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Nano Research 2020年第1期13卷 145-150页

作者： dogan kaya Richard J.Cobley Richard E.Palmer Department of Electronics and Automation Vocational School of AdanaCukurova University01160CukurovaAdanaTurkey Nanoscale Physics Research Laboratory School of Physics and AstronomyUniversity of BirminghamEdgbastonBirminghamB152TTUK College of Engineering Swansea UniversityBay CampusFabian WaySwanseaSA18ENUK

Understanding the atomistic formation of oxide layers on semiconductors is important for thin film fabrication,scaling down conventional devices and for the integration of emerging research ***,the initial oxidation of Si(111)is studied using the scanning tunneling *** to the complete saturation of the silicon surface with oxygen,we are able to probe the atomic nature of the oxide layer *** establish the threshold for local manipulation of inserted oxygen sites to be+3.8 *** by combining imaging with local atomic manipulation are we able to determine whether inserted oxygen exists beneath surface-bonded oxygen sites and differentiate between sites that have one and more than one oxygen atom inserted beneath the *** to the creation of the thin oxide film we observe a flip in the manipulation rates of inserted oxygen sites consistent with more oxygen inserting beneath the silicon surface.

关键词： scanning tunneling microscopy(STM) local manipulation Si(111) oxidation

Is sarcopenia effective on survival in patients with metastatic gastric cancer?

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1861-1868页

作者： Ozlem dogan Hayriye Sahinli Yakup Duzkopru Tuba Akdag Abdulkadir Kocanoglu Department of Medical Oncology Adıyaman University Training and Research HospitalAdiyaman 02100Turkey Department of Medical Oncology Ankara Etlik City HospitalAnkara 06170Turkey Department of Radiology University of Health SciencesDiskapi Yildirim Beyazit Training and Research HospitalAnkara 06000Turkey Department of Medical Oncology Ankara Ataturk Sanatoryum Training and Research HospitalAnkara 06170Turkey

BACKGROUND Sarcopenia is a progressively diminishing state characterized by the reduction of muscle mass and density,which is frequently observed in malignancies of solid *** To assess how sarcopenia affects the overall survival of individuals who have been diagnosed with metastatic gastric *** The study retrospectively included individuals who had been diagnosed with metastatic gastric cancer between January 2008 and December *** was identified through the calculation of the average Hounsfield units(HUAC)using computed tomography(CT)images taken at the time of diagnosis in *** A total of 118 patients with metastatic gastric cancer were *** was detected in 29 patients(24.6%).The median survival of all patients was 8(1-43)*** median survival of patients with sarcopenia was 2 mo,while it was 10 mo for those without sarcopenia(P<0.001).A significant relationship was found between sarcopenia and *** Sarcopenia has been observed to impact survival outcomes in various types of solid tumor *** patients can be identified in a short time,easily and inexpensively,by HUAC measurements from CT images used for diagnosis,and survival could be promoted with nutritional support.

关键词： Hounsfield units Sarcopenia Gastric cancer Survival Psoas muscle mass Muscle density

SYNTHESIS AND CHARACTERIZATION OF AN ACRYLATE POLYMER CONTAINING CHLORINE-1,3-DIOXALANE GROUPS IN SIDE CHAINS

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Chinese Journal of Polymer Science 2012年第5期30卷 642-651页

作者： Zulfiye Ilter Ferhat Alhanli Fatih dogan Ismet kaya Firat University Faculty of Science and ArtsDepartment of ChemistryElazigTurkey Canakkale Onsekiz Mart University Faculty of EducationSecondary Science and Mathematics Education 17100CanakkaleTurkey Canakkale Onsekiz Mart University Department of Chemistry17020CanakkaleTurkey

Poly[2-（4-chlorophenyl）-l,3-dioxolan-4-yl]methyl acrylate, poly（CPhDMA）, was synthesized with radical polymerization process using 2,2＇-azobisisobutyronitrile as radical initiator in 1,4-dioxane at 60℃. The structure of poly（CPhDMA） was confirmed by means of UV-Vis, FT-IR, 1H-NMR, and 13C-NMR spectral techniques. The molecular weight distribution values of the polymer were determined with gel permeation chromatography （GPC）. The number-average molecular weight （Mn）, weight-average molecular weight （Mw） and polydispersity index （PDI） values of poly（CPhDMA） were determined to be 10300, 21600 and 2.097, respectively. The thermal degradation kinetics of the polymer was investigated by using TG/DTG-DTA and DSC analyses at different heating rates in dynamic nitrogen atmosphere. The apparent activation energy values obtained by Flynn-Wall-Ozawa and Friedman methods were found to be 91.68 and 85.23 kJ mo1-1, respectively, for thermal decomposition of poly（CPhDMA）. Also, the thermal degradation activation energy value of poly（CPhDMA） was calculated by using the Kissinger method based on the DTG, DTA and DSC data. Then the mechanism function of it was determined by master plots method. Finally, electrical and optical properties of poly（CPhDMA） were determined by four-point probe and UV-Vis techniques, respectively.

关键词： Synthesis of acrylate polymer Thermal degradation Kinetic parameters.

Axial gas mixing in conical spouted beds with high density particles

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Particuology 2023年第10期81卷 45-57页

作者： Neslin dogan Murat Koksal Gorkem Kulah Department of Chemical Engineering Middle East Technical UniversityAnkaraTurkey Department of Mechanical Engineering Hacettepe UniversityBeytepeAnkaraTurkey

Conical spouted beds operating with high-density particles(ρp>2500 kg/m^(3))have recently gained attention because of their potential use as nuclear fuel coaters for next-generation nuclear *** the literature,the number of axial gas mixing studies in conical and conical-cylindrical spouted beds is very limited and all axial mixing studies were carried out with relatively light particles(ρp≤2500 kg/m^(3)).Therefore,the objective of this study was to generate experimental data that can be used to explain the gas axial mixing behavior in conical spouted beds operating with both low-and high-density *** were conducted in two(γ=30°,60°)conical spouted beds with three different types of particles:zirconia(ρp=6050 kg/m^(3)),zirconia toughened alumina(ρp=3700 kg/m^(3))and glass beads(ρp=2460 kg/m^(3)).In order to be able to compare experimental data obtained at different conditions,a 1-D convection-diffusion gas mixing model originally developed by San Joséet al.(1995)was implemented to determine the axial dispersion *** results show that the axial dispersion coefficients range between m^(2)/s and m^(2)/s,increase with superficial gas velocity and are higher than the corresponding dispersion coefficients of fixed beds,lower than the dispersion coefficients of fluidized beds and in the same range with the cylindrical spouted beds reported in the *** corresponding Peclet numbers were in the range of 0.6–7.8 for all operating conditions and slightly higher Peclet numbers were obtained with glass beads indicating the relative importance of gas convective transport over gas dispersion for light particles compared to heavy particles.

关键词： Conical spouted bed Gas dispersion coefficient Axial gas mixing High-density particles

Solving vehicle routing problem with time windows using metaheuristic approaches

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International Journal of Intelligent Computing and Cybernetics 2023年第1期16卷 121-138页

作者： Zeynep Aydınalp doganÖzgen Yıldız Technical University IstanbulTurkey

Purpose-Drugs are strategic products with essential functions in human *** optimum design of the pharmaceutical supply chain is critical to avoid economic damage and adverse effects on human *** vehicle-routing problem,focused on finding the lowest-cost routes with available vehicles and constraints,such as time constraints and road length,is an important aspect of *** this paper,the vehicle routing problem(VRP)for a pharmaceutical company in Turkey is ***/methodology/approach-A mixed-integer programming(MIP)model based on the vehicle routing problem with time windows(VRPTW)is presented,aiming to minimize the total route cost with certain *** the model provides an optimum solution for small problem sizes with the GUROBI®solver,for large problem sizes,metaheuristic methods that simulate annealing and adaptive large neighborhood search algorithms are proposed.A real dataset was used to analyze the effectiveness of the metaheuristic *** proposed simulated annealing(SA)and adaptive large neighborhood search(ALNS)were evaluated and compared against GUROBI®and each other through a set of real problem ***-The model is solved optimally for a small-sized dataset with exact algorithms;for solving a larger dataset,however,metaheuristic algorithms require significantly lesser *** the problem addressed in this study,while the metaheuristic algorithms obtained the optimum solution in less than one minute,the solution in the GUROBI®solver was limited to one hour and three hours,and no solution could be obtained in this time ***/value-The VRPTW problem presented in this paper is a real-life *** vehicle fleet owned by the factory cannot be transported between certain suppliers,which complicates the solution of the problem.

关键词： Pharmaceutical supply chain Network design Mixed-integer linear programming Vehicle routing problem Simulated annealing Adaptive large neighborhood search

Hemoglobin, albumin, lymphocyte, and platelet score as a predictor of prognosis in metastatic gastric cancer

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World Journal of Gastrointestinal Oncology 2023年第9期15卷 1626-1635页

作者： Yakup Duzkopru Abdulkadir Kocanoglu Ozlem dogan Hayriye Sahinli Ebru Cilbir Mustafa Altinbas Department of Medical Oncology Ankara Etlik City HospitalAnkara 06170Turkey

BACKGROUND The hemoglobin,albumin,lymphocyte,and platelet(HALP)score,derived from a composite evaluation of markers reflecting the tumor-inflammation relationship and nutritional status,has been substantiated as a noteworthy prognostic determinant for diverse *** To investigate how the HALP score relates to prognosis in patients with metastatic gastric *** The cutoff values for the HALP score,neutrophil/lymphocyte ratio,and platelet/lymphocyte ratio were determined using receiver operating characteristic *** HALP scores were defined as those less than 24.79 and high HALP scores as those greater than *** The study cohort comprised 147 patients and 110 of them(74.8%)were *** patients'median age was 63(22-89)*** median overall survival was significantly superior in the patients with high HALP scores than in those with low HALP scores(10.4 mo vs 7.5 mo,respectively;P<0.001)CONCLUSION The HALP score was found to be a prognostic factor in patients with metastatic gastric cancer.

关键词： Biomarker Hemoglobin,albumin,lymphocyte,and platelet score Gastric cancer Nutritional index Prognosis Survival

Evaluation of macular choroidal and microvascular network changes by activity scores and serum antibodies in thyroid eye patients and healthy subjects

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2089-2094页

作者： Mehmet Erkan dogan Ibrahim Basol Hatice Deniz Ilhan Yusuf Ayaz Olgar Ocal Department of Ophthalmology Akdeniz UniversityKonyaalti 07070AntalyaTurkey Department of Ophthalmology Kepez State HospitalAntalya 07320Turkey Department of Ophthalmology Suruc State HospitalSanliurfa 63800Turkey

AIM:To investigate the choroidal thickness and the microvascular network changes around the macula in thyroid eye disease(TED)patients at different stages and the relationship of those changes with risk factors,serum antibodies and the severity of ***:A total of 85 participants were *** participants underwent ophthalmology and endocrinology *** choroidal thickness(SFCT),superficial(s)and deep(d)foveal avascular zone(FAZ)area,mean(m)and central(c)superficial vascular density(SVD),deep vascular density(DVD)measurements of the enrolled cases were performed with Topcon swept source optical coherence tomography(OCT)/OCT angiography(OCTA)DRI OCT *** linear regression analysis was used to explore the associations between SFCT,FAZ area,SVD,DVD and the relevant factors of ***:Those with active TED patients had higher c-DVD and m-DVD levels(P<0.05),however there is no statistically significant difference in SFCT between active and stable TED *** the serum antibodies,it was observed that s-FAZ and d-FAZ increased,c-SVD and m-SVD decreased in patients with high thyroid stimulating hormone-receptor autoantibodies(TRAB)level,whereas SFCT thickened in patients with high levels of both TRAB and human thyroglobulin(hTG).There was no significant difference in SFCT,FAZ,SVD and DVD measurement at gender,between hyperthyroid and euthyroid patients and among those with or without thyroid papillary ***:The results show that both disease activation and serum antibodies differentially affect both superficial and deep retinal vascular *** has also been shown that high serum antibody levels affect choroidal thickness independent of clinical activity.

关键词： thyroid eye disease optic coherence tomography angiography vascular density choroidal thickness foveal avascular zone area

Effect of Mixing Strategy on the Structure-Properties of the PLA/PBAT Blends Incorporated with CNC

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Journal of Renewable Materials 2022年第1期10卷 149-164页

作者： Deniz Sema Sarul dogan Arslan Emre Vatansever Yusuf Kahraman Ali Durmus Reza Salehiyan Mohammadreza Nofar Polymer Science and Technology Program Institute of Science and TechnologyIstanbul Technical UniversityIstanbul34469Turkey Metallurgical&Materials Engineering Department Faculty of Chemical and Metallurgical EngineeringIstanbul Technical UniversityIstanbul34469Turkey Department of Chemical Engineering Faculty of EngineeringIstanbul University-CerrahpasaIstanbul34320Turkey Department of Materials Research and Technology Luxembourg Institute of Science and TechnologyEsch-sur-Alzette4362Luxembourg

Polylactide(PLA)/poly(butylene adipate-co-terephthalate)(PBAT)blend nanocomposites including 3 wt%of cel-lulose nanocrystals(CNCs)were prepared by melt compounding method in a twin-screw extruder and an inter-nal *** nanocomposites were formulated by diluting three different masterbatches prepared by solution casting method that contained 7 wt%of *** masterbatches were:(m1)PLA/PBAT/CNC masterbatch;(m2)PLA/CNC masterbatch;and(m3)PBAT/CNC *** were to explore how different prepara-tion methods affect the dispersion and localization of CNC and hence the properties of PLA/PBAT/CNC blend *** electron microscopy(SEM)was used to study the structural changes of the *** properties of PLA/PBAT blends and PLA/PBAT/CNC blend nanocomposites were also *** the samples prepared by internal mixer,the rheological behavior of blend nanocomposite prepared through premixing of CNC particles with PLA showed a transition from liquid-like to a gel-like *** to the rheological results and differential scanning calorimetry(DSC)analysis,it was found that the CNC overall enhanced the viscoelastic properties of blends and improved the PLA crystallization,*** mechanical analysis(DMA)illustrated that the incorporation of CNC also enhanced the elastic modulus of PLA/PBAT blends specifically above the glass transition temperature of *** expected improvements in mechanical properties did not occur due to the possible existence of residual solvent in the blends.

关键词： Polylactide poly(butylene adipate-co-terephthalate) cellulose nanocrystals blend nanocomposite morphology rheology

Streamlined CFD simulation framework to generate wind-pressure coefficients on building facades for airflow network simulations

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Building Simulation 2021年第4期14卷 1189-1200页

作者： Timur dogan Patrick Kastner Cornell University Department of ArchitectureEnvironmental Systems LaboratoryEast Sibley HallIthacaNY14850USA

Building energy modeling software generally comes with capable airflow network solvers for natural ventilation evaluation in multi-zone building energy models. These approaches rely on arrays of pressure coefficients representing different wind directions derived from simple box-shaped buildings without contextual obstructions. For urban or obstructed sites, or more complex building shapes, however, further evaluation is needed to avoid geometric oversimplification. In this study, we present an automated and easy-to-use simulation workflow for OpenFOAM-based exterior airflow simulations to generate arrays of pressure coefficients for arbitrary building shapes and contextual situations. The workflow is compared to other methods commonly used to obtain pressure coefficients for natural ventilation analysis. Finally, we assess for which climate zones and building types modelers should rely on more accurate CFD-based pressure coefficients and where it may be justifiable to rely on easier and readily available analytical approaches to determine pressure coefficients. Results suggest that existing workflows lead to significant error in predicted comfort hours for climates in the Global South and modelers should consider CFD-based facade pressure coeficients.

关键词： natural ventilation airflow networks EnergyPlus pressure coefficients computational fluid dynamics

Social media video analysis methodology for sarin exposure

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Forensic Sciences Research 2022年第2期7卷 279-284页

作者： Sadik Toprak Emine Yilmaz Can Bulent Altinsoy John Hart Zekeriya dogan Mustafa Ozcetin Department of Forensic Medicine Istanbul UniversityIstanbulTurkey Department of Medical Pharmacology Bulent Ecevit UniversityZonguldakTurkey Department of Pulmonary Medicine Bulent Ecevit UniversityZonguldakTurkey James Martin Center for Nonproliferation Studies MontereyCAUSA Department of Civil Engineering Bulent Ecevit UniversityZonguldakTurkey Department of Pediatrics Istanbul UniversityIstanbulTurkey

As social media becomes increasingly ubiquitous,many events are recorded and released on social media platforms,including chemical weapon *** develop an objective tool in order to evaluate brief and unstructured social media videos for analysing sarin exposure from a civilian medical pathology *** developed and validated this new questionnaire using a standardized procedure that includes content domain specification,item pool generation,content validity evaluation,a pilot study,and assessment of reliability and *** total,51 sarin attacks and 48 matched videos were ***’s a for all 20 items was 0.75,which indicates adequate internal *** test–retest reliability was 0.96,which indicates good internal *** inter-observer intraclass correlation coefficient was *** verifying sampling adequacy with the Kaiser–Meyer–Olkin measure and the factorability of the items with Barlett’s test of sphericity,a factor analysis was *** to the principal axis factoring,a six-factor solution explained 51.86%of the total *** receiver-operating characteristic curve analysis showed that the Video Score Questionnaire has a sensitivity of 0.817,a specificity of 0.478,and an efficiency of ***,the Video Score Questionnaire is reliable and valid for evaluating sarin attacks from brief and unstructured social media videos.

关键词： Forensic sciences social media sarin scale questionnaire chemical weapon nerve agent YouTube