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Antinociceptive activity of Ricinus communis ***

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Asian Pacific journal of Tropical Biomedicine 2011年第2期1卷 139-141页

作者： dnyaneshwar j taur Maruti G Waghmare Rajendra S Bandal Ravindra Y Patil Department of Pharmacognosy SVPM's College of Pharmacy Department of Pharmaceutical Chemistry SVPM's College of Pharmacy Department of Pharmacognosy PDEA's Shankarrao Ursal College of Pharmaceutical Sciences and Research Center

Objective:To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves(MRCL).Methods:Antinociceptive activity was evaluated using acetic acid induced writhing test,formalin induced paw licking and tail immersion method in mice at doses of 100,125 and 130 mg/kg ***:The results indicated that MRCL exhibited considerable antinociceptive activity against three classical models of pain in *** phytochemical analysis suggested the presence of saponin,steroids and ***:It can be concluded that MRCL possesses antinociceptive potential that may be due to saponin,steroids and alkaloids in it.

关键词： Ricinus communis Analgesic Antinociceptive Writhing Formalin

Mast Cell Stabilizing,Antianaphylactic and Antihistaminic Activity of Coccinia grandis Fruits in Asthma

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中国天然药物 2011年第5期9卷 359-362页

作者： dnyaneshwar j taur Ravindra Y Patil Department of Pharmacognosy SVPM's College of PharmacyMalegaon(bk)Baramati-413115MaharashtraIndia Department of Pharmacognosy PDEA's SU College of Pharmaceutical Sciences and Research CenterKharadiPune-411014MaharashtraIndia

Coccinia grandis Linn(Curcubitaceae) is a climber herb cultivated throughout *** traditional medicine fruits have been used to treat leprosy,fever,asthma,bronchitis and *** present study,ethanol extract of *** fruit(ECGF) at 100,125 and 150 mg·kg-1,i.p.,was evaluated for mast cell stabilizing,antianaphylactic and antihistaminic activity using egg albumin induced mast cell degranulation in mice;passive cutaneous anaphylaxis in rats and clonidine induced catalepsy in mice *** at(100-150 mg·kg-1,i.p.) significantly protected egg albumin induced degranulations of mast cells and caused reduction of blue dye leakage in passive cutaneous anaphylaxis in dose *** treatment ECGF also inhibited clonidine induced catalepsy in dose dependent *** studies observed presence of saponin,steroids,alkaloids,flavonoids and *** conclusion ECGF possesses mast cell stabilizing;anti anaphylactic and antihistaminic potential which might be used in treatment of asthma.

关键词： Coccinia grandis Allergy Asthma Clonidine Mast cell degranulations

1,2,3-Triazole incorporated coumarin derivatives as potential antifungal and antioxidant agents

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Chinese Chemical Letters 2016年第2期27卷 295-301页

作者： Mubarak H.Shaikh dnyaneshwar D.Subhedar Firoz A.Kalam Khan jaiprakash N.Sangshetti Bapurao B.Shingate Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Department of Pharmaceutical Chemistry Y. B. Chavan College of Pharmacy Dr. Rafiq Zakaria Campus

A series of novel ethyl-7-（（1-（benzyl）-1H-1,2,3-triazol-4-yl）methoxy）-2-oxo-2H-chromene-3-carboxylates 8a-h as potential antifungal agents were synthesized via click chemistry. The antifungal activity was evaluated against five human pathogenic fungal strains, such as Candida albicans, Fusarium oxysporum, Aspergillus flavus, Aspergillus niger and Cryptococcus neoformans. Compound 8c, 8d, 8e and 8h were found to be equipotent against C. albicans when compared with miconazole and compound 8f was found to be two-fold more active compared with miconazole and equipotent to fluconazole against ***. The coumarin-based triazole derivatives were also evaluated for antioxidant activity and compound 8a was found to be potent antioxidant when compared with standard drug. Furthermore,molecular docking study of the newly synthesized compounds was performed and results showed good binding mode in the active site of fungal C. albicans enzyme P450 cytochrome lanosterol 14 ademethylase. Moreover, the synthesized compounds were also analyzed for ADME properties and showed potential to build up as good oral drug candidates.

关键词： ADME prediction Antifungal Antioxidant Docking study 1,2,3-Triazole

1,2,3-Triazole tethered acetophenones: Synthesis, bioevaluation and molecular docking study

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Chinese Chemical Letters 2016年第7期27卷 1058-1063页

作者： Mubarak H.Shaikh dnyaneshwar D.Subhedar Vijay M.Khedkar Prakash C.jha Firoz A.Kalam Khan jaiprakash N.Sangshetti Bapurao B.Shingate UGC-SAP and DST-FIST Sponsored Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University School of Health Sciences University of Kwa Zulu Natal Westville Campus School of Chemical Sciences Central University of Gujarat Department of Pharmaceutical Chemistry Y. B. Chavan College of Pharmacy Dr. Rafiq Zakaria Campus

A small focused library of eighteen new 1,2,3-triazole tethered acetophenones has been efficiently prepared via click chemistry approach and evaluated for their antifungal and antioxidant *** antifungal activity was evaluated against five human pathogenic fungal strains：Candida albicans,Fusarium oxysporum,Aspergillus flavus,Aspergillus niger,and Cryptococcus *** the synthesized compounds,9c,9i,and 9p found to be more potent antifungal agents that the reference *** 1,2,3-triazole based derivatives were also evaluated for antioxidant activity,and compound 9h was found to be the most potent antioxidant as compared to the standard ***,molecular docking study of the newly synthesized compounds was performed and results showed good binding mode in the active site of fungal *** enzyme P450 cytochrome ***,the synthesized compounds were also analyzed for ADME properties and showed potential as good oral drug candidates.

关键词： 1,2,3-Triazole Antifungal Antioxidant Molecular docking ADME prediction

Large Ameloblastoma of Mandible: Our Experience with Intermaxillary Fixation

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International journal of Otolaryngology and Head & Neck Surgery 2016年第1期5卷 17-22页

作者： Anoop Attakkil Vandana Thorawade Rajesh Kar Shobhna Chandran Devkumar Rengaraja Karthik Rao dnyaneshwar Rohe Department of ENT Grant Medical College & Sir J.J. Hospital Mumbai India

Ameloblastomas are benign dental tumors, constituting 15% of oral neoplasms, most frequent odontogenic tumor of the jaw. Patient presenting at a late stage usually presents with large swelling with facial deformity. We present a case of 50 years old male who presented with recurrent ameloblastoma on the left side of the mandible causing facial disfigurement and functional impairment. Adequate removal of the tumor required hemimandibulectomy and intermaxillary fixation was done without any bony reconstruction. We would like to focus on the excellent postoperative result with regard to facial symmetry and functional improvement obtained in this case, though the available management protocols differ and are more advanced in current scenario. This case report gives hope and guidance to the surgeons who face difficulty in managing the deforming benign bony tumors due to the unavailability of facility and funds to reconstruct.

关键词： Ameloblastoma Resection Intermaxillary Fixation Mandible

An Unusal Case of Epidermal Cyst in Submandibular Space

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International journal of Otolaryngology and Head & Neck Surgery 2014年第5期3卷 213-215页

作者： Rajesh Kar Vandana Thorawade Mohan jagade Anoop Attakkil Shubhangi Kedar dnyaneshwar Rohe Kartik Parelkar Rajanala Nataraj Devkumar Rengaraja Department of ENT & Head & Neck Surgery Grant Government Medical College & Sir J.J. Group of Hospitals Mumbai India

Epidermal cysts are very common skin lesions and 1.6% are seen in oral cavity. But epidermal cyst in submandibular region is extremely rare with only 3 such reported cases in last 25 years. Here we present a rare case... 详细信息

关键词： Epidermal Cyst Submandibular Space Epidermoid Cyst

An Entangled Fish Hook in Nose: A Tricky Case

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International journal of Otolaryngology and Head & Neck Surgery 2014年第3期3卷 137-139页

作者： Rajesh Kar M. V. jagade A. Anoop Shubhangi Kedar dnyaneshwar Rohe Poonam Khairnar Vandana P. Thorawade Reshma Chavan Department of ENT & Head & Neck Surgery Grant Government Medical College & Sir J. J Group of Hospitals Mumbai India

ENT practitioners encounter different types of nasal foreign bodies in their daily practices. A variety of nasal foreign bodies have been described in literature. Here we present a case of an entangled fish hook in th... 详细信息

关键词： Nasal Foreign Bodies Fishhook

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肠道真菌对造血干细胞移植临床结果的影响

肠道真菌对造血干细胞移植临床结果的影响