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Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

Light(Science & Applications) 2020年第1期9卷 346-357页

作者： Timur Ermatov Roman E.Noskov Andrey AMachnev Ivan Gnusov Vsevolod Atkin Ekaterina N.Lazareva Sergei V.German Sergey S.Kosolobov Timofei S.Zatsepin Olga V.Sergeeva Julia S.Skibina Pavel Ginzburg Valery V.Tuchin Pavlos G.Lagoudakis dmitry a.gorin Skolkovo Institute of Science and Technology 3 Nobelya str.Moscow 121205Russia Department of Electrical Engineering Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Light-Matter Interaction Centre Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Saratov State University 83 Astrakhanskaya str.Saratov 410012Russia Tomsk State University 36 Lenin’s av.Tomsk 634050Russia M.V.Lomonosov Moscow State University Leninskie Gory1-3Moscow 119992Russia SPE LLC Nanostructured Glass Technology 10150 Let OktjabrjaSaratov 410033Russia Center for Photonics and 2D Materials Moscow Institute of Physics and TechnologyDolgoprudny 141700Russia Institute of Precision Mechanics and Control of the Russian Academy of Sciences 24 Rabochaya str.Saratov 410028Russia

The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical *** common strategy,however,disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral ***,we address this issue by introducing the approach of in-fibre multispectral optical sensing(IMOS).The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid *** offers a unique opportunity to measure the refractive index at 42 wavelengths,with a sensitivity up to ~3000 nm per refractive index unit(RIU)and a figure of merit reaching 99 RIU^(−1) in the visible and near-infra-red spectral *** apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.

关键词： refractive spectral microstructure

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Flexible surface-enhanced Raman scattering-active substrates based on nanofibrous membranes

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Nano Research 2018年第9期11卷 4468-4488页

作者： Ekaterina S. Prikhozhdenko Daniil N. Bratashov dmitry A. gorin Alexey M. Yashchenok Remote Controlled Theranostic Systems Lab Education and Research Institute of Nanostructures and Biosystems Saratov State University 83 As trakhanskaya Str. Saratov 410012 Russia Skoltech Center for Photonics and Quantum Materials Skolkovo Institute of Science and Technology Skolkovo Innovation Center 3 Nobel Str. Moscow 143026 Russia

Surface-enhanced Raman scattering （SERS） has emerged as an excellent analytical tool for the effective detection and fingerprint identification of various chemicals. Recently, significant progress has been made in the fabrication of SERS-active substrates using simple, inexpensive, and affordable methods. The full potential of universal SERS diagnostics will likely be realized with the development of approaches and devices capable of effectively detecting analytes on various surfaces as well as in multicomponent media. In addition, the combination of implantable or wearable SERS-active substrates and remote portable devices enables real-time diagnostics that ideally fit the concept of personalized medicine. In this paper, we summarize recent achievements in fabricating flexible SERS substrates made of cellulose paper, polymer membranes, and textile fibrous films. Emphasis is placed on the in-situ extraction and detection of various chemicals in real-world surfaces and complex media using flexible nanofibrous SERS platforms. The potential SERS applications and future perspectives in on-site diagnostics are also discussed.

关键词： paper electrospun membrane fabric surface-enhanced Ramanspectroscopy on-site diagnostics swabbing

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