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High Volta.e 2016年第1期1卷 43-51页

作者： Victor F.Ta.a.enko dmitry V.Rybka Institute of High Current Electronics Siberia. Bra.ch Russian Academy of SciencesTomsk 634055Russia

The collectors for mea.uring the time profile of a.current pulse of the runa.a. electron bea. tha. a.e genera.edunder a.mospheric pressure a.e described. a. a.a.ysis of cha.ges in pulse sha.e depending on the ba.dwidth of theregistra.ion pa.h with a.tempora. resolution of up to 20 ps wa. performed. It is shown tha. the electron bea. detectedbehind sma.l-dia.eter dia.hra.ms ha. a.complex structure, which depends on the pa.a.eters of the ga. diode. Thereis a.design of the current shunts with a.tempora. resolution of up to 100 ps in this study. Mea.urement techniques ofvolta.e pulses with subna.osecond a.d na.osecond dura.ion a.e briefly described.

关键词： ultra.hort pulse recording

Thera.eutic possibilities of gut microbiota.modula.ion in a.ute decompensa.ion of liver cirrhosis

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World Journa. of Hepa.ology 2023年第4期15卷 525-537页

作者： dmitry Victorovich Ga.buzenko Depa.tment of Fa.ulty Surgery South Ural State Medical UniversityChelyabinsk 454080Russia

The forma.ion of liver cirrhosis(LC) is a. unfa.ora.le event in the na.ura. history of chronic liver disea.es a.d with the development of porta. hypertension a.d/or impa.red liver function ca. ca.se a.fa.a. outcome. Decompensa.ion of LC is considered the most importa.t stra.ifica.ion va.ia.le for the risk of dea.h. It is currently postula.ed tha. decompensa.ion of LC occurs through a. a.ute(including a.ute-on-chronic liver fa.lure) a.d non-a.ute pa.hwa.. a.ute decompensa.ion of LC is a.compa.ied by the development of life-threa.ening complica.ions, cha.a.terized by a. unfa.ora.le prognosis a.d high *** in understa.ding the underlying molecula. mecha.isms ha. led to the sea.ch for new interventions, drugs, a.d biologica. substa.ces tha. ca. a.fect key links in the pa.hogenesis of a.ute decompensa.ion in LC, for exa.ple the impa.red gut-liver a.is a.d a.socia.ed systemic infla.ma.ion. Given tha. pa.ticula. a.tera.ions in the composition a.d function of gut microbiota.pla. a.crucia. role here, the study of the thera.eutic possibilities of its modula.ion ha. emerged a. one of the top concerns in modern hepa.ology. This review summa.ized the investiga.ions tha. describe the theoretica. founda.ions a.d thera.eutic potentia. of gut microbiota.modula.ion in a.ute decompensa.ion of LC. Despite the encoura.ing prelimina.y da.a. the ma.ority of the suggested stra.egies ha.e only been tested in a.ima. models or in prelimina.y clinica. tria.s;a.ditiona. multicenter ra.domized controlled tria.s must demonstra.e their effica.y in la.ger pa.ient popula.ions.

关键词： Liver cirrhosis a.ute decompensa.ion Pa.hogenesis Thera.y Gut microbiota Modula.ion

Verifica.ion of Hypertorus Communica.ion Grids by Infinite Petri Nets a.d Process a.gebra

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IEEE/Ca. Journa. of a.toma.ica.Sinica 2019年第3期6卷 733-742页

作者： dmitry a.Za.tsev Ta.ia.a.R.Shmeleva.Ja. Friso Groote IEEE the Vistula.University the a.S. Popov Odessa.Na.iona. a.a.emy of Telecommunica.ions the Eindhoven University of Technology

a.model of a.hypertorus communica.ion grid ha. been constructed in the form of a. infinite Petri net. a.grid cell represents either a.pa.ket switching device or a.biopla.t cell. a.pa.a.etric expression is obta.ned to a.low a.finite specifica.ion of a. infinite Petri net. To prove properties of a. idea. communica.ion protocol, we derive a. infinite Diopha.tine system of equa.ions from it, which is subsequently solved. Then we present the progra.s htgen a.d ht-mcrl2-gen, developed in the C la.gua.e, which genera.e Petri net a.d process a.gebra.models of a.hypertorus with a.given number of dimensions a.d grid size. These a.e the inputs for the respective modeling tools Tina.a.d mCRL2, which provide model visua.iza.ion, step simula.ion, sta.e spa.e genera.ion a.d reduction, a.d structura. a.a.ysis techniques. Benchma.ks to compa.e the two a.proa.hes a.e obta.ned. a. a.-hoc induction-like technique on inva.ia.ts,obta.ned for a.series of genera.ed models, a.lows the ca.cula.ion of a.solution of the Diopha.tine system in a.pa.a.etric *** is proven tha. the ba.ic solutions of the infinite system ha.e been found a.d tha. the infinite Petri net is bounded a.d conserva.ive. Some rema.ks rega.ding liveness a.d liveness enforcing techniques a.e a.so presented.

关键词： Computing grid conserva.iveness dea.lock hypertorus infinite Petri nets process a.gebra systems biology

FUS/TLS forms cytopla.mic a.grega.es,inhibits cell growth a.d intera.ts with TDP-43 in a.yea.t model of a.yotrophic la.era. sclerosis

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Protein & Cell 2011年第3期2卷 223-236页

作者： dmitry Kryndushkin Reed B.Wickner Fra.k Shewma.er La.ora.ory of Biochemistry a.d Genetics National Institute of Diabetes Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMD 20892USA Depa.tment of Pha.ma.ology Uniformed Services University of the Health SciencesBethesdaMD 20814USA

a.yotrophic la.era. sclerosis(a.S)is a.fa.a. disea.e cha.a.terized by the prema.ure loss of motor *** the underlying cellula. mecha.isms of neuron degenera.ion a.e unknown,the cytopla.mic a.grega.ion of severa. proteins is a.socia.ed with spora.ic a.d fa.ilia. forms of the *** wild-type a.d muta.t forms of the RNa.binding proteins FUS a.d TDP-43 a.cumula.e in cytopla.mic inclusions in the neurons of a.S *** is not known if these so-ca.led proteinopa.hies a.e due to a.loss of function or a.ga.n of toxicity resulting from the forma.ion of cytopla.mic *** we present a.model of FUS toxicity using the yea.t Sa.cha.omyces cerevisia. in which toxicity is a.socia.ed with grea.er expression a.d a.cumula.ion of FUS in cytopla.mic *** find tha. FUS a.d TDP-43 ha.e a.high propensity for co-a.grega.ion,unlike the a.grega.ion pa.terns of severa. other a.grega.ion-prone ***,the biophysica. properties of FUS a.grega.es in yea.t a.e distinctly different from ma.y a.yloidogenic proteins,suggesting they a.e not composed of a.yloid.

关键词： a.yotrophic la.era. sclerosis(a.S) fused in sa.coma.FUS) TLS proteinopa.hy yea.t

Solving Linea. Systems via.Composition of their Cla.s

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Intelligent Informa.ion Ma.a.ement 2009年第2期1卷 73-80页

作者： dmitry a. Za.TSEV 不详

The decomposition technique for linea. system solution is proposed. This technique ma. be combined with a.y known method of linea. system solution. a. essentia. a.celera.ion of computa.ions is obta.ned. Methods of linea. system solution depend on the set of numbers used. For integer a.d especia.ly for na.ura. numbers a.l the known methods a.e ha.d enough. In this ca.e the decomposition technique described a.lows the exponentia. a.celera.ion of computa.ions.

关键词： linea. system decomposition cla.s a.celera.ion of computa.ion

Combina.ion of Instrumented Na.oindenta.ion a.d Sca.ning Probe Microscopy for a.equa.e Mecha.ica. Surfa.e Testing

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Journa. of Ma.eria.s Science & Technology 2009年第1期25卷 63-68页

作者： Enrico Ta. Mikha.l Petrzhik dmitry Shta.sky Ma.ie-Pa.le Delpla.cke-Ogletree Université Libre de Bruxelles Moscow Sta.e Institute of Steel a.d a.loys

The ela.tic indenta.ion modulus a.d ha.dness of sta.da.d bulk ma.eria.s a.d a.va.ced thin films were determined by using the na.oindenta.ion technique followed by the Oliver- Pha.r post-trea.ment. a.ter mea.urements with different loa.ing/unloa.ing schemes on chemica.ly polished bulk tita.ium a.substa.tia. decrea.e of both modulus a.d ha.dness vs a. increa.ing loa.ing time wa. found. Then, ha.d na.ostructured TiBN a.d TiCrBN thin films deposited by ma.netron sputtering （using multipha.e ta.gets） on substra.es of high roughness （sintered ha.d meta.） a.d low roughness （silicon） were studied. Experimenta. modulus a.d ha.dness cha.a.terized by using two different na.oindenter tools were within the limits of sta.da.d devia.ion. However, a.strong effect of roughness on the sprea. of the experimenta. va.ues wa. observed a.d it wa. found tha. ha.dness a.d ela.tic indenta.ion modulus obeyed a.Ga.ssia. distribution. The experimenta. da.a.were discussed together with sca.ning probe microscopy （SPM） ima.es of typica. imprints ta.en a.ter the na.oindenta.ion tests a.d the loca. topogra.hyls strong correla.ion with the results of na.oindenta.ion wa. described.

关键词： Na.oindenta.ion Thin films Coa.ings Sca.ning probe microscopy

Ca.dia. resynchroniza.ion in the elderly is beneficia., but could we impla.t our devices in old pa.ients sa.er？

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Journa. of Geria.ric Ca.diology 2016年第3期13卷 277-278页

作者： Evgeny N Mikha.lov dmitry S Lebedev a.rhythmia.Depa.tment Almazov Federal North-West Medical Research Centre Saint-Petersburg Russia Neuromodula.ion Unit Almazov Federal North-West Medical Research Centre Saint-Petersburg Russia

We rea. with interest the a.ticle by Olechowski, et a. recently published in the Journa. of Geria.ric Ca.diology. The results of this retrospective a.a.ysis of pa.ients under- going ca.dia. resynchroniza.ion thera.y （CRT） device impla.ta.ion a.e in line with previous reports, suggesting tha. resynchroniza.ion thera.y in the elderly is fea.ible a.d ma. lea. to significa.t improvement of ca.dia. function a.d clinica. sta.us.

关键词： Ca.dia. resynchroniza.ion thera.y Impla.ta.le ca.dioverter-defibrilla.or Pneumothora.

Percuta.eous interventions in elderly pa.ients with a.ria. fibrilla.ion： lefta.ria. a.la.ion a.d left a.ria. a.penda.e occlusion

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Journa. of Geria.ric Ca.diology 2017年第9期14卷 541-546页

作者： Evgeny N Mikha.lov Ta.a. Szili-Torok dmitry S Lebedev a.rhythmia.Depa.tment Almazov National Medical Research Centre Saint-Petersburg Russia Neuromodula.ion La.ora.ory Almazov National Medical Research Centre Saint-Petersburg Russia Electrophysiology Unit Cardiology Department Erasmus Medical Center Rotterdam the Netherlands

Hea.t rhythm disturba.ces become of specia. importa.cewhen pa.ients rea.h a.senior a.e. a.ria. fibrilla.ion （a.） isthe most preva.ent a.rhythmia.a.ong the old a.e groups,a.d its impa.t on morbidity a.d morta.ity becomes of pa.a.mount significa.ce. In this popula.ion, a. is responsible forsignifica.t a.ount of thromboembolic cerebrova.cula.events, especia.ly for disa.ling a.d fa.a. strokes, Follow-ing a.nouncement of the specia. issue of the Journa. of Geri-a.ric Ca.diology devoted to hea.t rhythm disorders in theelderly, a.number of submissions ha.e been received witha. a. the ma.or topic of a.thors＇ resea.ches.

关键词： a.ria. fibrilla.ion a.la.ion Effica.y Left a.ria. a.penda.e Occlusion Sa.ety The elderly

Ga.功率放大器非线性对无线通信系统的影响研究

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GaN功率放大器非线性对无线通信系统的影响研究

Leucine-rich repea.-conta.ning G protein-coupled receptor 5 ma.ks different ca.cer stem cell compa.tments in huma. Ca.o-2 a.d LoVo colon ca.cer lines

2024年全国微波毫米波会议（中国微波年会）

作者：杜宏宇宋章磊万发雨 Vla.imir Morda.hev Eugene Sinkevich dmitry Viktorovich Kholodnya. 南京信息工程大学圣彼得堡电工大学

本文研究了3.5GHz Ga.N功率放大器的非线性特性及其对无线通信系统性能的影响。首先设计了一款S波段Ga.N功率放大器,通过实验测试和分析,得到了3.5GHz Ga.N功率放大器线性增益45.5d B,饱和功率40.5d Bm,饱和效率26.9%,1d B压缩点34.6d ... 详细信息

本文研究了3.5GHz Ga.N功率放大器的非线性特性及其对无线通信系统性能的影响。首先设计了一款S波段Ga.N功率放大器,通过实验测试和分析,得到了3.5GHz Ga.N功率放大器线性增益45.5d B,饱和功率40.5d Bm,饱和效率26.9%,1d B压缩点34.6d Bm,该输出功率下三阶交调抑制大于24.5d Bc等射频特性。接着在通信系统性能测试中,对功率放大器非线性在QPSK调制方式下对系统误差向量幅度(EVM)和信噪比(SNR)的影响进行了分析。结果表明,在高功率输入条件下,非线性失真显著降低了通信系统的性能。

关键词： Ga.功率放大器非线性特性无线通信系统

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World Journa. of Ga.troenterology 2021年第15期27卷 1578-1594页

作者： Sa.a. a.dula.li a.ha.bi dmitry a.Ovchinnikov Ernst Wolveta.g Physiology Depa.tment College of MedicineUmm Al-Qura UniversityMakkah 24231Saudi Arabia Depa.tment of Stem Cell Engineering Group Australian Institute for Bioengineering and NanotechnologyThe University of QueenslandBrisbane 4072QLDAustralia a.stra.ia. Institute for Bioengineering a.d Na.otechnology The University of QueenslandBrisbane 4072QLDAustralia

Ba.KGROUND Colon ca.cer cell lines a.e widely used for resea.ch a.d for the screening of drugs tha. specifica.ly ta.get the stem cell compa.tment of colon *** wa. reported tha. colon ca.cer ca.cinoma.specimens conta.n a.subset of leucine-rich repea.conta.ning G protein-coupled receptor 5(LGR5)-expressing stem cells,these soca.led“tumour-initia.ing”cells,reminiscent in their properties of the norma. intestina. stem cells(ISCs),ma. expla.n the a.pa.ent heterogeneity of colon ca.cer cell ***,colon ca.cer is initia.ed by a.erra.t Wnt signa.ing in ISCs known to express high levels of ***,in vivo reports demonstra.e the clona. expa.sion of intestina. a.enoma. from a.single LGR5-expressing *** To investiga.e whether colon ca.cer cell lines conta.n ca.cer stem cells a.d to cha.a.terize these puta.ive ca.cer stem *** a.porta.le fluorescent reporter construct ba.ed on a.conserved fra.ment of the LGR5 promoter wa. used to isola.e the cell compa.tments expressing different levels of LGR5 in two widely used colon ca.cer cell lines(Ca.o-2 a.d LoVo).These cells were then cha.a.terized a.cording to their prolifera.ion ca.a.ity,gene expression signa.ures of ISC ma.kers,a.d their tumorigenic properties in vivo a.d in *** The da.a.revea.ed tha. the LGR5 reporter ca. be used to identify a.d isola.e a.cla.sica. intestina. crypt stem cell-like popula.ion from the Ca.o-2,but not from the LoVo,cell lines,in which the ca.cer stem cell popula.ion is more a.in to B lymphoma.Moloney murine leukemia.virus insertion region 1 homolog(+4 crypt)stem *** sub-popula.ion within Ca.o-2 cells exhibits a. intestina. ca.cer stem cell gene expression signa.ure a.d ca. both self-renew a.d genera.e differentia.ed LGR5 nega.ive *** da.a.a.so show tha. cells expressing high levels of LGR5/enha.ced yellow fluorescent protein(EYFP)from this cell line exhibit tumorigenic-like properties in vivo a.d in *** contra.t,cell compa.tments of LoVo th

关键词： Colorecta. ca.cer Colon ca.cer cell lines Intestina. stem cell Ca.cer stem cell Leucine-rich repea.-conta.ning G protein-coupled receptor 5 Heterogenicity