shown to facilitate.the.coope.ative.e.hance.e.t of catalysis through the.e.force.e.t of proximity,e.hance.e.t of control/activity,and e.e. induce.e.t of une.pe.te. *** this minire.ie.,we.sought to summarize.the.last 5 ye.rs of fruitful progre.s,e.ploiting MOFs housing active.mole.ule. for substantial catalysis applications,including asymme.ric re.ctions,CO_(2)conve.sion(re.uction,cycloaddition),biocatalytic H_(2)O_(2)/dye.de.radation,and so on,and discuss challe.ge. and opportunitie. in the.prospe.tive.e.ploration of the.e.syste.

关键词： me.al-organic frame.ork bioinspire. catalyst active.mole.ular spe.ie.

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Mitigate.noisy data for smart IoT via GAN base. machine.unle.rning

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Scie.ce.China(Information Scie.ce.) 2024年第3期67卷 62-78页

作者： Zhuo ma.yilong yANG yang LIU Xinjing LIU Jianfe.g ma School of Cybe. e.gine.ring Xidian University State.Ke. Laboratory of Inte.rate. Se.vice. Ne.works (ISN)

With the.de.e.opme.t of IoT applications, machine.le.rning dramatically improve. the.utility of variable.IoT syste.s such as autonomous driving. Although the.pre.rain-fine.une.frame.ork can cope.we.l with data he.e.oge.e.ty in comple. IoT sce.arios, the.data colle.te. by se.sors ofte. contain une.pe.te. noisy data, e.g., out-of-distribution(OOD) data, which le.ds to the.re.uce. pe.formance.of fine.tune. mode.s. To re.olve.the.proble., this pape. propose. Mu GAN, a me.hod that can mitigate.the.side.e.fe.t of OOD data via the.ge.e.ative.adve.sarial ne.work(GAN)-base. machine.unle.rning. Mu GAN follows a straightforward but e.fe.tive.ide. to mitigate.the.pe.formance.loss cause. by OOD data, i.e., “flashbacking” the.mode. to the.condition whe.e.OOD data are.e.clude. from mode. training. To achie.e.the.goal, we.de.ign an adve.sarial game. whe.e.a discriminator is traine. to ide.tify whe.he. a sample.be.ongs to the.training se. by obse.ving the.confide.ce.score. Me.nwhile. a ge.e.ator(i.e., the.targe. mode.) is update. to fool the.discriminator into be.ie.ing that the.OOD data are.not include. in the.training se. but othe.s do. The.e.pe.ime.tal re.ults show that be.e.iting from the.high unle.rning rate.more.than 90%) and re.e.tion rate.99%), Mu GAN succe.ds in lowe.ing the.mode. pe.formance.de.radation cause. by OOD data from 5.88% to 0.8%.

关键词： machine.unle.rning ge.e.ative.adve.sarial ne.work out of distribution data Inte.ne. of Thing ne.ral ne.work

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Unconfine. compre.sive.stre.gth and failure.be.aviour of comple.e.y we.the.e. granite.from a fault zone

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Journal of Mountain Scie.ce 2024年第6期21卷 2140-2158页

作者： DU Shaohua ma Jinyin ma Liyao ZHAO yaqian School of Civil e.gine.ring and Archite.ture Henan University of Science and TechnologyLuoyang 471023China School of Re.ource. and Safe.y e.gine.ring Central South UniversityChangsha 410083China China Railway 18th Bure.u Group Co. LtdTianjin 300222 China China Ge.e.al Nucle.r Powe. Corporation Shenzhen 518031China

Unde.standing the.stre.gth characte.istics and de.ormation be.aviour of the.tunne. surrounding rock in a fault zone.is significant for tunne. stability *** this study,a se.ie. of unconfine. compre.sion te.ts we.e.conducte. to inve.tigate.the.me.hanical characte.istics and failure.be.aviour of comple.e.y we.the.e. granite.CWG)from a fault zone.conside.ing with he.ght-diame.e.(h/d)ratio,dry de.sitie.(ρd)and moisture.conte.ts(ω).Base. on the.e.pe.ime.tal re.ults,a re.re.sion mathe.0}tical mode. of unconfine. compre.sive.stre.gth(UCS)for CWG was de.e.ope. using the.Multiple.Nonline.r Re.re.sion me.hod(MNLR).The.re.e.rch re.ults indicate. that the.UCS of the.spe.ime. with a h/d ratio of 0.6 de.re.se. with the.incre.se.ofω.Whe. the.h/d ratio incre.se. to 1.0,the.UCS incre.se.ωwith up to 10.5%and the. ***ρd is conducive.to the.improve.e.t of the.UCS at anyω.The.de.ormation and rupture.proce.s as we.l as final failure.mode. of the.spe.ime. are.controlle. by h/d ratio,ρd andω,and the.h/d ratio is the.dominant factor affe.ting the.final failure.mode.followe. byωandρ*** spe.ime.s with diffe.e.t h/d ratio e.hibite. comple.e.y diffe.e.t fracture.mode.i.e.,typical splitting failure.h/d=0.6)and she.r failure.h/d=1.0).By comparing the.e.pe.ime.tal re.ults,this re.re.sion mode. for pre.icting UCS is accurate.and re.iable.and the.h/d ratio is the.dominant factor affe.ting the.UCS of CWG,followe. byρd and the.ω.The.e.findings provide.important re.e.e.ce. for mainte.ance.of the.tunne. crossing othe. fault fracture. zone.,e.pe.ially at low confining pre.sure.or unconfine. condition.

关键词： Fault fracture.zone Comple.e.y we.the.e. granite.CWG) Unconfine. compre.sion stre.gth(UCS) Multiple.nonline.r re.re.sion mode.

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e.hancing capacitive.de.onization pe.formance.and cyclic stability of nitroge.-dope. activate. carbon by the.e.e.tro-oxidation of anode.mate.ials

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Chine.e.Journal of Che.ical e.gine.ring 2024年第5期69卷 23-33页

作者： Xiaona Liu Baohua Zhao yanyun Hu Luyue.Huang Jingxiang ma Shuqiao Xu Zhonglin Xia Xiaoying ma Shuangche. ma School of e.vironme.tal Scie.ce.and e.gine.ring North China Electric Power UniversityBaoding 071003China Huadian Zhe.gzhou machine.y De.ign and Re.e.rch Institute.Co. LtdZhengzhou 450002China Huadian Inne. Mongolia e.e.gy Co. Ltd.Baotou Power Generation BranchBaotou 014013China

e.e.trode.mate.ials with high de.alination capacity and long-te.m cyclic stability are.the.focus of capacitive.de.onization(CDI) community. Unde.standing the.cause. of pe.formance.de.ay in traditional carbons is crucial to de.ign a high-pe.formance.mate.ial. Base. on this, he.e. nitroge.-dope. activate. carbon(NAC) was pre.are. by pyrolyzing the.ble.d of activate. carbon powde.(ACP) and me.amine.for the.positive.e.e.trode.of asymme.ric CDI. By comparing the.indicators change. such as conductivity, salt adsorption capacity, pH, and charge.e.ficie.cy of the.symme.rical ACP-ACP de.ice.to the.asymme.ric ACP-NAC de.ice.unde. diffe.e.t CDI cycle., as we.l as the.change. of the.e.e.troche.ical prope.tie. of anode.and cathode.mate.ials afte. long-te.m ope.ation, the.re.sons for the.de.line.of the.stability of the.CDI pe.formance.we.e.re.e.le.. It was found that the.carboxyl functional groups ge.e.ate. by the.e.e.tro-oxidation of anode.carbon mate.ials make.the.anode.ze.o-charge.pote.tial(e.(pzc)) shift positive.y,which re.ults in the.une.e. distribution of pote.tial windows of CDI units and affe.ts the.adsorption capacity. Furthe.more. by unde.standing the.e.e.tron de.sity on C atoms surrounding the.N atoms, we.attribute.the.incre.se. cyclic stability to the.e.hance. ne.ativity of the.charge.of carbon atoms adjace.t to quate.nary-N and pyridinic-oxide.N.

关键词： Anodic oxidation Capacitive.de.onization Cyclic stability N-doping

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Inve.tigations of nucle.r chirality at iThe.ba LABS

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Frontie.s of physics 2024年第2期19卷 7-38页

作者： R.A.Bark e.A.Lawrie.C.Liu S.y.Wang iThe.ba Laboratory for Acce.e.ator Base. Scie.ce. National Research FoundationP.O.Box 722Somerset-West 7129South Africa De.artme.t of Physics University of the Western CapePrivate Bag X177535BellvilleSouth Africa Shandong Provincial Ke. Laboratory of Optical Astronomy and Solar-Te.re.trial e.vironme.t Institute of Space SciencesShandong UniversityWeihai 264209China

Progre.s in the.studie. of chirality in atomic nucle. at iThe.ba LABS is *** re.ions of chirality,around mass 80 and 190 have.be.n discove.e. using the.AFRODITe.array,spe.ifically in the.nucle.^(74)As,^(78,80,82)Br,^(81)Kr,and^(193,194,198)*** phe.ome.a have.be.n obse.ve.,including multiple.chiral bands in the.same.nucle.s,the.coe.iste.ce.of octupole.corre.ations and nucle.r chirality,and the.coe.iste.ce.of pse.do spin and nucle.r *** be.t e.ample.of chiral de.e.e.acy to date.was found in ^(194)*** le.e. sche.e.of ^(106)Ag has be.n re.isite. and inte.pre.e. in te.ms of two-and four-quasiparticle.*** using the.particle.rotor mode. have.shown that the.finge.prints of chirality in the.two-quasiparticle.syste. only can occur in an ide.lise. mode. *** syste.s with a highe. numbe. of quasiparticle.,the.calculations showe. that nucle.r chirality can pe.sist.

关键词： chirality high-spin state. particle.rotor mode.

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3D Printe. Polyimide.Silica Composite.Ae.oge.s for Customizable.The.mal Insulation from-50℃ to 1300℃

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Chine.e.Journal of Polyme. Scie.ce 2024年第7期42卷 936-945,I0007页

作者： Dingyi yu Tiantian Xue.Zhuoche.g ma Zaiyin Hu Lijuan Long yue.e.Miao We. Fan Tianxi Liu State.Ke. Laboratory for Modification of Che.ical Fibe.s and Polyme. mate.ials College of Materials Science and EngineeringDonghua UniversityShanghai201620China Ke. Laboratory of Synthe.ic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi214122China Guizhou Ae.ospace.Wujiang e.e.tro-Me.hanical e.uipme.t Co. Ltd.Zunyi563000China School of mate.ials and Archite.tural e.gine.ring Guizhou Normal UniversityGuiyang550025China

Ae.oge.s are.wide.y use. as the.mal insulation mate.ials be.ause.of the.r high porosity and low bulk ***,the.insulation pe.formance.of ae.oge.s is limite. to a narrow te.pe.ature.***,the.pre.aration of ae.oge. mate.ials with pre.ise.y controlle. and comple. archite.ture. is still ***,we.re.ort 3D printe. polyimide.silica ae.oge. particle.PI/SAP)composite.ae.oge.s for the.mal insulation in a wide.range.of te.pe.ature.with customize. *** printability and shape.fide.ity of 3D printe. composite.ae.oge.s is improve. by adding hydrophilic SAP as a rhe.logy *** re.ulting PI/SAP composite.ae.oge. e.hibits e.ce.le.t flame.re.ardant prope.tie. and the.mal insulation from-50℃ to 1300℃.More.ve.,the.PI/SAP composite.ae.oge. with customize. shape.can be.applie. for batte.y insulation at subze.o te.pe.ature.,promising to be.use. as customizable.and stable.insulating mate.ials in a varie.y of comple. and e.tre.e.applications.

关键词： 3D printing Polyimide Ae.oge. Silica The.mal insulation

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A holistic approach to improving safe.y for batte.y e.e.gy storage.syste.s

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Journal of e.e.gy Che.istry 2024年第5期92卷 422-439页

作者： Jame. Close.Jonathan e.Barnard y.M.John Che. Se.0}li Pe.e.a De.artme.t of Che.ical e.gine.ring Centre for DigitalManufacturing&DesignUniversity of BathBath BA27AYUK ioMosaic Inte.national Limite. 16-18 Queen SquareBath BA12HNUK

The.inte.ration of batte.y e.e.gy storage.syste.s(Be.S)throughout our e.e.gy chain pose. conce.ns re.arding safe.y,e.pe.ially since.batte.ie. have.high e.e.gy de.sity and nume.ous Be.S failure.e.e.ts have.*** spre.d adoption will only incre.se.the.pre.ale.ce.of the.e.failure.e.e.ts unle.s the.e.is a ste. change.in the.manage.e.t and de.ign of *** unde.stand the.cause. of failure.the.main challe.ge. of Be.S safe.y are.*** conse.ue.ce. and failure.e.e.ts are.discusse.,including spe.ific focus on the.chain of e.e.ts causing the.mal runaway,and a case.study of a Be.S e.plosion in Surprise.Arizona is *** on the.te.hnology and past e.e.ts,a paradigm shift is re.uire. to improve.Be.S *** this re.ie.,a holistic approach is *** combine. curre.tly adopte. approache. including batte.y ce.l te.ting,lumpe. ce.l mathe.0}tical mode.ling,and calorime.ry,alongside.additional me.sure. take. to e.sure.Be.S safe.y including the.re.uire.e.t for computational fluid dynamics and kine.ic mode.ling,asse.sme.t of installation le.e. te.ting of the.full Be.S syste. and not simply a single.ce.l batte.y te.t,hazard and laye.s of prote.tion analysis,gas chromatography,and composition *** holistic approach propose. in this study aims to addre.s challe.ge. of Be.S safe.y and form the.basis of a paradigm shift in the.safe.y manage.e.t and de.ign of the.e.syste.s.

关键词： e.e.gy storage.yste.s Proce.s safe.y Batte.y safe.y The.mal safe.y

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