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Endoscopic endonasal transclival removal of tumors of the clivus and anterior region of the posterior cranial fossa (results of surgical treatment of 140 patients)

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Chinese Neurosurgical Journal 2018年第4期4卷 219-232页

作者： Alexey N. Shkarubo Konstantin v. Koval Ilia v. Chernov dmitry N. Andreev Alexey B. Kurnosov Andrey A. Panteleyev federal State Autonomous Institution N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation (N.N. Burdenko NMRCN) 4-ya Tverskaya-YAmskaya street 16 Moscow Russian Federation

Background: Until recently, tumors of the clivus and the anterior region of the posterior cranial fossa were considered extremely difficult to access and often inoperable using standard transcranial approaches. With the introduction into the neurosurgical practice of minimally invasive methods utilizing endoscopic techniques, it became possible to effectively remove hard-to-reach tumors, including central tumors of the anterior region of the posterior cranial fossa. Methods: From 2008 to the present time, the inpatient institution has operated on 140 patients with various tumors of the base of the skull, localized to the clivus and anterior region of the posterior cranial fossa (65 men and 75 women). The age of patients ranged from 3 to 74 years. Tumor distribution according to the histopathological features was as follows: chordomas, 103 (73.57%);meningiomas, 12 (8.57%);pituitary adenomas, 9 (6.43%);fibrous dysplasia, 4 (2.86%);cholesteatoma, 3 (2.14%);craniopharyngiomas, 2 (1.43%);plasmacytomas, 2 (1.43%);and other tumors (giant cell tumor, neurohypophyseal glioma, osteoma, carcinoid, chondroma), 5 (3.57%). The tumors had the following size distribution: giant (more than 60 mm), 35 (25%);large (35–59 mm), 83 (59.3%);medium (21–35 mm), 21 (15%);and small (less than 20 mm), 1 (0.7%). In 11 cases, intraoperative monitoring of the cranial nerves was performed (21 cranial nerves were identified). Results: Upper, middle, and lower transclival approaches provide access to the anterior surface of the upper, middle, and lower neurovascular complexes of the posterior cranial fossa. The chordoma cases were distributed as follows according to extent of removal: total removal, 68 (66.02%);subtotal removal, 25 (24.27%);and partial removal, 10 (9.71%). The adenomas of the pituitary gland were removed totally in 6 cases, subtotally in 1 case and partially in 2 cases. The meningiomas were removed totally in 1 case, subtotally in 5 cases, and partially in 5 cases, with less than 50

关键词： Clivus Clival chordoma Endoscopic endonasal transclival approach Monitoring of cranial nerves Posterior cranial fossa Skull base anatomy Skull base surgery

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IR-transparent MgO-Gd_(2)O_(3) composite ceramics produced by self-propagating high-temperature synthesis and spark plasma sintering

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Journal of Advanced Ceramics 2021年第2期10卷 237-246页

作者： dmitry A.Permin Maksim S.Boldin Alexander v.Belyaev Stanislav S.Balabanov vitaly A.Koshkin Atrem A.Murashov Igor v.Ladenkov Evgeny A.Lantsev Ksenia E.Smetanina Nadia M.Khamaletdinova G.G.Devyatykh institute of chemistry of high-purity substances of the ras nizhny novgorod603137russia Lobachevsky state university of nizhny novgorod nizhny novgorod603950russia “Joint-stock company”research and production enterprise“salut” nizhny novgorod603950russia G.A.Razuvaev institute of organometallic chemistry of the ras nizhny novgorod603137russia

A glycine–nitrate self-propagating high-temperature synthesis(SHS)was developed to produce composite MgO-Gd_(2)O_(3) *** X-ray powder diffraction(XRD)analysis confirmed the SHS-product consists of cubic MgO and Gd_(2)O_(3) phases with nanometer crystallite size and retains this structure after annealing at temperatures up to 1200℃.Near full dense high IR-transparent composite ceramics were fabricated by spark plasma sintering(SPS)at 1140℃and 60 *** in-line transmittance of 1 mm thick MgO-Gd_(2)O_(3) ceramics exceeded 70%in the range of 4–5 mm and reached a maximum of 77%at a wavelength of 5.3 *** measured microhardness Hv0.5 of the MgO-Gd2O3 ceramics is 9.5±0.4 GPa,while the fracture toughness(KIC)amounted to 2.0±0.5МPa·m1/*** characteristics demonstrate that obtained composite MgO-Gd_(2)O_(3) ceramic is a promising material for protective infra-red(IR)windows.

关键词： MgO-Gd_(2)O_(3) self-propagating high-temperature synthesis(SHS) spark plasma sintering(SPS) optical properties infra-red(IR)ceramics

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Phylogeny of Brucella abortus strains isolated in the Russian federation

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Asian Pacific Journal of Tropical Medicine 2021年第7期14卷 323-329页

作者： dmitry A.Kovalev Dmitriy G.Ponomarenko Sergey v.Pisarenko Nikolay A.Shapakov Anna A.Khachaturova Natalia S.Serdyuk Olga v.Bobrysheva Alexander N.Kulichenko Stavropol Research Anti-Plague Institute 355035StavropolRussian Federation

Objective: To study Brucella(B.) abortus strains isolated in the Russian federation, in order to identify their detailed position in the phylogenetic structure of the species global population as well as to determine genetic relationships for isolates from different geographical ***: Based on Bayesian method, the whole genome singlenucleotide polymorphism(SNP) analysis of 258 B. abortus strains from different geographical areas of the world including 20 B. abortus strains isolated in Russia was carried out. Results: The core genome SNP analysis of the B. abortus isolates allowed describing the main genetic lineages. The Russian strains entered two separate clades, including the basal branch and the C1 branch that is widely spread in Eurasia. The data on the isolation time was used for the dating of phylogenetic tree, and also the estimated time frame for the B. abortus genotype diversification was determined. There were sets of specific SNPs identified, which defined each of the genotypes and ***: A significant genetic diversity of the brucellosis pathogen strains from Russia has been proven. The sets of unique specific SNPs described in our study may become one of the elements within a bio-informational analysis algorithm to be used for epidemiological study of brucellosis outbreaks, including those caused by new(atypical) genetic variants of B. abortus.

关键词： Brucella abortus Phylogeny Evolution Genome SNP

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Review of supershort avalanche electron beam during nanosecond-pulse discharges in some gases

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Matter and Radiation at Extremes 2017年第3期2卷 105-116页

作者： victor F.Tarasenko Cheng Zhang Evgenii Kh.Baksht Alexander G.Burachenko Tao Shao dmitry v.Beloplotov Mikhail I.Lomaev Ping Yan Andrey v.Kozyrev Natalia S.Semeniuk Laboratory of Optical Radiation of the Institute of High Current Electronics Tomsk 634055Russia National Research Tomsk State University Tomsk 634050Russia National Research Tomsk Polytechnic University Tomsk 634050Russia Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China

Supershort avalanche electron beam(SAEB)plays an important role in nanosecond-pulse *** paper aims at reviewing ex-periments results on characteritics of SAEB and its spectra in different gases in nanosecond-pulse *** the joint experiments were carried in the Institute of High Current Electronics of the Russian Academy of Sciences and the Institute of Electrical Engineering of the Chinese Academy of *** these experiments,the generation of a SAEB in SF 6 in an inhomogeneous electric field was studied on three generators with pulse rise times of 0.3,0.5 and~2 ***,the comparison of SAEB parameters in SF 6 with those obtained in other gases(air,nitrogen,argon,and krypton)is ***,the SAEB spectra in SF 6 and air at pressures of 10 kPa(75 torr),and 0.1 MPa(750 torr)are reviewed and ***,1.5-D theoretical simulation of the supershort pulse of the fast electron beam in a coaxial diode filled with SF 6 at atmospheric pressure is *** simulation was carried out in the framework of hybrid model for discharge and runaway electron *** above research progress can provide better understanding of the investigation into the mechanism of nanosecond-pulse discharges.

关键词： Runaway electrons Supershort avalanche electron beam(SAEB) SF 6 Gas diode High pressure Simulation Hybrid model

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COMPLEX OPTICAL CHARACTERIZATION OF MESHIMPLANTS AND ENCAPSULATION AREA

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Journal of Innovative Optical Health Sciences 2013年第2期6卷 3-10页

作者： vALERIY P.ZAKHAROv IvAN A.BRATCHENKO vLADIMIR I.BELOKONEv dmitry v.KORNILIN OLEG O.MYAKININ Samara State Aerospace University Samara 443086 Moskovskoe Shosse 34Russia Samara Medical University Samara 443099 Polevaya Street 80Russia

Complex investigation of mesh implants was per formed involving laser confocal microscopy,backscattered probing and OCT imaging *** growth of endomysium and fat tissue with microcirculation vessels was observed in the mesh encapsulation *** microscopy analysis shows that such pat hologies complications such as necrosis formation and microcavities were localized in the area near implant fibers with the size compatible with fiber *** the number of such formnations increase with the increase of the size,number and density of microdefects on the implant *** of mumerical sinulations show that it is possible to control implant installation up to the depth to 4mm with a help of bac kscattering *** applicability of OCT imaging for mesh implant control was *** two stage OCT image noise reduction algorithm,including empirical mode decomposition,was proposed for contrast increase and better abnormalities visualization by halving the signal-to-noise *** usage of backscattered probing and OCT allows to accurately ascertain implant and surrounding tissue conditions,which reduces the risk of relapse probability.

关键词： Encapsulation area laser confocal microscopy mathematical simulation OCT image

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Tumor cell death visualization of renal cell carcinoma under the combined effect of the Gratiola officinalis extract and cyclophosphamide using fluorescent staining methods

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Journal of Innovative Optical Health Sciences 2021年第5期4卷 46-52页

作者： Artyom Mylnikov Nikita Navolokin dmitry Mudrak Natalya Polukonova Alla Bucharskaya Galina Maslyakova Saratov State Medical University named after V.I.Razumovsky 112 Bolshaya Kazachia Street Saratov 410012Russia National Research Saratov State University 83 Astrakhanskaya Street Saratov 410012Russia National Research Tomsk State University 36 Lenin Avenue Tomsk 634050Russia

Objective of the study:We used fluorescence imaging methods of apoptosis and necrosis in human renal carcinoma A498 tumor cells in vitro to reveal the indicated forms of cell death under the combined effect of flavonoid-containing extract of Gratiola officinalis and cytostatic(cyclo-phosphamide).Materials and methods:The dyes were propidium iodide and acridine orange,which were used in the"alive and dead"*** test helped us to identify the total number of dead cells in the forms of necrosis and apoptosis and the number of cells in which apoptosis had started,it was characterized by the appearance of apoptotic bodies or nucleus ***:We found the most pronounced cytotoxic activity at the ratio of extract of Gratiola officinalis and cyclophosphamide concentrations of 1∶*** number of living cells decreased when exposed to the ratio of extract and cytostatic concentrations of 2∶*** the ratio of concentration of the extract relative to the cytostatic increased to 3∶1,the cytostatic activity of the extract began to appear,the total number of tumor cells *** number of cells with nucleus pyknosis and the number of cells with apoptosis signs significantly increased at a 3∶1 ratio of extract and cytostatic concentrations,which confirms the presence of pro-apoptotic activity of the studied *** trend indicates the dependence of a certain form of cell death(apoptosis,necrosis)on the ratio of extract and cytostatic doses,and it also demon-strates the cytostatic and cytotoxic effects of this ***:Fluorescence methods of investigation in the"alive and dead"test allowed us to visualize the forms of cell death of human kidney carcinoma A498 by combined exposure to the fiavonoid-containing extract of Gratiola officinalis and cytostatic(cyclophosphamide)24 h after *** found that the combination with a concentration ratio of the extract and cyclophosphamide of 3:1 has the greatest effectiveness due to stimulation of t

关键词： A498 cell line Gratiola officinalis extract antitumor activity cytostatic activity flavonoids fluorescent methods kidney cancer

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Growth of carbon nanotube arrays on various CtxMey alloy films by chemical vapour deposition method

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Journal of Materials Science & Technology 2018年第3期34卷 472-480页

作者： Pawel Mierczynski Sergey v.Dubkov Sergey v.Bulyarskii Alexander A.Pavlov Sergey N.Skorik Alexey Yu Trifonov Agnieszka Mierczynska Eugene P.Kitsyuk Sergey A.Gavrilov Tomasz P.Maniecki dmitry G.Gromov Institute of General and Ecological Chemistry Lodz University of TechnologyZeromskiego 116Lodz 90-924Poland National Research University of Electronic Technology Shokin SquareZelenogradMoscow 124498Russia Institute of Nanotechnology of Microelectronics of the RAS INMEMoscow 11-9991Russia Scientific-Manufacturing Complex'Technological Center' ZelenogradMoscow 124498Russia Scientific Research Institute of Physical Problems named after F v.Lukin Proezd 4806.6ZelenogradMoscow 124460Russia The Australian Wine Research Institute Waite PrecinctHartley Grove cnr Paratoo RoadUrrbrae AdelaideSA 5064Australia

Carbon nanotube （CNT） arrays were fabricated on Ct-Me-N-（O） alloys with content of Ct in the range of 6-40 at.% by chemical vapour deposition. The Ct was a catalytic metal from the group of the following elements： Ni, Co, fe, Pd, while Me was a transition metal from the group of Iv-vII of the periodic table （where Me=Ti, v, Cr, Zr, Nb, Mo, Ta, W, Re）. Carbon nanotubes were found to grow efficiently on the alloy surface with its composition containing Ti, v, Cr, Zr, Hf, Nb or Ta. The growth of CNTs was not observed when the alloy contained W or Re. Additions of oxygen and nitrogen in the alloy facilitated the formation of oxynitrides and catalyst extrusion on the alloy surface. Replacement of the metals in alloy composition affected the diameter of the resulting CNTs. The obtained results showed that the alloy films of varying thickness （10-500 nm） may be used for the CNTs growth. The resulting CNT material was highly homogenous and its synthesis reproducible.

关键词： Carbon nanotubes Amorphous alloys Chemical vapour deposition Catalytic processes Thin films

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value of two-phase dynamic multidetector computed tomography in differential diagnosis of post-inflammatory strictures from esophageal cancer

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World Journal of Gastroenterology 2015年第29期21卷 8878-8887页

作者： Grigory G Karmazanovsky Svetlana A Buryakina Evgeny v Kondratiev Qin Yang dmitry v Ruchkin dmitry v Kalinin Department of Radiology Vishnevsky Institute of Surgery Department of Thoracic Surgery (Esophageal Surgery group) Vishnevsky Institute of Surgery Department of Pathomorphology Vishnevsky Institute of Surgery

AIM: To characterize the computed tomography(CT) findings in patients with post-inflammatory esophageal strictures(corrosive and peptic) and reveal the optimal scanning phase protocols for distinguishing postinflammatory esophageal stricture and esophageal ***: Sixty-five patients with esophageal strictures of different etiology were included in this study: 24 patients with 27 histopathologically confirmed corrosive strictures, 10 patients with 12 peptic strictures and 31 patients with esophageal cancer were evaluated with a two-phase dynamic contrast-enhanced MDCT. Arterial and venous phases at 10 and 35 s after the attenuation of 200 HU were obtained at the descending aorta, with a delayed phase at 6-8 min after the start of injection of contrast media. For qualitative analysis, CT scans of benign strictures were reviewed for the presence/absence of the following features: "target sign", luminal mass, homogeneity of contrast medium uptake, concentric wall thickening, conically shapedsuprastenotic dilatation, smooth boundaries of stenosis and smooth mucous membrane at the transition to stenosis, which were compared with a control group of 31 patients who had esophageal cancer. The quantitative analysis included densitometric parameter acquisition using regions-of-interest measurement of the zone of stenosis and normal esophageal wall and the difference between those measurements(ΔCT) at all phases of bolus contrast enhancement. Esophageal wall thickening, length of esophageal wall thickening and size of the regional lymph nodes were also evaluated. RESULTS: The presence of a concentric esophageal wall, conically shaped suprastenotic dilatation, smooth upper and lower boundaries, "target sign" and smooth mucous membrane at the transition to stenosis were suggestive of a benign cause, with sensitivities of 92.31%, 87.17%, 94.87%, 76.92% and 82.05%, respectively, and specificities of 70.96%, 89.66%, 80.65%, 96.77% and 93.55%, respectively. The features that

关键词： Multidetector computed tomography Esophageal cancer Corrosive stricture Peptic stricture

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Microscopic theory of exciton and trion polaritons in doped monolayers of transition metal dichalcogenides

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npj Computational Materials 2022年第1期8卷 891-900页

作者： Yaroslav vladimirovich Zhumagulov Salvatore Chiavazzo dmitry Romanovich Gulevich vasili Perebeinos Ivan Andreevich Shelykh Oleksandr Kyriienko University of Regensburg Regensburg93040Germany Department of Physics and Engineering ITMO UniversitySt.Petersburg197101Russia Department of Physics and Astronomy University of ExeterStocker RoadExeterEX44QLUnited Kingdom Department of Electrical Engineering University at BuffaloThe State University of New YorkBuffaloNY14260USA Science Institute University of IcelandDunhagi-3IS-107ReykjavikIceland

We study a doped transition metal dichalcogenide (TMDC) monolayer in an optical *** the microscopic theory,we simulate spectra of quasiparticles emerging due to the interaction of material excitations and a high-finesse optical mode,providing a comprehensive analysis of optical spectra as a function of fermi energy and predicting several modes in the strong light-matter coupling *** addition to exciton-polaritons and trion-polaritons,we report polaritonic modes that become bright due to the interaction of excitons with free *** large doping,we reveal strongly coupled modes corresponding to excited trions that hybridize with a cavity *** also demonstrate that the increase of carrier concentration can change the nature of the system’s ground state from the dark to the bright *** results offer a unified description of polaritonic modes in a wide range of free electron densities.

关键词： polar transition theory

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Boron nitride nanotube growth via boron oxide assisted chemical vapor transport-deposition process using LiNO3 as a promoter

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Nano Research 2015年第6期8卷 2063-2072页

作者： Andrei T. Matveev Konstantin L. Firestein Alexander E. Steinman Andrey M. Kovalskii Oleg I. Lebedev dmitry v. Shtansky Dmitri Golberg National University of Science and Technology 'MISIS' Leninskiy prospect 4 Moscow 119049 Russia CRISMAT UMR 6508 CNRS-ENSICAEN 6BdMarechalJuin Caen 14050 France Institute for Materials Science (NIMS) Namiki 1 Ibaraki Tsukuba 3050044 Japan

高纯净的直、分离的 multiwalled 硼氮化物 nanotubes (BNNT ) 作为一个倡导者用浮雕 3 与氨经由硼氧化物蒸汽反应被种。硼氧化物的仅仅踪迹数量被精力散的 X 光检查(EDX ) 和拉曼光谱学在 BNNT 作为杂质检测。硼氧化物蒸汽从 B 的混合... 详细信息

高纯净的直、分离的 multiwalled 硼氮化物 nanotubes (BNNT ) 作为一个倡导者用浮雕 3 与氨经由硼氧化物蒸汽反应被种。硼氧化物的仅仅踪迹数量被精力散的 X 光检查(EDX ) 和拉曼光谱学在 BNNT 作为杂质检测。硼氧化物蒸汽从 B 的混合物被产生， feO ，吗并且 MgO 粉末加热了到 1,150 爠灥潲畤楣汢?湡?楨桧祬愠瑣癩??卒攠晦'太B?獕湩?桴?牵档湩氭歩?杁??牡慲獹愠??卒猠'T瑳慲整?ㄠ????猯灵￣?楤畢祴?桰桴污瑡?愨洠浥敢?景瀠慬瑳捩穩牥?慦業祬?湡??‵殣?岣僫篤蔿藏????鐿???????脿???鯀魈鱋??︿????????????璣阿??鲣??觎????鑔鍽???????????恘? 恘？？

关键词：氮化硼纳米管生长机理化学气相传输氧化硼沉积过程硼氮纳米管温度范围卷曲纤维

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