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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 24-25页

作者： Khamaysi Z. dodiuk- gad r.p. Weltfriend S. r.Bergman 李政霄 Dr. Department of Dermatology Rambam Medical Center Haifa 31096 Israel

A cutaneous er.p.ion simulating insect bites has been r.p.atedly described in association with chronic lymphocytic leukemia (CLL). It was only rarely described with mantle cell lymphoma (MCL). Our study was performed to elucidate the clinical, histologic, immunopathological, and molecular characteristics of insect bite like reaction (IBLr) associated with MCL. The clinical presentation and histologic findings in 3 IBLr cases associated with MCL were found to be similar to 3 IBLr cases associated with CLL. The er.p.ions consisted of itchy erythematous papules, nodules, plaques, and vesicles. Non- vesicular lesions were characterized histologically by normal or mildly spongiotic epidermis. Vesicular lesions were characterized by marked spongiosis and intraepidermal spongiotic vesicles containing eosinophils, or marked subepidermal edema occasionally leading to a dermoepidermal separation. Most of the lesions were characterized by superficial and mid dermal to deep perivascular and interstitial, and occasionally periadnexal, inflammatory- cell infiltrate consisting of mononuclear cells and eosinophils. The densities of the infiltrates varied and the inflammatory- cell infiltrate extended often into the fat lobules. Neutr.p.ils and nuclear dust were found more frequently and abundantly in the IBLr lesions associated with MCL. Immunophenotyping, direct immunofluorescence (DIF)- tests, and IgH gene rearrangement studies were performed in the lesions associated with MCL only. The majority of the infiltrating lymphocytes were CD3+ , CD5+ and CD43+ , more CD4+ than CD8+ , and only a small minority was CD20+ . The cells did not stain for bcl- 1 protein and CD30, and with no evidence of clonality. The DIF test result was negative. The IBLr er.p.ion associated with MCL resembles clinically and histologically IBLr associated with CLL. The er.p.ion seems to be reactive rather than neoplastic, because there is no evidence of MCL involvement in the skin lesions.

关键词：套细胞淋巴瘤免疫病理学临床病理学基因重排红斑丘疹克隆形成炎细胞浸润嗜酸性粒细胞直接免疫荧光脂肪小叶

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与外套膜细胞淋巴瘤相关的昆虫咬伤样反应:2例报道和文献回顾

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 17-17页

作者： dodiuk-gad r.p. Dann E.J. Bergman r. 刘超 Department of Dermato logy Rambam Medical Center POB 9602 31096 Haifa IsraelDr.

Background. An insect bite-like reaction and exaggerated reactions to insec t bites are nonspecific phenomena described primarily in association with chroni c lymphocytic leukemia (CLL), but also with other hematological malignancies. Tw o cases of mantle cell lymphoma (MCL), one associated with an insect bite-like reaction and the other with a true hypersensitivity to mosquito bites, have pre viously been r.p.rted in the English language literature. The pathogenesis of th e skin er.p.ion may be related to the release of different cytokines that also t rigger an IgE elevation and dermal eosinophils. Case r.p.rt. We describe two add itional cases of MCL associated with an insect bite-like reaction. One patient had been diagnosed with MCL 4.5 years prior to the appearance of the skin er.p. ion, and in the other.p.tient the skin symptoms preceded the diagnosis of the MC L by 2 years and led to its diagnosis. Conclusions. Insect bite-like reaction may appear in patients with MCL. It is important to recognize this entity becaus e it may be the presenting sign of MCL.

关键词：淋巴瘤文献回顾英文文献特异性

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Ectopic Cushing's syndrome in a patient with metastatic Merkel cell carcinoma:A case r.p.rt

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World Journal of Clinical Cases 2022年第22期10卷 7989-7993页

作者： Avraham Ishay Elia Touma Olga Vornicova roni dodiuk-gad Tal Goldman Naiel Bisharat Endocrine and Diabetes Unit Emek Medical CenterAfula 18134Israel ruth and Bruce r.p.aport Faculty of Medicine Technion-Israel Institute of TechnologyHaifa 3200003Israel Department of Internal Medicine D Emek Medical CenterAfula 18134Israel Department of Oncology Emek Medical CenterAfula 18134Israel Department of Dermatology Emek Medical CenterAfula 18134Israel Department of pathology Emek Medical CenterAfula 18134Israel Department of Medicine D Emek Medical CenterAfula 18134Israel

BACKGrOUND Ectopic Cushing syndrome(ECS)is a rare condition commonly associated with neuroendocrine tumors(NET),mainly bronchial *** association of paraneoplastic syndrome with Merkle cell carcinoma(MCC)is limited to individual case *** SUMMArY In this article we r.p.rt an unusual and striking presentation of ECS in a patient with known metastatic *** elderly patient presented with new onset severe hypertension,hyperglycemia and hypokalemia,muscle wasting,and per.p.eral edema.A diagnosis of adrenocorticotr.p.c hormone dependent,non-pituitary,Cushing syndrome was *** ther.p. inhibiting adrenal function was promptly started but unfortunately the patient survived only a few days after *** The occurrence of an aggressive form of ECS in patients with NET should be recognized as an ominous *** our knowledge,the association of this complication in a patient with MCC had not been r.p.rted.

关键词： Merkle cell carcinoma paraneoplastic syndrome Ectopic Cushing's syndrome Neuroendocrine tumor Hypercortisolism Skin cancer Case r.p.rt

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米诺环素诱导的皮肤色素沉着症:共聚焦激光扫描电子显微镜分析

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世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 10-10页

作者： dodiuk-gad r.p. de Morentin H.M. Schafer J. S. Brenner 党倩丽 Department of Dermatology Tel Aviv Sourasky Medical Center 6Weizmann Street Tel Aviv 64239 Israel

Background: Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. Objective: To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. Methods: Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). results: A yellow-green fluorescencewas observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. Conclusion: Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.

关键词：共聚焦激光扫描皮肤色素沉着色素沉着症米诺环素电子显微镜分析扫描电子显微镜光学显微镜黄绿色荧光特征性

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