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SARS-CoV-2 in inflammatory bowel disease population:Antibodies,disease and correlation with therapy

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World Journal of Gastrointestinal Endoscopy 2022年第3期14卷 153-162页

作者： Clara Benedetta Conti Elsa Mainardi Sara soro Sophie Testa Annalisa De Silvestri Andrea Drago Fabrizio Cereatti Roberto Grassia Department of Gastroenterology and Digestive Endoscopy ASST CremonaCremona 26100Italy Department of Laboratory Medicine Haemostasis and Thrombosis CenterASST CremonaCremona 26100Italy Department of Clinic Epidemiology and Biometric Scientific DirectionFondazione IRCCS Policlinico San MatteoPavia 27100Italy

BACKGROUND Guidelines recommend to cease inflammatory bowel disease(IBD)biologic therapy during coronavirus disease 2019(COVID-19).AIM To investigate severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)antibody positivity in an IBD cohort,COVID-19 disease severity and to evaluate the correlation with clinical/therapeutic *** Prospective observational cohort *** patients were tested for SARS-CoV-2 *** on COVID-19 disease,demographics/therapeutics and clinical features of the IBD population were ***≥7 was set for SARS-CoV-2 antibody *** swab was performed in cases of IgG *** between antibody positivity or COVID-19 symptoms and therapeutic/clinical data were *** In total,103 IBD patients were *** them,18.4%had IgG≥*** analysis of antibody positivity correlated only with IBD *** IgG≥7,the odds ratio was 1.44 and 0.16 for azathioprine and mesalazine,respectively,vs biologic drugs(P=0.0157 between them).COVID-19 related symptoms were reported in 63%of patients with IgG *** but one patient with COVID-19 symptoms did not require ceasing IBD treatment or hospitalization. IBDtreatment and body mass index correlated with COVID-19 disease development with *** IBD population does not have a higher risk of severe COVID-19. The relative risk of havingSARS-CoV-2 antibodies and symptoms was higher for patients taking azathioprine, then biologictherapy and lastly mesalazine. None of the patients under biologic therapy developed severeCOVID-19.

关键词： Inflammatory bowel disease SARS-CoV-2 COVID-19 Biologic treatment SARS-CoV-2 antibody Inflammatory bowel disease therapy

Multi-Spectral and Fluorescence Imaging in Prevention of Overdose of Herbicides: The Case of Maize

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Spectral Analysis Review 2017年第2期5卷 11-24页

作者： Anicet K. Kouakou Adama P. soro Alvarez K. Taky Jérémie T. Zoueu Laboratoire de Cristallographie et Physique Moléculaire Université Félix Houphou&euml t Boigny Abidjan C&ocirc te d’Ivoire Laboratoire d’Instrumentation Image et Spectroscopie INP-HB DFR-GEE Yamoussoukro C&ocirc te d’Ivoire

Evaluation of the impact of herbicides on maize was done through multi- spectral and multi-modal imaging and multi-spectral fluorescence imaging combined with statistical methods. Spectra containing 13 wavelengths ranging from 375 nm to 940 nm were derived from multi-spectral images in transmission, reflection and scattering mode and fluorescence images obtained using high-pass filters (F450 nm, F500 nm, F550 nm, F600 nm, F650 nm) on control maize samples and maize samples treated with Herbextra herbicide were used. The appearance of the spectra allowed us to characterize the effect of the herbicide on the maize pigment concentration. The fluorescence images allowed us to track the fate of absorbed energy and through PLS-DA and SVM-DA to discriminate the two leaf categories with very low error rates for the test, i.e. 4.9% and 2% respectively. The results of this technique can be used in the context of precision agriculture.

关键词： Maize Herbextra Multi-Spectral Imaging Multimodal Imaging Fluorescence PLS-DA SVM-DA

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俄罗斯东部中—新生代构造和矿床建造

国外矿床地质 1995年第4期 41-42页

作者： soro.,AP 董建华

Pancreatic Cancer: Epidemiological, Clinical and Therapeutic Aspects in Abidjan (Ivory Coast)

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Open Journal of Gastroenterology 2017年第8期7卷 223-229页

作者： Amadou Ouattara Siaka Kone Dramane soro Constant Assi Emile Allah-Kouadio Rodrigue Irie Gohi Bi Fanoucoffi Denis Marie-Jeanne Lohoues-Kouacou Teaching Hospital Center of Cocody Abidjan C&ocirc te d’Ivoire

Aim: The aim was to study the epidemiological, clinical and therapeutic aspects of pancreatic cancers in Ivory Coast. Materials and methods: A retrospective multi-center and multidisciplinary study aimed at describing sixteen years and four months from January 1, 2000 to April 30, 2016 in several hospitals in the city of Abidjan taking charge of pancreatic cancers (hepato-gas troenterology services of the universities hospitals of Cocody and Yopougon), internal medicine departments of University Hospital of Treichville and Abidjan Military Hospital, the department of oncology of the university hospital center of Treichville, private clinics (DANGA, PISAM and GMP), the COBA center in Treichville. The diagnosis of cancer was based on either histological criteria or a set of clinical and paraclinical arguments. Patients whose files did not include imaging were excluded from this study. The following parameters were collected: age, sex, reason for consultation, physical signs, personal and family antecedents, tumor characteristics, delay in diagnosis and the nature of the treatment administered. Results: We have observed 150 cases of pancreatic cancer. The mean age of patients was 59.09 years with extremes ranging from 24 years to 88 years. Our study population consisted of 98 men and 52 women (sex ratio 1.88). Risk factors were dominated by diabetes 20.7%. Epigastralgia is the main reason for consultation (48%). The tumor was localized at the cephalic level in 84.67%. In 13 cases the diagnosis was histological and was dominated by adenocarcinoma (100%). The majority of our patients was seen at an advanced stage of the disease: stage IV (74.56%). The average time to diagnosis was 2.76 months. Fourteen of our patients (9.33%) had benefited surgery. This was curative surgery in 35.71% (n = 5) and palliative in 64.29% (n = 9). Among those who benefited from this curative surgery, three died two months after surgery and two lost to follow-up. The majority (90.67%) of our pa

关键词： Pancreas Cancer Epidemiological Ivory Coast

Endoscopic ultrasound diagnostic gain over computed tomography and magnetic resonance cholang-iopancreatography in defining etiology of idiopathic acute pancreatitis

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World Journal of Gastrointestinal Endoscopy 2022年第6期14卷 376-386页

作者： Stefano Mazza Biagio Elvo Clara Benedetta Conti Andrea Drago Maria Chiara Verga Sara soro Annalisa De Silvestri Fabrizio Cereatti Roberto Grassia Gastroenterology and Digestive Endoscopy Unit ASST CremonaCremona 26100Italy Gastroenterology and Endoscopy Unit Federico Ⅱ UniversityNapoli 80131Italy Interventional Endoscopy Unit ASST MonzaMonza 20900Italy Biometry and Clinical Epidemiology Scientific DirectionIRCCS San Matteo Hospital FoundationPavia 27100Italy Department of Gastroenterology and Digestive Endoscopy Castelli HospitalAriccia(Rm)00040Italy

BACKGROUND About 10%-30%of acute pancreatitis remain idiopathic(IAP)even after clinical and imaging tests,including abdominal ultrasound(US),contrast-enhanced computed tomography(CECT)and magnetic resonance cholangiopancreatography(MRCP).This is a relevant issue,as up to 20%of patients with IAP have recurrent episodes and 26%of them develop chronic *** data are available on the role of EUS in clarifying the etiology of IAP after failure of one or more cross-sectional *** To evaluate the diagnostic gain after failure of one or more previous crosssectional *** We retrospectively collected data about consecutive patients with AP and at least one negative test between US,CECT and MRCP,who underwent linear EUS between January 2017 and December *** investigated the EUS diagnostic yield and the EUS diagnostic gain over different combinations of these crosssectional imaging techniques for the etiologic diagnosis of *** and frequency of EUS diagnosis were also analyzed,and EUS diagnosis was compared with the clinical *** EUS,patients were followed-up for a median of 31.5 mo to detect cases of pancreatitis *** We enrolled 81 patients(63%males,mean age 61±18,23%with previous cholecystectomy,17%with recurrent pancreatitis).Overall EUS diagnostic yield for AP etiological diagnosis was 79%(20%lithiasis,31%acute on chronic pancreatitis,14%pancreatic solid or cystic lesions,5%pancreas divisum,5%autoimmune pancreatitis,5%ductal abnormalities),while 21%remained ***,CECT and MRCP,taken alone or in combination,led to AP etiological diagnosis in 16(20%)patients;among the remaining 65 patients,49(75%)obtained a diagnosis at EUS,with an overall EUS diagnostic gain of 61%.Sixty-eight patients had negative US;among them,EUS allowed etiological diagnosis in 59(87%).Sixty-three patients had a negative CECT;among them,47(74%)obtained diagnosis with ***-four had a negative MRCP;among them,20(83%)had EUS diag

关键词： Endoscopic ultrasound Idiopathic acute pancreatitis Diagnostic gain Computed tomography Magnetic resonance cholangiopancreatography

Developmental Effects of Malathion Exposure on Recognition Memory and Spatial Learning in Males Wistar Rats

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Journal of Behavioral and Brain Science 2013年第3期3卷 331-340页

作者： Pacome Kouadio N’Go Fatima-Zahra Azzaoui Porlo Rigobert soro Majda Samih Ahmed Omar Touhami Ahami Mohamed Najimi Fatiha Chigr Unit of Clinics and Cognitives Neurosciences Laboratory of Biology and HealthDepartment of BiologyFaculty of SciencesUniversity Ibn TofailKenitraMorocco Laboratory of Physiology Animal Department of BiologyFaculty of Sciences and TechnologyUniversity Sultan Moulay SlimaneBeni MellalMorocco

Most cognitive effects of Organophosphate Pesticides (OP) are induced after exposure to parathion, chlorpyrifos and diazinon, which the usage has been restricted because of overt signs of their toxicities. In this study, we investigate whether developmental exposure to Malathion could impair spatial learning and recognition memory in male rats. Animals exposed by intragastric route, from in utero to young adult stage, to incremental doses of Malathion dissolved in corn oil;100, 200 and 300 mg/kg of body weight, and one control group are given corn oil. Then, cognitive and behaveioral abilities are assessed using Barnes maze and object recognition memory task. Malathion administration at 300 mg/kg is toxic to pregnant dams, and pups are stillborns. Rats exposed to 200 mg/kg make a significant working memory error, and require more time to find an escape box during the initial training phase of Barnes maze. However, fewer errors are made in rats exposed to 100 mg/kg. For reversal learning task, the high dose group shows great deficits in spatial strategy to locate the new position of the box. With respect to recognition task, both dose 100 and 200 mg/kg impair significant short-term (2 h after habituation phase) object recognition memory, but long-term (24 h after habituation phase) recognition memory is intact in high dose group. The current study also reveals that all treatments induce high significant neocortex acetylcholinesterase (AChE) activity inhibition, but 100 mg/kg dose is not sufficient to disrupt great hippocampal activity alteration. These results suggest that developmental exposure to Malathion, despite low toxicity described, may induce late-emerging spatial learning and recognition memorialterations. Moreover, Cortical and hippocampal area that support strongly these behaviors remain sensitive to incremental doses of Malathion.

关键词： AChE Developmental Neurotoxicity Malathion Organophosphate Pesticide Recognition Memory Spatial Learning

Interest of SAAG in Etiological Diagnosis of Ascites in African Black

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Open Journal of Gastroenterology 2018年第10期8卷 337-347页

作者： Okon Anassi Jean Baptiste soro Dramane Doffou Stanislass Diakite Mamadou Koné Amadou Aké Fabrice Thot’o Amani Sroboua N’dri N’guessan Hepato-Gastroenterology Department University Hospital Center Bouaké Ivory Coast Hepato-Gastroenterology Department University Hospital Center Abidjan Ivory Coast

Purpose: To show the interest of the serum-ascites concentration gradient in albumin (SAAG) in the etiological diagnosis of ascites in African black. Materiel and Methods: This was a monocentric observational and analytical study performed on patients over 15 years old and hospitalized in the Hepato-Gastroenterology department of Cocody from January 1st, 2010 to March 31st, 2017 for ascites. The cytology and chemistry of the ascites fluid and the protidogram were performed. The main outcome measure was the prediction of portal hypertension (PHT) or non-portal hypertension related causes of ascites from SAAG. Results: The hospital prevalence of ascites was 11%. There were 82 women (46.9%) and 93 men (53.1%) with a sex ratio (M/F) of 1.1. SAAG was low in 68.6% of cases and high in 31.4% of cases. The most common etiologies were post-viral cirrhosis (74%), HCC (16.60%) and peritoneal tuberculosis (13.7%) respectively. In the case of high SAAG, 91% of ascites related to PHT were observed, but also 77.5% of a low SAAG corresponded to ascites related to PHT (p = 0.024) with Se = 35% Sp = 84% and accuracy = 44%. All patients with peritoneal tuberculosis had a SAAG low of less than 1.1 g/dl significantly (p = 0.002). SAAG had a diagnostic performance of 89% in peritoneal tuberculosis at the cutoff value of ?1.24 g/dl (AUROC = 0.91, Se = 96%, Sp = 86%) while in post viral hepatitis cirrhosis at a threshold of 0.58 g/dl the diagnostic performance was 60% (AUROC = 0.69, Se = 53%, Sp = 79%). Conclusion: The simple technical SAAG, allowing to distinguish the ascites linked to the PHT and the ascites not bound to the PHT, can be used like a method of diagnosis of the etiologies of the ascites especially in the peritoneal tuberculosis in the African countries low income.

关键词： SAAG Ascites Peritoneal Tuberculosis Cirrhosis PHT

Mapping of Malaria Risk Related to Climatic and Environmental Factors by Multicriteria Analysis in the MarahouéRegion of Côte d’Ivoire

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Journal of Geoscience and Environment Protection 2022年第6期10卷 234-252页

作者： Assikohon Pulchérie Gouzile Martial Bama Bi Yourou Guillaume Zamina Ellélé Aimé Yapi Gneneyougo Emile soro Bi Tie Albert Goula Tiembré Issiaka National Institute of Public Hygiene Abidjan C&#244 te d’Ivoire Félix Houphouë t Boigny University Abidjan C&#244 te d’Ivoire Nangui-Abrogoua University Abidjan C&#244 te d’Ivoire

Malaria, a febrile human disease transmitted by female anopheles whose ecology is linked to water, is a major public health problem in Côte d’Ivoire, more precisely in the Marahoué region located in the southwest of the country. In order to effectively control this disease, it is necessary to understand the etiology and the diffusion pattern of the vectors. This justifies this study, which proposes to determine the areas at risk of malaria transmission in order to carry out an effective fight against this disease in this region of Côte d’Ivoire. To achieve this, a combined approach of geographic information systems and multicriteria analysis was adopted. The analysis reveals that the south and northwest of the Marahoué region present a high risk for malaria transmission. This risk is linked to indicators such as climatic factors that cover 48.36% of the study area, environmental factors such as vegetation cover (NDVI), soil moisture (NDWI), altitude, hydrography (water point) and population that covers 55.29% of the area and land use. Also, the results indicated that 50.70% of the region has favorable conditions for malaria transmission. Overall, climatic and environmental indicators are the risk factors associated with the resurgence of malaria.

关键词： Mapping Palustrum Multicriteria Analysis Marahoué Ivory Coast

Hydrological Characterization of Water Resources Used for Sugarcane Production in the Sugar Complexes of Ferkessedougou (North of Côte d’Ivoire)

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Journal of Geoscience and Environment Protection 2021年第12期9卷 1-15页

作者： Affoué Berthe Yao Sampah Georges Eblin Gla Blaise Ouedé Kouakou Lazare Kouassi Do Ange Désiré soro Arona Diedhiou Bi Crépin Péné Laboratory of Environmental Sciences and Technologies UFR Environment Jean Lorougnon Guédé University Daloa C&#244 te d’Ivoire Laboratory NEXUS “Climate Water Agriculture Energy Nexus and Climate Services” Research and Development Institute Felix Houphou&#235 t Boigny University Abidjan C&#244 te d’Ivoire Research and Development Department SUCAF-CI Ferkessedougou C&#244 te d’Ivoire

Water resources, although renewable, are limited and threatened by climate change and anthropic activities. Assessment and forecasting of these resources can provide valuable information for water resource planners. This study aims to quantify the surface water resources used for sugarcane production in sugar complexes of Ferkessedougou. This is based on the morphological characterization of the river Morrison and Lopkoho dams and on extreme daily flow probability of occurrence estimation using frequency analysis method. The bathymetric survey showed that the Morrison Dam impoundment had a maximum depth of 11.98 m;a water capacity of 11,656,735.5 m3. For the Lokpoho dam, the reservoir had a maximum depth of 8.82 m, which corresponds to a water volume of 4,354,531.5 m3. Nevertheless, the water capacity of these reservoirs is greatly reduced by a large volume of sediment estimated at 1,013,058.96 m3 for Morrison and 599,740 m3 for Lokpoho. Statistical analysis of maximum daily flows shows that flows between 73.9 and 100 m3/s have the potential to occur every five years at the Route Korhogo Badikaha hydrometric station. The recurrence of the decennial (298 m3) and quinquenal (248 m3) flows shows the importance of the flood flows of the Bandama River. It also shows that the low water levels of the Bandama are very pronounced. The minimum flow that SUCAF-CI water managers should expect every five years is 1.36 m3/s and the ten-year low flow is 2.10 m3/s. These results are indicators of water scarcity risks and could guide decision making in the Ferkessedougou sugar complexes.

关键词： Bathymetric Survey Flow Quantile Return Period Sugar Complexes Côte d’Ivoire