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Pharmacogenetic-Guided Warfarin Dosing in Russian Patients： A Meta-analysis

Journal of Pharmacy and Pharmacology 2014年第5期2卷 313-321页

作者： dmitriy sychev dmitriy Ivashchenko Ilya Rusin Department of Therapeutics and Clinical Pharmacology Russian State Medical Academy of Postgraduate Education Moscow123995 Russian Federation Department of Clinical Pharmacology I.M. Sechenov First Moscow State Medical University Moscow 119991 Russian Federation Department of Biological Therapy of Mental Disorders SaintPetersburg V.M. Bekhterev Psychoneurological Research InstituteSaintPetersburg192019 Russian Federation Medical Faculty I.M. Sechenov First Moscow State Medical University Moscow 119991 Russian Federation

We performed the first meta-analysis of Russian prospective studies and compared a dose-selection strategy that used pharmacogenetic information to one that did not. We searched PubMed and eLibrary through September 30, 2013. We included seven Russians prospective studies that compared pharmacogenetic-guided warfarin dosing group, using polymorphisms of CYP2C9, VKORC1 and CYP4F2, to a dosing algorithm that did not incorporate genetic testing. Clinical outcomes were both the major and minor bleedings and the cases of elevated INR. Quantitative data synthesis was performed using MIX Pro 2.0. 6 studies compared the cases of bleedings between two groups. There was no evidence of statistical heterogeneity, so patient＇s characteristics could not impact on results. Genetic-based warfarin dosing decreases the risk of bleeding. Pooled odds ratio was significant for＂major＂（OR = 0.07, 95% CI 0.008-0.54; P = 0.01） and both ＂minor＂ and ＂major＂ bleedings （OR = 0.49; 95% CI 0.31-0.78; P = 0.002）. Six studies evaluated the cases of elevated INR. There was no evidence of statistical heterogeneity （Q-test P = 0.13, 12 = 40%）. Four studies were powered to show a difference in elevated INR （P 〈 0.05）. Pooled odds ratio was significant （OR = 0.21, 95% CI 0.15-0.3; P 〈 0.01）. The intervention groups contained the fewer cases of elevated INR compared to the control groups. Genotype-based warfarin dosing reduces the risk ofbleedings （especially major bleedings） and cases of elevated INR. Results of meta-analysis depend on the quality of included studies and should be interpreted with caution.

关键词： Warfarin pharmacogenomics bleeding INR meta-analysis Russian.

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CYP2C19＊2, CYP2C19＊3, CYP2C19＊17 Allele and Genotype Frequencies in Clopidogrel-Treated Patients with Coronary Heart Disease in Russian

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Journal of Pharmacy and Pharmacology 2014年第5期2卷 322-326页

作者： Karin Badavievich Mirzaev dmitriy Alekseyevich sychev Alia Sergeyevna Yugay Andrey Vladimirovich Grachev Ruslan Yevgenyevich Kazakov Department of Clinical Pharmacology 1.M. Sechenov First Moscow State Medical University Moscow 119991 Russian Federation Department of Therapeutics and Clinical Pharmacology Russian Medical Academy of Postgraduate Education Moscow 123995Russian Federation Department of Cardiology "SM-clinic" Medical Center Moscow 134544 Russian Federation Center for Clinical Pharmacology Scientific Center on Expertise of Medical Application Products Moscow 109240 Russian Federation

Individual variation in the response to drug therapy has been mainly attributed to the genetic polymorphism of cytochrome P 450 isoenzymes. Mutation in the gene CYP2C19 （cytochrome P450 2C19） has been shown to influence the clinical efficiency of clopidogrel. The aim is to investigate the frequencies of CYP2C19＊2 （c.G681A; rs4244285）, CYP2C19＊3 （c.G636A; rs4986893）, CYP2C19＊17 （c.C806T; rs12248560） and to compare the allele and genotype frequencies of CYP2C19＊2 in patients with CHD （coronary heart disease） to healthy volunteers. We examined 53 patients with CHD received clopidogrel and 146 healthy volunteers. CYP2C19＊2, CYP2C19＊3, CYP2C19＊17 carriages were determined by a polymerase-chain reaction. The observed genotype distribution did not deviate from Hardy-Weinberg equilibrium, it was determined by a Chi-square test with Yates correction. The frequency of CYP2C19＂2 allele reported in patients with CHD and in the healthy volunteers was 16.6% and 13.3%, respectively （P = 0.584）. The results of the present study may be helpful in developing current and future directions for its management.

关键词： CYP2C19*2 CYP2C19*17 CYP2C19 polymorphism pharmacogenetics clopidogrel resistance Russian population.

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A hybrid machine learning approach based study of production forecasting and factors influencing the multiphase flow through surface chokes

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Petroleum 2024年第2期10卷 354-371页

作者： Waquar Kaleem Saurabh Tewari Mrigya Fogat dmitriy A.Martyushev Department of Industrial and Manufacturing Engineering The Pennsylvania State University Department of Data Sciences Gyan Ganga Institute of Technology and Sciences Department of Petroleum and Geo-Engineering Rajiv Gandhi Institute of Petroleum Technology Jais Department of Oil and Gas Technologies Perm National Research Polytechnic University

Surface chokes are widely utilized equipment installed on wellheads to control hydrocarbon flow *** correlations have been suggested to model the multiphase flow of oil and gas via surface ***, substantial errors have been reported in empirical fitting models and correlations to estimate hydrocarbon flow because of the reservoir's heterogeneity, anisotropism, variance in reservoir fluid characteristics at diverse subsurface depths, which introduces complexity in production data. Therefore,the estimation of daily oil and gas production rates is still challenging for the petroleum ***, hybrid data-driven techniques have been reported to be effective for estimation problems in various aspects of the petroleum domain. This paper investigates hybrid ensemble data-driven approaches to forecast multiphase flow rates through the surface choke(viz. stacked generalization and voting architectures), followed by an assessment of the impact of input production control ***, machine learning models are also trained and tested individually on the production data of hydrocarbon wells located in North Sea. Feature engineering has been properly applied to select the most suitable contributing control variables for daily production rate forecasting. This study provides a chronological explanation of the data analytics required for the interpretation of production data. The test results reveal the estimation performance of the stacked generalization architecture has outperformed other significant paradigms considered for production forecasting.

关键词： Machine learning Tree-based methods Stacking ensemble Multiphase flow Data analytics Wellhead choke variables

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Early Neoproterozoic Granite-Gneisses of the Junggar Alataw(Southeastern Kazakhstan):Age,Petrogenesis and Tectonic Implications

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 67-82页

作者： Nadezhda KANYGINA Andrey TRETYAKOV dmitriy ALEXEIEV Kirill DEGTYAREV Anfisa SKOBLENKO Natalia SOLOSHENKO Boris ERMOLAEV Geological Institute Russian Academy of SciencesMoscow 119017Russia A.N.Zavaritsky Institute of Geology and Geochemistry Ural Branch of the Russian Academy of SciencesYekaterinburg 620016Russia

The combined petrographic,petrological,geochemical and geochronological study of the Neoproterozoic gneisses of the Sarychabyn and Baskan complexes of the Junggar Alataw of South Kazakhstan elucidate the Precambrian tectonic evolution of the Aktau–Yili *** is one of the largest Precambrian crustal blocks in the western Central Asian orogenic *** U-Pb single-grain zircon ages indicate that granite-gneisses formed from the same source and crystallised in the early Neoproterozoic ca.930–920 *** chemical composition of gneisses corresponds to A2-type *** whole-rock Nd isotopic characteristics(εNd(t)=−4.9 to−1.0 and TNd(DM-2st)=1.9 to 1.7 Ga)indicate the involvement of Paleoproterozoic crustal rocks in magma *** Neoproterozoic ca.930–920 Ma A-type granitoids in the Aktau–Yili terrane of South and Central Kazakhstan might reflect within-plate magmatism adjacent to the collisional belt or a local extension setting in back-arc areas of the continental arc.

关键词： granitoid magmatism geochemistry geochronology Sm-Nd isotope systematics Neoproterozoic Junggar Alataw Kazakhstan Central Asian orogenic belt

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Acute Colonic Pseudo-Obstruction (ACPO): An Expanding Colon with Unusual Risk Factors

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Open Journal of Internal Medicine 2024年第2期14卷 167-174页

作者： Kelly Schulte Alyson Terry Grace Boyle dmitriy Scherbak HCA Healthone Sky Ridge Medical Center Lone Tree Colorado USA

The distention of the colon without mechanical or anatomical obstruction, Acute Colonic Pseudo-obstruction (ACPO), is a common condition occurring in the critically ill. ACPO in the setting of an acute pulmonary embolism and embolic stroke is a rarity. A 76-year-old female with shortness of breath, left hemiparesis and right-sided paresthesias presented with acute pulmonary embolism and acute infarcts of the left caudate nucleus, thalamus and occipital lobe. Her hospitalization was complicated with persistent distention of the large bowel without dilation of the small bowel. Empiric antibiotics were initiated without improvement and laboratory studies including Clostridium difficile were negative. She underwent nasogastric decompression and two decompressive colonoscopies with a resolution of her symptoms. This case illustrates an example of acute abdominal distension, without underlying etiology, in the setting of acute embolism of the pulmonary and cerebral vasculature. Early identification and action with decompressive colonoscopy were key to preventing further bowel damage or rupture.

关键词： Acute Colonic Pseudo-Obstruction ACPO Ogilvie’s Syndrome Colonic Dilation Acute Embolic Infarcts Cerebrovascular Accident Pulmonary Embolism PE

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Elucidating elusive quaternary selenide EuCeCuSe3:Synthesis,crystal structure,properties and theoretical studies

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Journal of Rare Earths 2024年第1期42卷 163-171,I0006页

作者： Maxim V.Grigoriev Anna V.Ruseikina Maxim S.Molokeev Vladimir A.Chernyshev Aleksandr S.Aleksandrovsky Alexander S.Krylov Svetlana N.Krylova Nikolai P.Shestakov dmitriy A.Velikanov Alexander A.Garmonov Alexey V.Matigorov Evgeny A.Ostapchuk Thomas Schleid Damir A.Safin Laboratory of Theory and Optimization of Chemical and Technological Processes University of TyumenVolodarskogo Str.6625003TyumenRussian Federation Kirensky Institute of Physics Federal Research Center KSC SB RASAkademgorodok 50 Bld.38660036KrasnoyarskRussian Federation Department of Physics Far Eastern State Transport UniversitySerysheva Str.47680021KrasnoyarskRussian Federation Institute of Natural Sciences and Mathematics Ural Federal University Named After the First President of Russia B.N.YeltsinMira Str.19620002EkaterinburgRussian Federation Department of Photonics and Laser Technology Siberian Federal UniversitySvobodnii Ave.79660079KrasnoyarskRussian Federation Institute of Physics and Technology University of TyumenVolodarskogo Str.6625003 TyumenRussian Federation Institute for Inorganic Chemistry University of StuttgartPfaffenwaldring 55D-70569StuttgartGermany Scientific and Educational and Innovation Center for Chemical and Pharmaceutical Technologies Ural Federal University named after the First President of Russia B.N.YeltsinMira Str.19620002 EkaterinburgRussian Federation University of Tyumen Volodarskogo Str.6625003TyumenRussian Federation

We report on the novel heterometallic quaternary selenide EuCeCuSe3,the fabrication of which has been a challenge until this *** structure of the reported selenide was elucidated from the powder X-ray diffraction data,which revealed the formation of EuCeCuSe3with excellent yield(96.7%)accompanied with a minor fraction of CeSe2(3.3%),and was best solved in orthorhombic space group Pnma with the BaLaCuS3structural ***,the crystal structure of the title compound completes the row of the heterometallic quaternary selenides EuRECuSe3(RE=La,Pr,Nd,Sm,Eu,Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y),of which the cerium-based derivative exclusively belongs to the BaLaCuS3structural *** distortion of the CuSe4polyhedron was compared for the whole series of EuRECuSe3compounds using theτ4-descriptor for four coordinated ions,which revealed the highest degree of distortion for the Ce3+-containing selenide,followed by the La3+-based ***,the crystallographic and geometrical parameters of the reported selenide were discussed in comparison to the Ce3+-based sulfides SrCeCuS3and *** initio calculations of the crystal structure,a phonon spectrum and elastic constants for the crystal of EuCeCuSe3were also *** types and wavenumbers of fundame ntal modes were determined and the involvement of ions participating in the phonon modes was *** experimental IR spectrum of the reported selenide was interpreted and found to be in agreement with the calculated *** experimental direct band gap of EuCeCuSe3was measured to be 1.36 eV that is consistent with the concept of its origin due to interband transitions between orbitals emerging mainly from 4f(valence band)and 5d(conduction band)levels of the Eu2+*** dependence of the Young’s modulus on the direction demonstrates the anisotropy of the elastic properties,while the Vickers hardness for EuCeCuSe3was calculated to be 5.2 ***,the title compound is paramagnetic above 4 K.

关键词： Quaternary selenide Synthesis Crystal structure Ab initio calculations Magnetic measurements Spectroscopy

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Polariton lasing in Mie-resonant perovskite nanocavity

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Opto-Electronic Advances 2024年第4期7卷 27-42页

作者： Mikhail A.Masharin Daria Khmelevskaia Valeriy I.Kondratiev Daria I.Markina Anton D.Utyushev dmitriy M.Dolgintsev Alexey D.Dmitriev Vanik A.Shahnazaryan Anatoly P.Pushkarev Furkan Isik Ivan V.Iorsh Ivan A.Shelykh Hilmi V.Demir Anton K.Samusev Sergey V.Makarov UNAM-Institute of Materials Science and Nanotechnology National Nanotechnology Research CenterDepartment of Electrical and Electronics EngineeringDepartment of PhysicsBilkent UniversityAnkara 06800Turkey ITMO University School of Physics and EngineeringSt.Petersburg 197101Russia Abrikosov Center for Theoretical Physics MIPTDolgoprudnyiMoscow Region 141701Russia LUMINOUS!Center of Excellence for Semiconductor Lighting and Displays School of Electrical and Electronic EngineeringSchool of Physical and Mathematical SciencesSchool of Materials Science and EngineeringNanyang Technological UniversitySingapore 639798Singapore Department of Physics Engineering Physics and AstronomyQueen’s UniversityKingstonOntario K7L 3N6Canada Science Institute University of IcelandDunhagi 3IS-107ReykjavikIceland Experimentelle Physik 2 Technische Universität DortmundDortmund 44227Germany Qingdao Innovation and Development Center Harbin Engineering UniversityQingdao 266000China

Deeply subwavelength lasers(or nanolasers)are highly demanded for compact on-chip bioimaging and sensing at the *** of the main obstacles for the development of single-particle nanolasers with all three dimensions shorter than the emitting wavelength in the visible range is the high lasing thresholds and the resulting *** we ex-ploit exciton-polariton condensation and mirror-image Mie modes in a cuboid CsPbBr3 nanoparticle to achieve coherent emission at the visible wavelength of around 0.53μm from its ultra-small(≈0.007μm3 or≈λ3/20)semiconductor *** polaritonic nature of the emission from the nanocavity localized in all three dimensions is proven by direct com-parison with corresponding one-dimensional and two-dimensional waveguiding systems with similar material *** a deeply subwavelength nanolaser is enabled not only by the high values for exciton binding energy(≈35 meV),re-fractive index(>2.5 at low temperature),and luminescence quantum yield of CsPbBr3,but also by the optimization of po-laritons condensation on the Mie resonances with quality factors improved by the metallic ***,the key parameters for optimal lasing conditions are intermode free spectral range and phonons spectrum in CsPbBr3,which govern polaritons condensation *** chemically synthesized colloidal CsPbBr3 nanolasers can be potentially de-posited on arbitrary surfaces,which makes them a versatile tool for integration with various on-chip systems.

关键词： nanolaser perovskite polariton Mie resonance exciton-polariton

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Exploring van der Waals materials with high anisotropy:geometrical and optical approaches

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Light(Science & Applications) 2024年第4期13卷 645-653页

作者： Aleksandr S.Slavich Georgy A.Ermolaev Mikhail K.Tatmyshevskiy Adilet N.Toksumakov Olga G.Matveeva dmitriy V.Grudinin Kirill V.Voronin Arslan Mazitov Konstantin V.Kravtsov Alexander V.Syuy Dmitry M.Tsymbarenko Mikhail S.Mironov Sergey M.Novikov Ivan Kruglov Davit A.Ghazaryan Andrey A.Vyshnevyy Aleksey V.Arsenin Valentyn S.Volkov Kostya S.Novoselov Moscow Center for Advanced Studies Kulakova str.20Moscow 123592Russia. Emerging Technologies Research Center XPANCEOInternet CityEmmay TowerDubaiUnited Arab Emirates. Donostia International Physics Center(DIPC) Donostia/San-Sebastián 20018Spain. Institute of Materials Ecole Polytechnique Federale de Lausanne1015 LausanneSwitzerland. Department of Chemistry Lomonosov Moscow State UniversityMoscow 119991Russia. Laboratory of Advanced Functional Materials Yerevan State UniversityYerevan 0025Armenia. National Graphene Institute(NGI) University of ManchesterManchester M139PLUK. Department of Materials Science and Engineering National University of SingaporeSingapore 03-09 EASingapore. Institute for Functional Intelligent Materials National University of Singapore117544 SingaporeSingapore

The emergence of van der Waals(vdW)materials resulted in the discovery of their high optical,mechanical,and electronic anisotropic properties,immediately enabling countless novel phenomena and *** success inspired an intensive search for the highest possible anisotropic properties among vdW ***,the identification of the most promising among the huge family of vdW materials is a challenging quest requiring innovative ***,we suggest an easy-to-use method for such a survey based on the crystallographic geometrical perspective of vdW materials followed by their optical *** our approach,we found As2S3 as a highly anisotropic vdW *** demonstrates high in-plane optical anisotropy that is~20%larger than for rutile and over two times as large as calcite,high refractive index,and transparency in the visible range,overcoming the century-long record set by *** these benefits,As2S3 opens a pathway towards nextgeneration nanophotonics as demonstrated by an ultrathin true zero-order quarter-wave plate that combines classical and the Fabry–Pérot optical phase ***,our approach provides an effective and easy-to-use method to find vdW materials with the utmost anisotropic properties.

关键词： anisotropy anisotropic high

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Geothermal Model of the Fore-Yenisey Sedimentary Basin——Transitional Structure between the Ancient Siberian Platform and the Young West Siberian Plate

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Acta Geologica Sinica(English Edition) 2022年第2期96卷 582-590页

作者： dmitriy NOVIKOV Fedor DULTSEV Yuriy FILIPPOV Trofimuk Institute of Petroleum Geology and Geophysics SB RASNovosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090Russia

Results of the investigation into the geothermal regime of the Fore-Yenisey sedimentary basin, formed during the collision and subsidence of the Kas-Turukhan microcontinent and the western margin of the Siberian craton in the late Neoproterozoic and early Paleozoic are reported. It was established that the structural and geothermal conditions of the upper Precambrian–Paleozoic sections are similar to those in the western regions of the Siberian platform and are characterized by rather low geothermal gradients(12.5–25.5 ℃/km). In the western parts of the basin, formation temperatures in the uppermost pre-Jurassic sediments are 50℃–85℃, decreasing eastward to 30℃–55℃. For the first time, the detailed geothermal model of the basin sedimentary fill was developed. This model allows predictions of the geothermal conditions of Earth’s interior.

关键词： geothermal model formation temperature Fore-Yenisey sedimentary basin West Siberia

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Modeling of rotational supercavitating evaporator and the geometrical characteristics of supercavity within

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Science China(Physics,Mechanics & Astronomy) 2014年第3期57卷 541-554页

作者： LIKHACHEV dmitriy S. LI FengChen Complex Flow and Heat Transfer Laboratory School of Energy Science and EngineeringHarbin Institute of Technology

In this paper,a rotational supercavitating evaporator(RSCE)was at first modeled by means of theoretical analysis *** geometrical characteristics of supercavity in the modeled RSCE were then studied through numerical *** current research objectives consist in determination of shape of the supercavitator(which in the plane of rotation generates supercavity occupying the most volume between blades),and location of the area suitable for steam extraction by revealing the inner structure of *** analysis was performed by solving empirical equations for the shape of RSCE,through which an evaluation of two-dimensional relative position of supercavity trailing edge for different shapes of the supercavitator has been *** simulation was then carried out,by numerically solving the unsteady Navier-Stokes equations in their conservation form coupled with the Rayleigh-Plesset cavitation and Shear-Stress Transport turbulence models,for verification of the results obtained from empirical *** unreliable assumption of applicability of empirical equations we have confirmed similarity of the supercavity shapes obtained by both methods for the same ***,the shape of supercavitator calculated by using empirical equations is acceptable,which provides a simple but reliable approach for design of *** inner structure of supercavity obtained by numerical simulation has indicated position and parameters for steam extraction openings for further numerical and experimental studies on the performance of *** application of steam or gas extraction is suggested for solving of some problems associated with cavitating pumping of cryogenic liquid.

关键词： supercavitation rotational supercavitating evaporator geometrical characteristics theoretical analysis computationalfluid dynamics

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