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Self-supported VO_(2) on polydopamine-derived pyroprotein-based fibers for ultrastable and flexible aqueous zinc-ion batteries

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Carbon Energy 2024年第7期6卷 1-13页

作者： Jeong Seok Yeon Sul Ki Park Shinik kim Santosh VMohite Won Il kim gun Jang Hyun-Seok Jang Jiyoung Bae Sang Moon Lee Won GHong Byung Hoon kim Yeonho kim Ho Seok Park School of Chemical Engineering College of EngineeringSungkyunkwan UniversityGyeonggi-doRepublic of Korea Department of Engineering University of CambridgeCambridgeUK Department of Applied Chemistry Konkuk UniversityChungjuRepublic of Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)College of Natural SciencesUlsanRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea Intelligent Sensor Convergence Research Center Incheon National UniversityIncheonRepublic of Korea Institute of Basic Science Incheon National UniversityIncheonRepublic of Korea Division of Material Analysis and Research Korea Basic Science InstituteDaejeonRepublic of Korea

A conventional electrode composite for rechargeable zinc-ion batteries(ZIBs)includes a binder for strong adhesion between the electrode material and the current ***,the introduction of a binder leads to electrochemical inactivity and low electrical conductivity,resulting in the decay of the capacity and a low rate *** present a binder-and conducting agent-free VO_(2) composite electrode using in situ polymerization of dopamine on a flexible current collector of pyroprotein-based *** as-fabricated composite electrode was used as a substrate for the direct growth of VO_(2) as a self-supported form on polydopamine-derived pyroprotein-based fibers(pp-fibers@VO_(2)(B)).It has a high conductivity and flexible nature as a current collector and moderate binding without conventional binders and conducting agents for the VO_(2)(B) *** addition,their electrochemical mechanism was *** energy storage is induced by Zn^(2+)/H^(+) coinsertion during discharging,which can be confirmed by the lattice expansion,the formation of by-products including Zn_(x)(OTf)_(y)(OH)_(2x−y)·nH_(2)O,and the reduction of V^(4+)to V^(3+).Furthermore,the assembled Zn//pp-fibers@VO_(2)(B) pouch cells have excellent flexibility and stable electrochemical performance under various bending states,showing application possibilities for portable and wearable power sources.

关键词： aqueous battery binder free conducting agent‐free flexible electrode zinc‐ion battery

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Keystone design perforator island flap in facial defect reconstruction

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World Journal of Clinical Cases 2020年第10期8卷 1832-1847页

作者： Soo Yeon Lim Chi Sun Yoon Hyun gun Lee Kyu Nam kim Department of Plastic and Reconstructive Surgery Konyang University HospitalUniversity of Konyang College of MedicineMyunggok Medical Research CenterDaejeon 35365South Korea Department of Plastic and Reconstructive Surgery Wonkwang University HospitalWonkwang University School of MedicineIksan 54538South Korea

Facial defect coverage is a common subject in the field of reconstructive *** are many methods for facial defect reconstruction,and reconstructive surgeons should choose the most appropriate method on a case-by-case basis to achieve both functional and aesthetic *** various options for facial reconstruction,the local flap technique is considered the best reconstructive modality to provide good tissue matches of color and texture,which is consistent with the ideal goal of reconstruction(replacement of like-with-like).Keystone design perforator island flap(KDPIF),devised by Behan in 2003,has been applied to various fields of reconstructive surgery in the past decade due to its design simplicity,robust vascular supply,and *** studies have reported KDPIF reconstruction of facial defects,such as large parotid defects,small-to-moderate nasal defects,and eyelid ***,KDPIF has been used relatively less in facial defects than in other body regions,such as the trunk and *** purpose of this review is to provide an organized overview of facial KDPIF reconstruction including the classification of KDPIF,modifications,physiology,mechanism of flap movement,consideration of facial relaxed skin tension lines and aesthetics,surgical techniques,clinical applications,and precautions for successful execution of KDPIF reconstruction.

关键词： Keystone design perforator island flap Reconstructive surgery Facial defects Aesthetics Plastic surgery Flap surgery

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A case of intussuscepted Meckel’s diverticulum

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World Journal of Gastroenterology 2009年第40期15卷 5109-5111页

作者： Tae Hee Lee Jin-Oh kim Jae Joon kim Seong Sook Hong So Young Jin Hyun gun kim Joo Young Cho Joon Seong Lee Institute for Digestive Research SoonChunHyang College of Medicine Department of Surgery SoonChunHyang College of Medicine Department of Radiology SoonChunHyang College of Medicine Department of Pathology SoonChunHyang College of Medicine

We report colonoscopic features of an intussuscepted Meckel's diverticulum, presenting with hematochezia. A 35-year-old woman presented to the emergency room with acute onset, transient, sharp, severe epi-gastric pain that began 6 h earlier. Colonoscopy re-vealed a reddish, soft, fi st-sized polypoid lesion in the terminal ileum. The lesion was misinterpreted as a hematoma by an inexperienced endoscopist. The pa-tient began to complain of intermittent, severe peri-umbilical pain following the colonoscopic examination. Subsequent computed tomography showed an enteric intussusception. An exploratory laparotomy revealed an intussuscepted Meckel's diverticulum, with trans-mural infarction. Colonoscopy was of little use in as-sessing the intussusception. However, colonoscopic examination may be performed initially, especially in an intussuscepted Meckel's diverticulum present-ing with hematochezia. Endoscopists should note the endoscopic features of an intussuscepted Meckel's diverticulum.

关键词： Colonoscopy Intussusception Meckel's diverticulum

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does immunohistochemical staining have a clinical impact in early gastric cancer conducted endoscopic submucosal dissection?

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World Journal of Gastroenterology 2012年第33期18卷 4578-4584页

作者： Seong Ran Jeon Joo Young Cho Gene Hyun Bok Tae Hee Lee Hyun gun kim Won Young Cho So Young Jin Yeon Soo kim Institute for Digestive Research Digestive Disease Center Soonchunhyang University College of Medicine Seoul 140-743 South Korea Department of Pathology Soonchunhyang University College of Medicine Seoul 140-743 South Korea Department of Internal Medicine Daejeon St. Mary's Hospital The Catholic University of Korea School of Medicine Daejeon 301-723 South Korea

AIM: To evaluate clinicopathologic parameters and the clinical significance related lymphovascular invasion (LVI) by immunohistochemical staining (IHCS) in endoscopic submucosal dissection (ESD). METHODS: Between May 2005 and May 2010, a total of 348 lesions from 321 patients (mean age 63 ± 10 years, men 74.6%) with early gastric cancer (EGC) who met indication criteria after ESD were analyzed retrospectively. The 348 lesions were divided into the absolute (n = 100, differentiated mucosal cancer without ulcer ≤ 20 mm) and expanded (n = 248) indica-tion groups after ESD. The 248 lesions were divided into four subgroups according to the expanded ESD indication. The presence of LVI was determined by factor Ⅷ-related antigen and D2-40 assessment. We compared LVI IHCS-negative group with LVI IHCSpositive in each group. RESULTS: LVI by hematoxylin-eosin staining (HES) and IHCS were all negative in the absolute group, while was observed in only the expanded groups. The positive rate of LVI by IHCS was higher than that of LVI by HES (n = 1, 0.4% vs n = 11, 4.4%, P = 0.044). LVI IHCS-positivity was observed when the cancer invaded to the mucosa 3 (M3) or submucosa 1 (SM1) levels, with a predominance of 63.6% in the subgroup that included only SM1 cancer (P < 0.01). In a univariate analysis, M3 or SM1 invasion by the tumor was significantly associated with a higher rate of LVI by IHCS, but no factor was significant in a multivariate analysis. There were no cases of tumor recurrence or metastasis during the median 26 mo follow-up. CONCLUSION: EGCs of the absolute group are immunohistochemically stable. The presence of LVI may be carefully examined by IHCS in an ESD expanded indication group with an invasion depth of M3 or greater.

关键词： Gastric cancer Endoscopic submucosal dis- section Immunohistochemical staining Lymphovascu- lar invasion Depth

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Evaluation of prognostic factors on recurrence after curative resections for hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第45期20卷 17132-17140页

作者： Jae Hyun Han dong Goo kim gun Hyung Na Eun Young kim Soo Ho Lee Tae Ho Hong Young Kyoung You Department of Surgery The Catholic University of Korea Seoul St.Mary’s Hospital

AIM: To select appropriate patients before surgical resection for hepatocellular carcinoma (HCC), especially those with advanced tumors.

关键词： Carcinoma Hepatocellular Hepatectomy Prognostic factor Survival Recurrence

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Inflammatory markers as selection criteria of hepatocellular carcinoma in living-donor liver transplantation

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World Journal of Gastroenterology 2014年第21期20卷 6594-6601页

作者： gun Hyung Na dong Goo kim Jae hyun Han Eun Young kim Soo Ho Lee Tae Ho Hong Young Kyoung You Department of Surgery Seoul St. Mary’s HospitalThe Catholic University of KoreaSeoul 137-701South Korea

AIM: To investigate that inflammatory markers can predict accurately the prognosis of hepatocelluar carcinoma (HCC) patients in living-donor liver transplantation (LDLT).

关键词： C-reactive protein Hepatocellular carcinoma Liver transplantation Neutrophil-lymphocyte ratio Selection criteria

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Trends in colorectal cancer incidence according to an increase in the number of colonoscopy cases in Korea

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 51-60页

作者： Ga Hee kim Yeong Chan Lee Tae Jun kim Sung Noh Hong dong Kyung Chang Young-Ho kim dong-Hoon Yang Chang Mo Moon Kyunga kim Hyun gun kim Eun-Ran kim Division of Gastroenterology Department of Internal MedicineAsan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Digital Health Samsung Advanced Institute for Health Science and TechnologySungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineEwha Womans UniversitySeoul 07985South Korea Biomedical Statistics Center Samsung Medical CenterSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of MedicineSeoul 04401South Korea

BACKGROUND The incidence of colorectal cancer(CRC)and preinvasive CRC(e.g.,early colon cancer and advanced adenoma)is gradually increasing in several *** To evaluate the trend in incidence of CRC and preinvasive CRC according to the increase in the number of colonoscopies performed in *** This retrospective cohort study enrolled Korean patients from 2002 to 2020 to evaluate the incidence of CRC and preinvasive CRC,and assess the numbers of diagnostic colonoscopies and colonoscopic ***-related complications by age group were also *** The incidence of CRC showed a rapid increase,then decreased after 2012 in the 50-75 year-age *** the study period,the rate of incidence of preinvasive CRC increased at a similar level in patients under 50 and 50-75 years of *** 2009,the increase has been rapid,showing a pattern similar to the increase in *** rate of colonoscopic polypectomy in patients aged under 50 was similar to the rate in patients over 75 years of age after *** rate of complications after colonoscopy and related deaths within 3 mo was high for those over 75 years of *** The diagnosis of preinvasive CRC increased with the increase in the number of colonoscopies *** the risk of colonoscopy-related hospitalization and death is high in the elderly,if early lesions at risk of developing CRC are diagnosed and treated under or at the age of 75,colonoscopy-related complications can be reduced for those aged 76 years or over.

关键词： Colorectal cancer Preinvasive colorectal cancer Colorectal polypectomy Colonoscopy

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Long-term result of endoscopic Histoacryl （N-butyl-2-cyanoacrylate）injection for treatment of gastric varices

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World Journal of Gastroenterology 2011年第11期17卷 1494-1500页

作者： Eun Jung Kang Soung Won Jeong Jae Young Jang Joo Young Cho Sae Hwan Lee Hyun gun kim Sang Gyune kim Young Seok kim Young Koog Cheon Young Deok Cho Hong Soo kim Boo Sung kim Institute for Digestive Research Department of Internal MedicineSoonchunhyang University College of MedicineSeoul HospitalSeoul 140-743South Korea

AIM:To evaluate the long-term efficacy and safety of endoscopic obliteration with Histoacryl  for treatment of gastric variceal bleeding and ***:Between January 1994 and March 2010 at SoonChunHyang University Hospital,a total of 127 patients with gastric varices received Histoacryl  injections *** hundred patients underwent endoscopic Histoacryl  injections because of variceal bleeding,the other 27 patients received such injections as a prophylactic ***:According to Sarin classification,56 patients were GOV1,61 patients were GOV2 and 10 patients were *** of the varices were large(F2 or F3,111 patients).The average volume of Histoacryl  per each session was 1.7±1.3 cc and mean number of sessions was 1.3±0.6.(1 session-98 patients,2 sessions-25 patients,≥3 sessions-4 patients).Twenty-seven patients with high risk of bleeding(large or fundal or RCS+or Child C) received Histoacryl  injection as a primary prophylactic *** these patients,hepatitis B virus was the major etiology of cirrhosis,25 patients showed GOV1 or 2(92.6%)and F2 or F3 accounted for 88.9%(n=24).The rate of initial hemostasis was 98.4%and recurrent bleeding within one year occurred in 18.1%of *** hemostasis during episodes of rebleeding was achieved in 73.9%of *** survival was 50 mo (95%CI 30.5-69.5).Major complications occurred in 4 patients(3.1%).The rebleeding rate in patients with hepatocellular carcinoma or GOV2 was higher than in those with other *** of the 27 subjects who were treated prophylactically experienced treatment-related *** survival rates of the 127 patients at 6 mo,1,3,and 5 years were 92.1%,84.2%,64.2%,and 45.3%,*** 6 mo cumulative survival rate of the 27 patients treated prophylactically was 75%.CONCLUSION:Histoacryl  injection therapy is an effective treatment for gastric varices and also an effective prophylactic treatment of gastric varices which

关键词： Gastric varix Prophylaxis Histoacryl  (Nbutyl-2-cyanoacrylate) Histoacryl  injection Treatment of gastric varix

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A novel device for endoscopic submucosal dissection,the Fork knife

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World Journal of Gastroenterology 2008年第43期14卷 6726-6732页

作者： Hyun gun kim Joo Young Cho Gene Hyun Bok Won Young Cho Wan Jung kim Bong Min Ko Jin Oh kim Joon Seong Lee Moon Sung Lee Chan Sup Shim Institute for Digestive Research Digestive Disease Research CenterSoonChunHyang University College of MedicineSeoul 140-743South Korea

AIM： To introduce and evaluate the efficacy and technical aspects of endoscopic submucosal dissection （ESD） using a novel device, the Fork knife. METHODS： From March 2004 to April 2008, ESD was performed on 265 gastric lesions using a Fork knife （Endo FS）（group A） and on 72 gastric lesions using a Flexknife （group B） at a single tertiary referral center. We retrospectively compared the endoscopic characteristics of the tumors, pathological findings, and sizes of the resected specimens. We also compared the en b/oc resection rate, complete resection rate, complications, and procedure time between the two groups. RESULTS： The mean size of the resected specimens was 4.27 ± 1.26 cm in group A and 4.29 ± 1.48 cm in group B. The en b/oc resection rate was 95.8% （254/265 lesions） in group A and 93.1% （67/72） in group B. Complete ESD without tumor cell invasion of the resected margin was obtained in 81.1% （215/265） of group A and in 73.6% （53/72） of group B. The perforation rate was 0.8% （2/265） in group A and 1.4% （1/72） in group B. The mean procedure time was 59.63 ± 56.12 min in group A and 76.65 ± 70.75 min in group B （P 〈 0.05）. CONCLUSION： The Fork knife （Endo FS） is useful for clinical practice and has the advantage of reducing the procedure time.

关键词： Fork knife Novel device Endoscopic submucosal dissection Flexknife Procedure

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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku gun Young Yoon Hyun-Woo Moon Chonsaeng kim Mi-Hwa kim Yoon-Sun Yi Sangmi Jun Bum-Tae kim Jong-Won Oh Aleem Siddiqui Seong-Jun kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

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