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BCI induces apoptosis via generation of reactive oxygen species and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells

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Science China(Life Sciences) 2018年第10期61卷 1243-1253页

作者： Jong-Woon Shin Sae-Bom Kwon Yesol Bak Sang-Ku Lee do-Young yoon Department of Bioscience and Biotechnology Konkuk University Targeted Medicine Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB)

The compound(E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1 H-inden-1-one(BCI) is known as an inhibitor of dual specific phosphatase 1/6 and mitogen-activated protein kinase. However, its precise anti-lung cancer mechanism remains unknown. In this study, the effects of BCI on the viability of non-small cell lung cancer cell lines NCI-H1299, A549, and NCI-H460 were evaluated. We confirmed that BCI significantly inhibited the viability of p53(-) NCI-H1299 cells as compared to NCI-H460 and A549 cells, which express wild-type p53. Furthermore, BCI treatment increased the level of cellular reactive oxygen species and pre-treatment of cells with N-acetylcysteine markedly attenuated BCI-mediated apoptosis of NCI-H1299 cells. BCI induced cellular morphological changes, inhibited viability, and produced reactive oxygen species in NCI-H1299 cells in a dose-dependent manner. BCI induced processing of caspase-9, caspase-3, and poly ADP-ribose polymerase as well as the release of cytochrome c from the mitochondria into the cytosol. In addition, BCI downregulated Bcl-2 expression and enhanced Bax expression in a dose-dependent manner in NCI-H1299 cells. However, BCI failed to modulate the expression of the death receptor and extrinsic factor caspase-8 and Bid, a linker between the intrinsic and extrinsic apoptotic pathways in NCI-H1299 cells. Thus, BCI induces apoptosis via generation of reactive oxygen species and activation of the intrinsic pathway in NCI-H1299 cells.

关键词： non-small cell lung cancer apoptosis BCI cytotoxicity anticancer ROS

Effect of intra-arterial infusion with triolein emulsion on rabbit liver

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World Journal of Gastroenterology 2014年第39期20卷 14442-14449页

作者： Yong-Woo Kim Young Mi Park Sik yoon Hak Jin Kim do yoon Park Byung Mann Cho Seon Hee Choi Department of Radiology Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Pusan National University College of Medicine Yangsan 626-770 South Korea Department of Radiology Busan Paik Hospital Inje University Pusan 614-735 South Korea Department of Anatomy Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Department of Radiology Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Department of Pathology Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Preventive Medicine Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Pusan National University Postgraduate School Pusan National University Pusan 602-739 South Korea

AIM: To determine whether intra-arterial infusion of triolein emulsion has biochemical and histopathologic effect on rabbit liver.

关键词： Triolein Emulsions Hepatology Liver dysfunction Histopathology

Advances in flexible sensors for intelligent perception system enhanced by artificial intelligence

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InfoMat 2023年第5期5卷 55-110页

作者： Hongsen Niu Feifei Yin Eun-Seong Kim Wenxiao Wang do-Young yoon Cong Wang Junge Liang Yang Li Nam-Young Kim RFIC Centre Kwangwoon UniversitySeoulRepublic of Korea Department of Electronics Engineering Kwangwoon UniversitySeoulRepublic of Korea NDAC Centre Kwangwoon UniversitySeoulRepublic of Korea Department of Chemical Engineering Kwangwoon UniversitySeoulRepublic of Korea School of Electronics and Information Engineering Harbin Institute of TechnologyHarbinthe People's Republic of China Department of Electronic Engineering Jiangnan UniversityWuxithe People's Republic of China School of Information Science and Engineering University of JinanJinanthe People's Republic of China

Intelligent perception means that with the assistance of artificial intelligence(AI)-motivated brain,flexible sensors achieve the ability of memory,learning,judgment,and reasoning about external information like the human *** to the superiority of machine learning(ML)algorithms in data processing and intelligent recognition,intelligent perception systems possess the ability to match or even surpass human perception ***,the built-in flexible sensors in these systems need to work on dynamic and irregular surfaces,inevitably affecting the precision and fidelity of the acquired *** recent years,the strategy of introducing the developed functional materials and innovative structures into flexible sensors has made some progress toward the above challenges,and with the blessing of ML algorithms,accurate perception and reasoning in various scenarios have been ***,the most representative functional materials and innovative structures for constructing flexible sensors are comprehensively reviewed,the research progress of intelligent perception systems based on flexible sensors and ML algorithms is further summarized,and the intersection of the two is expected to unlock new opportunities for next-stage AI development.

关键词： flexible sensor intelligent perception artificial intelligence machine learning

Fabrication of Variable Optical Attenuator With Low Insertion Loss

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光学学报 2003年第S1期23卷 305-306页

作者： Yone-Gon Seo Yong-Tak Kim Jemin Kim Hyung-do yoon Young-Min Im Korea Electronics Technology Institute 455-6 MaSan-Ri JinWi-Myon PyungTaek-Si KyungGi-Do Korea Department of Advanced Materials Engineering Sungkyunkwan University Jangan-gu Suwon 440-746 Korea

A voltage-controlled variable optical attenuator (VOA) based on silica-based planar lightwave circuits (PLC) was fabricated by flame hydrolysis deposition (FHD). The variable attenuator with Cr heater achieves 20dB attenuation with 318mW electrical power at 1550 nm. The insertion loss and the polarization dependent loss (PDL) at 0 attenuation are 1dB and 0.23dB, respectively.

关键词： electrical power insertion loss

A Dynamical System-Based Framework for Dimension Reduction

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Communications on Applied Mathematics and Computation 2024年第2期6卷 757-789页

作者： Ryeongkyung yoon Braxton Osting Department of Mathematics University of UtahSalt Lake CityUTUSA

We propose a novel framework for learning a low-dimensional representation of data based on nonlinear dynamical systems,which we call the dynamical dimension reduction(DDR).In the DDR model,each point is evolved via a nonlinear flow towards a lower-dimensional subspace;the projection onto the subspace gives the low-dimensional *** the model involves identifying the nonlinear flow and the *** the equation discovery method,we represent the vector field that defines the flow using a linear combination of dictionary elements,where each element is a pre-specified linear/nonlinear candidate function.A regularization term for the average total kinetic energy is also introduced and motivated by the optimal transport *** prove that the resulting optimization problem is well-posed and establish several properties of the DDR *** also show how the DDR method can be trained using a gradient-based optimization method,where the gradients are computed using the adjoint method from the optimal control *** DDR method is implemented and compared on synthetic and example data sets to other dimension reduction methods,including the PCA,t-SNE,and Umap.

关键词： Dimension reduction Equation discovery Dynamical systems Adjoint method Optimal transportation

Negative Stiffness Mechanism on An Asymmetric Wave Energy Converter by Using A Weakly Nonlinear Potential Model

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China Ocean Engineering 2024年第4期38卷 689-700页

作者： Sunny Kumar POGULURI dongeun KIM yoon Hyeok BAE Department of Ocean Engineering IIT MadrasChennaiIndia Multidisciplinary Graduate School Program for Wind Energy Jeju National UniversityJejuRepublic of Korea Mechanical and System Design Engineering Hongik UniversitySeoulRepublic of Korea

Salter's duck,an asymmetrical wave energy converter(WEC)device,showed high efficiency in extracting energy from 2D regular waves in the past;yet,challenges remain for fluctuating wave *** can potentially be addressed by adopting a negative stiffness mechanism(NSM)in WEC devices to enhance system efficiency,even in highly nonlinear and steep 3D waves.A weakly nonlinear model was developed which incorporated a nonlinear restoring moment and NSM into the linear formulations and was applied to an asymmetric WEC using a time domain potential flow *** model was initially validated by comparing it with published experimental and numerical computational fluid dynamics *** current results were in good agreement with the published *** was found that the energy extraction increased in the range of 6%to 17%during the evaluation of the effectiveness of the NSM in regular *** irregular wave conditions,specifically at the design wave conditions for the selected test site,the energy extraction increased by 2.4%,with annual energy production increments of approximately *** findings highlight the potential of NSM in enhancing the performance of asymmetric WEC devices,indicating more efficient energy extraction under various wave conditions.

关键词： asymmetric wave energy converter negative stiffness mechanism weakly nonlinear potential flow power

Phytochemicals and antioxidant activity of Korean black soybean(Glycine max. L.) landraces

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Phytochemicals and antioxidant activity of Korean black soyb...

100 W-class green hydrogen production from ammonia at a dual-layer electrode containing a Pt-Ir catalyst for an alkaline electrolytic process

2019年中国作物学会学术年会

作者： Jung-Ro Lee Kyung Jun Lee do yoon Hyun Gyu-Taek Cho Raveendar Sebastin Myoung-Jae Shin National Agrobiodiversity Center National Institute of Agricultural Sciences(NAS)RDA

Black soybean(Glycine max.L.)has been used as a food source and in traditional medicines because their seed coats contain natural phenolic *** objective of this study is to reveal the genetic variation in the agricultural traits,phytochemicals,and antioxidant activity of 172 Korean black soybean landraces(KBSLs)and

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Journal of Energy Chemistry 2024年第6期93卷 352-360,I0009页

作者： donghyun yoon Sunki Chung Minjun Choi Eunhyeok Yang Jaeyoung Lee School of Earth Sciences and Environmental Engineering Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea International Future Research Center of Chemical Energy Storage and Conversion Processes GISTGwangju 61005Republic of Korea Ertl Center for Electrochemistry and Catalysis GISTGwangju 61005Republic of Korea TKG Huchems Co.Ltd 963Sangam-roYeosu-siJeollanam-do 59614Republic of Korea

Ammonia allows storage and transport of hydrogen over long distances and is an attractive potential hydrogen *** decomposition has recently been used for the conversion of ammonia to hydrogen and is regarded as a future technology for production of CO_(2)-free pure ***,a heterostructural Pt-Ir dual-layer electrode is developed and shown to achieve successful long-term operation in an ammonia electrolyzer with an anion exchange membrane(AEM).This electrolyzer consisted of eight membra ne electrode assemblies(MEAs)with a total geometric area of 200 cm~2 on the anode side,which resulted in a hydrogen production rate of 25 L h~(-1).We observed the degradation in MEA performance attributed to changes in the anode catalyst layer during hydrogen production via ammonia ***,we demonstrated the relationship between the ammonia oxidation reaction(AOR)and the oxygen evolution reaction(OER).

关键词： Ammonia oxidation Dual-layer catalyst Green hydrogen Electrolytic process Oxygen evolution reaction

Application of Genotyping-by-sequencing to discriminate the species within the Genus Triticum(Poaceae)

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Application of Genotyping-by-sequencing to discriminate the ...