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Evolving strategies: Enhancements in managing eosinophilic esophagitis in pediatric patients

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World Journal of Clinical Pediatrics 2024年第1期13卷 14-22页

作者： ahmed Elghoudi doaa Zourob Eman Al Atrash Fatima Alshamsi Manal Alkatheeri Hassib Narchi Rana Bitar Department of Pediatric Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Division of Pediatric Gastroenterology Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Pediatric Residency Program Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates College of Medicine and Health Sciences United Arab Emirates UniversityAlainAbu DhabiUnited Arab Emirates

Eosinophilic esophagitis is a newly recognized disease first described about 50 years *** definition,diagnosis,and management have evolved with new published consensus guidelines and newly approved treatment available to pediatricians,enabling a better understanding of this disease and more targeted treatment for *** describe the definition,presentation,and diagnosis of eosinophilic esophagitis including management,challenges,and future directions in *** definition,diagnosis,and management of eosinophilic esophagitis have evolved over the last 50 *** guidelines and newly approved biologic treatment have enabled pediatricians to better understand this disease and allow for more targeted treatment for *** describe the definition,presentation,diagnosis,management,and treatment in addition to the challenges and future directions of eosinophilic esophagitis management in children.

关键词： Eosinophilic esophagitis Esophagitis Gastroesophageal reflux disease Food allergy Dysphagia

Enhancing Wireless Sensor Network Efficiency through Al-Biruni Earth Radius Optimization

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Computers, Materials & Continua 2024年第6期79卷 3549-3568页

作者： Reem Ibrahim Alkanhel doaa Sami Khafaga ahmed Mohamed Zaki Marwa M.Eid Abdyalaziz A.Al-Mooneam Abdelhameed Ibrahim S.K.Towfek Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Computer Science and Intelligent Systems Research Center BlacksburgVirginia24060USA Delta Higher Institute for Engineering and Technology Mansoura35511Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Artificial Intelligence and Computational Intelligence Research Center MeridenConnecticut06450USA School of ICT Faculty of EngineeringDesign and Information&Communications Technology(EDICT)Bahrain PolytechnicP.O.Box 33349Isa TownBahrain

The networks of wireless sensors provide the ground for a range of applications,including environmental moni-toring and industrial *** the networks can overcome obstacles like power and communication reliability and sensor coverage is the crux of network *** infrastructure planning should be focused on increasing performance,and it should be affected by the detailed data about node *** work recommends the creation of each sensor’s specs and radius of influence based on a particular geographical location,which will contribute to better network planning and *** using the ARIMA model for time series forecasting and the Al-Biruni Earth Radius algorithm for optimization,our approach bridges the gap between successive terrains while seeking the equilibrium between exploration and *** implementing adaptive protocols according to varying environments and sensor constraints,our study aspires to improve overall network *** compare the Al-Biruni Earth Radius algorithm along with Gray Wolf Optimization,Particle Swarm Optimization,Genetic Algorithms,and Whale Optimization about performance on real-world *** the most efficient in the optimization process,Biruni displays the lowest error rate at *** two other statistical techniques,like ANOVA,are also useful in discovering the factors influencing the nature of sensor data and network-specific *** to the multi-faceted support the comprehensive approach promotes,there is a chance to understand the dynamics that affect the optimization outcomes better so decisions about network design can be *** delivering better performance and reliability for various in-situ applications,this research leads to a fusion of time series forecasters and a customized optimizer algorithm.

关键词： Wireless sensor networks optimization ARIMA model BER algorithm metaheuristic algorithms

Sodium-Glucose Cotransporter-2 Inhibitors: Who, When & How? Guidance for Use from a Multidisciplinary Practical Approach

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International Journal of Clinical Medicine 2024年第9期15卷 413-435页

作者： khalifa Abdullah Magdy ElSharkawy Emad R. Issak ahmed Shawky ElSerafy Samah Idris ahmed Bendary Haytham Reda Badr May Shehata Ashraf Reda Internal Medicine Department Diabetes & Metabolism Unit Faculty of Medicine Alexandria University Alexandria Egypt Nephrology Department Faculty of Medicine Ain Shams University Cairo Egypt Internal Medicine Department Faculty of Medicine Ain Shams University Cairo Egypt Cardiology Department Faculty of Medicine Ain Shams University Cairo Egypt Internal Medicine and Nephrology Department Faculty of Medicine Alexandria University Alexandria Egypt Cardiology Department Faculty of Medicine Benha University Benha Egypt Internal Medicine Department Diabetes and Endocrinology Unit Faculty of Medicine Menoufia University Menoufia Egypt Product Manager Al-Esraa Pharma Cairo Egypt Cardiology Department Faculty of Medicine Menoufia University Menoufia Egypt

Sodium-glucose cotransporter-2 inhibitors (SGLT-2 inhibitors) have transformed diabetes management by targeting renal glucose reabsorption. Designed initially as antidiabetic agents, their ability to lower blood glucose levels independently of insulin is well-documented. Beyond glycemic control, emerging research has unveiled their profound cardiorenal benefits. By inhibiting SGLT-2 protein, these drugs enhance glucose excretion in urine, reducing blood glucose levels. This mechanism has translated into significant cardiovascular and renal protection, establishing SGLT-2 inhibitors as pivotal in managing not only diabetes but also cardiovascular and renal diseases. Recent studies have illuminated the broader therapeutic potential of SGLT-2 inhibitors beyond diabetes. Evidence indicates their efficacy in managing heart failure, chronic kidney disease (CKD), and cardiovascular complications in individuals with or without diabetes. This expanded therapeutic landscape has catalyzed a paradigm shift in SGLT-2 inhibitor use, positioning them as key agents in the cardiorenal metabolic continuum. Moreover, their role in the secondary prevention of cardiovascular events and slowing CKD progression in T2DM patients has garnered considerable attention. This consensus-based review aims to offer practical guidance in an algorithmic approach to primary care healthcare professionals to optimize SGLT-2 inhibitors utilization and maximize their benefits. The review seeks to empower clinicians to effectively manage patients who may benefit from SGLT-2 inhibitor therapy by addressing common initiation barriers and optimizing treatment strategies. Additionally, it aims to raise awareness among primary care physicians regarding the multifaceted benefits of these medications and overcome clinical inertia in their adoption into routine clinical practice.

关键词： Sodium-Glucose Cotransporter-2 Inhibitors Cardiorenal Benefits Therapeutic Potential Cardiovascular Protection Primary Care Optimization

From seawater to hydrogen via direct photocatalytic vapor splitting: A review on device design and system integration

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Frontiers in Energy 2024年第3期18卷 291-307页

作者： Hongxia LI Khaja WAHAB ahmed Mohamed A.ABDELSALAM Michael FOWLER Xiao-Yu WU Technology Innovation Institute Masdar CityAbu Dhabi 9639United Arab Emirates Department of Chemical Engineering University of WaterlooWaterlooON N2L 3G1Canada Department of Mechanical and Nuclear Engineering Khalifa University of Science and TechnologyAbu Dhabi 127788United Arab Emirates Department of Mechanical and Mechatronics Engineering University of WaterlooWaterlooON N2L 3G1Canada

Solar-driven hydrogen production from seawater attracts great interest for its emerging role in decarbonizing global energy consumption. Given the complexity of natural seawater content, photocatalytic vapor splitting offers a low-cost and safe solution, but with a very low solar-to-hydrogen conversion efficiency. With a focus on cutting-edge photothermal–photocatalytic device design and system integration, the recent research advances on vapor splitting from seawater, as well as industrial implementations in the past decades were reviewed. In addition, the design strategies of the key processes were reviewed, including vapor temperature and pressure control during solar thermal vapor generation from seawater, capillary-fed vaporization with salt repellent, and direct photocatalytic vapor splitting for hydrogen production. Moreover, the existing laboratory-scale and industrial-scale systems, and the integration principles and remaining challenges in the future seawater-to-hydrogen technology were discussed.

关键词： seawater hydrogen photocatalytic vapor splitting solar-driven

Effect of Aging on the Toughness of Austenitic and Duplex Stainless Steel Weldments

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Journal of Materials Science & Technology 2010年第9期26卷 810-816页

作者： Omyma Hassan Ibrahim Ibrahim Soliman Ibrahim Tarek ahmed Fouad khalifa Metallurgy Dept. Nuclear Research CentreAtomic Energy Authority(Egypt) Nuclear Safety Centre Atomic Energy Authority(Egypt) Shoubra Faculty of Engineering Benha University

In the present study,the effect of aging heat treatment at 650,750,and 850？C on the impact toughness of 316L austenitic stainless steel,2205 duplex stainless steel and their weldments has been *** process was conducted using the TIG（tungsten inert gas） welding *** impact testing,at room temperature,was employed to determine the effect of aging treatment on the impact properties of investigated *** treatment resulted in degradation in the impact toughness as demonstrated by the reduction in the impact fracture energy and deformation parameters（strain hardening capacity,fracture deffection,and crack initiation and propagation energy）.The degree of embrittlement was more noticeable in duplex stainless steel parent and weld-metal than in 316L stainless steel and became greater with the increase of aging *** degradation in impact toughness was discussed in relation to the observed precipitation of the intermetallic sigma phase in the microstructure of the stainless steel weldments and the corresponding fracture surface morphology.

关键词： Austenitic and duplex stainless steels Aging Instrumented impact Toughness

Walking experience:Exploring the trilateral interrelation of walkability,temporal perception,and urban ambiance

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Frontiers of Architectural Research 2021年第3期10卷 516-539页

作者： doaa K.Hassan ahmed Elkhateeb Department of Architecture Faculty of EngineeringAin Shams UniversityCairoEgypt

Walking experience through urban spaces is a frequent daily ***,planning and designing for walkability become crucial for building up quality of *** daily walks around the city are affected by fulfilling the needed psychological contentment that is in turn measured unconsciously by our temporal *** contentment is inherent in what we experience in accordance with urban ambiance that goes beyond the spatial attributes of spaces to include their social and sensorial ***,the question here is how walkability of urban routes is affected by urban ambiance and therefore perceived in terms of ***,this study aims to understate the trilateral interrelation of walkability,temporal perception,and urban ambiance in walkable routes for daily routine *** work depends on an experimental study where participants are asked to walk along two selected ***-gathering tools rely on documenting the lived experience of the target group via reporting their trips and answering a *** analysis demonstrates this trilateral interrelation to clarify the *** study concludes specific qualities of walkable routes for routine use that reduce sense of time,which is highly crucial to be realized in such daily walk journeys.

关键词： Walkability Urban ambiance Temporal perception People’s needs in open spaces

Preparation of PVC/PVP composite polymer membranes via phase inversion process for water treatment purposes

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Chinese Journal of Chemical Engineering 2018年第4期26卷 715-722页

作者： ahmed Bhran Abeer Shoaib doaa Elsadeq Ayman El-gendi Heba Abdallah Chemical Engineering Department College of Engineering Al Imam Mohammad Ibn Saud Islamic University (IMSIU) Department of Petroleum Refining and Petrochemical Engineering Faculty of Petroleum and Mining Engineering Suez University Chemical Engineering and Pilot Plant Department Engineering Research Division National Research Centre Chemical and Materials Engineering Department King Abdulaziz University

In this work, new composite membranes were successfully prepared via phase inversion technique using polyvinyl chloride(PVC) and polyvinylpyrrolidone(PVP) as polymers and tetrahydrofuran(THF) and N-methyl-2-pyrrolidone(NMP) as solvents. The prepared membranes have been characterized by scanning electron microscope(SEM), and fourier transforms infrared spectroscopy(FTIR). The scanning electron microscope results prove that the prepared membranes are smooth and their pores are distributed throughout the whole surface and bulk body of the membrane without any visible cracks. The stress–strain mechanical test showed an excellent mechanical behavior enhanced by the presence of PVP in the prepared membranes. The membranes performance results showed that the salt rejection reached 98% with a high flux. This, in turn, makes the prepared membranes can be applied for sea and brackish water treatment through membrane distillation technology.

关键词： Membrane Polyvinylchloride Polyvinylpyrrolidone Phase inversion

Validation of a serum microRNA panel as biomarkers for early diagnosis of hepatocellular carcinoma post-hepatitis C infection in Egyptian patients

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World Journal of Gastroenterology 2017年第21期23卷 3864-3875页

作者： Moustafa Nouh Elemeery ahmed Noah Badr Marwa Anwar Mohamed doaa ahmed Ghareeb Medical Biotechnology Laboratory Genetic Engineering and Biotechnology Research DivisionNational Research Centre Toxicology and Food Contaminant Laboratory Food Science and Nutrition Research DivisionNational Research Centre Department of Chemical Pathology Medical Research InstituteAlexandria University Molecular Biology Laboratory Faculty of ScienceAlexandria University

AIM To investigate the prospective importance of serum micro(mi)RNAs(mi R-125 b, mi R-138 b, mi R-1269, mi R-214-5p, mi R-494, mi R375 and mi R-145) as early biomarkers for the diagnosis of hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC).METHODS Two-hundred and fifty HCV4 a patients, 224 HCV4 aHCC patients, and 84 healthy controls were enrolled in the study. Expression levels of mi R214-5p, mi R-125 b, mi R-1269 and mi R-375 were quantified using quantitative real-time *** Expression of the selected mi RNAs in serum wassignificantly lower in HCC patients than in the healthy controls, except for mi R-1269 and mi R-494. There was a significant difference between HCC and HCV patients, in particular for HCC and late stage fibrosis, rather than HCV patients and early fibrosis. It is obvious that mi R-1269 was significantly upregulated in HCC cases compared to hepatic fibrosis cases. Each mi RNA can show HCC progression. Multivariate logistic regression analysis indicated that the tested panel of mi RNAs(mi R214-5p, mi R-125 b, mi R-1269 and mi R-375) represent accurate and specific indictors of HCC *** This study presents a panel of mi RNAs with strong power as putative diagnostic and prognostic biomarkers for HCV-induced HCC. Moreover, mi R-214-5p and mi R-1269 could be considered as early biomarkers for tracking the progress of liver fibrosis to HCC.

关键词： Micro RNA Hepatocellular carcinoma Fibrosis progression

An Energy-Efficient Protocol for Internet of Things Based Wireless Sensor Networks

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Computers, Materials & Continua 2023年第5期75卷 2397-2412页

作者： Mohammed Mubarak Mustafa ahmed Abelmonem khalifa Korhan Cengiz Nikola Ivkovic Department of Information Technology Sri Krishna College of Engineering&TechnologyCoimbatoreIndia Department of Networking and Security College of Information TechnologyUniversity of FujairahFujairahUAE Switching and Traffic Department National Telecommunication InstituteCairoEgypt Department of Computer Engineering Istinye UniversityZeytinburnuIstanbulTurkey Faculty of Organization and Informatics University of ZagrebVarazdinCroatia

The performance of Wireless Sensor Networks(WSNs)is an important fragment of the Internet of Things(IoT),where the current WSNbuilt IoT network’s sensor hubs are enticing due to their critical *** grouping hubs,a clustering convention offers a useful solution for ensuring energy-saving of hubs andHybridMedia Access Control(HMAC)during the course of the ***,current grouping standards suffer from issues with the grouping structure that impacts the exhibition of these conventions *** this investigation,we recommend an Improved Energy-Proficient Algorithm(IEPA)for HMAC throughout the lifetime of the WSN-based *** consecutive segments are *** the covering of adjusted clusters,an ideal number of clusters is determined ***,fair static clusters are shaped,based on an updated calculation for fluffy cluster heads,to reduce and adapt the energy use of the sensor *** heads(CHs)are,ultimately,selected in optimal locations,with the pivot of the cluster heads working among cluster ***,the proposed convention diminishes and balances the energy utilization of hubs by improving the grouping structure,where the IEPAis reasonable for systems that need a long *** assessment results demonstrate that the IEPA performs better than existing conventions.

关键词： Energy consumption improved energy-proficient algorithm internet of things wireless sensor network