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Biocompatibility and internalization of molecularly imprinted nanoparticles

Nano Research 2016年第11期9卷 3463-3477页

作者： Francesco Canfarotta Alicia Waters Robyn Sadler Paul McGill Antonio Guerreiro dmitri papkovsky Karsten Haupt Sergey Piletsky MIP Diagnostics Ltd. University of Leicester Fielding Johnson Building University Road Leicester LE 1 7RH UK School of Biochemistry and Cell Biology University College Cork College Road Cork Ireland GSK David Jack Centre for R&D Park Road Ware Hertfordshire SG 12 0DP UK Chemistry Department University of Leicester Leicester LE1 7RH UK Compiegne University of Technology CNRS Enzyme and Cell Engineering Laboratory Rue Roger Couttolenc CS 50319 50203 Compiegne Cedex France

Molecularly imprinted polymers （MIP） are receiving increasing attention thanks to their robustness, stability, and inexpensive manufacture compared with their bio-analogues such as antibodies. The molecular imprinting process can be defined as the generation of molecular recognition sites in a synthetic polymer. The template-derived sites created within a polymeric matrix allow MIPs （often referred as plastic antibodies） to selectively recognize and bind to the target molecule. Therefore, MIPs can be used in sensors and in separation and diagnostics. Owing to their size and functional properties, MIP nanoparticles （NPs） can potentially be used in biomedicine, but comprehensive analysis of their interaction with cells and in vitro toxicological tests must be performed first. Herein, we report the synthesis of bare and core-shell imprinted NPs using an innovative solid-phase approach and the toxicological evaluation of such NPs in different cell lines （HaCaT, MEFs, HT1080, and macrophages）. We also evaluated the influence of the protein corona on particle stability, the internalization of NPs in cells, and the influence of various surface coatings. Studies on the metabolic effects of imprinted NPs on fibroblasts showed that bare MIPs do not alter cell metabolism, whereas some issues arise when specific particle coatings are used. Furthermore, in vitro cytokine release studies revealed that macrophages were not activated in the presence of the MIPs evaluated in this study. The results suggest that MIP NPs are biocompatible, paving the way for their in vivo application.

关键词： pegylation core-shell toxicology inflammatory response particle uptake metabolism

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High temperature deformation and recrystallization behavior of magnesium bicrystals with 90°<1010>and 90°<1120>tilt grain boundaries

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Journal of Magnesium and Alloys 2024年第2期12卷 625-638页

作者： Kevin Bissa Talal Al-Samman dmitri A.Molodov Institute of Physical Metallurgy and Materials Physics RWTH Aachen University52056 AachenGermany International Research Organization for Advanced Science and Technology(IROAST) Kumamoto UniversityKumamoto 860-8555Japan

The deformation mechanisms and dynamic recrystallization(DRX)behavior of specifically grown bicrystals with a symmetric 90°and 90°tilt grain boundary,respectively,were investigated under deformation in plane strain compression at 200℃and 400℃.The microstructures were analyzed by panoramic optical microscopy and large-area electron backscatter diffraction(EBSD)orientation *** analysis employed a meticulous approach utilizing hundreds of individual,small EBSD maps with a small step size that were stitched together to provide comprehensive access to orientation and misorientation data on a macroscopic *** slip primarily governed the early stages of deformation at the two temperatures,and the resulting shear induced lattice rotation around the transverse direction(TD)of the *** existence of the grain boundary gave rise to dislocation pile-up in its vicinity,leading to much larger TD-lattice rotations within the boundary region compared to the *** increasing temperature,the deformation was generally more uniform towards the bulk due to enhanced dislocation mobility and more uniform stress *** recrystallization at 200℃was initiated in{1011}-compression twins at strains of 40%and *** 400℃,DRX consumed the entire grain boundary region and gradually replaced the deformed microstructure with progressing *** recrystallized grains displayed characteristic orientations,such that their c-axes were perpendicular to the TD and additionally scattered between 0°and 60°from the loading *** recrystallized grains displayed mutual rotations of up to 30°around the c-axes of the initial grains,forming a discernible basal fiber texture component,prominently visible in the{1120}pole *** is noteworthy that the deformation and DRX behaviors of the two analyzed bicrystals exhibited marginal variations in response to strain and deformation temperature.

关键词： Elevated deformation temperatures Plain strain compression Magnesium bicrystals Panorama EBSD Dynamic Recrystallization

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The influence of the leading-edge angle of subgrade on the aerodynamic loads of a high-speed train in a wind tunnel

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Transportation Safety and Environment 2024年第2期6卷 45-54页

作者： Zeyun Yang Gang Xu Fan Wu Lei Zhang Jian Du dmitri Vainchtein Key Labor atory of Traffic Safety on Track Ministry of EducationSchool of Traffic&Transportation EngineeringCentral South UniversityChangsha 410075HunanChina CRRC Academy(Qingdao)Co. Ltd.Qingdao 266111ShandongChina CRRC Qingdao Sifang Co. Ltd.Qingdao 266111ShandongChina Nyheim Plasma Institute Drexel UniversityCamden 08103USA

The purpose of this study is to establish the correlation between the boundary layer over the subgrade and the aerodynamic loads act-ing on the train model in conventional wind tunnel ***,flow characteristics around the subgrade with different leading-edge angles(15°,30°and 45°)are investigated through the particle image velocimetry(PIV)experimental test ***,wind tunnel tests of the aerodynamic performance of a high-speed train are carried *** results are compared with previous experimental data obtained by moving model *** show that,due to the presence of a boundary layer,the pressure acting on the lower part of the train head decreases,while other locations are not significantly *** is the reason for the reduction of the aerodynamic drag and lift on the *** addition,the reduction effects become more obvious when the thickness of the boundary layer *** experimental results obtained could serve as a calibration of aerodynamic forces for wind tunnel tests on high-speed trains.

关键词： high-speed train ground effect aerodynamic performance wind tunnel test PIV experiment

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Expanded Porphyrin Exhibiting Off-Centered Out-of-Plane Coordination to Dysprosium

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CCS Chemistry 2024年第7期6卷 1731-1738页

作者： Dmitry I.Nazarov Jorge Labella Alexey V.Kuzmin Maxim A.Faraonov Evgenii N.Ivanov Salavat S.Khasanov Tomas Torres Mikhail K.Islyaikin dmitri V.Konarev Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS 142432 Chernogolovka Department of Organic Chemistry Universidad Autonoma de Madrid28049 Madrid Institute of Solid-State Physics RAS 142432 Chernogolovka Research Institute of Macroheterocycles Ivanovo State University of Chemistry and Technology15300 Ivanovo G.A.Krestov Institute of Solution Chemistry of the Russian Academy of Sciences 153045 Ivanovo Institute for Advanced Research in Chemical Sciences Universidad Autonoma de Madrid28049 Madrid IMDEA-Nanociencia 28049 Madrid

The complexation of high-spin lanthanides to porphyrinoids is a powerful strategy for the development of advanced molecular *** this context,the use of expanded porphyrinoids remains elusive since their coordination chemistry is challenging to ***,taking inspiration from on-surface chemistry,we explored the coordination of Dy^(3+)to a six-membered porphyrinoid,namely,the hemihexaphyrazine ***,we observed the selective formation of a mono-nuclear off-centered,out-of-plane H_(2)Hhp-Dy^(3+)complex when performing the complexation under reductive *** this reaction,the oxidation state of the macrocycle did not *** X-ray diffraction analysis,we found that the coordination number of Dy in this complex was *** macrocycle cocrystallized with decamethylcobaltocene(Cp_(2)^(*)Co)molecules,giving rise to a wellordered solid-state packing,governed byπ-π*** a result of this organization,a small magnetic coupling between the neighboring molecules was *** in all,this work provides key insights into the coordination of magnetically active metals with expanded porphyrinoids,thus motivating the development of advanced spintronic devices.

关键词： porphyrins dysprosium macrocycle coordination chemistry magnetism

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圣彼得堡国立大学百年汉籍收藏钩沉

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东方论坛（青岛大学学报） 2024年第2期 136-148页

作者：张云 [俄]马义德济南大学文学院山东济南250024 圣彼得堡国立大学东方系俄罗斯圣彼得堡199034

圣彼得堡大学的汉籍收藏始于1930年代,一直持续至20世纪中叶,百余年时间共收藏汉籍2200余部。这些汉籍是以王西里院士为代表的圣大东方系几代汉学家积累的遗产。通过对馆藏汉籍的调查,结合文献档案,梳理圣大汉籍收藏历史,重点探讨了西... 详细信息

圣彼得堡大学的汉籍收藏始于1930年代,一直持续至20世纪中叶,百余年时间共收藏汉籍2200余部。这些汉籍是以王西里院士为代表的圣大东方系几代汉学家积累的遗产。通过对馆藏汉籍的调查,结合文献档案,梳理圣大汉籍收藏历史,重点探讨了西维洛夫、沃伊采霍夫斯基、王西里、米哈伊尔·赫拉波维茨基、柏百福等10余位汉学家的汉籍收藏及特点,进一步探清了圣大汉籍收藏相关问题。圣大所藏汉籍孕育了王西里学派,为俄罗斯汉学繁荣奠定了基础,考察其来源对俄国汉学与汉籍研究具有重要的意义。

关键词：圣彼得堡大学汉籍来源

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Deformation behaviour of magnesium bicrystals with symmetrical 90°<1120>tilt grain boundaries analysed by large area EBSD mapping

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Journal of Magnesium and Alloys 2023年第5期11卷 1556-1566页

作者： Kevin Bissa Talal Al-Samman dmitri A.Molodov Institute of Physical Metallurgy and Materials Physics RWTH Aachen University52056AachenGermany International Research Organization for Advanced Science and Technology(IROAST) Kumamoto UniversityKumamoto 860-8555Japan

Grain boundaries play a significant role in the deformation of *** response to deformation is however not completely understood,particularly with respect to how they accommodate lattice rotation of adjoining crystallites by changing their structure and *** current study thus investigates the deformation behaviour of Mg bicrystals with 90°symmetric tilt boundary strained in plane-strain compression up to different final *** to the initial soft orientation of the two crystals,activation of basal slip in each crystal gave rise to lattice rotation around the transverse direction towards the compression direction of the *** of single EBSD maps with a small step size were obtained from the GB region and stitched together to produce large panoramic maps of a macroscopic *** very time-consuming,this technique has proven useful in clarifying the origin of the non-uniform deformation zones in the vicinity of the grain boundary and explains the mechanisms,by which the grain boundary was able to cope with the imposed strain before ***,several variants of extension twins were observed as an additional deformation mechanism despite having negative Schmid *** investigation of their resulting combined shear components with respect to the sample coordinate system revealed an alignment along the longitudinal direction of the channel-die,therefore justifying their nucleation.

关键词： Panorama EBSD Plain strain compression Lattice rotation Magnesium bicrystal Anomalous twins

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Use of folic acid nanosensors with excellent photostability for hybrid imaging

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第9期23卷 784-790页

作者： Denis KUZNETSOV Sergey DEZHUROV dmitri KRYLSKY Valery NOVIKOV Valery NESCHISLIAEV Anastasia KUZNETSOVA G.N.Gabrichevsky Scientific and Research Institute of Epidemiology and Microbiology Moscow125212Russia Research Institute of Applied Acoustics Center of High TechnologiesDubna141980Russia Perm State Medical University Perm614000Russia Perm State Pharmaceutical Academy Perm614990Russia Perm State Humanitarian Pedagogical University Perm614990Russia

Sentinel lymph node(SLN)mapping and tumorboundary delineation play a key role in cancer surgery,as they have great potential to reduce surgical intervention and increase relapse-free survival rates of *** autofluorescence imaging(AFI)method can improve the efficiency of tumor delineation and optimize the scope of surgical intervention,but there are still no fluorescent drugs that can be used with such a method to form a hybrid imaging *** problem is bleaching when fluorescent dyes are conjugated with folic *** study reports,for the first time,nanosensors with excellent photostability and compatibility with endoscopes for AFI,which makes simultaneous hybrid imaging *** functionalization of the quantum dot(QD)surfaces,we found that they bound effectively to MCF-7 cancer *** diagnostic value of simultaneous hybrid imaging using common AFI equipment in delineating tumor boundaries and mapping SLN can reduce the cost of diagnosis and increase its reliability.

关键词： diagnosis drugs mapping

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Carbonated Big Mantle Wedge Extending to the NE Edge of the Stagnant Pacific Slab:Constraints from Late Mesozoic-Cenozoic Basalts from Far Eastern Russia

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Journal of Earth Science 2022年第1期33卷 121-132页

作者： Ronghua Cai Shan Xu dmitri AIonov Jian Huang Sheng-Ao Liu Shuguang Li Jingao Liu State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesBeijing 100083China Géosciences Montpellier Universitéde Montpellier34095 MontpellierFrance CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China

It has been suggested that the carbonated mantle reflected by Mg-Zn isotopic anomalies of Cenozoic intraplate basalts from East Asia coincides with the stagnant West Pacific slab in the mantle transition ***,the northern boundary of such carbonated domain beneath East Asia is *** Mesozoic-Cenozoic intraplate basalts are widespread in far eastern Russia and thus provide an opportunity to examine this *** we report major-trace element contents and Sr-NdMg-Zn isotopic compositions for 9 Late Mesozoic-Cenozoic basaltic samples from the Khanka Block and Sikhote-Alin accretionary *** are characterized by large variations in SiO_(2)contents(41 wt.%to 50 wt.%)and CaO/Al_(2)O_(3)(0.50 to 0.97),enrichments of large-ion lithophile elements(LILE),positive Nb-Ta anomalies and strongly negative K,Pb,Zr,Hf,Ti,Y anomalies in primitive mantle-normalized trace element spider ***,the rocks show good correlations of Ti/Ti^(*)with Hf/Hf^(*),La/Yb,Fe/Mn and trace element contents(e.g.,Nb).In addition,they have lighter Mg and heavier Zn isotope compositions than the BSE estimates,coupled with depleted Sr-Nd isotope *** elemental and isotopic characteristics cannot be explained by alteration,magma differentiation or diffusion,but are consistent with the partial melting of carbonated *** and large,the Late Mesozoic-Cenozoic basalts from far eastern Russia bear very similar geochemical characteristics as those Na-series Cenozoic basalts from eastern *** extended region of Mg-Zn isotopic anomalies is roughly coincident with the stagnant West Pacific slab beneath East Asia,and all of these alkali basalts can be generated from mantle sources hybridized by recycled Mg-carbonates from the Pacific slab stagnant in the mantle transition *** infer that(1)the carbonated big mantle wedge extends to the NE edge of the West Pacific slab and may have also appeared in the Late Mesozoic due to the effect of the Paleo-Pac

关键词： Mg-Zn isotopes deep carbon cycling far eastern Russia isotopes big mantle wedge

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Revealing the dynamics of the alloying and segregation of Pt-Co nanoparticles via in-situ environmental transmission electron microscopy

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Nano Research 2023年第2期16卷 3055-3062页

作者： Xing Li Shaobo Cheng Yanghua He Lixiang Qian dmitri Zakharov Gang Wu Chongxin Shan Liang Zhang Dong Su Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material PhysicsSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Center for Functional Nanomaterials Brookhaven National LaboratoryUptonNY 11973USA Department of Chemical and Biological Engineering University at BuffaloThe State University of New YorkBuffaloNY 14260USA Center for Combustion Energy School of Vehicle and MobilityTsinghua UniversityBeijing 100084China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Thermal treatment is a general and efficient way to synthesize intermetallic catalysts and may involve complicated physical *** far,the mechanisms leading to the size and composition heterogeneity,as well as the phase segregation behavior in Pt-Co nanoparticles(NPs)are still not well *** in-situ environmental transmission electron microscopy,the formation dynamics and segregation behaviors of Pt-Co alloyed NPs during the thermal treatment were *** is found that Pt-Co NPs on zeolitic imidazolate frameworks-67-derived nanocarbon(NC)are formed consecutively through both particle migration coalescence and the Ostwald ripening *** existence of Pt NPs is found to affect the movement of Co NPs during their *** the help of theoretical calculations,the correlations between the composition and migration of the Pt and Co during the ripening process were *** complex alloying processes are revealed as key factors leading to the heterogeneity of the synthesized Pt-Co alloyed *** oxidation environment,the Pt-Co NPs become surface faceted gradually,which can be attributed to the oxygen facilitated relatively higher segregation rate of Co from the(111)*** work advances the fundamental understanding of design,synthesis,and durability of the Pt-based nanocatalysts.

关键词： intermetallic catalyst alloying ripening segregation dynamics environmental transmission electron microscopy(ETEM)

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Recent Progress in One-dimensional ZnS Nanostructures:Syntheses and Novel Properties

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Journal of Materials Science & Technology 2008年第4期24卷 512-519页

作者： Yoshio BANDO dmitri GOLBERG Nanoscale World Premier International Center for Materials Nanoarchitectonics and Nanoscale Materials Center National Institute for Materials ScienceNamiki 1-1TsukbaIbaraki 305-0044Japan

In this review, the progress made during the last two years with respect to the syntheses and novel properties of one-dimensional （1D） ZnS nanostructures is presented. Primarily the research on 1D ZnS nanostructures has been of growing interest owing to their promising applications in nanoscale optoelectronic devices. Diverse 1D ZnS nanostructures with delicately-tuned morphologies, sizes, and microstructures have been synthesized through relatively simple and well-controlled techniques. Some novel properties of the nanomaterials have been explored and the relationships between their structural features and functions have been understood gradually.

关键词： Semiconductors ZnS Nanomaterlals Nanostructures Filed-emitters

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