检索结果-南通市图书馆

Chinese Journal of Natural Medicines 2021年第1期19卷 46-55页

作者： Park Jeong-Bae kim do-Wan Lim Kye-Tack Oh Sejong Lee Sei-Jung Department of Pharmaceutical Engineering Daegu Haany UniversityGyeongsan 38610South Korea Division of Animal Science Chonnam National UniversityGwangju 61186South Korea

Cudrania tricuspidata Bureau(CTB),a species of the Moraceae plant,has been used as a bruise recovery *** study aimed to determine whether the 75 kDa phytoglycoprotein extracted from CTB has a regulatory effect on the proliferation of human colon epithelial cells and the pathological process of inflammatory bowel disease(IBD).We found that CTB glycoprotein significantly induces the proliferation of human colon epithelial HT-29 cells by activating protein kinase *** glycoprotein stimulated the phosphorylation of c-Jun N-terminal kinase and transcription factor nuclear factor-κB,which are responsible for the expression of cell-cycle-related proteins(CDK2,CDK4,cyclin D1 and cyclin E)during its promotion of cell *** colitis was induced in mice by adding dextran sulfate sodium to their drinking water at a concentration of 4%(W/V)for seven *** found that CTB glycoprotein ameliorates the pathological process of IBD and lowers the disease activity index score,which was composed of body weight change,diarrhea,and hematochezia in ICR mice treated with dextran sulfate ***,we suggest that CTB glycoprotein has the ability to prevent IBD by promoting cell proliferation signaling events via the activation of PKC,JNK and NF-κB in colon epithelial cells.

关键词： Cell cycle Cell proliferation Colon epithelial cells Cudrania tricuspidata Glycoprotein Inflammatory bowel disease Protein kinase C

Role of bile acids in colon carcinogenesis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2018年第13期6卷 577-588页

作者： Thi Thinh Nguyen Trong Thuan Ung Nam Ho kim Young do Jung Department of Biochemistry Chonnam National University Medical School Department of Nephrology Chonnam National University Medical School

Bile acids(BAs)are cholesterol derivatives synthesized in the liver and then secreted into the intestine for lipid *** are numerous scientific reports describing BAs,especially secondary BAs,as strong carcinogens or promoters of colon ***,BAs act as strong stimulators of colorectal cancer(CRC)initiation by damaging colonic epithelial cells,and inducing reactive oxygen species production,genomic destabilization,apoptosis resistance,and cancer stem cells-like ***,BAs promote CRC progression via multiple mechanisms,including inhibiting apoptosis,enhancing cancer cell proliferation,invasion,and *** are diverse signals involved in the carcinogenesis mechanism of BAs,with a major role of epidermal growth factor receptor,and its down-stream signaling,involving mitogen-activated protein kinase,phosphoinositide 3-kinase/Akt,and nuclear factor kappa-light-chain-enhancer of activated B *** regulate numerous genes including the human leukocyte antigen class I gene,p53,matrix metalloprotease,urokinase plasminogen activator receptor,Cyclin D1,cyclooxygenase-2,interleukin-8,and miRNAs of CRC cells,leading to CRC *** evidence suggests that targeting BAs is an efficacious strategies for CRC prevention and treatment.

关键词： Apoptosis resistance Cancer stemness Bile acids Colorectal cancer Reactive oxygen species Angiogenesis

CRISPR/Cas9-mediated gene editing to confer turnip mosaic virus (TuMV) resistance in Chinese cabbage (Brassica rapa)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2023年第6期10卷 135-143页

作者： Ye-Rin Lee Muhammad Irfan Siddique do-Sun kim Eun Su Lee Koeun Han Sang-Gyu kim Hye-Eun Lee Vegetable Research Division National Institute of Horticultural and Herbal ScienceRural Development AdministrationWanju55365Republic of Korea Department of Horticultural Sciences North Carolina State University Mountain Horticultural Crops ResearchExtension Center 455 Research DriveMills RiverNC 28759USA Department of Biological Sciences Korea Advanced Institute for Science and TechnologyDaejeon34141Republic of Korea

Genome editing approaches,particularly the CRISPR/Cas9 technology,are becoming state-of-the-art for trait development in numerous breeding *** advances in improving plant traits are enabled by this influential tool,especially for disease resistance,compared to traditional *** of the potyviruses,the turnip mosaic virus(TuMV),is the most widespread and damaging virus that infects Brassica *** generated the targeted mutation at the eIF(iso)4E gene in the TuMV-susceptible cultivar“Seoul”using CRISPR/Cas9 to develop TuMV-resistant Chinese *** detected several heritable indel mutations in the edited T0 plants and developed T1 through generational *** was indicated in the sequence analysis of the eIF(iso)4E-edited T1 plants that the mutations were transferred to succeeding *** edited T1 plants conferred resistance to *** was shown with ELISA analysis the lack of accumulation of viral ***,we found a strong negative correlation(r=-0.938)between TuMV resistance and the genome editing frequency of eIF(iso)***,it was revealed in this study that CRISPR/Cas9 technique can expedite the breeding process to improve traits in Chinese cabbage plants.

关键词： CRISPR/Cas9 TuMV breeding

Spatial Control of Lithium Deposition by Controlling the Lithiophilicity with Copper(Ⅰ)Oxide Boundaries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2023年第5期6卷 183-191页

作者： Ju Ye kim Oh B.Chae Gukbo kim Woo-Bin Jung Sungho Choi do Youb kim San Moon Jungdon Suk Yongku Kang Mihye Wu Hee-Tae Jung Department of Chemical and Biomolecular Engineering(BK-21 four)and Institute for Nanocentury Korea Advanced Institute of Science and Technology(KAIST)DaejeonKorea Chemical&Process Technology Division Korea Research Institute of Chemical TechnologyDaejeon 34114Korea School of Engineering Brown UniversityProvidence 02912USA Department of Chemistry University of Rhode IslandKingston 02881USA School of Engineering and Applied Sciences Harvard UniversityCambridge 02138USA Advanced Materials Division Korea Research Institute of Chemical TechnologyDaejeon 34114Korea

Spatial control of lithium deposition is the most important issue in lithium-metal batteries because of the considerable control of lithium dendrite suppression via the uniform distribution of Li^(+)*** seed materials are crucial for the behavior of lithium deposition,in-depth studies on their physical and chemical control have not been ***,we describe a new design of seed structure comprising a wrinkled Cu/graphene substrate surrounded by copper(Ⅰ)oxide(Cu_(2)O)on a graphene grain boundary over a large area,which is fabricated by the oxidation of the Cu surface via graphene boundary defects by using chemical vapor deposition(CVD).Scanning and transmission electron microscopy results reveal that Cu_(2)O on the graphene boundary can render a preferential reaction with lithium during the first deposition and assist in the uniform deposition of lithium by preventing the agglomeration of lithium clusters during the second *** two-step process is attributed to the degree of selectivity due to the difference in lithium affinity,which allows long-term electrochemical stability and a high rate capability via boundary *** study highlights the significance of the boundary effect,which can open new avenues for the formation of a large family of seed structures in lithium-metal batteries.

关键词： Cu_(2)O boundary dendrite-free lithium deposition lithium-metal battery lithium spatial control seed boundary effect

Dynamics modeling and motion control for high-speed underwater vehicles using H-infinity synthesis with anti-windup compensator

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean Engineering and Science 2022年第1期7卷 84-91页

作者： Phuc Duc Hong Bui Sam-Sang You Hwan-Seong kim Sang-do Lee Department of Mechanical Engineering The University of TulsaTulsaOK 74104United States Division of Mechanical Engineering Korea Maritime and Ocean UniversityBusan 49112Republic of Korea Division of Logistics Engineering Korea Maritime and Ocean UniversityBusan 49112Republic of Korea Division of Navigation and Information System Mokpo National Maritime UniversityMokpoJeollanam-do 58628Republic of Korea

The control synthesis of a high-speed supercavitating vehicle(HSSV)faces many difficulties such as the stability,control,and maneuvering with dynamical uncertainties due to parameter perturbations,exter-nal disturbances,unmodeled dynamics,measurement noises,and actuator *** by the HSSV dynamical analysis,this paper proposes the H∞(i.e."H-infinity")robust control synthesis to gen-erate a robust low-order controller,which is intended for real implementations to ensure active control ***,the presented control scheme includes a feedback component and an anti-windup *** anti-windup synthesis is to provide system stability under actuator ***-tensive simulations show that the designed controller provides good performances with high robustness for vertical plane manoeuver while effectively eliminating planning forces,exogenous disturbances and noises as well as overcoming cavitator saturations.

关键词： Vehicle dynamics Planing force Vertical maneuver H-infinity control Anti-windup Actuator saturation

Is ineffective esophageal motility associated with gastropharyngeal reflux disease?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第39期14卷 6030-6035页

作者： Kyung Yup kim Gwang Ha kim dong Uk kim Soo Geun Wang Byung Joo Lee Jin Choon Lee do Youn Park Geun Am Song Department of Internal Medicine Pusan National University School of MedicineBusanSouth Korea Department of Otolaryngology Pusan National University School of MedicineBusanSouth Korea Department of Pathology Pusan National University School of MedicineBusanSouth Korea

AIM： TO evaluate the association between IEM and gastropharyngeal reflux disease （GPRD） in patients who underwent ambulatory 24-h dual-probe pH monitoring for the evaluation of supraesophageal symptoms. METHODS： A total of 632 patients who underwent endoscopy, esophageal manometry and ambulatory 24-h dual-pH monitoring due to supraesophageal symptoms （e.g. globus, hoarseness, or cough） were enrolled. Of them, we selected the patients who had normal esophageal motility and IEM. The endoscopy and ambulatory pH monitoring findings were compared between the two groups. RESULTS;： A total of 264 patients with normal esophageal motility and 195 patients with the diagnosis of IEM were included in this study. There was no difference in the frequency of reflux esophagitis and hiatal hernia between the two groups. All the variables showing gastroesophageal reflux and gastropharyngeal reflux were not different between the two groups. The frequency of GERD and GPRD, as defined by ambulatory pH monitoring, was not different between the two groups. CONCLUSION： There was no association between IEM and GPRD as well as between IEM and GERD. IEM alone cannot be considered as a definitive marker for reflux disease.

关键词： Ineffective esophageal motility Gastroesophageal reflux disease Gastropharyngeal reflux disease

Development of dilated cardiomyopathy with a long latent period followed by viral fulminant myocarditis:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第36期10卷 13451-13457页

作者： Seung do Lee Hyo Jin Lee Hye Ree kim Min Gyu Kang Kyehwan kim Jeong Rang Park Division of Cardiology Department of Internal MedicineGyeongsang National University School of Medicine and Gyeongsang National University HospitalJinju 52727South Korea

BACKGROUND The clinical course of acute myocarditis ranges from the occurrence of a few symptoms to the development of fatal fulminant ***,fulminant myocarditis causes clinical deterioration very rapidly and *** long-term prognosis of myocarditis is varied,and it fully recovers without leaving any special ***,even after recovery,heart failure may occur and eventually progress to dilated cardiomyopathy(DCM),which causes serious left ventricular *** the case of follow-up observation,no clear guidelines have been *** SUMMARY We report the case of a 21-year-old woman who presented with *** became hemodynamically unstable and showed sustained fatal arrhythmias with decreased heart *** was clinically diagnosed with fulminant myocarditis based on her echocardiogram and cardiac magnetic resonance *** 2 d,she was readmitted to the emergency department under cardiopulmonary resuscitation and received mechanical ventilation and extracorporeal membrane *** implantable cardioverter defibrillator was inserted for secondary *** recovered and was *** to being hospitalized for sudden cardiac function decline and arrhythmia,she had been well for 7 years without any *** was finally diagnosed with dilated *** DCM may develop unexpectedly in patients who have been cured of acute fulminant myocarditis and have been stable with a long period of ***,they should be carefully and regularly observed clinically throughout long-term follow-up.

关键词： Myocarditis Fulminant Dilated cardiomyopathy Outcome Remission Case report

A combination strategy of functionalized polymer coating with Ta ion implantation for multifunctional and biodegradable vascular stents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2021年第6期9卷 2195-2207页

作者： Kwang-Hee Cheon Cheonil Park Min-Ho Kang Suhyung Park Jinyoung kim Seol-Ha Jeong Hyoun-Ee kim Hyun-do Jung Tae-Sik Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon-si 03083Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon-si 14662Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea

Biodegradable stents made of magnesium(Mg)and its alloys have been developed to minimize persistent inflammation or in-stent restenosis,which are the main problems for permanent ***,their rapid corrosion behavior under physiological conditions leads to poor vascular compatibility and premature structural failure,which remains an important unsolved clinical ***,we demonstrate a new strategy for solving this problem by combining poly(ether imide)(PEI)coating and subsequent tantalum(Ta)ion *** PEI coating covers the whole surface of the Mg stent uniformly via a spray coating technique and provides Mg with superior corrosion resistance and stable sirolimus-carrying *** ion implantation is conducted by a sputtering-based plasma immersion ion implantation technique only onto the luminal surface of the PEI-coated Mg *** extremely short processing time(dothelial cell adhesion/proliferation and suppression of platelet adhesion/activation regardless of sirolimus *** results indicate that the combination of PEI coating and Ta ion implantation has significant innovative potential to provide excellent vascular compatibility and prevent in-stent restenosis and thrombosis.

关键词： Magnesium stent Biodegradability Tantalum Plasma immersion ion implantation Multifunctionality

Biocompatible custom ceria nanoparticles against reactive oxygen species resolve acute inflammatory reaction after intracerebral hemorrhage

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano Research 2017年第8期10卷 2743-2760页

作者： dong-Wan Kang Chi Kyung kim Han-Gil Jeong Min Soh Taeho kim In-Young Choi SeuI-Ki Ki do Yeon kim Wookjin Yang Taeghwan Hyeon Seung-Hoon Lee Laboratory of Innovative Nanobiotechnology Biomedical Research Institute Seoul National University Hospital Seoul 03080 Republic of Korea Department of Neurology Seoul National University Hospital Seou103080 Republic of Korea Department of Neurology Korea University Guro Hospital and Korea University College of Medicine Seou108308 Republic of Korea Center for Nanoparticle Research Institute for Basic Science (IBS) Seoul 151-742 Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National University Seoul 151-742 Republic of Korea

Intracerebral hemorrhage （ICH） is a devastating subtype of stroke with a high mortality rate, for which there currently is no effective treatment. A perihematomal edema caused by an intense inflammatory reaction is more deleterious than the hematoma itself and can result in neurological deterioration and death. Ceria nanoparticles （CeNPs） are potent free radical scavengers with potential for biomedical applications. As oxidative stress plays a major role in post-ICH inflammation, we hypothesized that CeNPs might protect against ICH. To test this hypothesis, core CeNPs were synthesized using a modified reverse micelle method and covered with phospholipid-polyethylene glycol （PEG） to achieve biocompatibility. We investigated whether our custom-made biocompatible CeNPs have protective effects against ICH. The CeNPs reduced oxidative stress, hemin-induced cytotoxicity, and inflammation in vitro. In a rodent ICH model, intravenously administered CeNPs were mainly distributed in the hemorrhagic hemisphere, suggesting that they could diffuse through the damaged blood-brain barrier. Moreover, CeNPs attenuated microglia/macrophage recruitment around the hemorrhagic lesion and inflammatory protein expression. Finally, CeNP treatment reduced the brain edema by 68.4% as compared to the control. These results reveal the great potential of CeNPs as a novel therapeutic agent for patients with ICH.

关键词： ceria nanoparticles intracerebral hemorrhage free radical injury anti-inflammation neuroprotective agents biomedical application

Multimodal treatments of right gastroepiploic arterial leiomyosarcoma with hepatic metastasis:A case report and review of the literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2018年第8期6卷 219-223页

作者： Hyung-Il Seo dong-Il kim Youngsoo Chung Chang In Choi Minjoo kim Sungpil Yun Suk kim do Youn Park Department of Surgery Biomedical Research InstitutePusan National University Hospital Department of Surgery Pusan National University Yangsan Hospital Department of Surgery On Hospital Department of Radiology Biomedical Research Institute Pusan National University Hospital Department of Pathology Biomedical Research Institute Pusan National University Hospital

Leiomyosarcoma of an artery is very rare, and cases with hepatic metastasis are even rarer. We describe a case of a 70-year-old man who after follow up due to rectal cancer, presented with an intra-abdominal hypervascular mass and a hepatic mass. After surgical resection, it was diagnosed as a leiomyosarcoma of the right gastroepiploic artery with hepatic metastasis. Multiple metastases had recurred at the liver. He has survived more than 53 mo through multimodal treatments(three surgical resections, radiofrequency ablation, transarterial chemoembolization, chemotherapies, and targeted therapy). Multimodal treatments, including active surgical resection, may behelpful in the treatment of aggressive diseases such as arterial leiomyosarcoma with metastasis.

关键词： Multimodal treatments Intra-abdominal arterial leiomyosarcoma Hepatic metastasis Arterial leiomyosarcoma Surgical resection