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Population-specific effects of temperature and photoperiod on development and body mass in Cassida vibex (Coleoptera: Chrysomelidae)

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Insect Science 2023年第6期30卷 1810-1826页

作者： dmitry Kutcherov Elena b.Lopatina Department of Entomology St.Petersburg State UniversitySt.PetersburgRussia

An interplay of genetic divergence and phenotypic plasticity in shaping geographic variation is increasingly receiving attention in the entomological literature. Two major environmental variables that govern life histories are temperature and photoperiod. Studies of thermal and photoperiodic reaction norms help us understand how insect diversity evolved and how insects respond to environmental change. We studied survival, development, and body mass in three geographic populations of the beetle Cassida vibex reared in the laboratory under several combinations of constant temperature (16, 19, 22, 25, and 28 °C) and photoperiod (short-day and long-day). The three collection sites are situated along a climatic gradient and separated by hundreds of kilometers. Each population subtly but significantly differs in the absolute values of survival rate, developmental rate, and body mass as well as in the thermal and photoperiodic plasticity of these traits, but the geographic differences do not form a latitudinal cline. The southernmost population from a relatively warm climate survives worse at low temperatures than the other two, but the overall survival is lowest in the latitudinally intermediate population. Short-day conditions tend to accelerate postembryonic development and increase the slope of the developmental rate–temperature relationship, especially so in the intermediate population, followed by the southernmost population and then by the northernmost population. The latter, which inhabits a harsh climate, has the fastest and most temperature-sensitive development, regardless of photoperiod, and attains the largest body mass among the three populations. The intermediately located and photoperiodically plastic population, which lives in a cool but mild climate, in contrast, has the smallest body size. Hence, although the importance of short-day conditions as a seasonal cue increases poleward, the photoperiodic responses do not always become more pronounced in colder

关键词： adaptation life history photoperiodism plasticity reaction norm temperature

FUS/TLS forms cytoplasmic aggregates,inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis

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Protein & Cell 2011年第3期2卷 223-236页

作者： dmitry Kryndushkin Reed b.Wickner Frank Shewmaker Laboratory of biochemistry and Genetics National Institute of Diabetes Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMD 20892USA Department of Pharmacology Uniformed Services University of the Health SciencesBethesdaMD 20814USA

Amyotrophic lateral sclerosis(ALS)is a fatal disease characterized by the premature loss of motor *** the underlying cellular mechanisms of neuron degeneration are unknown,the cytoplasmic aggregation of several proteins is associated with sporadic and familial forms of the *** wild-type and mutant forms of the RNA-binding proteins FUS and TDP-43 accumulate in cytoplasmic inclusions in the neurons of ALS *** is not known if these so-called proteinopathies are due to a loss of function or a gain of toxicity resulting from the formation of cytoplasmic *** we present a model of FUS toxicity using the yeast Saccharomyces cerevisiae in which toxicity is associated with greater expression and accumulation of FUS in cytoplasmic *** find that FUS and TDP-43 have a high propensity for co-aggregation,unlike the aggregation patterns of several other aggregation-prone ***,the biophysical properties of FUS aggregates in yeast are distinctly different from many amyloidogenic proteins,suggesting they are not composed of amyloid.

关键词： amyotrophic lateral sclerosis(ALS) fused in sarcoma(FUS) TLS proteinopathy yeast

E-beam generation in discharges initiated by voltage pulses with a rise time of 200 ns at an air pressure of 12.5-100 kPa

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Plasma Science and Technology 2019年第4期21卷 52-60页

作者： Victor TARASENKO dmitry bELOPLOTOV Mikhail LOMAEV dmitry SOROKIN Institute of High Current Electronics Siberian Bran ch.Russian Academy of Sciences.Tomsk&34055.Russia National Research Tomsk State University.Tomsk 634050 Russia

The effect of air pressure(12.5,25,50,and 100 kPa)on the gen eration of runaway electron beams in a non-uniform electric field when applying voltage pulses(~35 kV)with a rise time of?200 ns has been *** results show that the discharge has various stages:streamer,diffuse,and ***,a wide streamer develops in the gap and a diffuse discharge is formed.A spark is formed u 100 ns after the *** current pulse of a supershort avalanche electron beam(SAEb)was measured with a collector at various pressures of *** show that there are two modes of generation of run away *** an air pressure of 25-100 kPa,a single SAEb current pulse with a full width at half-maximum(FWHM)of 120-140 ps is *** the air pressure of 12.5 kPa,two current pulses of the electron beam are *** of the first and second current pulses are ul40ps and u300 ps,*** current pulse amplitude of the second electron beam is higher than that of the first one,but the electron energy is less.

关键词： diffuse discharge runaway electrons streamer breakdown displacement current

Were Late Cretaceous extinctions of gastropods selective by generic longevity?

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Geoscience Frontiers 2013年第1期4卷 87-93页

作者： dmitry A.Ruban Division of Mineralogy and Petrography Geology and Geography FacultySouthern Federal University

Many gastropod taxa went extinct during the Late Cretaceous. The stratigraphic ranges of 268 genera permit to establish the longevity of extinction victims for each stage of this epoch. ＂Young＂ taxa （originated within b epochs before the extinction） prevailed among victims of the extinctions in all stages. The proportion of ＂old＂ taxa （originated before the Cretaceous） that went extinct was the highest in the Cenomanian, and it was the lowest in the Coniacian and the Maastrichtian. It appears that the end-Cretaceous mass extinction affected chiefly ＂young＂ taxa. However, the comparison with the earlier time intervals suggests that this pattern of selectivity by generic longevity was not specific for the noted catastrophe, but, in contrast, it was typical for the entire Late Cretaceous. The latest Cenomanian environmental perturbation （OAE2） caused a stronger extinction of＂old＂ taxa, and thus, this biotic crisis was less selective by generic longevity. This hypothesis, however, is not proven by the statistical test.

关键词： Gastropods Extinction Longevity Selectivity Late Cretaceous

Microstructure and thermal properties of dissimilar M300–CuCr1Zr alloys by multi-material laser-based powder bed fusion

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 118-128页

作者： Xiaoshuang Li dmitry Sukhomlinov Zaiqing Que Aerosint SA B-4040 HerstalBelgium Aalto University Department of Chemical and Metallurgical EngineeringEspoo 02150Finland VTT Technical Research Centre of Finland Espoo 02044Finland

Multi-material laser-based powder bed fusion (PbF-Lb) allows manufacturing of parts with 3-dimensional gradient and additional functionality in a single step. This research focuses on the combination of thermally-conductive CuCr1Zr with hard M300 tool *** interface configurations of M300 on CuCr1Zr and CuCr1Zr on M300 were investigated. Ultra-fine grains form at the interface due to the low mutual solubility of Cu and steel. The material mixing zone size is dependent on the configurations and tunable in the range of0.1–0.3 mm by introducing a separate set of parameters for the interface layers. Microcracks and pores mainly occur in the transition *** of these defects, the thermal diffusivity of bimetallic parts with 50vol% of CuCr1Zr significantly increases by 70%–150%compared to pure M300. The thermal diffusivity of CuCr1Zr and the hardness of M300 steel can be enhanced simultaneously by applying the aging heat treatment.

关键词： multi-material additive manufacturing laser-based powder bed fusion thermal diffusivity dissimilar metals copper alloy

Plasma-Assisted Chemistry in High-Speed Flow

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Plasma Science and Technology 2007年第6期9卷 760-765页

作者： Sergey b.LEONOV dmitry A.YARANTSEV Anatoly P.NAPARTOVICH Igor V.KOCHETOV Joint Institute for High Temperature Russian Academy of Science Izhorskaya str.13/19Moscow 125412Russia State

Fundamental problems related to the high-speed combustion are analyzed. The result of plasma-chemical modeling is presented as a motivation of experimental activity. Numerical simulations of the effect of uniform non-equilibrium discharge on the premixed hydrogen and ethylene-air mixture in supersonic flow demonstrate an advantage of such a technique over a heating. Experimental results on multi-electrode non-uniform discharge maintenance behind wallstep and in cavity of supersonic flow are presented. The model test on hydrogen and ethylene ignition is demonstrated at direct fuel injection to low-temperature high-speed airflow.

关键词： high-speed combustion electrical discharge nonequilibrium kinetics

Multivariate statistical and bioinformatic analyses for the seasonal variations of actinobacterial community structures in a drinking water reservoir

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Journal of Environmental Sciences 2024年第3期137卷 1-17页

作者： Haihan Zhang Sixuan Pan benMa Tinglin Huang dmitry b.Kosolapov Manli Ma Xiang Liu Huan Liu Xiaoyan Liu Shaanxi Key Laboratory of Environmental Engineering Key Laboratory of Northwest Water ResourceEnvironment and EcologyMOEXi’an University of Architecture and TechnologyXi’an 710055China School of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Papanin Institute for biology of Inland Waters of Russian Academy of Sciences(IbIW RAS) 109BorokNekouzYaroslavl152742Russia

Actinobacterial community is a conspicuous part of aquatic ecosystems and displays an important role in the case of biogeochemical cycle,but little is known about the seasonal variation of actinobacterial community in reservoir ecological *** this study,the high-throughput techniques were used to investigate the structure of the aquatic actinobacterial community and its inducing water quality parameters in different *** results showed that the highest diversity and abundance of actinobacterial community occurred in winter,with Sporichthya(45.42%)being the most abundant genus and Rhodococcus sp.(29.32%)being the most abundant *** analysis and correlation analysis suggested that in autumn the dynamics of actinobacterial community were infuenced by more factors and Nocardioides ***2R5S2 was the potential keystone species which was negatively correlated with temperature(R=-0.72,Pbacterial community,and the dynamics of temperature,dissolved oxygen(DO),and turbidity are potential conspicuous factors infuencing seasonal actinobacterial community *** partial least squares path modeling further elucidated that the combined effects of DO and temperature not only in the diversity of actinobacterial community but also in other water qualities,while the physiochemical parameters(path coefficient=1.571,Pbacterial community in the drinking water reservoirs and provide scientific guidance for further water quality management and protection in water sources.

关键词： Source water reservoir High-throughput sequencing Correlation analysis Network analysis Partial least squares path modeling

Transformation of the TiNi Alloy Microstructure and the Mechanical Properties Caused by Repeated b2-b190' Martensitic Transformations

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Acta Metallurgica Sinica(English Letters) 2015年第10期28卷 1230-1237页

作者： Anna Churakova dmitry Gunderov Alexander Lukyanov Niklas Nollmann Institute of Molecule and Crystal Physics RAS Ufa State Aviation Technical University Institute of Materials Physics University of Münster

The influences of thermal cycling treatment in the temperature range of b2-b19 martensitic transformations（-150 to 150 °C） on the Ti Ni alloy structure and properties were studied. Different states named the initial coarse-grained（CG） state, the ultrafine-grained（UFG） state after ECAP（with a grain size of 200 nm）, the state after ECAP and cold upsetting by 30% were considered. The results show that the microhardness and the strength increase in all the three *** to the XRD analysis, a more significant increment in the dislocation density, resulting from thermal cycling, is observed in the UFG alloy than in the CG alloy.

关键词： Thermal cycling TiNi alloy Equal-channel angular pressing Martensitic transformation

Leucine-rich repeat-containing G protein-coupled receptor 5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines

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World Journal of Gastroenterology 2021年第15期27卷 1578-1594页

作者： Samah Abdulaali Alharbi dmitry A Ovchinnikov Ernst Wolvetang Physiology Department College of MedicineUmm Al-Qura UniversityMakkah 24231Saudi Arabia Department of Stem Cell Engineering Group Australian Institute for Bioengineering and NanotechnologyThe University of QueenslandBrisbane 4072QLDAustralia Australian Institute for bioengineering and Nanotechnology The University of QueenslandBrisbane 4072QLDAustralia

bACKGROUND Colon cancer cell lines are widely used for research and for the screening of drugs that specifically target the stem cell compartment of colon *** was reported that colon cancer carcinoma specimens contain a subset of leucine-rich repeatcontaining G protein-coupled receptor 5(LGR5)-expressing stem cells,these socalled“tumour-initiating”cells,reminiscent in their properties of the normal intestinal stem cells(ISCs),may explain the apparent heterogeneity of colon cancer cell ***,colon cancer is initiated by aberrant Wnt signaling in ISCs known to express high levels of ***,in vivo reports demonstrate the clonal expansion of intestinal adenomas from a single LGR5-expressing *** To investigate whether colon cancer cell lines contain cancer stem cells and to characterize these putative cancer stem *** A portable fluorescent reporter construct based on a conserved fragment of the LGR5 promoter was used to isolate the cell compartments expressing different levels of LGR5 in two widely used colon cancer cell lines(Caco-2 and LoVo).These cells were then characterized according to their proliferation capacity,gene expression signatures of ISC markers,and their tumorigenic properties in vivo and in *** The data revealed that the LGR5 reporter can be used to identify and isolate a classical intestinal crypt stem cell-like population from the Caco-2,but not from the LoVo,cell lines,in which the cancer stem cell population is more akin to b lymphoma Moloney murine leukemia virus insertion region 1 homolog(+4 crypt)stem *** sub-population within Caco-2 cells exhibits an intestinal cancer stem cell gene expression signature and can both self-renew and generate differentiated LGR5 negative *** data also show that cells expressing high levels of LGR5/enhanced yellow fluorescent protein(EYFP)from this cell line exhibit tumorigenic-like properties in vivo and in *** contrast,cell compartments of LoVo th

关键词： Colorectal cancer Colon cancer cell lines Intestinal stem cell Cancer stem cell Leucine-rich repeat-containing G protein-coupled receptor 5 Heterogenicity