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International recognition of the Ilizarov bone reconstruction techniques: Current practice and research (dedicated to 100th birthday of G. A. Ilizarov)

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World Journal of Orthopedics 2021年第8期12卷 515-533页

作者： Tatiana A Malkova dmitry Y Borzunov Department of Medical Information and Analysis Ilizarov National Medical Research Center for Traumatology and OrthopedicsKurgan 640014Russia Department of Traumatology and Orthopedics Ural State Medical UniversityEkaterinburg 620109Russia

The Ilizarov method is one of the current methods used in bone *** originated in the middle of the past century and comprises a number of bone reconstruction techniques executed with a ring external fixator developed by Ilizarov *** main merits are viable new bone formation through distraction osteogenesis,high union rates and functional use of the limb throughout the course of *** study of the phenomenon of distraction osteogenesis induced by tension stress with the Ilizarov apparatus was the impetus for advancement in bone reconstruction *** then,the original method has been used along with a number of its modifications developed due to emergence of new fixation devices and techniques of their application such as hexapod external fixators and motorized intramedullary lengthening *** gave rise to a relatively new orthopedic subspecialty termed“limb lengthening and reconstruction surgery”.Based on a comprehensive literature search,we summarized the recent clinical practice and research in bone reconstruction by the Ilizarov method with a special focus on its modification and recognition by the world orthopedic *** international influence of the Ilizarov method was reviewed in regard to the origin country of the authors and journal’s *** Ilizarov method and other techniques based on distraction osteogenesis have been used in many countries and on all populated *** proves its international significance and confirms the greatest contribution of Ilizarov GA to bone reconstruction surgery.

关键词： Ilizarov method Ilizarov apparatus Distraction osteogenesis Bone lengthening Bone defect Bone transport Arthrodesis

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Immortalized hippocampal astrocytes from 3xTg-AD mice,a new model to study disease-related astrocytic dysfunction:a comparative review

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Neural Regeneration Research 2023年第8期18卷 1672-1678页

作者： Laura Tapella Giulia Dematteis Armando A Genazzani Massimiliano De Paola dmitry Lim Department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly Department of Neuroscience Mario Negri Institute for Pharmacological Research IRCCSMilanoItaly

Alzheimer's disease(AD)is characterized by complex etiology,long-lasting pathogenesis,and celltype-specific ***,there is no cure for AD,emphasizing the urgent need for a comprehensive understanding of cell-specific ***,principal homeostatic cells of the central nervous system,are key players in the pathogenesis of neurodegenerative diseases,including *** models greatly facilitate the investigation of cell-specific pathological alterations and the dissection of molecular mechanisms and ***-derived and immortalized astrocytic cell lines,alongside the emerging technology of adult induced pluripotent stem cells,are widely used to study cellular dysfunction in ***,no stable cell lines were available from genetic mouse AD ***,we established immortalized hippocampal astroglial cell lines from amyloid-βprecursor protein/presenilin-1/Tau triple-transgenic(3xTg)-AD mice(denominated as wild type(WT)-and 3Tg-iAstro cells)using retrovirus-mediated transduction of simian virus 40 large T-antigen and propagation without clonal selection,thereby maintaining natural heterogeneity of primary *** groups have successfully used 3Tg-iAstro cells for single-cell and omics approaches to study astrocytic AD-related alterations of calcium signaling,mitochondrial dysfunctions,disproteostasis,altered homeostatic and signaling support to neurons,and blood-brain barrier *** we provide a comparative overview of the most used models to study astrocytes in vitro,such as primary culture,tumor-derived cell lines,immortalized astroglial cell lines,and induced pluripotent stem cell-derived *** conclude that immortalized WT-and 3Tg-iAstro cells provide a noncompetitive but complementary,low-cost,easy-to-handle,and versatile cellular model for dissection of astrocyte-specific AD-related alterations and preclinical drug discovery.

关键词： Alzheimer's disease astrocytes immortalization astroglial Alzheimers's disease model blood-brain barrier calcium signaling central nervous system homeostasis disproteostasis endoplasmic reticulum-mitochondria contacts induced pluripotent stem cell-derived astrocytes protein synthesis

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＂Malignant＂ right coronary artery presenting as an ST-segment elevation myocardial infarction -a case report

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Journal of Geriatric Cardiology 2018年第6期15卷 467-468页

作者： Cherisse Baldeo Karan Seegobin dmitry Yaranov Fabiana Rollini Department of Internal Medicine University of Florida Jacksonville Florida USA Department of Cardiology University of Florida Jacksonville Florida USA

ST elevation on ECG in the setting of mesenteric ischemia has been reported.[1] From three prior reports, only one had a true ST elevation myocardial infarction （STEMI） coexisting with mesenteric ischemia. In patients with a strong cardiac history, distinguishing between these two conditions can be challenging. We present the case of a 79-year-old Caucasian female presented with 3-h history acute-onset epigastric pain. Medical history was significant for ischemic heart disease with prior coronary artery bypass grafts.

关键词： Anomalous Myocardial infarction Right coronary artery

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Antiangiogenic therapy for portal hypertension in liver cirrhosis: Current progress and perspectives

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World Journal of Gastroenterology 2018年第33期24卷 3738-3748页

作者： dmitry Victorovich Garbuzenko Nikolay Olegovich Arefyev Evgeniy Leonidovich Kazachkov Department of Faculty Surgery South Ural State Medical University Department of Pathological Anatomy and Forensic Medicine South Ural State Medical University

Developing medicines for hemodynamic disorders that are characteristic of cirrhosis of the liver is a relevant problem in modern hepatology. The increase in hepatic vascular resistance to portal blood flow and subsequent hyperdynamic circulation underlie portal hypertension(PH) and promote its progression, despite the formation of portosystemic collaterals. Angiogenesis and vascular bed restructurization play an important role in PH pathogenesis as well. In this regard, strategic directions in the therapy for PH in cirrhosis include selectively decreasing hepatic vascular resistance while preserving or increasing portal blood flow, and correcting hyperdynamic circulation and pathological angiogenesis. The aim of this review is to describe the mechanisms of angiogenesis in PH and the methods of antiangiogenic therapy. The Pub Med database, the Google Scholar retrieval system, and the reference lists from related articles were used to search for relevant publications. Articles corresponding to the aim of the review were selected for 2000-2017 using the keywords: "liver cirrhosis", "portal hypertension", "pathogenesis", "angiogenesis", and "antiangiogenic therapy". Antiangiogenic therapy for PH was the inclusion criterion. In this review, we have described angiogenesis inhibitors and their mechanism of action in relation to PH. Although most of them were studie donly in animal experiments, this selective therapy for abnormally growing newly formed vessels is pathogenetically reasonable to treat PH and associated complications.

关键词： Liver cirrhosis Portal hypertension Pathogenesis Angiogenesis Antiangiogenic therapy

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Influence of wing flexibility on the aerodynamic performance of a tethered flapping bumblebee

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Theoretical & Applied Mechanics Letters 2020年第6期10卷 382-389页

作者： Hung Truong Thomas Engels dmitry Kolomenskiy Kai Schneider Aix-Marseille Université CNRSCentrale MarseilleI2MMarseilleFrance University of Rostock Institute of BiosciencesAnimal PhysiologyRostockGermany Global Scientific Information and Computing Center Tokyo Institute of TechnologyMegurokuTokyoJapan

The sophisticated structures of flapping insect wings make it challenging to study the role of wing flexibility in insect *** this study,a mass-spring system is used to model wing structural dynamics as a thin,flexible membrane supported by a network of *** vein mechanical properties can be estimated based on their diameters and the Young's modulus of *** order to analyze the effect of wing flexibility,the Young's modulus is varied to make a comparison between two different wing models that we refer to as flexible and highly *** wing models are coupled with a pseudo-spectral code solving the incompressible Navier–Stokes equations,allowing us to investigate the influence of wing deformation on the aerodynamic efficiency of a tethered flapping *** to the bumblebee model with rigid wings,the one with flexible wings flies more efficiently,characterized by a larger lift-to-power ratio.

关键词： Insect flight Wing elasticity Mass-spring model Fluid-structure interaction Spectral method Volume penalization method

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Features of adult neurogenesis and neurochemical signaling in the Cherry salmon Oncorhynchus masou brain

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Neural Regeneration Research 2013年第1期8卷 13-23页

作者： Evgeniya V. Pushchina dmitry K. Obukhov Anatoly A. Varaksin Laboratory of Cytophysiology Institute of Marine Biology Far East Branch Russian Academy of Sciences St. Petersburg State University

We investigated the distribution of gamma aminobutyric acid, tyrosine hydroxylase and nitric oxide-producing elements in a cherry salmon Oncorhynchus masou brain at various stages of postnatal ontogenesis by immunohistochemical staining and histochemical staining. The periventricular region cells exhibited the morphology of neurons and glia including radial glia-like cells and contained several neurochemical substances. Heterogeneous populations of tyrosine hydroxylase-, gamma aminobutyric acid-immunoreactive, as well as nicotinamide adenine dinucleotide phosphate diaphorase-positive cells were observed in proliferating cell nuclear antigen-immunoreactive proliferative zones in periventricular area of diencephalon, central grey layer of dorsomedial tegmentum, medulla and spinal cord. Immunolocalization of Pax6 in the cherry salmon brain revealed a neuromeric construction of the brain at various stages of postnatal ontogenesis, and this was confirmed by tyrosine hydroxylase and gamma aminobutyric acid labeling.

关键词： neural regeneration neurogenesis teleostei adult neurogenesis neurotransmitter signaling migration tyrosine hydroxylase gamma aminobutyric acid development Pax6 NADPH-diaphorase proliferation grant-supported paper neuroregeneration

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Lagoonal carbonate deposition preceding rifting-related uplift:evidence from the Bartonian-Priabonian(Eocene)of the northwestern Gulf of Suez(Egypt)

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Journal of Palaeogeography 2022年第1期11卷 8-30页

作者： Emad S.Sallam dmitry A.Ruban A.J.(Tom)Van Loon Department of Geology Faculty of ScienceBen ha UniversityFarid Nad a Street 15Ben ha 13518Egypt K.G.Razumovsky Moscow State University of Technologies and Management(the First Cossack University) Zemlyanoy Val Street 73Moscow 109004Russia c College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590ShandongChina

Sedimentary successions in the northwestern Gulf of Suez provide important clues to the understanding of the geological evolution of NE Africa during the middle and late *** study focuses on detailed facies analyses in order to characterize the depositional environments and system tracts of the Bartonian-Priabonian succession cropping out in this ***-Priabonian carbonate deposits in five stratigraphic sections constitute,from base to top,the Gebel Hof,Observatory,Sannur,Qurn,and Wadi Hof *** formations contain four local assemblage zones of larger benthic *** of litho-,bio-,and microfacies in the succession resulted in the recognition of 12 lithofacies *** lithofacies are represented by packages of lime-mudstones,wackestones,packstones,pack-to grainstones,grainstones,rudstones,boundstones and *** lithofacies have been grouped into four geneticallyrelated facies associations that represent,respectively,tidal flats/shallow subtidal,restricted-shelf/lagoonal,shoal bar,and outer-shelf lagoon/reefal depositional environments in a downslope shallow-marine inner-ramp *** vertical transitions of these facies associations,representing facies changes through time,imply fluctuations of the regional sea *** two peaks in the Bartonian correspond to well-known global eustatic sea-level rises;the pronounced Priabonian regression must be ascribed to the known global eustatic sea-level fall in combination with regional tectonic *** facies distribution suggests that the study area was located in the direct vicinity of some islands during the Bartonian-Priabonian.

关键词： Lagoonal facies Sea-level fluctuations Middle Eocene Late Eocene Eastern Desert

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Electrical Excitation of Long-Range Surface Plasmons in PC/OLED Structure with Two Metal Nanolayers

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Nano-Micro Letters 2020年第3期12卷 69-76页

作者： Valery Konopsky Valery Prokhorov dmitry Lypenko Artem Dmitriev Elena Alieva Giovanni Dietler Sergey Sekatskii Institute of Spectroscopy Russian Academy of SciencesFizicheskaya5TroitskMoscowRussia 108840 Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of Sciences Leninsky pr.31/4MoscowRussia 119071 Laboratoire de Physique de La Matière Vivante IPHYSEcole Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland

A current-driven source of long-range surface plasmons(LRSPs)on a duplex metal nanolayer is *** excitation of LRSPs was experimentally observed in a planar structure,where an organic light-emitting film was sandwiched between two metal nanolayers that served as *** achieve the LRSP propagation in these metal nanolayers at the interface with air,the light-emitting structure was bordered by a one-dimensional photonic crystal(PC)on the other *** dispersion of the light emitted by such a hybrid PC/organic-light-emitting-diode structure(PC/OLED)comprising two thin metal electrodes was obtained,with a clearly identified LRSP resonance peak.

关键词： Surface plasmons Photonic crystal waveguides Light-emitting polymers

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Tumor cell death visualization of renal cell carcinoma under the combined effect of the Gratiola officinalis extract and cyclophosphamide using fluorescent staining methods

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Journal of Innovative Optical Health Sciences 2021年第5期4卷 46-52页

作者： Artyom Mylnikov Nikita Navolokin dmitry Mudrak Natalya Polukonova Alla Bucharskaya Galina Maslyakova Saratov State Medical University named after V.I.Razumovsky 112 Bolshaya Kazachia Street Saratov 410012Russia National Research Saratov State University 83 Astrakhanskaya Street Saratov 410012Russia National Research Tomsk State University 36 Lenin Avenue Tomsk 634050Russia

Objective of the study:We used fluorescence imaging methods of apoptosis and necrosis in human renal carcinoma A498 tumor cells in vitro to reveal the indicated forms of cell death under the combined effect of flavonoid-containing extract of Gratiola officinalis and cytostatic(cyclo-phosphamide).Materials and methods:The dyes were propidium iodide and acridine orange,which were used in the"alive and dead"*** test helped us to identify the total number of dead cells in the forms of necrosis and apoptosis and the number of cells in which apoptosis had started,it was characterized by the appearance of apoptotic bodies or nucleus ***:We found the most pronounced cytotoxic activity at the ratio of extract of Gratiola officinalis and cyclophosphamide concentrations of 1∶*** number of living cells decreased when exposed to the ratio of extract and cytostatic concentrations of 2∶*** the ratio of concentration of the extract relative to the cytostatic increased to 3∶1,the cytostatic activity of the extract began to appear,the total number of tumor cells *** number of cells with nucleus pyknosis and the number of cells with apoptosis signs significantly increased at a 3∶1 ratio of extract and cytostatic concentrations,which confirms the presence of pro-apoptotic activity of the studied *** trend indicates the dependence of a certain form of cell death(apoptosis,necrosis)on the ratio of extract and cytostatic doses,and it also demon-strates the cytostatic and cytotoxic effects of this ***:Fluorescence methods of investigation in the"alive and dead"test allowed us to visualize the forms of cell death of human kidney carcinoma A498 by combined exposure to the fiavonoid-containing extract of Gratiola officinalis and cytostatic(cyclophosphamide)24 h after *** found that the combination with a concentration ratio of the extract and cyclophosphamide of 3:1 has the greatest effectiveness due to stimulation of t

关键词： A498 cell line Gratiola officinalis extract antitumor activity cytostatic activity flavonoids fluorescent methods kidney cancer

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A room-temperature magnetic semiconductor from a Co-Fe-Nb-B metallic glass

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Science China(Physics,Mechanics & Astronomy) 2023年第4期66卷 94-99页

作者： Yu-Zhang Jiao dmitry VLouzguine-Luzgin Ke-Fu Yao Zheng-Jun Zhang Na Chen Laboratory for Advanced Materials Processing Technology(MOE) State Key Laboratory of New Ceramics and Fine ProcessingSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials(MOE) Schoolof Materials Science and EngineeringTsinghua UniversityBeijing 100084China Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversitySendai 980-8577Japan Mathematics for Advanced Materials-OIL National Institute of Advanced Industrial Science and Technology(AIST)Sendai 980-8577Japan

Magnetic semiconductors with Curie temperatures higher than room temperature show potential for developing spintronic devices with combined data processing and storage functions for next-generation computing *** this study,we present an n-type Co_(19.8)Fe_(8.6)Nb_(4.3)B_(6.0)O_(61.3) magnetic semiconductor with a high Curie temperature of~559 *** magnetic semiconductor has a room-temperature resistivity of~2.10×10^(4)Ωcm and a saturation magnetization of~76 emu/cm^(3).The n-type Co_(19.8)Fe_(8.6)Nb_(4.3)B_(6.0)O_(61.3)magnetic semiconductor was deposited on p-type silicon to form a heterojunction,exhibiting a rectifying *** results provide the design principles for discovering high Curie temperature magnetic semiconductors with determined conduction types,which would play an essential role in realizing nonvolatile spin-based transistors that break free from the confines of currently established Si-based information technology.

关键词： magnetic semiconductor ferromagnetic metallic glass high Curie temperature

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